메뉴 건너뛰기




Volumn 18, Issue , 2016, Pages 63-70

β-Cell adaptation in pregnancy

Author keywords

gestational diabetes; Htr1d; Htr2b; Htr3a; insulin; placenta; placental lactogen; pregnancy; serotonin; cell

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FOXD3 PROTEIN; FOXM1 PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACENTA LACTOGEN; PROLACTIN; PROLACTIN RECEPTOR; PROTEIN KINASE B; RAF PROTEIN; RAP PROTEIN; RAS PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SEROTONIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; GLUCOSE; INSULIN;

EID: 84987794556     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12716     Document Type: Review
Times cited : (163)

References (86)
  • 1
    • 0026201106 scopus 로고
    • Energy and substrate requirements of the placenta and fetus
    • Hay WW Jr. Energy and substrate requirements of the placenta and fetus. Proc Nutr Soc. 1991;50:321–336.
    • (1991) Proc Nutr Soc , vol.50 , pp. 321-336
    • Hay, W.W.1
  • 2
    • 0018279410 scopus 로고
    • Principal substrates of fetal metabolism: fuel and growth requirements of the ovine fetus
    • Battaglia FC. Principal substrates of fetal metabolism: fuel and growth requirements of the ovine fetus. Ciba Found Symp. 1978;63:57–74.
    • (1978) Ciba Found Symp , vol.63 , pp. 57-74
    • Battaglia, F.C.1
  • 3
    • 0036822277 scopus 로고    scopus 로고
    • Placental glucose transfer and fetal growth
    • Baumann MU, Deborde S, Illsley NP. Placental glucose transfer and fetal growth. Endocrine. 2002;19:13–22.
    • (2002) Endocrine , vol.19 , pp. 13-22
    • Baumann, M.U.1    Deborde, S.2    Illsley, N.P.3
  • 4
    • 0014553313 scopus 로고
    • Glucose stimulation of insulin secretion from the isolated pancreas of foetal and newborn rats
    • Asplund K, Westman S, Hellerstrom C. Glucose stimulation of insulin secretion from the isolated pancreas of foetal and newborn rats. Diabetologia. 1969;5:260–262.
    • (1969) Diabetologia , vol.5 , pp. 260-262
    • Asplund, K.1    Westman, S.2    Hellerstrom, C.3
  • 5
    • 0014966840 scopus 로고
    • Insulin release from isolated human fetal pancreatic islets
    • Espinosa de los M, Driscoll SG, Steinke J. Insulin release from isolated human fetal pancreatic islets. Science. 1970;168:1111–1112.
    • (1970) Science , vol.168 , pp. 1111-1112
    • Espinosa de los, M.1    Driscoll, S.G.2    Steinke, J.3
  • 6
    • 0028075428 scopus 로고
    • The feto-placental glucose steal phenomenon is a major cause of maternal metabolic adaptation during late pregnancy in the rat
    • Nolan CJ, Proietto J. The feto-placental glucose steal phenomenon is a major cause of maternal metabolic adaptation during late pregnancy in the rat. Diabetologia. 1994;37:976–984.
    • (1994) Diabetologia , vol.37 , pp. 976-984
    • Nolan, C.J.1    Proietto, J.2
  • 8
    • 0013642517 scopus 로고
    • The islets of Langerhans in the rat during pregnancy and lactation, with special reference to the changes in the B/A cell ratio
    • Hellman B. The islets of Langerhans in the rat during pregnancy and lactation, with special reference to the changes in the B/A cell ratio. Acta Obstet Gynecol Scand. 1960;39:331–342.
    • (1960) Acta Obstet Gynecol Scand , vol.39 , pp. 331-342
    • Hellman, B.1
  • 9
    • 0015381073 scopus 로고
    • Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans
    • Green IC, Taylor KW. Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans. J Endocrinol. 1972;54:317–325.
    • (1972) J Endocrinol , vol.54 , pp. 317-325
    • Green, I.C.1    Taylor, K.W.2
  • 10
    • 0015946703 scopus 로고
    • Quantitative morphologic and histoenzymatic study of the endocrine pancreas in nonpregnant and pregnant rats
    • Van Assche FA. Quantitative morphologic and histoenzymatic study of the endocrine pancreas in nonpregnant and pregnant rats. Am J Obstet Gynecol. 1974;118:39–41.
