IRF3 promotes adipose inflammation and insulin resistance and represses browning

Journal of Clinical Investigation

Volumn 126, Issue 8, 2016, Pages 2839-2854

  Kumari, Manju ^a   Wang, Xun ^a   Lantier, Louise ^b   Lyubetskaya, Anna ^a   Eguchi, Jun ^c   Kang, Sona ^a   Tenen, Danielle ^a   Roh, Hyun Cheol ^a   Kong, Xingxing ^a   Kazak, Lawrence ^a   Ahmad, Rasheed ^d   Rosen, Evan D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

^d DASMAN DIABETES INSTITUTE   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INTERFERON REGULATORY FACTOR 3; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; GLUCOSE BLOOD LEVEL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRF3 PROTEIN, HUMAN; IRF3 PROTEIN, MOUSE; SLC2A4 PROTEIN, HUMAN; SLC2A4 PROTEIN, MOUSE; TLR3 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIET INDUCED OBESITY; ENERGY EXPENDITURE; ENERGY METABOLISM; EPIDIDYMIS FAT; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE GENE; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SUBCUTANEOUS FAT; THERMOGENESIS; TRANSCRIPTION REGULATION; UPREGULATION; WHITE ADIPOSE TISSUE; 3T3-L1 CELL LINE; ADIPOSE TISSUE; ADULT; ANIMAL; CYTOLOGY; DIET; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE CLAMP TECHNIQUE; HEK293 CELL LINE; HOMEOSTASIS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; OBESITY; TRANSGENIC MOUSE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ADIPOSITY; ADULT; ANIMALS; BLOOD GLUCOSE; DIET; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORTER TYPE 4; HEK293 CELLS; HOMEOSTASIS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTERFERON REGULATORY FACTOR-3; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; NF-KAPPA B; OBESITY; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 84987786665     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI86080     Document Type: Article

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