Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex

Nature Medicine

Volumn 20, Issue 5, 2014, Pages 484-492

  Wang, Linyuan ^a,b   Opland, Darren ^c   Tsai, Sue ^a   Luk, Cynthia T ^a,b   Schroer, Stephanie A ^a   Allison, Margaret B ^c   Elia, Andrew J ^d   Furlonger, Caren ^d   Suzuki, Akira ^e   Paige, Christopher J ^b,d   Mak, Tak W ^b,d   Winer, Daniel A ^a,b,f   Myers, Martin G ^c   Woo, Minna ^a,b,f  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d PRINCESS MARGARET HOSPITAL   (Canada)

^e KYUSHU UNIVERSITY   (Japan)

^f UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GAMMA INTERFERON; INSULIN; INTERLEUKIN 10; INTERLEUKIN 6; JANUS KINASE 2; LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C FOS; PROTEIN KINASE B; STAT3 PROTEIN; TRANSCRIPTION FACTOR FKHR; UNCOUPLING PROTEIN 1;

ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DORSAL STRIATUM; ENERGY EXPENDITURE; ENZYME ACTIVITY; FLOW CYTOMETRY; FOREBRAIN; GENE DELETION; GENE EXPRESSION; GENETIC MANIPULATION; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPOTHALAMUS; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAPERITONEAL FAT; LIPID DIET; LIVER; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; MUSCLE; NERVE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PERITONEUM MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; SIGNAL TRANSDUCTION; SPLEEN; SUBCUTANEOUS FAT; TH1 CELL; VAGOTOMY;

EID: 84988227670     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3527     Document Type: Article

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