    • (1974) Am J Obstet Gynecol , vol.118 , pp. 39-41
    • Van Assche, F.A.1
  • 11
    • 0017099464 scopus 로고
    • Metabolic adaptation to pregnancy shown by increased biosynthesis of insulin in islets of Langerhans isolated from pregnant rat
    • Bone AJ, Taylor KW. Metabolic adaptation to pregnancy shown by increased biosynthesis of insulin in islets of Langerhans isolated from pregnant rat. Nature. 1976;262:501–502.
    • (1976) Nature , vol.262 , pp. 501-502
    • Bone, A.J.1    Taylor, K.W.2
  • 12
    • 0018182423 scopus 로고
    • A morphological study of the endocrine pancreas in human pregnancy
    • Van Assche FA, Aerts L, De Prins F. A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol. 1978;85:818–820.
    • (1978) Br J Obstet Gynaecol , vol.85 , pp. 818-820
    • Van Assche, F.A.1    Aerts, L.2    De Prins, F.3
  • 13
    • 0026573783 scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
    • Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology. 1992;130:1459–1466.
    • (1992) Endocrinology , vol.130 , pp. 1459-1466
    • Parsons, J.A.1    Brelje, T.C.2    Sorenson, R.L.3
  • 14
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res. 1997;29:301–307.
    • (1997) Horm Metab Res , vol.29 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 15
    • 38449099624 scopus 로고    scopus 로고
    • Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
    • Karnik SK, Chen H, McLean GW, et al. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science. 2007;318:806–809.
    • (2007) Science , vol.318 , pp. 806-809
    • Karnik, S.K.1    Chen, H.2    McLean, G.W.3
  • 16
    • 77958040076 scopus 로고    scopus 로고
    • Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
    • Butler AE, Cao-Minh L, Galasso R, et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia. 2010;53:2167–2176.
    • (2010) Diabetologia , vol.53 , pp. 2167-2176
    • Butler, A.E.1    Cao-Minh, L.2    Galasso, R.3
  • 17
    • 77949324263 scopus 로고    scopus 로고
    • Expansion of beta-cell mass in response to pregnancy
    • Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab. 2010;21:151–158.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 151-158
    • Rieck, S.1    Kaestner, K.H.2
  • 18
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell. 2007;12:817–826.
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 19
    • 77953511021 scopus 로고    scopus 로고
    • Non-β-cell progenitors of β-cells in pregnant mice
    • Abouna S, Old RW, Pelengaris S, et al. Non-β-cell progenitors of β-cells in pregnant mice. Organogenesis. 2010;6:125–133.
    • (2010) Organogenesis , vol.6 , pp. 125-133
    • Abouna, S.1    Old, R.W.2    Pelengaris, S.3
  • 20
    • 84875452820 scopus 로고    scopus 로고
    • No evidence for beta cell neogenesis in murine adult pancreas
    • Xiao X, Chen Z, Shiota C, et al. No evidence for beta cell neogenesis in murine adult pancreas. J Clin Invest. 2013;123:2207–2217.
    • (2013) J Clin Invest , vol.123 , pp. 2207-2217
    • Xiao, X.1    Chen, Z.2    Shiota, C.3
  • 22
    • 0021045550 scopus 로고
    • The endocrine pancreas during pregnancy and lactation in the rat
    • Marynissen G, Aerts L, Van Assche FA. The endocrine pancreas during pregnancy and lactation in the rat. J Dev Physiol. 1983;5:373–381.
    • (1983) J Dev Physiol , vol.5 , pp. 373-381
    • Marynissen, G.1    Aerts, L.2    Van Assche, F.A.3
  • 23
    • 0028845665 scopus 로고
    • Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas
    • Scaglia L, Smith FE, Bonner-Weir S. Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology. 1995;136:5461–5468.
