메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages

Dopamine cytotoxicity involves both oxidative and nonoxidative pathways in SH-SY5Y cells: Potential role of alpha-synuclein overexpression and proteasomal inhibition in the etiopathogenesis of parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA SYNUCLEIN; DOPAMINE; LACTACYSTIN;

EID: 84899522351     PISSN: None     EISSN: 20420080     Source Type: Journal    
DOI: 10.1155/2014/878935     Document Type: Article
Times cited : (40)

References (52)
  • 1
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • DOI 10.1146/annurev.neuro.22.1.123
    • Olanow C. W., Tatton W. G., Etiology and pathogenesis of Parkinson's disease. Annual Review of Neuroscience 1999 22 123 144 2-s2.0-0032936755 10.1146/annurev.neuro.22.1.123 (Pubitemid 29144883)
    • (1999) Annual Review of Neuroscience , vol.22 , pp. 123-144
    • Olanow, C.W.1    Tatton, W.G.2
  • 2
    • 33644543761 scopus 로고    scopus 로고
    • Expanding insights of mitochondrial dysfunction in Parkinson's disease
    • DOI 10.1038/nrn1868, PII N1868
    • Abou-Sleiman P. M., Muqit M. M. K., Wood N. W., Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nature Reviews Neuroscience 2006 7 3 207 219 2-s2.0-33644543761 10.1038/nrn1868 (Pubitemid 43292466)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.3 , pp. 207-219
    • Abou-Sleiman, P.M.1    Muqit, M.M.K.2    Wood, N.W.3
  • 3
    • 0242363670 scopus 로고    scopus 로고
    • Molecular Pathways of Neurodegeneration in Parkinson's Disease
    • DOI 10.1126/science.1087753
    • Dawson T. M., Dawson V. L., Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003 302 5646 819 822 2-s2.0-0242363670 10.1126/science.1087753 (Pubitemid 37339614)
    • (2003) Science , vol.302 , Issue.5646 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 4
    • 0029845140 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man
    • DOI 10.1007/BF01291788
    • Gerlach M., Riederer P., Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. Journal of Neural Transmission 1996 103 8-9 987 1041 2-s2.0-0029845140 10.1007/BF01291788 (Pubitemid 26383833)
    • (1996) Journal of Neural Transmission , vol.103 , Issue.8-9 , pp. 987-1041
    • Gerlach, M.1    Riederer, P.2
  • 5
    • 0033557640 scopus 로고    scopus 로고
    • Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
    • Lotharius J., Dugan L. L., O'Malley K. L., Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. Journal of Neuroscience 1999 19 4 1284 1293 2-s2.0-0033557640 (Pubitemid 29088911)
    • (1999) Journal of Neuroscience , vol.19 , Issue.4 , pp. 1284-1293
    • Lotharius, J.1    Dugan, L.L.2    O'Malley, K.L.3
  • 6
    • 66249144714 scopus 로고    scopus 로고
    • Chronic, low-dose rotenone reproduces lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
    • 2-s2.0-66249144714 10.1186/1750-1326-3-21, ARTICLE 21
    • Borland M. K., Trimmer P. A., Rubinstein J. D., Keeney P. M., Mohanakumar K. P., Liu L., Bennett J. P. Jr., Chronic, low-dose rotenone reproduces lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells. Molecular Neurodegeneration 2008 3 1, article 21 2-s2.0-66249144714 10.1186/1750-1326-3-21
    • (2008) Molecular Neurodegeneration , vol.3 , Issue.1
    • Borland, M.K.1    Trimmer, P.A.2    Rubinstein, J.D.3    Keeney, P.M.4    Mohanakumar, K.P.5    Liu, L.6    Bennett Jr., J.P.7
  • 7
    • 0034676997 scopus 로고    scopus 로고
    • MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
    • Kowall N. W., Hantraye P., Brouillet E., Beal M. F., McKee A. C., Ferrante R. J., MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. NeuroReport 2000 11 1 211 213 2-s2.0-0034676997 (Pubitemid 30053420)
