An Evolved Orthogonal Enzyme/Cofactor Pair

Journal of the American Chemical Society

Volumn 138, Issue 38, 2016, Pages 12451-12458

  Reynolds, Evan W ^a   McHenry, Matthew W ^a   Cannac, Fabien ^a   Gober, Joshua G ^a   Snow, Christopher D ^b   Brustad, Eric M ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b Engineering Research Center and Hydraulics Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PORPHYRINS;

ARTIFICIAL METALLOENZYMES; BINDING SURFACE; CARBENOIDS; CYTOCHROME P450; HEME VINYL GROUPS; HEMOPROTEINS; OLEFIN CYCLOPROPANATION; TRANSPORT PROTEINS;

ENZYMES;

ALKENE; BINDING PROTEIN; CARBENOID; CARRIER PROTEIN; CHUA PROTEIN; CYTOCHROME P450 BM3; DEUTEROPORPHYRIN DERIVATIVE; ENZYME; ENZYME COFACTOR; HEME; HEME DERIVATIVE; HEMOPROTEIN; IRON DERIVATIVE; IRON DEUTEROPORPHYRIN IX; UNCLASSIFIED DRUG; VINYL DERIVATIVE; BACTERIAL PROTEIN; CYTOCHROME P450; FLAVOCYTOCHROME P450 BM3 MONOXYGENASES; IRON; METALLOPORPHYRIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; BACILLUS MEGATERIUM; BACTERIAL STRAIN; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOPROPANATION; ENZYME SPECIFICITY; GENE MUTATION; IN VIVO STUDY; NONHUMAN; PROTEIN FUNCTION; STEREOSELECTIVITY; STEREOSPECIFICITY; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; COENZYME; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR MODEL; MUTATION; OXIDATION REDUCTION REACTION;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; COENZYMES; CYTOCHROME P-450 ENZYME SYSTEM; DIRECTED MOLECULAR EVOLUTION; IRON; METALLOPORPHYRINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION;

EID: 84989260406     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b05847     Document Type: Article

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