    • (1995) Endocrinology , vol.136 , pp. 5461-5468
    • Scaglia, L.1    Smith, F.E.2    Bonner-Weir, S.3
  • 24
    • 0024434434 scopus 로고
    • Effect of prolactin versus growth hormone on islet function and the importance of using homologous mammosomatotropic hormones
    • Brelje TC, Allaire P, Hegre O, Sorenson RL. Effect of prolactin versus growth hormone on islet function and the importance of using homologous mammosomatotropic hormones. Endocrinology. 1989;125:2392–2399.
    • (1989) Endocrinology , vol.125 , pp. 2392-2399
    • Brelje, T.C.1    Allaire, P.2    Hegre, O.3    Sorenson, R.L.4
  • 25
    • 0025974318 scopus 로고
    • Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy
    • Brelje TC, Sorenson RL. Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy. Endocrinology. 1991;128:45–57.
    • (1991) Endocrinology , vol.128 , pp. 45-57
    • Brelje, T.C.1    Sorenson, R.L.2
  • 26
    • 0027439729 scopus 로고
    • Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy
    • Brelje TC, Scharp DW, Lacy PE, et al. Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology. 1993;132:879–887.
    • (1993) Endocrinology , vol.132 , pp. 879-887
    • Brelje, T.C.1    Scharp, D.W.2    Lacy, P.E.3
  • 27
    • 18344382724 scopus 로고    scopus 로고
    • Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance
    • Freemark M, Avril I, Fleenor D, et al. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology. 2002;143:1378–1385.
    • (2002) Endocrinology , vol.143 , pp. 1378-1385
    • Freemark, M.1    Avril, I.2    Fleenor, D.3
  • 28
    • 11244338107 scopus 로고    scopus 로고
    • Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy
    • Amaral ME, Cunha DA, Anhe GF, et al. Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy. J Endocrinol. 2004;183:469–476.
    • (2004) J Endocrinol , vol.183 , pp. 469-476
    • Amaral, M.E.1    Cunha, D.A.2    Anhe, G.F.3
  • 29
    • 63849322132 scopus 로고    scopus 로고
    • Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy
    • Huang C, Snider F, Cross JC. Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy. Endocrinology. 2009;150:1618–1626.
    • (2009) Endocrinology , vol.150 , pp. 1618-1626
    • Huang, C.1    Snider, F.2    Cross, J.C.3
  • 30
    • 84943338594 scopus 로고    scopus 로고
    • Pregnancy hyperglycemia in prolactin receptor mutant, but not prolactin mutant, mice and feeding-responsive regulation of placental lactogen genes implies placental control of maternal glucose homeostasis
    • Rawn SM, Huang C, Hughes M, Shaykhutdinov R, Vogel HJ, Cross JC. Pregnancy hyperglycemia in prolactin receptor mutant, but not prolactin mutant, mice and feeding-responsive regulation of placental lactogen genes implies placental control of maternal glucose homeostasis. Biol Reprod. 2015;93:75.
    • (2015) Biol Reprod , vol.93 , pp. 75
    • Rawn, S.M.1    Huang, C.2    Hughes, M.3    Shaykhutdinov, R.4    Vogel, H.J.5    Cross, J.C.6
  • 31
    • 84928905267 scopus 로고    scopus 로고
    • Prolactin receptors and placental lactogen drive male mouse pancreatic islets to pregnancy-related mRNA changes
    • Goyvaerts L, Lemaire K, Arijs I, et al. Prolactin receptors and placental lactogen drive male mouse pancreatic islets to pregnancy-related mRNA changes. PLoS One. 2015;10:e0121868.
    • (2015) PLoS One , vol.10
    • Goyvaerts, L.1    Lemaire, K.2    Arijs, I.3
  • 32
    • 0027183368 scopus 로고
    • Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells
    • Moldrup A, Petersen ED, Nielsen JH. Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells. Endocrinology. 1993;133:1165–1172.
    • (1993) Endocrinology , vol.133 , pp. 1165-1172
    • Moldrup, A.1    Petersen, E.D.2    Nielsen, J.H.3
  • 33
    • 77954480533 scopus 로고    scopus 로고
    • Serotonin regulates pancreatic beta cell mass during pregnancy
    • Kim H, Toyofuku Y, Lynn FC, et al. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med. 2010;16:804–808.