    • (2000) NeuroReport , vol.11 , Issue.1 , pp. 211-213
    • Kowall, N.W.1    Hantraye, P.2    Brouillet, E.3    Beal, M.F.4    McKee, A.C.5    Ferrante, R.J.6
  • 9
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • DOI 10.1016/S0301-0082(01)00003-X, PII S030100820100003X
    • Blum D., Torch S., Lambeng N., Nissou M.-F., Benabid A.-L., Sadoul R., Verna J.-M., Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Progress in Neurobiology 2001 65 2 135 172 2-s2.0-0034993599 10.1016/S0301-0082(01)00003-X (Pubitemid 32524182)
    • (2001) Progress in Neurobiology , vol.65 , Issue.2 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.-F.4    Benabid, A.-L.5    Sadoul, R.6    Verna, J.-M.7
  • 10
    • 29644447278 scopus 로고    scopus 로고
    • Rotenone model of Parkinson disease: Multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication
    • DOI 10.1074/jbc.M508628200
    • Panov A., Dikalov S., Shalbuyeva N., Taylor G., Sherer T., Greenamyre J. T., Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. Journal of Biological Chemistry 2005 280 51 42026 42035 2-s2.0-29644447278 10.1074/jbc.M508628200 (Pubitemid 43023171)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.51 , pp. 42026-42035
    • Panov, A.1    Dikalov, S.2    Shalbuyeva, N.3    Taylor, G.4    Sherer, T.5    Greenamyre, J.T.6
  • 11
    • 79954581538 scopus 로고    scopus 로고
    • Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease
    • 2-s2.0-79954581538 10.1016/j.bbadis.2011.02.013
    • Jana S., Sinha M., Chanda D., Roy T., Banerjee K., Munshi S., Patro B. S., Chakrabarti S., Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease. Biochimica et Biophysica Acta: Molecular Basis of Disease 2011 1812 6 663 673 2-s2.0-79954581538 10.1016/j.bbadis.2011.02.013
    • (2011) Biochimica et Biophysica Acta: Molecular Basis of Disease , vol.1812 , Issue.6 , pp. 663-673
    • Jana, S.1    Sinha, M.2    Chanda, D.3    Roy, T.4    Banerjee, K.5    Munshi, S.6    Patro, B.S.7    Chakrabarti, S.8
  • 12
    • 0036160538 scopus 로고    scopus 로고
    • + on membrane permeability in brain mitochondria and cell viability in PC12 cells
    • DOI 10.1016/S0197-0186(01)00069-9, PII S0197018601000699
    • Lee C. S., Han J. H., Jang Y. Y., Song J. H., Han E. S., Differential effect of catecholamines and MPP+ on membrane permeability in brain mitochondria and cell viability in PC12 cells. Neurochemistry International 2002 40 4 361 369 2-s2.0-0036160538 10.1016/S0197-0186(01)00069-9 (Pubitemid 34131611)
    • (2002) Neurochemistry International , vol.40 , Issue.4 , pp. 361-369
    • Lee, C.S.1    Han, J.H.2    Jang, Y.Y.3    Song, J.H.4    Han, E.S.5
  • 13
    • 0033965940 scopus 로고    scopus 로고
    • Dopamine toxicity in neuroblastoma cells: Role of glutathione depletion by L-BSO and apoptosis
    • DOI 10.1016/S0006-8993(99)02329-X, PII S000689939902329X
    • Stokes A. H., Lewis D. Y., Lash L. H., Jerome W. G. III, Grant K. W., Aschner M., Vrana K. E., Dopamine toxicity in neuroblastoma cells: role of glutathione depletion byL-BSO and apoptosis. Brain Research 2000 858 1 1 8 2-s2.0-0033965940 (Pubitemid 30105774)
    • (2000) Brain Research , vol.858 , Issue.1 , pp. 1-8
    • Stokes, A.H.1    Lewis, D.Y.2    Lash, L.H.3    Jerome III, W.G.4    Grant, K.W.5    Aschner, M.6    Vrana, K.E.7
  • 14
    • 0031042677 scopus 로고    scopus 로고
    • Dopamine- and L-β-3,4-dihydroxyphenylalanine hydrochloride (L-DOPA)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors
    • DOI 10.1016/S0006-2952(96)00731-9, PII S00062952960007319
