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Volumn 20, Issue 10, 2016, Pages 1247-1257

Intraplaque neovascularization as a novel therapeutic target in advanced atherosclerosis

Author keywords

animal model; Atherosclerosis; cell metabolism; imaging; neoangiogenesis; neovascularization; VEGF

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPOIETIN; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN; FATTY ACID;

EID: 84987932384     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1080/14728222.2016.1186650     Document Type: Review
Times cited : (35)

References (112)
  • 1
    • 0037022910 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis
    • P.Libby Inflammation and atherosclerosis. Circulation. 2002;105:1135–1143.• An excellent review about inflammation in atherogenesis and advanced atherosclerosis.
    • (2002) Circulation , vol.105 , pp. 1135-1143
    • Libby, P.1
  • 3
    • 0025896795 scopus 로고
    • Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
    • M.I.Cybulsky, M.A.Gimbrone. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251:788–791.
    • (1991) Science , vol.251 , pp. 788-791
    • Cybulsky, M.I.1    Gimbrone, M.A.2
  • 4
    • 0027490115 scopus 로고
    • The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis
    • M.J.Davies, J.L.Gordon, A.J.Gearing, et al. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol. 1993;171:223–229.
    • (1993) J Pathol , vol.171 , pp. 223-229
    • Davies, M.J.1    Gordon, J.L.2    Gearing, A.J.3
  • 5
    • 36048979880 scopus 로고    scopus 로고
    • Vascular adhesion molecules in atherosclerosis
    • E.Galkina, K.Ley. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27:2292–2301.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2292-2301
    • Galkina, E.1    Ley, K.2
  • 6
    • 30844440555 scopus 로고    scopus 로고
    • Monocyte recruitment and foam cell formation in atherosclerosis
    • Y.V.Bobryshev. Monocyte recruitment and foam cell formation in atherosclerosis. Micron. 2006;37:208–222.
    • (2006) Micron , vol.37 , pp. 208-222
    • Bobryshev, Y.V.1
  • 7
    • 0034116663 scopus 로고    scopus 로고
    • Changing concepts of atherogenesis
    • P.Libby. Changing concepts of atherogenesis. J Intern Med. 2000;247:349–358.
    • (2000) J Intern Med , vol.247 , pp. 349-358
    • Libby, P.1
  • 8
    • 0034952970 scopus 로고    scopus 로고
    • Lymphocytes are important in early atherosclerosis
    • L.Song, C.Leung, C.Schindler. Lymphocytes are important in early atherosclerosis. J Clin Invest. 2001;108:251–259.
    • (2001) J Clin Invest , vol.108 , pp. 251-259
    • Song, L.1    Leung, C.2    Schindler, C.3
  • 9
    • 0642281745 scopus 로고    scopus 로고
    • T lymphocytes in atherogenesis-functional aspects and antigenic repertoire
    • O.Deboer, A.Becker, A.Vanderwal. T lymphocytes in atherogenesis-functional aspects and antigenic repertoire. Cardiovasc Res. 2003;60:78–86.
    • (2003) Cardiovasc Res , vol.60 , pp. 78-86
    • Deboer, O.1    Becker, A.2    Vanderwal, A.3
  • 11
    • 26244463577 scopus 로고    scopus 로고
    • Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage
    • R.Virmani, F.D.Kolodgie, A.P.Burke, et al. Atherosclerotic plaque progression and vulnerability to rupture:angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol. 2005;25:2054–2061.•• This article highlights the importance of intraplaque neovascularization and subsequent intraplaque hemorrhage in plaque destabilization.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2054-2061
    • Virmani, R.1    Kolodgie, F.D.2    Burke, A.P.3
  • 12
    • 0034791530 scopus 로고    scopus 로고
    • The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes
    • F.D.Kolodgie, A.P.Burke, A.Farb, et al. The thin-cap fibroatheroma:a type of vulnerable plaque:the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol. 2001;16:285–292.
    • (2001) Curr Opin Cardiol , vol.16 , pp. 285-292
    • Kolodgie, F.D.1    Burke, A.P.2    Farb, A.3
  • 13
    • 0141885294 scopus 로고    scopus 로고
    • From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I
    • M.Naghavi, P.Libby, E.Falk, et al. From vulnerable plaque to vulnerable patient:a call for new definitions and risk assessment strategies:part I. Circulation. 2003;108:1664–1672.
    • (2003) Circulation , vol.108 , pp. 1664-1672
    • Naghavi, M.1    Libby, P.2    Falk, E.3
  • 14
    • 33646056999 scopus 로고    scopus 로고
    • Pathology of the vulnerable plaque
    • R.Virmani, A.P.Burke, A.Farb, et al. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006;47:C13–C18.•• This review covers all aspects of vulnerable atherosclerotic plaques.
    • (2006) J Am Coll Cardiol , vol.47 , pp. C13-C18
    • Virmani, R.1    Burke, A.P.2    Farb, A.3
  • 15
    • 77951879344 scopus 로고    scopus 로고
    • Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study
    • W.E.Hellings, W.Peeters, F.L.Moll, et al. Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome:a prognostic study. Circulation. 2010;121:1941–1950.
