Reducing breast cancer recurrence: The role of dietary polyphenolics

Nutrients

Volumn 8, Issue 9, 2016, Pages

  Braakhuis, Andrea J ^a   Campion, Peta ^a   Bishop, Karen S ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Breast cancer; Human trials; Polyphenols

Indexed keywords

FLAVONOL; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; ISOFLAVONE; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUMOR MARKER; ANTIOXIDANT; BIOLOGICAL MARKER; CARCINOGEN; PLANT MEDICINAL PRODUCT; POLYPHENOL;

ANTIOXIDANT ACTIVITY; BIOAVAILABILITY; BREAST CANCER; CANCER RECURRENCE; CANCER RISK; DIET SUPPLEMENTATION; DIETARY INTAKE; DNA REPAIR; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE MUTATION; HUMAN; MEDITERRANEAN DIET; MISMATCH REPAIR; OBSERVATIONAL STUDY; PROTEIN INTAKE; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVOR; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; BLOOD; BREAST NEOPLASMS; CHEMISTRY; DNA DAMAGE; DRUG EFFECTS; FRUIT; GENETIC EPIGENESIS; PREVENTION AND CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TUMOR RECURRENCE; VEGETABLE;

ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; BIOMARKERS; BREAST NEOPLASMS; CARCINOGENS; DIET, MEDITERRANEAN; DNA DAMAGE; EPIGENESIS, GENETIC; FEMALE; FRUIT; HUMANS; NEOPLASM RECURRENCE, LOCAL; OBSERVATIONAL STUDIES AS TOPIC; PHYTOCHEMICALS; POLYPHENOLS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VEGETABLES;

EID: 84987730726     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8090547     Document Type: Review

References (91)

1. Hauner, H., Hauner, D. The Impact of Nutrition on the Development and Prognosis of Breast Cancer. Breast Care (Basel) 2010, 5, 377–381. [CrossRef] [PubMed]
2. Key, T.J., Allen, N.E., Spencer, E.A., Travis, R.C. The effect of diet on risk of cancer. Lancet 2002, 360, 861–868. [CrossRef]
3. Gandini, S., Merzenich, H., Robertson, C., Boyle, P. Meta-analysis of studies on breast cancer risk and diet: The role of fruit and vegetable consumption and the intake of associated micronutrients. Eur. J. Cancer 2000, 36, 636–646. [CrossRef]
4. Damianaki, A., Bakogeorgou, E., Kampa, M., Notas, G., Hatzoglou, A., Panagiotou, S., Gemetzi, C., Kouroumalis, E., Martin, P.M., Castanas, E. Potent inhibitory action of red wine polyphenols on human breast cancer cells. J. Cell. Biochem. 2000, 78, 429–441. [CrossRef]
5. Williamson, G., Manach, C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am. J. Clin. Nutr. 2005, 81, S243–S255.
6. Aiyer, H.S., Warri, A.M., Woode, D.R., Hilakivi-Clarke, L., Clarke, R. Influence of berry polyphenols on receptor signaling and cell-death pathways: Implications for breast cancer prevention. J. Agric. Food Chem. 2012, 60, 5693–5708. [CrossRef] [PubMed]
7. Abdulla, M., Gruber, P. Role of diet modification in cancer prevention. Biofactors 2000, 12, 45–51. [CrossRef] [PubMed]
