Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1

PLoS Pathogens

Volumn 10, Issue 12, 2014, Pages

  McCoy, Laura E ^a   Rutten, Lucy ^b   Frampton, Dan ^a   Anderson, Ian ^a   Granger, Luke ^c   Bashford Rogers, Rachael ^d   Dekkers, Gillian ^a   Strokappe, Nika M ^b   Seaman, Michael S ^e   Koh, Willie ^a   Grippo, Vanina ^f   Kliche, Alexander ^g   Verrips, Theo ^b   Kellam, Paul ^d   Fassati, Ariberto ^a   Weiss, Robin A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QVQ BV   (Netherlands)

^c GUY S HOSPITAL   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e HARVARD MEDICAL SCHOOL   (United States)

^f Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^g UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GLYCOPROTEIN GP 140; IMMUNOGLOBULIN HEAVY CHAIN; VIRUS ENVELOPE PROTEIN; CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN VARIABLE REGION; NEUTRALIZING ANTIBODY; VIRUS ANTIGEN;

AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR EVOLUTION; NONHUMAN; SEQUENCE HOMOLOGY; VIRUS NEUTRALIZATION; ANIMAL; DISEASE MODEL; GENETICS; HIV INFECTIONS; IMMUNOLOGY; MUTATION; NEW WORLD CAMELID;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; LAMA (MAMMAL); LAMA GLAMA;

AIDS VACCINES; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; ANTIGENS, VIRAL; BINDING SITES, ANTIBODY; CAMELIDS, NEW WORLD; DISEASE MODELS, ANIMAL; EVOLUTION, MOLECULAR; HIV INFECTIONS; HIV-1; IMMUNOGLOBULIN VARIABLE REGION; MUTATION;

EID: 84919683252     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004552     Document Type: Article

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