    • (2010) Circulation , vol.121 , pp. 1941-1950
    • Hellings, W.E.1    Peeters, W.2    Moll, F.L.3
  • 16
    • 84987986800 scopus 로고    scopus 로고
    • Angiogenesis in health and disease : therapeutic opportunities
    • P.Carmeliet. Angiogenesis in health and disease:therapeutic opportunities. Nat Med. 2002;66:653–660.•• A comprehensive review of the molecular processes and therapeutic options in angiogenesis.
    • (2002) Nat Med , vol.66 , pp. 653-660
    • Carmeliet, P.1
  • 17
    • 0001271809 scopus 로고
    • Endarteritis and arteritis
    • W.Koester. Endarteritis and arteritis. Berl Klin Woshenschr. 1876;13:454–455.
    • (1876) Berl Klin Woshenschr , vol.13 , pp. 454-455
    • Koester, W.1
  • 19
    • 0000483549 scopus 로고
    • Capillary rupture with intimal hemmorhage as a caustive factor in coronary thrombosis
    • J.C.Patterson. Capillary rupture with intimal hemmorhage as a caustive factor in coronary thrombosis. Arch Pathol. 1938;25:474–487.
    • (1938) Arch Pathol , vol.25 , pp. 474-487
    • Patterson, J.C.1
  • 20
    • 64649093618 scopus 로고    scopus 로고
    • Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage
    • J.C.Sluimer, F.D.Kolodgie, A.P.Bijnens, et al. Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol. 2009;53:1517–1527.• This article emphasizes the importance of compromised integrity of intraplaque microvessels in plaque destabilization.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1517-1527
    • Sluimer, J.C.1    Kolodgie, F.D.2    Bijnens, A.P.3
  • 21
    • 0037339854 scopus 로고    scopus 로고
    • Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis
    • M.M.Kockx, K.M.Cromheeke, M.W.M.Knaapen, et al. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:440–446.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 440-446
    • Kockx, M.M.1    Cromheeke, K.M.2    Knaapen, M.W.M.3
  • 22
    • 33845916502 scopus 로고    scopus 로고
    • Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques
    • B.J.Dunmore, M.J.McCarthy, A.R.Naylor, et al. Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques. J Vasc Surg. 2007;45:155–159.
    • (2007) J Vasc Surg , vol.45 , pp. 155-159
    • Dunmore, B.J.1    McCarthy, M.J.2    Naylor, A.R.3
  • 23
    • 4944229954 scopus 로고    scopus 로고
    • Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability
    • P.R.Moreno, K.R.Purushothaman, V.Fuster, et al. Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta:implications for plaque vulnerability. Circulation. 2004;110:2032–2038.• This study consolidates the significance of intraplaque neovessels in advanced human atherosclerotic plaques.
    • (2004) Circulation , vol.110 , pp. 2032-2038
    • Moreno, P.R.1    Purushothaman, K.R.2    Fuster, V.3
  • 24
    • 80052009179 scopus 로고    scopus 로고
    • Intraplaque haemorrhages as the trigger of plaque vulnerability
    • 1985a, 1985b, 1985c
    • J.-B.Michel, R.Virmani, E.Arbustini, et al. Intraplaque haemorrhages as the trigger of plaque vulnerability. Eur Heart J. 2011;32:1977–1985. 1985a, 1985b, 1985c.
    • (2011) Eur Heart J , vol.32 , pp. 1977-1985
    • Michel, J.-B.1    Virmani, R.2    Arbustini, E.3
  • 25
    • 0000582946 scopus 로고
    • Intimal vascularization and atherosclerosis
    • E.Geiringer. Intimal vascularization and atherosclerosis. J Pathol Bacteriol. 1951;63:201–211.
    • (1951) J Pathol Bacteriol , vol.63 , pp. 201-211
    • Geiringer, E.1
  • 26
    • 0014643862 scopus 로고
    • Comparison of abdominal and thoracic aortic medial structure in mammals
    • W.H.G.Seymour. Comparison of abdominal and thoracic aortic medial structure in mammals. Circ Res. 1969;25:677–686.
    • (1969) Circ Res , pp. 677-686
    • Seymour, W.H.G.1
  • 27
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • R.H.Thomlinson, L.H.Gray. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955;9:539–549.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 28
    • 66749187756 scopus 로고    scopus 로고
    • Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis
    • J.C.Sluimer, M.J.Daemen. Novel concepts in atherogenesis:angiogenesis and hypoxia in atherosclerosis. J Pathol. 2009;218:27–29.• This paper describes plaque hypoxia as a crucial initiator of intraplaque neovascularization.
    • (2009) J Pathol , vol.218 , pp. 27-29
    • Sluimer, J.C.1    Daemen, M.J.2
  • 29
    • 0034979273 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in regulation of physiological angiogenesis
    • N.Ferrara. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001;280:C1358–C1366.
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. C1358-C1366
    • Ferrara, N.1
  • 30
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • T.Cohen, D.Nahari, L.W.Cerem, et al. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 1996;271:736–741.
    • (1996) J Biol Chem , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3
  • 31
    • 77951686244 scopus 로고    scopus 로고
    • Extracellular matrix, inflammation, and the angiogenic response
    • A.G.Arroyo, M.L.Iruela-Arispe. Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res. 2010;86:226–235.
