Mobilization of copper ions by flavonoids in human peripheral lymphocytes leads to oxidative DNA breakage: A structure activity study

International Journal of Molecular Sciences

Volumn 16, Issue 11, 2015, Pages 26754-26769

  Arif, Hussain ^a   Rehmani, Nida ^a   Farhan, Mohd ^a   Ahmad, Aamir ^b   Hadi, Sheikh Mumtaz ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Comet assay; Flavonoids; Hydroxyl group positions; Isothermal titration calorimetric measurements; Molecular docking; Structure activity relationship

Indexed keywords

2, 9 DIMETHYL 1, 10 PHENANTHROLINE; CHLOROPLAST DNA; COPPER ION; FISETIN; GALANGIN; HISTIDINE; KAEMPFEROL; MYRICETIN; QUERCETIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CALF THYMUS DNA; CHELATING AGENT; COPPER; DIVALENT CATION; DNA; FLAVONOID; KAEMPFEROL DERIVATIVE;

ARTICLE; CALF (BOVINE); CELL VIABILITY ASSAY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; MOBILIZATION; MOLECULAR DOCKING; NONHUMAN; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; CHEMISTRY; CYTOLOGY; DNA FRAGMENTATION; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; OXIDATION REDUCTION REACTION; PRIMARY CELL CULTURE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATIONS, DIVALENT; CHELATING AGENTS; COMET ASSAY; COPPER; DNA; DNA FRAGMENTATION; FLAVONOIDS; HUMANS; KAEMPFEROLS; LEUKOCYTES, MONONUCLEAR; MOLECULAR DOCKING SIMULATION; OXIDATION-REDUCTION; PRIMARY CELL CULTURE; QUERCETIN; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84946882376     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms161125992     Document Type: Article

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