    • (2010) Nat Med , vol.16 , pp. 804-808
    • Kim, H.1    Toyofuku, Y.2    Lynn, F.C.3
  • 34
    • 84865984323 scopus 로고    scopus 로고
    • Molecular mechanisms of prolactin and its receptor
    • Brooks CL. Molecular mechanisms of prolactin and its receptor. Endocr Rev. 2012;33:504–525.
    • (2012) Endocr Rev , vol.33 , pp. 504-525
    • Brooks, C.L.1
  • 35
    • 0032460226 scopus 로고    scopus 로고
    • Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    • Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 1998;19:225–268.
    • (1998) Endocr Rev , vol.19 , pp. 225-268
    • Bole-Feysot, C.1    Goffin, V.2    Edery, M.3    Binart, N.4    Kelly, P.A.5
  • 36
    • 70349774453 scopus 로고    scopus 로고
    • The transcriptional response of the islet to pregnancy in mice
    • Rieck S, White P, Schug J, et al. The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol. 2009;23:1702–1712.
    • (2009) Mol Endocrinol , vol.23 , pp. 1702-1712
    • Rieck, S.1    White, P.2    Schug, J.3
  • 37
    • 78649329990 scopus 로고    scopus 로고
    • Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy
    • Schraenen A, Lemaire K, de Faudeur G, et al. Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy. Diabetologia. 2010;53:2589–2599.
    • (2010) Diabetologia , vol.53 , pp. 2589-2599
    • Schraenen, A.1    Lemaire, K.2    de Faudeur, G.3
  • 38
    • 78650067216 scopus 로고    scopus 로고
    • Regulation of pancreatic islet gene expression in mouse islets by pregnancy
    • Layden BT, Durai V, Newman MV, et al. Regulation of pancreatic islet gene expression in mouse islets by pregnancy. J Endocrinol. 2010;207:265–279.
    • (2010) J Endocrinol , vol.207 , pp. 265-279
    • Layden, B.T.1    Durai, V.2    Newman, M.V.3
  • 39
    • 82255185857 scopus 로고    scopus 로고
    • Convergence of the insulin and serotonin programs in the pancreatic beta-cell
    • Ohta Y, Kosaka Y, Kishimoto N, et al. Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011;60:3208–3216.
    • (2011) Diabetes , vol.60 , pp. 3208-3216
    • Ohta, Y.1    Kosaka, Y.2    Kishimoto, N.3
  • 40
    • 84964016553 scopus 로고    scopus 로고
    • Serotonin competence of mouse beta cells during pregnancy
    • Goyvaerts L, Schraenen A, Schuit F. Serotonin competence of mouse beta cells during pregnancy. Diabetologia. 2016;59:1356–1363.
    • (2016) Diabetologia , vol.59 , pp. 1356-1363
    • Goyvaerts, L.1    Schraenen, A.2    Schuit, F.3
  • 41
    • 84872580066 scopus 로고    scopus 로고
    • Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks
    • Amireault P, Sibon D, Cote F. Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks. ACS Chem Neurosci. 2013;4:64–71.
    • (2013) ACS Chem Neurosci , vol.4 , pp. 64-71
    • Amireault, P.1    Sibon, D.2    Cote, F.3
  • 42
    • 64549158645 scopus 로고    scopus 로고
    • The expanded biology of serotonin
    • Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Ann Rev Med. 2009;60:355–366.
    • (2009) Ann Rev Med , vol.60 , pp. 355-366
    • Berger, M.1    Gray, J.A.2    Roth, B.L.3
  • 43
    • 0035813197 scopus 로고    scopus 로고
    • Are 5-hydroxytryptamine-preloaded beta-cells an appropriate physiologic model system for establishing that insulin stimulates insulin secretion?
    • Zawalich WS, Tesz GJ, Zawalich KC. Are 5-hydroxytryptamine-preloaded beta-cells an appropriate physiologic model system for establishing that insulin stimulates insulin secretion? J Biol Chem. 2001;276:37120–37123.
    • (2001) J Biol Chem , vol.276 , pp. 37120-37123
    • Zawalich, W.S.1    Tesz, G.J.2    Zawalich, K.C.3
  • 44
    • 0028183017 scopus 로고
    • International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
    • Hoyer D, Clarke DE, Fozard JR, et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev. 1994;46:157–203.