    • (2010) Cardiovasc Res , vol.86 , pp. 226-235
    • Arroyo, A.G.1    Iruela-Arispe, M.L.2
  • 32
    • 65549135834 scopus 로고    scopus 로고
    • Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way
    • F.De Smet, I.Segura, K.De Bock, et al. Mechanisms of vessel branching:filopodia on endothelial tip cells lead the way. Arterioscler Thromb Vasc Biol. 2009;29:639–649.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 639-649
    • De Smet, F.1    Segura, I.2    De Bock, K.3
  • 33
    • 80052015813 scopus 로고    scopus 로고
    • Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    • S.P.Herbert, D.Y.R.Stainier. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol. 2011;12:551–564.• This review scrutinizes the different aspects of endothelial cell behavior during angiogenesis.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 551-564
    • Herbert, S.P.1    Stainier, D.Y.R.2
  • 34
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • M.Potente, H.Gerhardt, P.Carmeliet. Basic and therapeutic aspects of angiogenesis. Cell. 2011;146:873–887.
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 35
  • 36
    • 84860174750 scopus 로고    scopus 로고
    • Neovascularization and angiogenic factors in advanced human carotid artery stenosis
    • J.Pelisek, G.Well, C.Reeps, et al. Neovascularization and angiogenic factors in advanced human carotid artery stenosis. Circ J. 2012;76:1274–1282.
    • (2012) Circ J , vol.76 , pp. 1274-1282
    • Pelisek, J.1    Well, G.2    Reeps, C.3
  • 37
    • 62549114844 scopus 로고    scopus 로고
    • Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
    • J.J.Boyle, H.A.Harrington, E.Piper, et al. Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol. 2009;174:1097–1108.
    • (2009) Am J Pathol , vol.174 , pp. 1097-1108
    • Boyle, J.J.1    Harrington, H.A.2    Piper, E.3
  • 38
    • 0037076799 scopus 로고    scopus 로고
    • Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis
    • G.R.Y.De Meyer, D.M.M.De Cleen, S.Cooper, et al. Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis. Circ Res. 2002;90:1197–1204.
    • (2002) Circ Res , vol.90 , pp. 1197-1204
    • De Meyer, G.R.Y.1    De Cleen, D.M.M.2    Cooper, S.3
  • 39
    • 84855346179 scopus 로고    scopus 로고
    • Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques
    • A.V.Finn, M.Nakano, R.Polavarapu, et al. Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. J Am Coll Cardiol. 2012;59:166–177.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 166-177
    • Finn, A.V.1    Nakano, M.2    Polavarapu, R.3
  • 40
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • G.L.Wang, B.H.Jiang, E.A.Rue, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92:5510–5514.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3
  • 41
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • C.W.Pugh, P.J.Ratcliffe. Regulation of angiogenesis by hypoxia:role of the HIF system. Nat Med. 2003;9:677–684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 42
    • 26244432309 scopus 로고    scopus 로고
    • Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor
    • J.Yang, L.Zhang, P.J.A.Erbel, et al. Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor. J Biol Chem. 2005;280:36047–36054.
    • (2005) J Biol Chem , vol.280 , pp. 36047-36054
    • Yang, J.1    Zhang, L.2    Erbel, P.J.A.3
  • 43
    • 38449121857 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia
    • J.E.Ziello, I.S.Jovin, Y.Huang. Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J Biol Med. 2007;80:51–60.
    • (2007) Yale J Biol Med , vol.80 , pp. 51-60
    • Ziello, J.E.1    Jovin, I.S.2    Huang, Y.3
  • 44
    • 54049146968 scopus 로고    scopus 로고
    • The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
    • M.-P.Simon, R.Tournaire, J.Pouyssegur. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol. 2008;217:809–818.
    • (2008) J Cell Physiol , vol.217 , pp. 809-818
    • Simon, M.-P.1    Tournaire, R.2    Pouyssegur, J.3
  • 45
    • 46449093108 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible angiogenic proteins (hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and E26 transformation-specific-1) and plaque hemorrhage in human carotid atherosclerosis
    • T.Higashida, H.Kanno, M.Nakano, et al. Expression of hypoxia-inducible angiogenic proteins (hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and E26 transformation-specific-1) and plaque hemorrhage in human carotid atherosclerosis. J Neurosurg. 2008;109:83–91.
    • (2008) J Neurosurg , vol.109 , pp. 83-91
    • Higashida, T.1    Kanno, H.2    Nakano, M.3
  • 46
    • 33646823464 scopus 로고    scopus 로고
    • Increased angiogenesis and angiogenic gene expression in carotid artery plaques from symptomatic stroke patients
    • K.Türeyen, R.Vemuganti, M.S.Salamat, et al. Increased angiogenesis and angiogenic gene expression in carotid artery plaques from symptomatic stroke patients. Neurosurg. 2006;58:971–977.
    • (2006) Neurosurg , vol.58 , pp. 971-977
    • Türeyen, K.1    Vemuganti, R.2    Salamat, M.S.3
  • 48
    • 0032542072 scopus 로고    scopus 로고
    • Vascular Endothelial Growth Factor (VEGF) expression in human coronary atherosclerotic lesions : possible pathophysiological significance of VEGF in progression of atherosclerosis
    • M.Inoue, H.Itoh, M.Ueda, et al. Vascular Endothelial Growth Factor (VEGF) expression in human coronary atherosclerotic lesions:possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation. 1998;98:2108–2116.
