Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IκB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase inhibition

Molecular Pharmacology

Volumn 62, Issue 1, 2002, Pages 90-101

  Tsi, Chin Ju ^a   Chao, Yee ^a   Chen, Ching Wen ^a   Lin, Wan Wan ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AURINTRICARBOXYLIC ACID; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME MECHANISM; GENE ACTIVATION; GENE EXPRESSION; IMMUNOBLOTTING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; AURINTRICARBOXYLIC ACID; BINDING SITES; CELLS, CULTURED; DRUG INTERACTIONS; FLUORESCEIN-5-ISOTHIOCYANATE; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITROPRUSSIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTECTIVE AGENTS; PROTEIN-SERINE-THREONINE KINASES; RATS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 0036085386     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.1.90     Document Type: Article

References (40)

1. Role of nitric oxide I mediation of macrophage cytotoxicity and apoptosis
2. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity
3. Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells
4. Tlr4: Central component of the sole mammalian LPS sensor
5. Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization
6. The p38 mitogen-activated protein kinase is required for NF-κB dependent gene expression. The role of TATA-binding protein (TBP)
7. Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages
8. Pyrimidinoceptor-mediated potentiation of inducible nitric-oxide synthase induction in J774 macrophages
9. Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages
10. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms
11. Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway. Prevention by aurintri-carboxylic acid
12. The use of nitric oxide donors in pharmacological studies
13. In vivo footprinting of the mouse inducible nitric oxide synthase gene: Inducible protein occupation of numerous sites including Oct and NF-IL6
14. Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells
15. Aurintricarboxylic acid promotes survival and regeneration of axotomised retinal ganglion cells in vivo
16. Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages
17. Changes of caspase activities involved in apoptosis of a macrophage-like cell line J774.1/JA-4 treated with lipopolysaccharide (LPS) and cycloheximide
18. Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor
19. Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation
20. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
21. + content and p53 accumulation
22. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts
23. Inducible nitric oxide synthesis: What difference does it make?
24. A neuroprotective compound, aurintricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells
25. Tyrosine phosphorylation of ErbB4 is stimulated by aurintricarboxylic acid in human neuroblastoma SH-SY5Y cells
26. The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
27. Pretreatment with intraventricular aurintricarboxylic acid decreases infarct size by inhibiting apoptosis following transient global ischemia in gerbils
28. Activation of Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid
29. Endonucleolytic DNA fragmentation is not required for apoptosis of cultured rat cerebellar granule neurons
30. Aurine tricarboxylic acid, a potent metal-chelating inhibitor of NF-κB-DNA binding
31. Anticancer drug-induced apoptosis in human monocytic leukemic cell line U937 requires activation of endonuclease(s)
32. Induction of caspase-3 and nitric oxide synthase-2 during gastric mucosal inflammatory reaction to Helicobacter pylori lipopolysaccharide
33. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor
34. Relationship between different stages of the corpus luteum and the expression of the peroxisome proliferator-activated receptor γ protein in bovine large lutein cells
35. Nitric oxide induction of neuronal endonuclease activity in programmed cell death
36. Activation of AP-1 and nuclear factor-κB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes
37. Inducible macrophage apoptosis following sepsis is mediated by cysteine protease activation and nitric oxide release
38. LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-α
39. Aurintricarboxylic acid prevents NMDA-mediated excitotoxicity: Evidence for its action as an NMDA receptor antagonist
40. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β