8. Lambert, J.D., Yang, C.S. Mechanisms of cancer prevention by tea constituents. J. Nutr. 2003, 133, S3262–S3267.
9. Spagnuolo, C., Russo, G.L., Orhan, I.E., Habtemariam, S., Daglia, M., Sureda, A., Nabavi, S.F., Devi, K.P., Loizzo, M.R., Tundis, R., et al. Genistein and cancer: Current status, challenges, and future directions. Adv. Nutr. 2015, 6, 408–419. [CrossRef] [PubMed]
10. Rock, C.L., Natarajan, L., Pu, M., Thomson, C.A., Flatt, S.W., Caan, B.J., Gold, E.B., Al-Delaimy, W.K., Newman, V.A., Hajek, R.A., et al. Longitudinal biological exposure to carotenoids is associated with breast cancer-free survival in the Women’s Healthy Eating and Living Study. Cancer Epidemiol. Biomark. Prev. 2009, 18, 486–494. [CrossRef] [PubMed]
11. Mignone, L.I., Giovannucci, E., Newcomb, P.A., Titus-Ernstoff, L., Trentham-Dietz, A., Hampton, J.M., Willet, W.C., Egan, K.M. Dietary carotenoids and the risk of invasive breast cancer. Int. J. Cancer 2009, 124, 2929–2937. [CrossRef] [PubMed]
12. Baglietto, L., Krishnan, K., Severi, G., Hodge, A., Brinkman, M., English, D.R., McLean, C., Hopper, J.L., Giles, G.G. Dietary patterns and risk of breast cancer. Br. J. Cancer 2011, 104, 524–531. [CrossRef] [PubMed]
13. Pierce, J.P., Natarajan, L., Caan, B.J., Parker, B.A., Greenberg, E.R., Flatt, S.W., Rock, C.L., Kealey, S., Al-Delaimy, W.K., Bardwell, W.A., et al. Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: The Women’s Healthy Eating and Living (WHEL) randomized trial. JAMA 2007, 298, 289–298. [CrossRef] [PubMed]
14. Sartippour, M.R., Rao, J.Y., Apple, S., Wu, D., Henning, S., Wang, H., Elashoff, R., Rubio, R., Heber, D., Brooks, M.N. A pilot clinical study of short-term isoflavone supplements in breast cancer patients. Nutr. Cancer 2004, 49, 59–65. [CrossRef] [PubMed]
15. DiSilvestro, R.A., Goodman, J., Dy, E., Lavalle, G. Soy isoflavone supplementation elevates erythrocyte superoxide dismutase, but not plasma ceruloplasmin in postmenopausal breast cancer survivors. Breast Cancer Res. Treat. 2005, 89, 251–255. [CrossRef] [PubMed]
16. Inoue, M., Tajima, K., Mizutani, M., Iwata, H., Iwase, T., Miura, S., Hirose, K., Hamajima, N., Tominaga, S. Regular consumption of green tea and the risk of breast cancer recurrence: Follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. Cancer Lett. 2001, 167, 175–182. [CrossRef]
17. Centritto, F., Iacoviello, L., di Giuseppe, R., De Curtis, A., Costanzo, S., Zito, F., Grioni, S., Sieri, S., Donati, M.B., de Gaetano, G., et al. Dietary patterns, cardiovascular risk factors and C-reactive protein in a healthy Italian population. Nutr. Metab. Cardiovasc. Dis. 2009, 19, 697–706. [CrossRef] [PubMed]
18. Barbaresko, J., Koch, M., Schulze, M.B., Nothlings, U. Dietary pattern analysis and biomarkers of low-grade inflammation: A systematic literature review. Nutr. Rev. 2013, 71, 511–527. [CrossRef] [PubMed]
19. Calder, P.C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jonsson, L.S., Kolb, H., Lansink, M., et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br. J. Nutr. 2011, 106, S5–S78. [CrossRef] [PubMed]
20. Ramos, S. Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways. Mol. Nutr. Food Res. 2008, 52, 507–526. [CrossRef] [PubMed]
21. Bonaccio, M., Pounis, G., Cerletti, C., Donati, M.B., Iacoviello, L., de Gaetano, G. Mediterranean diet, dietary polyphenols and low-grade inflammation: Results from the moli-sani study. Br. J. Clin. Pharmacol. 2016. [CrossRef] [PubMed]
22. Lahmann, P.H., Schulz, M., Hoffmann, K., Boeing, H., Tjonneland, A., Olsen, A., Overvad, K., Key, T.J., Allen, N.E., Khaw, K.T., et al. Long-term weight change and breast cancer risk: The European prospective investigation into cancer and nutrition (EPIC). Br. J. Cancer 2005, 93, 582–589. [CrossRef] [PubMed]
23. National Cancer Institute. United States of America: Obesity and Cancer Risk, 2012. Available online: http://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet (accessed on 20 June 2016).
24. Expert Panel on Detection, Evaluation and Treatment of High Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). J. Am. Med. Assoc. 2001, 285, 2486–2497.