    • (1998) Circulation , vol.98 , pp. 2108-2116
    • Inoue, M.1    Itoh, H.2    Ueda, M.3
  • 49
    • 33750529948 scopus 로고    scopus 로고
    • VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
    • J.Gavard, J.S.Gutkind. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol. 2006;8:1223–1234.
    • (2006) Nat Cell Biol , vol.8 , pp. 1223-1234
    • Gavard, J.1    Gutkind, J.S.2
  • 50
    • 20344376933 scopus 로고    scopus 로고
    • Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation
    • R.Khurana, L.Moons, S.Shafi, et al. Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Circulation. 2005;111:2828–2836.
    • (2005) Circulation , vol.111 , pp. 2828-2836
    • Khurana, R.1    Moons, L.2    Shafi, S.3
  • 51
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • J.E.Park, H.H.Chen, J.Winer, et al. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem. 1994;269:25646–25654.
    • (1994) J Biol Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3
  • 52
    • 38049068685 scopus 로고    scopus 로고
    • Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization
    • K.Pilarczyk, K.J.E.Sattler, O.Galili, et al. Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization. Atherosclerosis. 2008;196:333–340.
    • (2008) Atherosclerosis , vol.196 , pp. 333-340
    • Pilarczyk, K.1    Sattler, K.J.E.2    Galili, O.3
  • 53
    • 65549139264 scopus 로고    scopus 로고
    • VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
    • F.Zhang, Z.Tang, X.Hou, et al. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci. 2009;106:6152–6157.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 6152-6157
    • Zhang, F.1    Tang, Z.2    Hou, X.3
  • 54
    • 79959690245 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects
    • S.Jauhiainen, S.-K.Häkkinen, P.I.Toivanen, et al. Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. Arterioscler Thromb Vasc Biol. 2011;31:1617–1624.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1617-1624
    • Jauhiainen, S.1    Häkkinen, S.-K.2    Toivanen, P.I.3
  • 55
    • 42349095246 scopus 로고    scopus 로고
    • VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis
    • A.V.Benest, S.J.Harper, S.Y.Herttuala, et al. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis. Cardiovasc Res. 2008;78:315–323.
    • (2008) Cardiovasc Res , vol.78 , pp. 315-323
    • Benest, A.V.1    Harper, S.J.2    Herttuala, S.Y.3
  • 56
    • 84876164584 scopus 로고    scopus 로고
    • Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia
    • D.Qin, T.Trenkwalder, S.Lee, et al. Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. PLoS One. 2013;8:e61831.
    • (2013) PLoS One , vol.8 , pp. 61831
    • Qin, D.1    Trenkwalder, T.2    Lee, S.3
  • 57
    • 0027360010 scopus 로고
    • Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages
    • E.Brogi, J.Winkles, R.Underwood, et al. Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages. J Clin Invest. 1993;92:2408–2418.
    • (1993) J Clin Invest , vol.92 , pp. 2408-2418
    • Brogi, E.1    Winkles, J.2    Underwood, R.3
  • 58
    • 0030245548 scopus 로고    scopus 로고
    • Localisation and differential expression of the Fibroblast Growth Factor Receptor (FGFR) multigene family in normal and atherosclerotic human arteries
    • S.E.Hughes. Localisation and differential expression of the Fibroblast Growth Factor Receptor (FGFR) multigene family in normal and atherosclerotic human arteries. Cardiovasc Res. 1996;32:557–569.
    • (1996) Cardiovasc Res , vol.32 , pp. 557-569
    • Hughes, S.E.1
  • 59
    • 0032890359 scopus 로고    scopus 로고
    • The angiopoietins: Yin and Yang in angiogenesis
    • S.Davis, G.D.Yancopoulos. The angiopoietins:Yin and Yang in angiogenesis. Curr Top Microbiol Immunol. 1999;237:173–185.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 173-185
    • Davis, S.1    Yancopoulos, G.D.2
  • 60
    • 84883780219 scopus 로고    scopus 로고
    • Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors
    • Y.Brudno, A.B.Ennett-Shepard, R.R.Chen, et al. Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors. Biomaterials. 2013;34:9201–9209.
    • (2013) Biomaterials , vol.34 , pp. 9201-9209
    • Brudno, Y.1    Ennett-Shepard, A.B.2    Chen, R.R.3
  • 61
    • 0035972251 scopus 로고    scopus 로고
    • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    • M.Hellstrom, H.Gerhardt, M.Kalen, et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543–554.
    • (2001) J Cell Biol , vol.153 , pp. 543-554
    • Hellstrom, M.1    Gerhardt, H.2    Kalen, M.3
  • 62
    • 34247262163 scopus 로고    scopus 로고
    • Synergistically therapeutic effects of VEGF165 and angiopoietin-1 on ischemic rat myocardium
    • X.Liu, Y.Chen, F.Zhang, et al. Synergistically therapeutic effects of VEGF165 and angiopoietin-1 on ischemic rat myocardium. Scand Cardiovasc J. 2007;41:95–101.