    • (1994) Pharmacol Rev , vol.46 , pp. 157-203
    • Hoyer, D.1    Clarke, D.E.2    Fozard, J.R.3
  • 45
    • 0018152188 scopus 로고
    • Association between 5-hydroxytryptamine release and insulin secretion
    • Gylfe E. Association between 5-hydroxytryptamine release and insulin secretion. J Endocrinol. 1978;78:239–248.
    • (1978) J Endocrinol , vol.78 , pp. 239-248
    • Gylfe, E.1
  • 46
    • 0033572839 scopus 로고    scopus 로고
    • Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells
    • Smith PA, Proks P, Ashcroft FM. Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells. J Physiol. 1999;521(Pt 3):651–664.
    • (1999) J Physiol , vol.521 , pp. 651-664
    • Smith, P.A.1    Proks, P.2    Ashcroft, F.M.3
  • 47
    • 84865601606 scopus 로고    scopus 로고
    • Glucose metabolism: key endogenous regulator of beta-cell replication and survival
    • Dadon D, Tornovsky-Babaey S, Furth-Lavi J, et al. Glucose metabolism: key endogenous regulator of beta-cell replication and survival. Diabetes Obes Metab. 2012;14(Suppl 3):101–108.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 101-108
    • Dadon, D.1    Tornovsky-Babaey, S.2    Furth-Lavi, J.3
  • 48
    • 84924390208 scopus 로고    scopus 로고
    • Galphai/o-coupled receptor signaling restricts pancreatic beta-cell expansion
    • Berger M, Scheel DW, Macias H, et al. Galphai/o-coupled receptor signaling restricts pancreatic beta-cell expansion. Proc Natl Acad Sci USA. 2015;112:2888–2893.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 2888-2893
    • Berger, M.1    Scheel, D.W.2    Macias, H.3
  • 49
    • 72649084796 scopus 로고    scopus 로고
    • A chemical-genetic approach to study G protein regulation of beta cell function in vivo
    • Guettier JM, Gautam D, Scarselli M, et al. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci USA. 2009;106:19197–19202.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19197-19202
    • Guettier, J.M.1    Gautam, D.2    Scarselli, M.3
  • 50
    • 0041426728 scopus 로고    scopus 로고
    • Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway
    • Amaral ME, Ueno M, Carvalheira JB, et al. Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway. Horm Metab Res. 2003;35:282–289.
    • (2003) Horm Metab Res , vol.35 , pp. 282-289
    • Amaral, M.E.1    Ueno, M.2    Carvalheira, J.B.3
  • 51
    • 37549045308 scopus 로고    scopus 로고
    • Rapamycin impairs in vivo proliferation of islet beta-cells
    • Zahr E, Molano RD, Pileggi A, et al. Rapamycin impairs in vivo proliferation of islet beta-cells. Transplantation. 2007;84:1576–1583.
    • (2007) Transplantation , vol.84 , pp. 1576-1583
    • Zahr, E.1    Molano, R.D.2    Pileggi, A.3
  • 52
    • 79951898986 scopus 로고    scopus 로고
    • Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation
    • Hughes E, Huang C. Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation. Endocrinology. 2011;152:847–855.
    • (2011) Endocrinology , vol.152 , pp. 847-855
    • Hughes, E.1    Huang, C.2
  • 53
    • 84907009884 scopus 로고    scopus 로고
    • Menin determines K-RAS proliferative outputs in endocrine cells
    • Chamberlain CE, Scheel DW, McGlynn K, et al. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest. 2014;124:4093–4101.
    • (2014) J Clin Invest , vol.124 , pp. 4093-4101
    • Chamberlain, C.E.1    Scheel, D.W.2    McGlynn, K.3
  • 54
    • 79959726397 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation
    • Hakonen E, Ustinov J, Mathijs I, et al. Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation. Diabetologia. 2011;54:1735–1743.
    • (2011) Diabetologia , vol.54 , pp. 1735-1743
    • Hakonen, E.1    Ustinov, J.2    Mathijs, I.3
  • 55
    • 84898885011 scopus 로고    scopus 로고
    • EGFR signaling promotes beta-cell proliferation and survivin expression during pregnancy
    • Hakonen E, Ustinov J, Palgi J, Miettinen PJ, Otonkoski T. EGFR signaling promotes beta-cell proliferation and survivin expression during pregnancy. PLoS One. 2014;9:e93651.
