Cardiac-restricted overexpression of TRAF3 interacting protein 2 (TRAF3IP2) results in spontaneous development of myocardial hypertrophy, fibrosis, and dysfunction

Journal of Biological Chemistry

Volumn 291, Issue 37, 2016, Pages 19425-19436

  Yariswamy, Manjunath ^a,b   Yoshida, Tadashi ^a   Valente, Anthony J ^c   Kandikattu, Hemanth Kumar ^a   Sakamuri, Siva S V P ^d   Siddesha, Jalahalli M ^d   Sukhanov, Sergiy ^a   Saifudeen, Zubaida ^e   Ma, Lixin ^a,b   Siebenlist, Ulrich ^f   Gardner, Jason D ^g   Chandrasekar, Bysani ^a,b  

^a University of Missouri   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d University School of Medicine   (United States)

^e TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^g LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; DIAGNOSIS; DISEASES; ECHOCARDIOGRAPHY; GENE EXPRESSION; MAGNETIC RESONANCE IMAGING; MAMMALS; PATHOLOGY; PROTEINS;

CONTRACTILE DYSFUNCTION; EXTRACELLULAR MATRIX PROTEIN; INFLAMMATORY DISEASE; INFLAMMATORY MEDIATORS; INFLAMMATORY RESPONSE; MYOCARDIAL HYPERTROPHY; PRO-INFLAMMATORY CYTOKINES; SPONTANEOUS DEVELOPMENT;

HEART;

BETA FIBROBLAST GROWTH FACTOR; CCAAT ENHANCER BINDING PROTEIN BETA; COLONY STIMULATING FACTOR 1; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRILLAR COLLAGEN; FRACTALKINE; GRANULOCYTE COLONY STIMULATING FACTOR; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PADGEM PROTEIN; PROTEIN TWEAK; PROTEIN TWEAKR; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; STROMELYSIN 2; TRAF3 INTERACTING PROTEIN 2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; CEBPB PROTEIN, MOUSE; CHEMOKINE; COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRAF3IP2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE CELL; CARDIOVASCULAR PARAMETERS; CELL DEATH; CONTRACTILE DYSFUNCTION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEART BODY WEIGHT RATIO; HEART CATHETERIZATION; HEART EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART OUTPUT; HEART PEAK EJECTION RATE; HEART STROKE VOLUME; HEART VENTRICLE HYPERTROPHY; MALE; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRAF3IP2 GENE; UPREGULATION; ANIMAL; BIOSYNTHESIS; CARDIAC MUSCLE; CARDIOMEGALY; DISEASE MODEL; FEMALE; FIBROSIS; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SEXUAL DEVELOPMENT; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARDIOMEGALY; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CHEMOKINES; COLLAGEN; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; GENE EXPRESSION REGULATION; MALE; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MYOCARDIUM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SEX CHARACTERISTICS; STROKE VOLUME; TRANSCRIPTION FACTOR AP-1;

EID: 84987615949     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.724138     Document Type: Article

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