    • (2007) Scand Cardiovasc J , vol.41 , pp. 95-101
    • Liu, X.1    Chen, Y.2    Zhang, F.3
  • 63
    • 62049085523 scopus 로고    scopus 로고
    • Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart
    • H.Su, J.Takagawa, Y.Huang, et al. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol. 2009;133:191–197.
    • (2009) Int J Cardiol , vol.133 , pp. 191-197
    • Su, H.1    Takagawa, J.2    Huang, Y.3
  • 64
    • 0036085728 scopus 로고    scopus 로고
    • Mast cells and angiogenesis
    • K.Norrby. Mast cells and angiogenesis. APMIS. 2002;110:355–371.
    • (2002) APMIS , vol.110 , pp. 355-371
    • Norrby, K.1
  • 65
    • 0034603748 scopus 로고    scopus 로고
    • IL-8 is an angiogenic factor in human coronary atherectomy tissue
    • A.Simonini, M.Moscucci, D.Muller, et al. IL-8 is an angiogenic factor in human coronary atherectomy tissue. Circulation. 2000;101:1519–1526.
    • (2000) Circulation , vol.101 , pp. 1519-1526
    • Simonini, A.1    Moscucci, M.2    Muller, D.3
  • 66
    • 0033536016 scopus 로고    scopus 로고
    • Distinct patterns of transforming growth factor- isoform and receptor expression in human atherosclerotic lesions : colocalization implicates TGF- in fibrofatty lesion development
    • A.Bobik, A.Agrotis, P.Kanellakis, et al. Distinct patterns of transforming growth factor- isoform and receptor expression in human atherosclerotic lesions:colocalization implicates TGF- in fibrofatty lesion development. Circulation. 1999;99:2883–2891.
    • (1999) Circulation , vol.99 , pp. 2883-2891
    • Bobik, A.1    Agrotis, A.2    Kanellakis, P.3
  • 67
    • 0035996581 scopus 로고    scopus 로고
    • Hepatocyte growth factor is a survival factor for endothelial cells and is expressed in human atherosclerotic plaques
    • H.Ma, T.M.Calderon, J.T.Fallon, et al. Hepatocyte growth factor is a survival factor for endothelial cells and is expressed in human atherosclerotic plaques. Atherosclerosis. 2002;164:79–87.
    • (2002) Atherosclerosis , vol.164 , pp. 79-87
    • Ma, H.1    Calderon, T.M.2    Fallon, J.T.3
  • 68
    • 3843136173 scopus 로고    scopus 로고
    • Platelet factor 4: an inhibitor of angiogenesis
    • A.Bikfalvi. Platelet factor 4:an inhibitor of angiogenesis. Semin Thromb Hemost. 2004;30:379–385.
    • (2004) Semin Thromb Hemost , vol.30 , pp. 379-385
    • Bikfalvi, A.1
  • 69
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    • M.S.O’Reilly, T.Boehm, Y.Shing, et al. Endostatin:an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997;88:277–285.
    • (1997) Cell , vol.88 , pp. 277-285
    • O’Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 70
    • 0027970092 scopus 로고
    • Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
    • M.O’Reilly. Angiostatin:a novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma. Cell. 1994;79:315–328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O’Reilly, M.1
  • 71
    • 84943229266 scopus 로고    scopus 로고
    • Angiogenesis inhibitor, endostar, prevents vasa vasorum neovascularization in a swine atherosclerosis model
    • X.Xu, W.Mao, Y.Chai, et al. Angiogenesis inhibitor, endostar, prevents vasa vasorum neovascularization in a swine atherosclerosis model. J Atheroscler Thromb. 2015;22:1100–1112.
    • (2015) J Atheroscler Thromb
    • Xu, X.1    Mao, W.2    Chai, Y.3
  • 72
    • 33847616049 scopus 로고    scopus 로고
    • The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells
    • Y.Sato, H.Sonoda. The vasohibin family:a negative regulatory system of angiogenesis genetically programmed in endothelial cells. Arterioscler Thromb Vasc Biol. 2007;27:37–41.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 37-41
    • Sato, Y.1    Sonoda, H.2
  • 73
    • 84941618512 scopus 로고    scopus 로고
    • Expression of vasohibin-1 in human carotid atherosclerotic plaque
    • R.Fukumitsu, M.Minami, K.Yoshida, et al. Expression of vasohibin-1 in human carotid atherosclerotic plaque. J Atheroscler Thromb. 2015;22:942–948.
    • (2015) J Atheroscler Thromb
    • Fukumitsu, R.1    Minami, M.2    Yoshida, K.3
  • 74
    • 0033528660 scopus 로고    scopus 로고
    • Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
    • K.S.Moulton, E.Heller, M.A.Konerding, et al. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation. 1999;99:1726–1732.
    • (1999) Circulation , vol.99 , pp. 1726-1732
    • Moulton, K.S.1    Heller, E.2    Konerding, M.A.3
  • 75
    • 0027773008 scopus 로고
    • Immunohistochemical study of intimal microvessels in coronary atherosclerosis
    • Y.Zhang, W.J.Cliff, G.I.Schoefl, et al. Immunohistochemical study of intimal microvessels in coronary atherosclerosis. Am J Pathol. 1993;143:164–172.