    • (2014) PLoS One , vol.9
    • Hakonen, E.1    Ustinov, J.2    Palgi, J.3    Miettinen, P.J.4    Otonkoski, T.5
  • 56
    • 33845534764 scopus 로고    scopus 로고
    • Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth
    • Miettinen PJ, Ustinov J, Ormio P, et al. Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal beta-cell growth. Diabetes. 2006;55:3299–3308.
    • (2006) Diabetes , vol.55 , pp. 3299-3308
    • Miettinen, P.J.1    Ustinov, J.2    Ormio, P.3
  • 57
    • 33645860514 scopus 로고    scopus 로고
    • Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats
    • Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO. Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology. 2006;147:2315–2324.
    • (2006) Endocrinology , vol.147 , pp. 2315-2324
    • Johansson, M.1    Mattsson, G.2    Andersson, A.3    Jansson, L.4    Carlsson, P.O.5
  • 58
    • 84860585020 scopus 로고    scopus 로고
    • Loss of HGF/c-Met signaling in pancreatic beta-cells leads to incomplete maternal beta-cell adaptation and gestational diabetes mellitus
    • Demirci C, Ernst S, Alvarez-Perez JC, et al. Loss of HGF/c-Met signaling in pancreatic beta-cells leads to incomplete maternal beta-cell adaptation and gestational diabetes mellitus. Diabetes. 2012;61:1143–1152.
    • (2012) Diabetes , vol.61 , pp. 1143-1152
    • Demirci, C.1    Ernst, S.2    Alvarez-Perez, J.C.3
  • 59
    • 84962191103 scopus 로고    scopus 로고
    • Beta-cell MicroRNAs: small but powerful
    • Filios SR, Shalev A. Beta-cell MicroRNAs: small but powerful. Diabetes. 2015;64:3631–3644.
    • (2015) Diabetes , vol.64 , pp. 3631-3644
    • Filios, S.R.1    Shalev, A.2
  • 60
    • 84867146719 scopus 로고    scopus 로고
    • MicroRNAs contribute to compensatory beta cell expansion during pregnancy and obesity
    • Jacovetti C, Abderrahmani A, Parnaud G, et al. MicroRNAs contribute to compensatory beta cell expansion during pregnancy and obesity. J Clin Invest. 2012;122:3541–3551.
    • (2012) J Clin Invest , vol.122 , pp. 3541-3551
    • Jacovetti, C.1    Abderrahmani, A.2    Parnaud, G.3
  • 61
    • 82355190878 scopus 로고    scopus 로고
    • Loss of Foxd3 results in decreased beta-cell proliferation and glucose intolerance during pregnancy
    • Plank JL, Frist AY, LeGrone AW, Magnuson MA, Labosky PA. Loss of Foxd3 results in decreased beta-cell proliferation and glucose intolerance during pregnancy. Endocrinology. 2011;152:4589–4600.
    • (2011) Endocrinology , vol.152 , pp. 4589-4600
    • Plank, J.L.1    Frist, A.Y.2    LeGrone, A.W.3    Magnuson, M.A.4    Labosky, P.A.5
  • 62
    • 77449086017 scopus 로고    scopus 로고
    • Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen
    • Zhang H, Zhang J, Pope CF, et al. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes. 2010;59:143–152.
    • (2010) Diabetes , vol.59 , pp. 143-152
    • Zhang, H.1    Zhang, J.2    Pope, C.F.3
  • 63
    • 33746587792 scopus 로고    scopus 로고
    • The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass
    • Zhang H, Ackermann AM, Gusarova GA, et al. The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol. 2006;20:1853–1866.
    • (2006) Mol Endocrinol , vol.20 , pp. 1853-1866
    • Zhang, H.1    Ackermann, A.M.2    Gusarova, G.A.3
  • 64
    • 34147173677 scopus 로고    scopus 로고
    • Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha
    • Gupta RK, Gao N, Gorski RK, et al. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes Dev. 2007;21:756–769.
