Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Cell Reports

Volumn 16, Issue 9, 2016, Pages 2327-2338

  McCoy, Laura E ^a,b   van Gils, Marit J ^c   Ozorowski, Gabriel ^a   Messmer, Terrence ^a   Briney, Bryan ^a   Voss, James E ^a   Kulp, Daniel W ^a   Macauley, Matthew S ^a   Sok, Devin ^a   Pauthner, Matthias ^a   Menis, Sergey ^a   Cottrell, Christopher A ^a   Torres, Jonathan L ^a   Hsueh, Jessica ^a   Schief, William R ^a,e   Wilson, Ian A ^a   Ward, Andrew B ^a   Sanders, Rogier W ^c,d   Burton, Dennis R ^a,e  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCAN; NEUTRALIZING ANTIBODY; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; POLYSACCHARIDE; PROTEIN BINDING; VIRUS ANTIBODY;

AMINO ACID SUBSTITUTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; IMMUNOGENICITY; INCIDENCE; NONHUMAN; PRIORITY JOURNAL; RESIDUE ANALYSIS; SENSITIVITY ANALYSIS; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; VIRUS STRAIN; ANIMAL; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; GENETICS; HIV INFECTIONS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; LEPORIDAE; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; VIROLOGY;

AIDS VACCINES; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIBODY SPECIFICITY; BINDING SITES; HIV ANTIGENS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; IMMUNIZATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEUTRALIZATION TESTS; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RABBITS;

EID: 84989809446     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.07.074     Document Type: Article

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