Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes

Journal of Biological Chemistry

Volumn 280, Issue 6, 2005, Pages 4553-4567

  Chandrasekar, Bysani ^a,f   Mummidi, Srinivas ^a,b   Claycomb, William C ^c   Mestril, Ruben ^d   Nemer, Mona ^e  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b Vet Aff Res Ctr AIDS/HIV 1 I   (United States)

^c LOUISIANA STATE UNIV HLTH SCI C   (United States)

^d LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^e CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^f UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; DISEASES; DNA; DRUG PRODUCTS; GENES; PATIENT MONITORING; PHOSPHATES; PROTEINS; SYNTHESIS (CHEMICAL);

HYPERTROPHY; INTERLEUKIN-18; PHOSPHORYLATION; SERUM LEVELS;

BIOCHEMISTRY;

2 MORPHOLINO 8 PHENYLCHROMONE; ATRIAL NATRIURETIC FACTOR; INTERLEUKIN 18; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN S6; TRANSCRIPTION FACTOR GATA 4; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURFACE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEART MUSCLE CELL; MOLECULAR MECHANICS; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; REPORTER GENE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ATRIAL NATRIURETIC FACTOR; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CHROMONES; CYTOKINES; DNA; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENES, REPORTER; HYPERTROPHY; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; MICE; MORPHOLINES; MYOCYTES, CARDIAC; PHENOTYPE; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-18; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 14244267812     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411787200     Document Type: Article

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