25. Agnoli, C., Berrino, F., Abagnato, C.A., Muti, P., Panico, S., Crosignani, P., Krogh, V. Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: A nested case-control study. Nutr. Metab. Cardiovasc. Dis. 2010, 20, 41–48. [CrossRef] [PubMed]
26. Chan, D.S., Vieira, A.R., Aune, D., Bandera, E.V., Greenwood, D.C., McTiernan, A., Navarro-Rosenblatt, D., Thune, I., Vieira, R., Norat, T. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann. Oncol. 2014, 25, 1901–1914. [CrossRef] [PubMed]
27. Roopchand, D.E., Carmody, R.N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P.J., Raskin, I. Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome. Diabetes 2015, 64, 2847–2858. [CrossRef] [PubMed]
28. Anhe, F.F., Roy, D., Pilon, G., Dudonne, S., Matamoros, S., Varin, T.V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 2015, 64, 872–883. [CrossRef] [PubMed]
29. Moreno-Indias, I., Sanchez-Alcoholado, L., Perez-Martinez, P., Andres-Lacueva, C., Cardona, F., Tinahones, F., Queipo-Ortuno, M.I. Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients. Food Funct. 2016, 7, 1775–1787. [CrossRef] [PubMed]
30. Ramos, S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J. Nutr. Biochem. 2007, 18, 427–442. [CrossRef] [PubMed]
31. Maraldi, T., Vauzour, D., Angeloni, C. Dietary polyphenols and their effects on cell biochemistry and pathophysiology 2013. Oxid. Med. Cell. Longev. 2014, 2014, 576363. [CrossRef] [PubMed]
32. Varinska, L., Gal, P., Mojzisova, G., Mirossay, L., Mojzis, J. Soy and breast cancer: Focus on angiogenesis. Int. J. Mol. Sci. 2015, 16, 11728–11749. [CrossRef] [PubMed]
33. Yang, C.S., Lambert, J.D., Sang, S. Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch. Toxicol. 2009, 83, 11–21. [CrossRef] [PubMed]
34. Di Domenico, F., Foppoli, C., Coccia, R., Perluigi, M. Antioxidants in cervical cancer: Chemopreventive and chemotherapeutic effects of polyphenols. Biochim. Biophys. Acta 2012, 1822, 737–747. [CrossRef] [PubMed]
35. Rahman, I., Biswas, S.K., Kirkham, P.A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol. 2006, 72, 1439–1452. [CrossRef] [PubMed]
36. Duell, E.J., Millikan, R.C., Pittman, G.S., Winkel, S., Lunn, R.M., Tse, C.K., Eaton, A., Mohrenweiser, H.W., Newman, B., Bell, D.A. Polymorphisms in the DNA repair gene XRCC1 and breast cancer. Cancer Epidemiol. Biomark. Prev. 2001, 10, 217–222.
37. Tresserra-Rimbau, A., Rimm, E.B., Medina-Remon, A., Martinez-Gonzalez, M.A., Lopex-Sabeter, M.C., Covas, M.I., Corella, D., Salas-Salvado, J., Gomez-Gracia, E., Lapetra, J., et al. Polyphenol intake and mortality risk: A re-analysis of the PREDIMED trial. BMC Med. 2014, 12, 77–89. [CrossRef] [PubMed]
38. Kosti, O., Byrne, C., Meeker, K.L., Watkins, K.M., Loffredo, C.A., Shields, P.G., Schwartz, M.D., Willey, S.C., Cocilovo, C., Zheng, Y.L. Mutagen sensitivity, tobacco smoking and breast cancer risk: A case-control study. Carcinogenesis 2010, 31, 654–659. [CrossRef] [PubMed]
39. Songserm, N., Promthet, S., Pientong, C., Ekalaksananan, T., Chopjitt, P., Wiangnon, S. Gene-environment interaction involved in cholangiocarcinoma in the Thai population: Polymorphisms of DNA repair genes, smoking and use of alcohol. BMJ Open 2014, 4, e005447. [CrossRef] [PubMed]
40. Collins, A.R. The comet assay for DNA damage and repair: Principles, applications, and limitations. Mol. Biotechnol. 2004, 26, 249–261. [CrossRef]
41. Rodeiro, I., Delgado, R., Garrido, G. Effects of a Mangifera indica L. stem bark extract and mangiferin on radiation-induced DNA damage in human lymphocytes and lymphoblastoid cells. Cell Prolif. 2014, 47, 48–55. [CrossRef] [PubMed]
42. Bishop, K.S., Erdrich, S., Karunasinghe, N., Han, D.Y., Zhu, S., Jesuthasan, A., Ferguson, L.R. An investigation into the association between DNA damage and dietary fatty acid in men with prostate cancer. Nutrients 2015, 7, 405–422. [CrossRef] [PubMed]
43. Powell, S.N., Riaz, N., Mutter, W., Ng, C.K.Y., Delsite, R., Piscuoglio, S., King, T.A., Martelotto, L., Sakr, R., Brogi, E., et al. Abstract S4–03: A functional assay for homologous recombination (HR) DNA repair and whole exome sequencing reveal that HR-defective sporadic breast cancers are enriched for genetic alterations in DNA repair genes. Cancer Res. 2016, 76. [CrossRef]
