Silica nanoparticles induce alpha-synuclein induction and aggregation in PC12-cells

Chemico-Biological Interactions

Volumn 258, Issue , 2016, Pages 197-204

  Xie, Hongjun ^a   Wu, Jie ^b  

^a LINYI PEOPLE'S HOSPITAL   (China)

^b Stomatology Department of Shandong Medical College   (China)

Author keywords

Alpha synuclein; Autophagy; Parkinson diseases; Silica nanoparticles; Ubiquitin proteasome system

Indexed keywords

20S PROTEASOME; ACETYLCYSTEINE; ALPHA SYNUCLEIN; AMYLOID; BECLIN 1; LC3 II PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PARKIN; PROTEASOME; PROTEIN; PROTEIN KINASE B; SILICA NANOPARTICLE; UBIQUITIN; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; NANOPARTICLE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AGGREGATE; SILICON DIOXIDE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; AUTOPHAGY LYSOSOMAL PATHWAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; MESENCEPHALON; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PC12 CELL LINE; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEINASE INHIBITION; RAT; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; METABOLISM; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; BIOMARKERS; MODELS, BIOLOGICAL; NANOPARTICLES; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN AGGREGATES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; SILICON DIOXIDE; TOR SERINE-THREONINE KINASES; UBIQUITIN;

EID: 84986322933     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2016.09.006     Document Type: Article

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