    • (1993) Am J Pathol , vol.143 , pp. 164-172
    • Zhang, Y.1    Cliff, W.J.2    Schoefl, G.I.3
  • 76
    • 84893865383 scopus 로고    scopus 로고
    • PET/CT imaging of integrin αvβ3 expression in human carotid atherosclerosis
    • A.J.Beer, J.Pelisek, P.Heider, et al. PET/CT imaging of integrin αvβ3 expression in human carotid atherosclerosis. JACC Cardiovasc Imaging. 2014;7:178–187.
    • (2014) JACC Cardiovasc Imaging , vol.7 , pp. 178-187
    • Beer, A.J.1    Pelisek, J.2    Heider, P.3
  • 77
    • 84927563455 scopus 로고    scopus 로고
    • Fatty acid carbon is essential for dNTP synthesis in endothelial cells
    • S.Schoors, U.Bruning, R.Missiaen, et al. Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature. 2015;520:192–197.
    • (2015) Nature
    • Schoors, S.1    Bruning, U.2    Missiaen, R.3
  • 78
    • 84881119066 scopus 로고    scopus 로고
    • Role of PFKFB3-driven glycolysis in vessel sprouting
    • K.De Bock, M.Georgiadou, S.Schoors, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154:651–663.
    • (2013) Cell , vol.154 , pp. 651-663
    • De Bock, K.1    Georgiadou, M.2    Schoors, S.3
  • 79
    • 84904730036 scopus 로고    scopus 로고
    • PET imaging of inflammation in atherosclerosis
    • J.M.Tarkin, F.R.Joshi, J.H.F.Rudd. PET imaging of inflammation in atherosclerosis. Nat Rev Cardiol. 2014;11:443–457.
    • (2014) Nat Rev Cardiol , vol.11 , pp. 443-457
    • Tarkin, J.M.1    Joshi, F.R.2    Rudd, J.H.F.3
  • 80
    • 84894078837 scopus 로고    scopus 로고
    • 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial
    • N.V.Joshi, A.T.Vesey, M.C.Williams, et al. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques:a prospective clinical trial. Lancet. 2014;383:705–713.
    • (2014) Lancet , vol.383 , pp. 705-713
    • Joshi, N.V.1    Vesey, A.T.2    Williams, M.C.3
  • 81
    • 84934784479 scopus 로고    scopus 로고
    • SPECT/CT imaging of high-risk atherosclerotic plaques using integrin-binding RGD dimer peptides
    • J.Sun Yoo, J.Lee, J.Ho Jung, et al. SPECT/CT imaging of high-risk atherosclerotic plaques using integrin-binding RGD dimer peptides. Sci Rep. 2015;5:11752.
    • (2015) Sci Rep , vol.5 , pp. 11752
    • Sun Yoo, J.1    Lee, J.2    Ho Jung, J.3
  • 82
    • 3242697895 scopus 로고    scopus 로고
    • The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond
    • S.B.Feinstein. The powerful microbubble:from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond. Am J Physiol Heart Circ Physiol. 2004;287:H450–H457.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , pp. H450-H457
    • Feinstein, S.B.1
  • 84
    • 84900134207 scopus 로고    scopus 로고
    • Quantitative contrast-enhanced ultrasound of intraplaque neovascularization in patients with carotid atherosclerosis
    • S.C.H.Van den Oord, Z.Akkus, J.G.Bosch, et al. Quantitative contrast-enhanced ultrasound of intraplaque neovascularization in patients with carotid atherosclerosis. Ultraschall Med. 2014;36:154–161.
    • (2014) Ultraschall Med
    • Van den Oord, S.C.H.1    Akkus, Z.2    Bosch, J.G.3
  • 85
    • 78650268522 scopus 로고    scopus 로고
    • Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis
    • C.Giannarelli, B.Ibanez, G.Cimmino, et al. Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis. JACC Cardiovasc Imaging. 2010;3:1256–1264.
    • (2010) JACC Cardiovasc Imaging , vol.3 , pp. 1256-1264
    • Giannarelli, C.1    Ibanez, B.2    Cimmino, G.3
  • 86
    • 84872679851 scopus 로고    scopus 로고
    • Current status and future developments of contrast-enhanced ultrasound of carotid atherosclerosis
    • G.L.Ten Kate, S.C.H.Van den Oord, E.J.G.Sijbrands, et al. Current status and future developments of contrast-enhanced ultrasound of carotid atherosclerosis. J Vasc Surg. 2013;57:539–546.
    • (2013) J Vasc Surg , vol.57 , pp. 539-546
    • Ten Kate, G.L.1    Van den Oord, S.C.H.2    Sijbrands, E.J.G.3
  • 87
    • 46249121352 scopus 로고    scopus 로고
    • Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity
    • S.Coli, M.Magnoni, G.Sangiorgi, et al. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries:correlation with histology and plaque echogenicity. J Am Coll Cardiol. 2008;52:223–230.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 223-230
    • Coli, S.1    Magnoni, M.2    Sangiorgi, G.3
  • 88
    • 0035047885 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances atherosclerotic plaque progression
    • F.L.Celletti, J.M.Waugh, P.G.Amabile, et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med. 2001;7:425–429.