44. Kumari, S., Rastogi, R., Singh, K., Singh, S., Sinha, R. DNA damage: Detection strategies. EXCLI J. 2008, 7, 44–62.
45. Lee, E., Levine, E.A., Franco, V.I., Allen, G.O., Gong, F., Zhang, Y., Hu, J.J. Combined genetic and nutritional risk models of triple negative breast cancer. Nutr. Cancer 2014, 66, 955–963. [CrossRef] [PubMed]
46. Campeau, P.M., Foulkes, W.D., Tischkowitz, M.D. Hereditary breast cancer: New genetic developments, new therapeutic avenues. Hum. Genet. 2008, 124, 31–42. [CrossRef] [PubMed]
47. Thomson, C.A., Stendell-Hollis, N.R., Rock, C.L., Cussler, E.C., Flatt, S.W., Pierce, J.P. Plasma and dietary carotenoids are associated with reduced oxidative stress in women previously treated for breast cancer. Cancer Epidemiol. Biomark. Prev. 2007, 16, 2008–2015. [CrossRef] [PubMed]
48. Adams, L.S., Phung, S., Yee, N., Seeram, N.P., Li, L., Chen, S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2010, 70, 3594–3605. [CrossRef] [PubMed]
49. Adams, L.S., Kanaya, N., Phung, S., Liu, Z., Chen, S. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J. Nutr. 2011, 141, 1805–1812. [CrossRef] [PubMed]
50. Meeran, S.M., Patel, S.N., Tollefsbol, T.O. Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS ONE 2010, 5, e11457. [CrossRef] [PubMed]
51. Meeran, S.M., Patel, S.N., Chan, T.H., Tollefsbol, T.O. A novel prodrug of epigallocatechin-3-gallate: Differential epigenetic hTERT repression in human breast cancer cells. Cancer Prev. Res. (Phila.) 2011, 4, 1243–1254. [CrossRef] [PubMed]
52. Meeran, S.M., Patel, S.N., Li, Y., Shukla, S., Tollefsbol, T.O. Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS ONE 2012, 7, e37748. [CrossRef] [PubMed]
53. Martin-Pelaez, S., Covas, M.I., Fito, M., Kusar, A., Pravst, I. Health effects of olive oil polyphenols: Recent advances and possibilities for the use of health claims. Mol. Nutr. Food Res. 2013, 57, 760–771. [CrossRef] [PubMed]
54. De la Torre-Robles, A., Rivas, A., Lorenzo-Tovar, M.L., Monteagudo, C., Mariscal-Arcas, M., Olea-Serrano, F. Estimation of the intake of phenol compounds from virgin olive oil of a population from southern Spain. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 2014, 31, 1460–1469. [CrossRef] [PubMed]
55. Covas, M.I., Nyyssonen, K., Poulsen, H.E., Kaikkonen, J., Zunft, H.J., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Baumler, H., et al. The effect of polyphenols in olive oil on heart disease risk factors: A randomized trial. Ann. Intern. Med. 2006, 145, 333–341. [CrossRef] [PubMed]
56. LeGendre, O., Breslin, P.A., Foster, D.A. (–)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization. Mol. Cell. Oncol. 2015, 2, e1006077. [CrossRef] [PubMed]
57. Wierzejska, R. Coffee consumption vs. cancer risk—A review of scientific data. Rocz. Panstwowego Zakladu Hig. 2015, 66, 293–298.