    • (2007) Genes Dev , vol.21 , pp. 756-769
    • Gupta, R.K.1    Gao, N.2    Gorski, R.K.3
  • 65
    • 16844366885 scopus 로고    scopus 로고
    • The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion
    • Gupta RK, Vatamaniuk MZ, Lee CS, et al. The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion. J Clin Invest. 2005;115:1006–1015.
    • (2005) J Clin Invest , vol.115 , pp. 1006-1015
    • Gupta, R.K.1    Vatamaniuk, M.Z.2    Lee, C.S.3
  • 66
    • 33646196920 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells
    • Miura A, Yamagata K, Kakei M, et al. Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells. J Biol Chem. 2006;281:5246–5257.
    • (2006) J Biol Chem , vol.281 , pp. 5246-5257
    • Miura, A.1    Yamagata, K.2    Kakei, M.3
  • 67
    • 0027504201 scopus 로고
    • Effects of steroid and lactogenic hormones on islets of Langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy
    • Sorenson RL, Brelje TC, Roth C. Effects of steroid and lactogenic hormones on islets of Langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy. Endocrinology. 1993;133:2227–2234.
    • (1993) Endocrinology , vol.133 , pp. 2227-2234
    • Sorenson, R.L.1    Brelje, T.C.2    Roth, C.3
  • 68
    • 84888310803 scopus 로고    scopus 로고
    • Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy
    • Ohara-Imaizumi M, Kim H, Yoshida M, et al. Serotonin regulates glucose-stimulated insulin secretion from pancreatic beta cells during pregnancy. Proc Natl Acad Sci USA. 2013;110:19420–19425.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 19420-19425
    • Ohara-Imaizumi, M.1    Kim, H.2    Yoshida, M.3
  • 69
    • 0029863097 scopus 로고    scopus 로고
    • Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets
    • Weinhaus AJ, Stout LE, Sorenson RL. Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets. Endocrinology. 1996;137:1640–1649.
    • (1996) Endocrinology , vol.137 , pp. 1640-1649
    • Weinhaus, A.J.1    Stout, L.E.2    Sorenson, R.L.3
  • 70
    • 0031657124 scopus 로고    scopus 로고
    • Role of cAMP in upregulation of insulin secretion during the adaptation of islets of Langerhans to pregnancy
    • Weinhaus AJ, Bhagroo NV, Brelje TC, Sorenson RL. Role of cAMP in upregulation of insulin secretion during the adaptation of islets of Langerhans to pregnancy. Diabetes. 1998;47:1426–1435.
    • (1998) Diabetes , vol.47 , pp. 1426-1435
    • Weinhaus, A.J.1    Bhagroo, N.V.2    Brelje, T.C.3    Sorenson, R.L.4
  • 71
    • 0023243052 scopus 로고
    • Prolactin (in vitro) decreases the glucose stimulation threshold, enhances insulin secretion, and increases dye coupling among islet B cells
    • Sorenson RL, Brelje TC, Hegre OD, Marshall S, Anaya P, Sheridan JD. Prolactin (in vitro) decreases the glucose stimulation threshold, enhances insulin secretion, and increases dye coupling among islet B cells. Endocrinology. 1987;121:1447–1453.
    • (1987) Endocrinology , vol.121 , pp. 1447-1453
    • Sorenson, R.L.1    Brelje, T.C.2    Hegre, O.D.3    Marshall, S.4    Anaya, P.5    Sheridan, J.D.6
  • 72
    • 33751092499 scopus 로고    scopus 로고
    • Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets
    • Cunha DA, Amaral ME, Carvalho CP, Collares-Buzato CB, Carneiro EM, Boschero AC. Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets. Biol Res. 2006;39:555–566.
    • (2006) Biol Res , vol.39 , pp. 555-566
    • Cunha, D.A.1    Amaral, M.E.2    Carvalho, C.P.3    Collares-Buzato, C.B.4    Carneiro, E.M.5    Boschero, A.C.6
  • 74
    • 40749135504 scopus 로고    scopus 로고
    • Placental growth hormone-related proteins and prolactin-related proteins
    • Haig D. Placental growth hormone-related proteins and prolactin-related proteins. Placenta. 2008;29(Suppl):36–41.
