Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets

Biological Research

Volumn 39, Issue 3, 2006, Pages 555-566

  Cunha, Daniel A ^a   Amaral, Maria E C ^a   Carvalho, Carolina P F ^a   Collares Buzato, Carla B ^a   Carneiro, Everardo M ^a   Boschero, Antonio C ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Insulin; Pancreatic islets; Pregnant rats; Prolactin; SNARE proteins; Synaptotagmin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROLACTIN; SNARE PROTEIN; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN 1; WORTMANNIN;

ADAPTATION; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GESTATION PERIOD; IMMUNOLOCALIZATION; IN VITRO STUDY; INSULIN RELEASE; MATURATION; MEMBRANE FUSION; NEWBORN; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PERINATAL PERIOD; PREGNANCY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STIMULUS SECRETION COUPLING; TISSUE CULTURE; WESTERN BLOTTING;

EID: 33751092499     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602006000300016     Document Type: Article

References (34)

1. AMARAL ME, UENO M, CARVALHEIRA JB, CARNEIRO EM, VELLOSO LA, SAAD MJ, BOSCHERO AC (2003) Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway. Horm Metab Res 35: 282-289
2. ARIEN H, WISER O, ARKIN IT, LEONOV H, ATLAS D (2003) Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative manner. J Biol Chem 278: 29231-29239.
3. BARTHOLOMEUSZ RK, BRUCE NW, MARTIN CE, HARTMANN PE (1976) Serial measurement of arterial plasma progesterone levels throughout gestation and parturition in individual rats. Acta Endocrinol (Copenh) 82: 436-445
4. BERLANGA JJ, GUALILLO O, BUTEAU H, APPLANAT M, KELLY PA, EDERY M (1997) Prolactin activates tyrosyl phosphorylation of insulin receptor substrate 1 and phosphatidylinositol-3-OH kinase. J Biol Chem 272: 2050-2052
5. BONE AJ, TAYLOR KW (1976) Metabolic adaptation to pregnancy shown by increased biosynthesis of insulin in islets of Langerhans isolated from pregnant rats. Nature 262: 501-502
6. BOSCHERO AC, CREPALDI SC, CARNEIRO EM, DELATTRE E, ATWATER I (1993) Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets. Endocrinology 133: 515-520
7. BRELJE TC, SCHARP DW, LACY PE, OGREN L, TALAMANTES F, ROBERTSON M, FRIESEN HG, SORENSON RL (1993) Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: Implication for placental lactogen regulation of islet function during pregnancy. Endocrinology 132: 879-887
8. COLLARES-BUZATO CB, LEITE AR, BOSCHERO AC (2001) Modulation of gap and adherens junctional proteins in cultured neonatal pancreatic islets. Pancreas 23: 177-185
9. CUI N, KANG Y, HE Y, LEUNG YM, XIE H, PASYK EA, GAO X, SHEU L, HANSEN JB, WAHLI P, TSUSHIMA RG, GAISANO HY (2004) H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2. J Biol Chem 279: 53259-53265
10. CURRY DL, BENNET LL, GRODSKY GM (1968) Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 83: 572-584
11. 2+-induced insulin secretion in pancreatic islet b-cells. J Biol Chem 275: 36079-36085
12. GUT A, KIRALY CE, FUKUDA M, MIKOSHIBA K, WOLLHEIM CB, LANG J (2001) Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: Their function in insulin exocytosis. J Cell Sci 114: 1709-1716
13. HANSON PI, ROTH R, MORISAKI H, JAHN R, HEUSER JE (1997) Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Cell 90: 523-535
14. HELLMAN B (1960) The islets of Langerhans in the rat during pregnancy and lactation, with special reference to the changes in the B/A cell ratio. Acta Obstet Gynecol Scand 39: 331-342
15. JACOBSSON G, BEAN AJ, SCHELLER RH, JUNTTI-BERGGREN L, DEENEY JT, BERGGREN PO, MEISTER B (1994) Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci USA 91: 12487-12491