58. Oleaga, C., Ciudad, C.J., Noe, V., Izquierdo-Pulido, M. Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells. Oxid. Med. Cell. Longev. 2012, 2012, 390385. [CrossRef] [PubMed]
59. Cui, L., Liu, X., Tian, Y., Xie, C., Li, Q., Cui, H., Sun, C. Flavonoids, flavonoid subclasses and breast cancer risk: A meta-analysis of epidemiologic studies. PLoS ONE 2013, 8, e54318.
60. Adebamowo, C.A., Cho, E., Sampson, L., Katan, M.B., Spiegelman, D., Willett, W.C., Holmes, M.D. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Int. J. Cancer 2005, 114, 628–633. [CrossRef] [PubMed]
61. Constantinou, A., Huberman, E. Genistein as an inducer of tumor cell differentiation: Possible mechanisms of action. Proc. Soc. Exp. Biol. Med. 1995, 208, 109–115. [CrossRef] [PubMed]
62. Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., et al. Soy, red clover, and isoflavones and breast cancer: A systematic review. PLoS ONE 2013, 8, e81968. [CrossRef] [PubMed]
63. Shike, M., Doane, A.S., Russo, L., Cabal, R., Reis-Filho, J.S., Gerald, W., Cody, H., Khanin, R., Bromberg, J., Norton, L. The effects of soy supplementation on gene expression in breast cancer: A randomized placebo-controlled study. J. Natl. Cancer Inst. 2014, 106. [CrossRef] [PubMed]
64. Messina, M.J., Persky, V., Setchell, K.D., Barnes, S. Soy intake and cancer risk: A review of the in vitro and in vivo data. Nutr. Cancer 1994, 21, 113–131. [CrossRef] [PubMed]
65. Shu, X.O., Zheng, Y., Cai, H., Gu, K., Chen, Z., Zheng, W., Lu, W. Soy food intake and breast cancer survival. JAMA 2009, 302, 2437–2443. [CrossRef] [PubMed]
66. Jacobs, D.R., Jr., Gross, M.D., Tapsell, L.C. Food synergy: An operational concept for understanding nutrition. Am. J. Clin. Nutr. 2009, 89, S1543–S1548. [CrossRef] [PubMed]
67. Tapsell, L.C. Foods and food components in the Mediterranean diet: Supporting overall effects. BMC Med. 2014, 12. [CrossRef] [PubMed]
68. Saura-Calixto, F., Goni, I. Antioxidant capacity of the Spanish Mediterranean Diet. Food Chem. 2006, 94, 442–447. [CrossRef]
69. Arts, I.C., Hollman, P.C. Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr. 2005, 81, S317–S325.
70. Scalbert, A., Manach, C., Morand, C., Remesy, C., Jimenez, L. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 2005, 45, 287–306. [CrossRef] [PubMed]
71. Chlebowski, R.T., Blackburn, G.L., Thomson, C.A., Nixon, D.W., Shapiro, A., Hoy, M.K., Goodman, M.T., Giuliano, A.E., Karanja, N., McAndrew, P., et al. Dietary fat reduction and breast cancer outcome: Interim efficacy results from the Women’s Intervention Nutrition Study. J. Natl. Cancer Inst. 2006, 98, 1767–1776. [CrossRef] [PubMed]
72. Hauner, D., Hauner, H. Metabolic syndrome and breast cancer: Is there a link? Breast Care (Basel) 2014, 9, 277–281. [CrossRef] [PubMed]
73. McTiernan, A., Irwin, M., Vongruenigen, V. Weight, physical activity, diet, and prognosis in breast and gynecologic cancers. J. Clin. Oncol. 2010, 28, 4074–4080. [CrossRef] [PubMed]
74. Protani, M., Coory, M., Martin, J.H. Effect of obesity on survival of women with breast cancer: Systematic review and meta-analysis. Breast Cancer Res. Treat. 2010, 123, 627–635. [CrossRef] [PubMed]
75. Villarini, A., Pasanisi, P., Traina, A., Mano, M.P., Bonanni, B., Panico, S., Scipioni, C., Galasso, R., Paduos, A., Simeoni, M., et al. Lifestyle and breast cancer recurrences: The DIANA-5 trial. Tumori 2012, 98, 1–18. [PubMed]
76. Berrino, F., Bellati, C., Secreto, G., Camerini, E., Pala, V., Panico, S., Allegro, G., Kaaks, R. Reducing bioavailable sex hormones through a comprehensive change in diet: The diet and androgens (DIANA) randomized trial. Cancer Epidemiol. Biomark. Prev. 2001, 10, 25–33.