    • Lai C.-T., Yu P. H., Dopamine- and L- β -3,4-dihydroxyphenylalanine hydrochloride (L-DOPA)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells: effects of oxidative stress and antioxidative factors. Biochemical Pharmacology 1997 53 3 363 372 2-s2.0-0031042677 10.1016/S0006-2952(96)00731-9 (Pubitemid 27114606)
    • (1997) Biochemical Pharmacology , vol.53 , Issue.3 , pp. 363-372
    • Lai, C.-T.1    Yu, P.H.2
  • 15
    • 0029051317 scopus 로고
    • Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA: Implications for the treatment of Parkinson's disease
    • 2-s2.0-0029051317
    • Walkinshaw G., Waters C. M., Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA: implications for the treatment of Parkinson's disease. Journal of Clinical Investigation 1995 95 6 2458 2464 2-s2.0-0029051317
    • (1995) Journal of Clinical Investigation , vol.95 , Issue.6 , pp. 2458-2464
    • Walkinshaw, G.1    Waters, C.M.2
  • 16
    • 0036471027 scopus 로고    scopus 로고
    • Protective effect of boldine on dopamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells
    • DOI 10.1016/S0006-2952(01)00852-8, PII S0006295201008528
    • Youn Y. C., Kwon O. S., Han E. S., Song J. H., Shin Y. K., Lee C. S., Protective effect of boldine on dopamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells. Biochemical Pharmacology 2002 63 3 495 505 2-s2.0-0036471027 10.1016/S0006-2952(01)00852-8 (Pubitemid 34169729)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.3 , pp. 495-505
    • Youn, Y.C.1    Kwon, O.S.2    Han, E.S.3    Song, J.H.4    Shin, Y.K.5    Lee, C.S.6
  • 17
    • 0035107766 scopus 로고    scopus 로고
    • Evidence for non-oxidative dopamine cytotoxicity: Potent activation of NF-κ B and lack of protection by anti-oxidants
    • DOI 10.1046/j.1471-4159.2001.00190.x
    • Weingarten P., Bermak J., Zhou Q.-Y., Evidence for non-oxidative dopamine cytotoxicity: potent activation of NF- B and lack of protection by anti-oxidants. Journal of Neurochemistry 2001 76 6 1794 1804 2-s2.0-0035107766 10.1046/j.1471-4159.2001.00190.x (Pubitemid 32221119)
    • (2001) Journal of Neurochemistry , vol.76 , Issue.6 , pp. 1794-1804
    • Weingarten, P.1    Bermak, J.2    Zhou, Q.-Y.3
  • 18
    • 0036945244 scopus 로고    scopus 로고
    • Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine
    • DOI 10.1038/sj.bjp.0704982
    • Pedrosa R., Soares-da-Silva P., Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine. British Journal of Pharmacology 2002 137 8 1305 1313 2-s2.0-0036945244 10.1038/sj.bjp.0704982 (Pubitemid 36071748)
    • (2002) British Journal of Pharmacology , vol.137 , Issue.8 , pp. 1305-1313
    • Pedrosa, R.1    Soares-da-Silva, P.2
  • 19
    • 0037025111 scopus 로고    scopus 로고
    • Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease
    • DOI 10.1016/S0304-3940(02)00296-3, PII S0304394002002963
    • McNaught K. S. P., Belizaire R., Jenner P., Olanow C. W., Isacson O., Selective loss of 20S proteasome α -subunits in the substantia nigra pars compacta in Parkinson's disease. Neuroscience Letters 2002 326 3 155 158 2-s2.0-0037025111 10.1016/S0304-3940(02)00296-3 (Pubitemid 34722448)
    • (2002) Neuroscience Letters , vol.326 , Issue.3 , pp. 155-158
    • McNaught, K.St.P.1    Belizaire, R.2    Jenner, P.3    Olanow C.Warren4    Isacson, O.5
  • 20
    • 0037227397 scopus 로고    scopus 로고
    • Altered proteasomal function in sporadic Parkinson's disease
    • DOI 10.1006/exnr.2002.8050
    • McNaught K. S. P., Belizaire R., Isacson O., Jenner P., Olanow C. W., Altered proteasomal function in sporadic Parkinson's disease. Experimental Neurology 2003 179 1 38 46 2-s2.0-0037227397 10.1006/exnr.2002.8050 (Pubitemid 36062617)
    • (2003) Experimental Neurology , vol.179 , Issue.1 , pp. 38-46