16. 2+-stimulated exocytosis of insulin. Biochem J 314: 199-203
17. LANG J, FUKUDA M, ZHANG H, MIKOSHIBA K, WOLLHEIM CB (1997) The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: Action of synaptotagmin at low micromolar calcium. J EMBO 16: 5837-5846
18. LI C, ULLRICH B, ZHANG JZ, ANDERSON RG, BROSE N, SUDHOF TC (1995) Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 375: 594-599
19. MARTIN F, MOYA F, GUTIÉRREZ LM, REIG JA, SORIA B (1995) Role of syntaxin in mouse pancreatic beta cells. Diabetologia 39: 860-863
20. MARTIN F, SALINAS E, VÁZQUEZ J, SORIA B, REIG JA (1996) Inhibition of insulin release by synthetic peptides shows that the H3 region at the C-terminal domain of syntaxin-1 is crucial for Ca(2+)- but not for guanosine 5′-[gamma-thio]triphosphate-induced secretion. Biochem J 320: 201-205
21. NAGAMATSU S, NAKAMICHI Y, OZAWA S, ISHIDA H (1999) Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: Restoration of decreased t-SNARE proteins improves impaired insulin secretion. Diabetes 48: 2367-2373
22. OGREN L, TALAMANTES F (1988) Prolactins of pregnancy and their cellular source. Int Rev Cytol 112: 1-65
23. PASYK EA, KANG Y, HUANG X, CUI N, SHEU L, GAISANO HY (2004) Syntaxin-1A binds the nucleoticle-binding folds of sulphonylurea receptor 1 to regulate the KATP channel. J Biol Chem 279: 4234-4240
24. PEVSNER J, HSU SC, BRAUN JEA, CALAKOS N, TING AE, BENNET ME, SCHELLER RH (1994) Specificity and regulation of a synaptic vesicle docking complex. Neuron 13: 353-361
25. SAEGUSA C, FUKUDA M, MIKOSHIBA K (2002) Synaptotagmin V is targeted to dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells. J Biol Chem 277: 24499-24505
26. SHAIKN AA (1971) Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy. Biol Reprod 5: 297-307
27. SHEU L, PASYK EA, JI J, HUANG X, GAO X, VAROQUEAUX F, BROSE N, GAISA HY (2003) Regulation of insulin exocytosis by Munc13-1. J. Biol Chem 278: 27556-27563
28. SORENSON RL, BRELJE TC, HEGRE OD, MARSHALL S, ANAYA P, SHERIDAN JD (1987) Prolactin (in vitro) decreases the glucose stimulation threshold, enhances insulin secretion, and increases dye coupling among islet B cells. Endocrinology 121: 1447-1453
29. SORENSON RL, BRELJE TC, ROTH C (1993) Effects of steroid and lactogenic hormones on islets of Langerhans: A new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy. Endocrinology 133: 2227-2234
30. TSUK S, MICHAELEVSKI I, BENTLEY GN, JOHO RH, CHIKVASHVILI D (2005) Lotan I. Kv2.1 channel activation and inactivation is influenced by physical interactions of both syntaxin 1A and the syntaxin 1A/soluble N-ethylmaleimide-sensitive factor-25 (t-SNARE) complex with the C terminus of the channel. Mol Pharmacol 67: 480-488
31. WHEELER MB, SHEU L, GHAI M, BOUQUILLON A, GRONDIN G, WELLER U, BEAUDOIN AR, BENNETT MK, TRIMBLE WS, GAISANO HY (1996) Characterization of SNARE protein expression in beta cell lines and pancreatic islets. Endocrinology 137: 1340-1348
32. YAMAUCHI T, KABURAGI Y, UEKI K, TSUJI Y, STARK GR, KERR IM, TSUSHIMA T, AKANUMA Y, KOMURO I, TOBE K, YAZAKI Y, KADOWAKI T (1998) Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase. J Biol Chem 273: 15719-15726
33. YOSHIDA A, OHO C, OMORI A, KUWAHARA R, ITO T, TAKAHASHI M (1992) HPC-1 is associated with synaptotagmin and omega-conotoxin receptor. J Biol Chem 267: 24925-24928
34. ZHANG W, EFANOV A, YANG SN, FRIED G, KOLARE S, BROWN H, ZAITSEV S, BERGGREN PO, MEISTER B (2000) Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell. J Biol Chem 275: 41521-41527