77. Berrino, F., Villarini, A., De Petris, M., Raimondi, M., Pasanisi, P. Adjuvant diet to improve hormonal and metabolic factors affecting breast cancer prognosis. Ann. N. Y. Acad. Sci. 2006, 1089, 110–118. [CrossRef] [PubMed]
78. Villarini, A., Pasanisi, P., Raimondi, M., Gargano, G., Bruno, E., Morelli, D., Evangelista, A., Curtosi, P., Berrino, F. Preventing weight gain during adjuvant chemotherapy for breast cancer: A dietary intervention study. Breast Cancer Res. Treat. 2012, 135, 581–589. [CrossRef] [PubMed]
79. Dahabreh, I.J., Linardou, H., Siannis, F., Fountzilas, G., Murray, S. Trastuzumab in the adjuvant treatment of early-stage breast cancer: A systematic review and meta-analysis of randomized controlled trials. Oncologist 2008, 13, 620–630. [CrossRef] [PubMed]
80. Engstrom, M.J., Opdahl, S., Hagen, A.I., Romundstad, P.R., Akslen, L.A., Haugen, O.A., Vatten, L.J., Bofin, A.M. Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients. Breast Cancer Res. Treat. 2013, 140, 463–473. [CrossRef] [PubMed]
81. Schnitt, S.J. Classification and prognosis of invasive breast cancer: From morphology to molecular taxonomy. Mod. Pathol. 2010, 23, S60–S64. [CrossRef] [PubMed]
82. Staaf, J., Ringner, M. Making breast cancer molecular subtypes robust? J. Natl. Cancer Inst. 2014, 107. [CrossRef] [PubMed]
83. Jonat, W., Pritchard, K.I., Sainsbury, R., Klijn, J.G. Trends in endocrine therapy and chemotherapy for early breast cancer: A focus on the premenopausal patient. J. Cancer Res. Clin. Oncol. 2006, 132, 275–286. [CrossRef] [PubMed]
84. Jenkins, E.O., Deal, A.M., Anders, C.K., Prat, A., Perou, C.M., Carey, L.A., Muss, H.B. Age-specific changes in intrinsic breast cancer subtypes: A focus on older women. Oncologist 2014, 19, 1076–1083. [CrossRef] [PubMed]
85. Vanden Berghe, W. Epigenetic impact of dietary polyphenols in cancer chemoprevention: Lifelong remodeling of our epigenomes. Pharmacol. Res. 2012, 65, 565–576. [CrossRef] [PubMed]
86. Link, A., Balaguer, F., Shen, Y., Lozano, J.J., Leung, H.C., Boland, C.R., Goel, A. Curcumin modulates DNA methylation in colorectal cancer cells. PLoS ONE 2013, 8, e57709. [CrossRef] [PubMed]
87. Tapiero, H., Tew, K.D., Ba, G.N., Mathe, G. Polyphenols: Do they play a role in the prevention of human pathologies? Biomed. Pharmacother. 2002, 56, 200–207. [CrossRef]
88. Bohn, T. Dietary factors affecting polyphenol bioavailability. Nutr. Rev. 2014, 72, 429–452. [CrossRef] [PubMed]
89. Huang, Q., Yu, H., Ru, Q. Bioavailability and delivery of nutraceuticals using nanotechnology. J. Food Sci. 2010, 75, R50–R57. [CrossRef] [PubMed]
90. Miller, P.E., Alexander, D.D., Weed, D.L. Uncertainty of results in nutritional epidemiology. Nutr. Today 2014, 49, 147–152. [CrossRef]
91. Alexander, D.D., Weed, D.L., Miller, P.E., Mohamed, M.A. Red Meat and Colorectal Cancer: A Quantitative Update on the State of the Epidemiologic Science. J. Am. Coll. Nutr. 2015, 34, 521–543. [CrossRef] [PubMed]