    • (2001) Nat Med , vol.7 , pp. 425-429
    • Celletti, F.L.1    Waugh, J.M.2    Amabile, P.G.3
  • 89
    • 6444243603 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells
    • K.Ohtani, K.Egashira, K.Hiasa, et al. Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells. Circulation. 2004;110:2444–2452.
    • (2004) Circulation , vol.110 , pp. 2444-2452
    • Ohtani, K.1    Egashira, K.2    Hiasa, K.3
  • 90
    • 84880512414 scopus 로고    scopus 로고
    • Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1α activation: a novel aspect of angiogenesis in atherosclerosis
    • R.Hutter, W.S.Speidl, C.Valdiviezo, et al. Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1α activation:a novel aspect of angiogenesis in atherosclerosis. J Cardiovasc Transl Res. 2013;6:558–569.
    • (2013) J Cardiovasc Transl Res , vol.6 , pp. 558-569
    • Hutter, R.1    Speidl, W.S.2    Valdiviezo, C.3
  • 91
    • 0034060198 scopus 로고    scopus 로고
    • Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE
    • M.C.Kowala, R.Recce, S.Beyer, et al. Characterization of atherosclerosis in LDL receptor knockout mice:macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE. Atherosclerosis. 2000;149:323–330.
    • (2000) Atherosclerosis , vol.149 , pp. 323-330
    • Kowala, M.C.1    Recce, R.2    Beyer, S.3
  • 92
    • 0027958084 scopus 로고
    • ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    • Y.Nakashima, A.S.Plump, E.W.Raines, et al. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb Vasc Biol. 1994;14:133–140.
    • (1994) Arterioscler Thromb Vasc Biol , vol.14 , pp. 133-140
    • Nakashima, Y.1    Plump, A.S.2    Raines, E.W.3
  • 93
    • 33846002305 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment
    • M.Lucerna, A.Zernecke, R.de Nooijer, et al. Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment. Blood. 2007;109:122–129.
    • (2007) Blood , vol.109 , pp. 122-129
    • Lucerna, M.1    Zernecke, A.2    de Nooijer, R.3
  • 94
    • 0037019950 scopus 로고    scopus 로고
    • Accelerated atherosclerosis and calcification in vein grafts: a study in APOE*3 leiden transgenic mice
    • J.H.P.Lardenoye. Accelerated atherosclerosis and calcification in vein grafts:a study in APOE*3 leiden transgenic mice. Circ Res. 2002;91:577–584.
    • (2002) Circ Res , vol.91 , pp. 577-584
    • Lardenoye, J.H.P.1
  • 95
    • 84867423643 scopus 로고    scopus 로고
    • Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression
    • M.R.de Vries, H.W.M.Niessen, C.W.G.M.Löwik, et al. Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression. PLoS One. 2012;7:e47134.
    • (2012) PLoS One , vol.7 , pp. 47134
    • de Vries, M.R.1    Niessen, H.W.M.2    Löwik, C.W.G.M.3
  • 96
    • 73349112566 scopus 로고    scopus 로고
    • Impaired fibrillin-1 function promotes features of plaque instability in apolipoprotein E-deficient mice
    • J.L.Van Herck, G.R.Y.De Meyer, W.Martinet, et al. Impaired fibrillin-1 function promotes features of plaque instability in apolipoprotein E-deficient mice. Circulation. 2009;120:2478–2487.
    • (2009) Circulation , vol.120 , pp. 2478-2487
    • Van Herck, J.L.1    De Meyer, G.R.Y.2    Martinet, W.3
  • 97
    • 84929359531 scopus 로고    scopus 로고
    • Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death
    • C.Van der Donckt, J.L.Van Herck, D.M.Schrijvers, et al. Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death. Eur Heart J. 2015;36:1049–1058.• This study describes a unique mouse model of atherosclerotic plaque rupture. Plaques in this mouse model show intraplaque neovascularization due to elastin fiber fragmentation.
    • (2015) Eur Heart J , vol.36 , pp. 1049-1058
    • Van der Donckt, C.1    Van Herck, J.L.2    Schrijvers, D.M.3
  • 98
    • 34548174479 scopus 로고    scopus 로고
    • Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis
    • A.D.Hauer, G.H.M.Van Puijvelde, N.Peterse, et al. Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 2007;27:2050–2057.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2050-2057
    • Hauer, A.D.1    Van Puijvelde, G.H.M.2    Peterse, N.3
  • 99
    • 84885622575 scopus 로고    scopus 로고
    • Systemic VEGF inhibition accelerates experimental atherosclerosis and disrupts endothelial homeostasis–implications for cardiovascular safety
    • S.Winnik, C.Lohmann, G.Siciliani, et al. Systemic VEGF inhibition accelerates experimental atherosclerosis and disrupts endothelial homeostasis–implications for cardiovascular safety. Int J Cardiol. 2013;168:2453–2461.
    • (2013) Int J Cardiol , vol.168 , pp. 2453-2461
    • Winnik, S.1    Lohmann, C.2    Siciliani, G.3
  • 100
    • 36048963335 scopus 로고    scopus 로고
    • Inhibition of plaque neovascularization and intimal hyperplasia by specific targeting vascular endothelial growth factor with bevacizumab-eluting stent: an experimental study
    • C.Stefanadis, K.Toutouzas, E.Stefanadi, et al. Inhibition of plaque neovascularization and intimal hyperplasia by specific targeting vascular endothelial growth factor with bevacizumab-eluting stent:an experimental study. Atherosclerosis. 2007;195:269–276.