    • McNaught, K.St.P.1    Belizaire, R.2    Isacson, O.3    Jenner, P.4    Olanow, C.W.5
  • 21
    • 0034595728 scopus 로고    scopus 로고
    • Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
    • DOI 10.1016/S0006-8993(00)02215-0, PII S0006899300022150
    • Zhou W., Huribert M. S., Schaack J., Prasad K. N., Freed C. R., Overexpression of human α -synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Research 2000 866 1-2 33 43 2-s2.0-0034595728 10.1016/S0006-8993(00)02215-0 (Pubitemid 30313005)
    • (2000) Brain Research , vol.866 , Issue.1-2 , pp. 33-43
    • Zhou, W.1    Huribert, M.S.2    Schaack, J.3    Prasad, K.N.4    Freed, C.R.5
  • 23
    • 77951915408 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells
    • 2-s2.0-77951915408 10.1186/1471-2202-11-41
    • Bisaglia M., Greggio E., Maric D., Miller D. W., Cookson M. R., Bubacco L., Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells. BMC neuroscience 2010 11, article 41 2-s2.0-77951915408 10.1186/1471-2202-11-41
    • (2010) BMC Neuroscience , vol.1141
    • Bisaglia, M.1    Greggio, E.2    Maric, D.3    Miller, D.W.4    Cookson, M.R.5    Bubacco, L.6
  • 24
    • 33645244513 scopus 로고    scopus 로고
    • α -Synuclein facilitates the toxicity of oxidized catechol metabolites: Implications for selective neurodegeneration in Parkinson's disease
    • 2-s2.0-33645244513 10.1016/j.febslet.2006.03.018
    • Hasegawa T., Matsuzaki-Kobayashi M., Takeda A., Sugeno N., Kikuchi A., Furukawa K., Perry G., Smith M. A., Itoyama Y., α -Synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease. FEBS Letters 2006 580 8 2147 2152 2-s2.0-33645244513 10.1016/j.febslet.2006.03.018
    • (2006) FEBS Letters , vol.580 , Issue.8 , pp. 2147-2152
    • Hasegawa, T.1    Matsuzaki-Kobayashi, M.2    Takeda, A.3    Sugeno, N.4    Kikuchi, A.5    Furukawa, K.6    Perry, G.7    Smith, M.A.8    Itoyama, Y.9
  • 25
    • 77951290337 scopus 로고    scopus 로고
    • α -Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease
    • 2-s2.0-77951290337 10.1016/j.febslet.2010.03.012
    • Banerjee K., Sinha M., Pham C. L. L., Jana S., Chanda D., Cappai R., Chakrabarti S., α -Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease. FEBS Letters 2010 584 8 1571 1576 2-s2.0-77951290337 10.1016/j.febslet.2010.03.012
    • (2010) FEBS Letters , vol.584 , Issue.8 , pp. 1571-1576
    • Banerjee, K.1    Sinha, M.2    Pham, C.L.L.3    Jana, S.4    Chanda, D.5    Cappai, R.6    Chakrabarti, S.7
  • 26
    • 0035920226 scopus 로고    scopus 로고
    • Induction of neuronal cell death by Rab5A-dependent endocytosis of α -synuclein
    • 2-s2.0-0035920226 10.1074/jbc.M101318200
    • Sung J. Y., Kim J., Paik S. R., Park J. H., Ahn Y. S., Chung K. C., Induction of neuronal cell death by Rab5A-dependent endocytosis of α -synuclein. Journal of Biological Chemistry 2001 276 29 27441 27448 2-s2.0-0035920226 10.1074/jbc.M101318200
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.29 , pp. 27441-27448
    • Sung, J.Y.1    Kim, J.2    Paik, S.R.3    Park, J.H.4    Ahn, Y.S.5    Chung, K.C.6
  • 28
    • 2942542719 scopus 로고    scopus 로고
    • Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: Protective effect of mitochondrial anti-apoptotic protein Bcl-2
    • DOI 10.1016/j.neuro.2003.09.014, PII S0161813X03001736
    • Kitazawa M., Anantharam V., Kanthasamy A., Kanthasamy A. G., Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. NeuroToxicology 2004 25 4 589 598 2-s2.0-2942542719 10.1016/j.neuro.2003. 09.014 (Pubitemid 38739115)
    • (2004) NeuroToxicology , vol.25 , Issue.4 SPEC. ISS. , pp. 589-598
    • Kitazawa, M.1    Anantharam, V.2    Kanthasamy, A.3    Kanthasamy, A.G.4
  • 29