    • (2008) Placenta , vol.29 , pp. 36-41
    • Haig, D.1
  • 75
    • 84944705104 scopus 로고    scopus 로고
    • Structural similarities and differences between the human and the mouse pancreas
    • Dolensek J, Rupnik MS, Stozer A. Structural similarities and differences between the human and the mouse pancreas. Islets. 2015;7:e1024405.
    • (2015) Islets , vol.7
    • Dolensek, J.1    Rupnik, M.S.2    Stozer, A.3
  • 77
    • 36649000083 scopus 로고    scopus 로고
    • Proliferation of sorted human and rat beta cells
    • Parnaud G, Bosco D, Berney T, et al. Proliferation of sorted human and rat beta cells. Diabetologia. 2008;51:91–100.
    • (2008) Diabetologia , vol.51 , pp. 91-100
    • Parnaud, G.1    Bosco, D.2    Berney, T.3
  • 78
    • 84962170665 scopus 로고    scopus 로고
    • Augmented Stat5 signaling bypasses multiple impediments to lactogen-mediated proliferation in human beta-cells
    • Chen H, Kleinberger JW, Takane KK, et al. Augmented Stat5 signaling bypasses multiple impediments to lactogen-mediated proliferation in human beta-cells. Diabetes. 2015;64:3784–3797.
    • (2015) Diabetes , vol.64 , pp. 3784-3797
    • Chen, H.1    Kleinberger, J.W.2    Takane, K.K.3
  • 79
    • 84962420556 scopus 로고    scopus 로고
    • 2. Classification and diagnosis of diabetes
    • American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2016;39(Suppl 1):S13–S22.
    • (2016) Diabetes Care , vol.39 , pp. S13-S22
  • 81
    • 84887231912 scopus 로고    scopus 로고
    • National Institutes of Health consensus development conference statement: diagnosing gestational diabetes mellitus, March 4-6, 2013
    • VanDorsten JP, Dodson WC, Espeland MA, et al. National Institutes of Health consensus development conference statement: diagnosing gestational diabetes mellitus, March 4-6, 2013. Obstet Gynecol. 2013;122:358–369.
    • (2013) Obstet Gynecol , vol.122 , pp. 358-369
    • VanDorsten, J.P.1    Dodson, W.C.2    Espeland, M.A.3
  • 82
    • 43249096940 scopus 로고    scopus 로고
    • Hyperglycemia and adverse pregnancy outcomes
    • Group HSCR, Metzger BE, Lowe LP, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358:1991–2002.
    • (2008) N Engl J Med , vol.358 , pp. 1991-2002
    • Group, H.S.C.R.1    Metzger, B.E.2    Lowe, L.P.3
  • 83
    • 70349629019 scopus 로고    scopus 로고
    • A multicenter, randomized trial of treatment for mild gestational diabetes
    • Landon MB, Spong CY, Thom E, et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009;361:1339–1348.
    • (2009) N Engl J Med , vol.361 , pp. 1339-1348
    • Landon, M.B.1    Spong, C.Y.2    Thom, E.3
  • 84
    • 0036781530 scopus 로고    scopus 로고
    • Gestational diabetes and the incidence of type 2 diabetes: a systematic review
    • Kim C, Newton KM, Knopp RH. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care. 2002;25:1862–1868.
    • (2002) Diabetes Care , vol.25 , pp. 1862-1868
    • Kim, C.1    Newton, K.M.2    Knopp, R.H.3
  • 85
    • 65649084159 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
    • Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–1779.
    • (2009) Lancet , vol.373 , pp. 1773-1779
    • Bellamy, L.1    Casas, J.P.2    Hingorani, A.D.3    Williams, D.4
  • 86
    • 0000001567 scopus 로고
    • The Boston gestational diabetes studies: review and perspectives
    • In, Sutherland HW, Stowers JM, Pearson DWM, eds., London, England, Springer
    • O'Sullivan JB. The Boston gestational diabetes studies: review and perspectives. In: Sutherland HW, Stowers JM, Pearson DWM, eds. Carbohydrate Metabolism in Pregnancy and the Newborn IV London, England: Springer; 1989:287–294.
    • (1989) Carbohydrate Metabolism in Pregnancy and the Newborn IV , pp. 287-294
    • O'Sullivan, J.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.