    • (2007) Atherosclerosis , vol.195 , pp. 269-276
    • Stefanadis, C.1    Toutouzas, K.2    Stefanadi, E.3
  • 101
    • 0344921396 scopus 로고    scopus 로고
    • Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
    • K.S.Moulton, K.Vakili, D.Zurakowski, et al. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci U S A. 2003;100:4736–4741.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4736-4741
    • Moulton, K.S.1    Vakili, K.2    Zurakowski, D.3
  • 102
    • 63649107910 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy with soluble VEGFR-1, −2, and −3 reduces the growth of solid human ovarian carcinoma in mice
    • H.Sallinen, M.Anttila, J.Narvainen, et al. Antiangiogenic gene therapy with soluble VEGFR-1, −2, and −3 reduces the growth of solid human ovarian carcinoma in mice. Mol Ther. 2009;17:278–284.
    • (2009) Mol Ther , vol.17 , pp. 278-284
    • Sallinen, H.1    Anttila, M.2    Narvainen, J.3
  • 103
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • T.Kamba, D.M.McDonald. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 2007;96:1788–1795.
    • (2007) Br J Cancer , vol.96 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 105
    • 85020154897 scopus 로고    scopus 로고
    • Abstract 642: vascular endothelial growth factor receptor 2 blockade in murine vein graft ameliorates lesion growth and enhances plaque stability by reducing intraplaque hemorrhage
    • M.R.de Vries, R.C.de Jong, E.A.Peters, et al. Abstract 642:vascular endothelial growth factor receptor 2 blockade in murine vein graft ameliorates lesion growth and enhances plaque stability by reducing intraplaque hemorrhage. Arter Thromb Vasc Biol. 2014;34:A642.
    • (2014) Arter Thromb Vasc Biol , vol.34 , pp. A642
    • de Vries, M.R.1    de Jong, R.C.2    Peters, E.A.3
  • 106
    • 77950688983 scopus 로고    scopus 로고
    • Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
    • K.J.Gotink, H.M.W.Verheul. Anti-angiogenic tyrosine kinase inhibitors:what is their mechanism of action? Angiogenesis. 2010;13:1–14.
    • (2010) Angiogenesis , vol.13 , pp. 1-14
    • Gotink, K.J.1    Verheul, H.M.W.2
  • 107
    • 38349183620 scopus 로고    scopus 로고
    • Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
    • B.Clem, S.Telang, A.Clem, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008;7:110–120.
    • (2008) Mol Cancer Ther , vol.7 , pp. 110-120
    • Clem, B.1    Telang, S.2    Clem, A.3
  • 108
    • 84891841003 scopus 로고    scopus 로고
    • Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis
    • S.Schoors, K.De Bock, A.R.Cantelmo, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014;19:37–48•• This paper contains innovative data about glycolysis in endothelial cells and indicates that cell metabolism is a promising target to inhibit pathological angiogenesis.
    • (2014) Cell Metab , vol.19 , pp. 37-48
    • Schoors, S.1    De Bock, K.2    Cantelmo, A.R.3
  • 109
    • 84893677011 scopus 로고    scopus 로고
    • PFKFB3 regulates oxidative stress homeostasis via its S-glutathionylation in cancer
    • M.Seo, Y.-H.Lee. PFKFB3 regulates oxidative stress homeostasis via its S-glutathionylation in cancer. J Mol Biol. 2014;426:830–842.
    • (2014) J Mol Biol , vol.426 , pp. 830-842
    • Seo, M.1    Lee, Y.-H.2
  • 110
    • 0037065914 scopus 로고    scopus 로고
    • Statins have biphasic effects on angiogenesis
    • M.Weis. Statins have biphasic effects on angiogenesis. Circulation.2002;105:736–745.
    • (2002) Circulation
    • Weis, M.1
  • 111
    • 84987973811 scopus 로고    scopus 로고
    • Cholesterol-independent effects of atorvastatin prevent cardiovascular morbidity and mortality in a novel murine model of atherosclerotic plaque rupture
    • L.Roth, M.Rombouts, D.M.Schrijvers, et al. Cholesterol-independent effects of atorvastatin prevent cardiovascular morbidity and mortality in a novel murine model of atherosclerotic plaque rupture. Atherosclerosis. 2016;244:e2–e3.
    • (2016) Atherosclerosis , vol.244 , pp. 2-3
    • Roth, L.1    Rombouts, M.2    Schrijvers, D.M.3
  • 112
    • 84947224641 scopus 로고    scopus 로고
    • The vulnerable atherosclerotic plaque: in vivo identification and potential therapeutic avenues
    • P.D.Adamson, M.R.Dweck, D.E.Newby. The vulnerable atherosclerotic plaque:in vivo identification and potential therapeutic avenues. Heart. 2015;101:1755–1766.
    • (2015) Heart , vol.101 , pp. 1755-1766
    • Adamson, P.D.1    Dweck, M.R.2    Newby, D.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.