    • 0031588923 scopus 로고    scopus 로고
    • 2 release from activated human leukocytes using a dihydroxyphenoxazine derivative
    • DOI 10.1016/S0022-1759(96)00244-X, PII S002217599600244X
    • 2 release from activated human leukocytes using a dihydroxyphenoxazine derivative. Journal of Immunological Methods 1997 202 2 133 141 2-s2.0-0031588923 10.1016/S0022- 1759(96)00244-X (Pubitemid 27128755)
    • (1997) Journal of Immunological Methods , vol.202 , Issue.2 , pp. 133-141
    • Mohanty, J.G.1    Jaffe, J.S.2    Schulman, E.S.3    Raible, D.G.4
  • 30
    • 0035937522 scopus 로고    scopus 로고
    • Dopamine induced protein damage in mitochondrial-synaptosomal fraction of rat brain
    • DOI 10.1016/S0006-8993(00)03284-4, PII S0006899300032844
    • Khan F. H., Saha M., Chakrabarti S., Dopamine induced protein damage in mitochondrial-synaptosomal fraction of rat brain. Brain Research 2001 895 1-2 245 249 2-s2.0-0035937522 10.1016/S0006-8993(00)03284-4 (Pubitemid 32231162)
    • (2001) Brain Research , vol.895 , Issue.1-2 , pp. 245-249
    • Khan, F.H.1    Saha, M.2    Chakrabarti, S.3
  • 31
    • 0037632905 scopus 로고    scopus 로고
    • Dopamine-dependent cytotoxicity of tetrahydrobiopterin: A possible mechanism for selective neurodegeneration in Parkinson's disease
    • DOI 10.1046/j.1471-4159.2003.01808.x
    • Choi H. J., Kim S. W., Lee S. Y., Hwang O., Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. Journal of Neurochemistry 2003 86 1 143 152 2-s2.0-0037632905 10.1046/j.1471-4159.2003.01808.x (Pubitemid 36753855)
    • (2003) Journal of Neurochemistry , vol.86 , Issue.1 , pp. 143-152
    • Choi, H.J.1    Kim, S.W.2    Lee, S.Y.3    Hwang, O.4
  • 32
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered α-synuclein metabolism and oxidative damage
    • Sherer T. B., Betarbet R., Stout A. K., Lund S., Baptista M., Panov A. V., Cookson M. R., Greenamyre J. T., An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered α -synuclein metabolism and oxidative damage. Journal of Neuroscience 2002 22 16 7006 7015 2-s2.0-0037104723 (Pubitemid 35379158)
    • (2002) Journal of Neuroscience , vol.22 , Issue.16 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 34
    • 26944463905 scopus 로고    scopus 로고
    • Standard deviations and standard errors
    • 2-s2.0-26944463905, ARTICLE 903
    • Altman D. G., Bland J. M., Standard deviations and standard errors. British Medical Journal 2005 331 7521, article 903 2-s2.0-26944463905
    • (2005) British Medical Journal , vol.331 , Issue.7521
    • Altman, D.G.1    Bland, J.M.2
  • 35
    • 0027268723 scopus 로고
    • Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line
    • Pardo B., Mena M. A., Fahn S., de Yebenes J. G., Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line. Movement Disorders 1993 8 3 278 284 2-s2.0-0027268723 (Pubitemid 23212535)
    • (1993) Movement Disorders , vol.8 , Issue.3 , pp. 278-284
    • Pardo, B.1    Mena, M.A.2    Fahn, S.3    De Yebenes, J.G.4
  • 36
    • 0029053242 scopus 로고
    • Toxic effects of L-DOPA on mesencephalic cell cultures: Protection with antioxidants
    • 2-s2.0-0029053242 10.1016/0006-8993(95)00341-M
    • Pardo B., Mena M. A., Casarejos M. J., Paino C. L., De Yebenes J. G., Toxic effects of L-DOPA on mesencephalic cell cultures: protection with antioxidants. Brain Research 1995 682 1-2 133 143 2-s2.0-0029053242 10.1016/0006-8993(95)00341-M
    • (1995) Brain Research , vol.682 , Issue.1-2 , pp. 133-143
    • Pardo, B.1    Mena, M.A.2    Casarejos, M.J.3    Paino, C.L.4    De Yebenes, J.G.5
  • 37
    • 0030249286 scopus 로고    scopus 로고
    • Prevention of dopamine-induced cell death by thiol antioxidants: Possible implications for treatment of Parkinson's disease
