Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Journal of Medicinal Chemistry

Volumn 59, Issue 17, 2016, Pages 8019-8029

  Huang, Kuan Wei ^a,b   Hsu, Kai Cheng ^c   Chu, Lee Ya ^b,d,e   Yang, Jinn Moon ^a   Yuan, Hanna S ^b   Hsiao, Yu Yuan ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d ACADEMIA SINICA   (Taiwan)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLIN 4 YLETHANESULFONIC ACID; AURINTRICARBOXYLIC ACID; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PONTACYL VIOLET 6R; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VIRAL PROTEIN; 2-(N-MORPHOLINO)ETHANESULFONIC ACID; ALKANESULFONIC ACID; CAENORHABDITIS ELEGANS PROTEIN; CRN-4 PROTEIN, C ELEGANS; DEOXYRIBONUCLEASE; EXONUCLEASE; EXORIBONUCLEASE; EXORIBONUCLEASE T; RNA; SINGLE STRANDED DNA;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME INHIBITION; IN VITRO STUDY; LASSA VIRUS; MOLECULAR DOCKING; NONHUMAN; PROTEIN EXPRESSION; SCREENING; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; X RAY CRYSTALLOGRAPHY;

ALKANESULFONIC ACIDS; CAENORHABDITIS ELEGANS PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA, SINGLE-STRANDED; ENDODEOXYRIBONUCLEASES; EXONUCLEASES; EXORIBONUCLEASES; LASSA VIRUS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MORPHOLINES; RNA; VIRAL PROTEINS;

EID: 84986552439     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00794     Document Type: Article

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