MPT64 protein from Mycobacterium tuberculosis inhibits apoptosis of macrophages through NF-kB-miRNA21-Bcl-2 pathway

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Wang, Qingmin ^a   Liu, Shupeng ^b   Tang, Ying ^a   Liu, Qiuhong ^a   Yao, Yongjie ^a  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BCG VACCINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 21; MPT64 PROTEIN; PROTEIN BCL 2; TUBERCULIN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; MICRORNA; MIRN21 MICRORNA, MOUSE; MPT64 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; SMALL INTERFERING RNA;

APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; LUCIFERASE ASSAY; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAW 264.7 CELL LINE; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ESCHERICHIA COLI; GENE SILENCING; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOUSE; MYCOBACTERIUM BOVIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANIMALS; ANTIGENS, BACTERIAL; APOPTOSIS; BASE SEQUENCE; CELL LINE; ESCHERICHIA COLI; GENE SILENCING; MACROPHAGES; MICE; MICRORNAS; MYCOBACTERIUM BOVIS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84904308807     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100949     Document Type: Article

References (37)

1. Harries AD, Dye C (2006) Tuberculosis.Ann Trop Med Parasitol 100(5-6):415-31. (Pubitemid 47050865)
2. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, et al. (2006) Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368:1575-80. (Pubitemid 44780738)
3. Russell DG (2001) Mycobacterium tuberculosis: here today, and here tomorrow. Nat Rev Mol Cell Biol 2(8):569-77.
4. López M, Sly LM, Luu Y, Young D, Cooper H, et al. (2003) The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2. J Immunol 170(5):2409-16. (Pubitemid 36245628)
5. Sanchez A, Espinosa P, Esparza MA, Colon M, Bernal G, et al. (2009) Mycobacterium tuberculosis 38-kDa lipoprotein is apoptogenic for human monocyte-derived macrophages. Scand J Immunol 69(1):20-8.
6. Derrick SC, Morris SL (2007) The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression.Cell Microbiol 9(6):1547-55. (Pubitemid 46774025)
7. Briken V, Miller JL (2008) Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis. Future Microbiol 3(4):415-22.
8. Spira A, Carroll JD, Liu G, Aziz Z, Shah V, et al. (2003) Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. Am J Respir Cell Mol Biol 29(5):545-551. (Pubitemid 37357705)
9. Yamamoto T (2006) Bacterial strategies for escaping the bactericidal mechanisms by macrophage.Yakugaku Zasshi 126(12):1235-43.
10. Danelishvili L, Yamazaki Y, Selker J, Bermudez LE (2010) Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis. PLoS One 5(5):e10474. doi: 10.1371/journal.pone.0010474.
11. Jayakumar D, Jacobs WR Jr, Narayanan S (2008) Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection. Cell Microbiol 10(2):365-74.
12. Su H, Yang JR, Xu T, Huang J, Xu L, et al. (2009) MicroRNA-101, downregulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer Res 69(3):1135-42.
13. Xiaojie Lin,Hongyu Guan,Zhimin Huang,Juan Liu,Hai Li, et al. (2014) Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis. J Diabetes Re http://dx.doi.org/10.1155/2014/258695.
14. Hossein A, Sean PC, Grace L, Michael JO, Steve MC, et al. (2004) Nuclear factor-κB modulates the p53 response in neurons exposed to DNA damage. J Neuroscience 24(12): 2963-2973.
15. Zhang J, Jiang R, Takayama H, Tanaka Y (2005) Survival of virulent Mycobacterium tuberculosis involves preventing apoptosis induced by Bcl-2 upregulation and release resulting from necrosis in J774 macrophages. Microbiol Immunol 49(9):845-52 (Pubitemid 41373935)
16. Wu Z, Lu H, Sheng J, Li L (2012) Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2. FEBS Lett 586(16):2459-67.
17. Barré B,Coqueret O,Perkins ND (2010) Regulation of activity and function of the p52 NF-κB subunit following DNA damage. Cell Cycle 9(24):4795-804.
18. Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, et al. (1999) Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284(5419):1520-3.
19. Rosenkrands I, King A, Weldingh K, Moniatte M, Moertz E, et al. (2000)Towards the proteome of Mycobacterium tuberculosis.Electrophoresis 21(17):3740-56.
20. Sohn H, Lee KS, Kim SY, Shin DM, Shin SJ, et al. (2009) Induction of cell death in human macrophages by a highly virulent Korean Isolate of Mycobacterium tuberculosis and the virulent strain H37Rv. Scand J Immunol 69(1):43-50.
21. Mustafa T, Wiker HG, Mørkve O, Sviland L (2008) Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Arch 452(4):449-56
22. Spira A, Carroll JD, Liu G, Aziz Z, Shah V, et al. (2003) Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. Am J Respir Cell Mol Biol 29(5):545-551. (Pubitemid 37357705)
23. Mogga SJ, Mustafa T, Sviland L, Nilsen R (2002) Increased Bcl-2 and reduced Bax expression in infected macrophages in slowly progressive primary murine Mycobacterium tuberculosis infection. Scand J Immunol 56(4):383-91.
24. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215-33.
25. Ambros V (2004)The functions of animal microRNAs. Nature 431(7006):350-5.
26. Sonkoly E, Ståhle M, Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18(2):131-40.
27. Taganov KD, Boldin MP, Baltimore D (2007) MicroRNAs and immunity: tiny players in a big field. Immunity 26(2):133-7. (Pubitemid 46329443)
28. Marquitz AR, Mathur A, Nam CS, Raab-Traub N (2011)The Epstein-Barr Virus BART microRNAs target the pro-apoptotic protein Bim. Virology 412(2):392-400.
29. Ghorpade DS, Leyland R, Kurowska-Stolarska M, Patil SA, Balaji KN (2012) MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Mol Cell Biol 32(12):2239-53.
30. Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, et al. (2007) MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?PLoS One 2(7):e610
31. Dong J, Zhao YP, Zhou L, Zhang TP, Chen G (2011)Bcl-2 upregulation induced by miR-21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells. Arch Med Res 42(1):8-14.
32. Yamada H, Mizuno S, Reza-Gholizadeh M, Sugawara I (2001) Relative importance of NF-kappaB p50 in mycobacterial infection. Infect Immun 69(11):7100-5. (Pubitemid 32995471)
33. Tato CM, Hunter CA (2002) Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection. Infect Immun 70(7):3311-7. (Pubitemid 34665964)
34. Bai X, Feldman NE, Chmura K, Ovrutsky AR, Su WL, et al. (2013) Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages. PLoS One 8(4):e61925.doi: 10.1371/journal.pone.0061925.
35. Philpott DJ, Yamaoka S, Israël A, Sansonetti PJ (2000) Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells. J Immunol 165(2):903-14. (Pubitemid 30484758)
36. Loeuillet C, Martinon F, Perez C, Munoz M, Thome M, et al. (2006) Mycobacterium tuberculosis subverts innate immunity to evade specific effectors. J Immunol 177(9):6245-55. (Pubitemid 44628842)
37. Wang Z, Potter BM, Gray AM, Sacksteder KA, Geisbrecht BV, et al. (2007) The solution structure of antigen MPT64 from Mycobacterium tuberculosis defines a new family of beta-grasp proteins. J Mol Biol 366(2):375-81. (Pubitemid 46136204)