Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis

JACC: Cardiovascular Imaging

Volumn 3, Issue 12, 2010, Pages 1256-1264

  Giannarelli, Chiara ^a   Ibanez, Borja ^a   Cimmino, Giovanni ^a   Garcia Ruiz, Jos M ^a   Faita, Francesco ^b   Bianchini, Elisabetta ^b   Zafar, M Urooj ^a   Fuster, Valentin ^a   Garcia, Mario J ^c   Badimon, Juan J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

angiogenesis; aorta; atherosclerosis; contrast enhanced ultrasound imaging

Indexed keywords

PERFLUTREN;

ADVENTITIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL DENSITY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; ECHOGRAPHY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; AORTIC DISEASES; ATHEROSCLEROSIS; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEASIBILITY STUDIES; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MUSCLE, SMOOTH, VASCULAR; NEOVASCULARIZATION, PATHOLOGIC; RABBITS; TIME FACTORS; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 78650268522     PISSN: 1936878X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcmg.2010.09.017     Document Type: Article

References (31)

1. E.S. Ford, and S. Capewell Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates J Am Coll Cardiol 50 2007 2128 2132
2. P. Carmeliet Angiogenesis in health and disease Nat Med 9 2003 653 660
3. P.R. Moreno, K.R. Purushothaman, and V. Fuster Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability Circulation 110 2004 2032 2038
4. K.S. Moulton Plaque angiogenesis: its functions and regulation Cold Spring Harb Symp Quant Biol 67 2002 471 482
5. F.D. Kolodgie, H.K. Gold, and A.P. Burke Intraplaque hemorrhage and progression of coronary atheroma N Engl J Med 349 2003 2316 2325
6. M. Fleiner, M. Kummer, and M. Mirlacher Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis Circulation 110 2004 2843 2850
7. M.M. Kockx, K.M. Cromheeke, and M.W. Knaapen Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis Arterioscler Thromb Vasc Biol 23 2003 440 446
8. M. Jeziorska, and D.E. Woolley Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries J Pathol 188 1999 189 196
9. R. Virmani, F.D. Kolodgie, and A.P. Burke Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage Arterioscler Thromb Vasc Biol 25 2005 2054 2061
10. P. Heppner, and J.R. Lindner Contrast ultrasound assessment of angiogenesis by perfusion and molecular imaging Expert Rev Mol Diagn 5 2005 447 455
11. S.B. Feinstein The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond Am J Physiol Heart Circ Physiol 287 2004 H450 H457
12. S.B. Feinstein Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization J Am Coll Cardiol 48 2006 236 243
13. E. Vicenzini, M.F. Giannoni, and F. Puccinelli Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent Stroke 38 2007 2841 2843
14. F. Shah, P. Balan, and M. Weinberg Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis? Vasc Med 12 2007 291 297
15. S. Coli, M. Magnoni, and G. Sangiorgi Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity J Am Coll Cardiol 52 2008 223 230
16. M. Magnoni, S. Coli, and M.M. Marrocco-Trischitta Contrast-enhanced ultrasound imaging of periadventitial vasa vasorum in human carotid arteries Eur J Echocardiogr 10 2009 260 264
17. R. Corti, J. Osende, and R. Hutter Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI Atherosclerosis 190 2007 106 113
18. B. Ibanez, G. Vilahur, and G. Cimmino Rapid change in plaque size, composition, and molecular footprint after recombinant apolipoprotein A-I Milano (ETC-216) administration: magnetic resonance imaging study in an experimental model of atherosclerosis J Am Coll Cardiol 51 2008 1104 1109
19. G. Helft, S.G. Worthley, and V. Fuster Progression and regression of atherosclerotic lesions: monitoring with serial noninvasive magnetic resonance imaging Circulation 105 2002 993 998
20. J. Biller, W.M. Feinberg, and J.E. Castaldo Guidelines for carotid endarterectomy: a statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association Circulation 97 1998 501 509 (Pubitemid 28090224)
21. S. Chaturvedi, A. Bruno, and T. Feasby Carotid endarterectomyan evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology Neurology 65 2005 794 801
22. R. Virmani, A.P. Burke, A. Farb, and F.D. Kolodgie Pathology of the vulnerable plaque J Am Coll Cardiol 47 2006 C13 C18
23. A.P. Burke, A. Farb, G.T. Malcom, Y. Liang, J.E. Smialek, and R. Virmani Plaque rupture and sudden death related to exertion in men with coronary artery disease JAMA 281 1999 921 926
24. M.J. McCarthy, I.M. Loftus, and M.M. Thompson Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology J Vasc Surg 30 1999 261 268
25. R. Mofidi, T.B. Crotty, P. McCarthy, S.J. Sheehan, D. Mehigan, and T.V. Keaveny Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease Br J Surg 88 2001 945 950
26. P.R. Moreno, E. Falk, I.F. Palacios, J.B. Newell, V. Fuster, and J.T. Fallon Macrophage infiltration in acute coronary syndromes Implications for plaque rupture Circulation 90 1994 775 778
27. D. Staub, A.F. Schinkel, and B. Coll Contrast-enhanced ultrasound imaging of the vasa vasorum: from early atherosclerosis to the identification of unstable plaques J Am Coll Cardiol Img 3 2010 761 771
28. F.S. Villanueva, R.J. Jankowski, and S. Klibanov Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells Circulation 98 1998 1 5
29. B.A. Kaufmann, J.M. Sanders, and C. Davis Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1 Circulation 116 2007 276 284
30. C.Z. Behm, B.A. Kaufmann, and C. Carr Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis Circulation 117 2008 2902 2911
31. O. Barreiro, R.J. Aguilar, and E. Tejera Specific targeting of human inflamed endothelium and in situ vascular tissue transfection by the use of ultrasound contrast agents J Am Coll Cardiol Img 2 2009 997 1005