    • DOI 10.1006/exnr.1996.0136
    • Offen D., Ziv I., Sternin H., Melamed E., Hochman A., Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease. Experimental Neurology 1996 141 1 32 39 2-s2.0-0030249286 10.1006/exnr.1996.0136 (Pubitemid 26317179)
    • (1996) Experimental Neurology , vol.141 , Issue.1 , pp. 32-39
    • Offen, D.1    Ziv, I.2    Sternin, H.3    Melamed, E.4    Hochman, A.5
  • 38
    • 0032531095 scopus 로고    scopus 로고
    • Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: Possible endogenous toxin to serotonin neurons
    • Kuhn D. M., Arthur R. Jr., Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons. Journal of Neuroscience 1998 18 18 7111 7117 2-s2.0-0032531095 (Pubitemid 28425798)
    • (1998) Journal of Neuroscience , vol.18 , Issue.18 , pp. 7111-7117
    • Kuhn, D.M.1    Arthur Jr., R.2
  • 39
    • 0032842040 scopus 로고    scopus 로고
    • Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: Possible relevance to Parkinson's disease
    • DOI 10.1046/j.1471-4159.1999.0731309.x
    • Kuhn D. M., Arthur R. E. Jr., Thomas D. M., Elferink L. A., Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease. Journal of Neurochemistry 1999 73 3 1309 1317 2-s2.0-0032842040 10.1046/j.1471-4159.1999. 0731309.x (Pubitemid 29395493)
    • (1999) Journal of Neurochemistry , vol.73 , Issue.3 , pp. 1309-1317
    • Kuhn, D.M.1    Arthur Jr., R.E.2    Thomas, D.M.3    Elferink, L.A.4
  • 40
    • 0037613733 scopus 로고    scopus 로고
    • +-ATPase activity in crude synaptosomal-mitochondrial fraction from rat brain
    • DOI 10.1080/1071576031000115651
    • Khan F. H., Sen T., Chakrabarti S., Dopamine oxidation products inhibit Na+, K+-ATPase activity in crude synaptosomal-mitochondrial fraction from rat brain. Free Radical Research 2003 37 6 597 601 2-s2.0-0037613733 10.1080/1071576031000115651 (Pubitemid 36603669)
    • (2003) Free Radical Research , vol.37 , Issue.6 , pp. 597-601
    • Khan, F.H.1    Sen, T.2    Chakrabarti, S.3
  • 41
    • 13244261152 scopus 로고    scopus 로고
    • Induction of C/EBPβ and GADD153 expression by dopamine in human neuroblastoma cells: Relationship with α-synuclein increase and cell damage
    • DOI 10.1016/j.brainresbull.2004.11.008, PII S0361923004002618
    • Gómez-Santos C., Barrachina M., Giménez-Xavier P., Dalfó E., Ferrer I., Ambrosio S., Induction of C/EBP β and GADD153 expression by dopamine in human neuroblastoma cells: relationship with α -synuclein increase and cell damage. Brain Research Bulletin 2005 65 1 87 95 2-s2.0-13244261152 10.1016/j.brainresbull.2004.11.008 (Pubitemid 40186934)
    • (2005) Brain Research Bulletin , vol.65 , Issue.1 , pp. 87-95
    • Gomez-Santos, C.1    Barrachina, M.2    Gimenez-Xavier, P.3    Dalfo, E.4    Ferrer, I.5    Ambrosio, S.6
  • 42
    • 77951842993 scopus 로고    scopus 로고
    • Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains
    • 2-s2.0-77951842993 10.1523/JNEUROSCI.6119-09.2010
    • Jowaed A., Schmitt I., Kaut O., Wüllner U., Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. Journal of Neuroscience 2010 30 18 6355 6359 2-s2.0-77951842993 10.1523/JNEUROSCI.6119-09.2010
    • (2010) Journal of Neuroscience , vol.30 , Issue.18 , pp. 6355-6359
    • Jowaed, A.1    Schmitt, I.2    Kaut, O.3    Wüllner, U.4
  • 43
    • 68949151944 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
    • 2-s2.0-68949151944 10.1016/j.biocel.2009.05.008
    • Parihar M. S., Parihar A., Fujita M., Hashimoto M., Ghafourifar P., Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells. International Journal of Biochemistry and Cell Biology 2009 41 10 2015 2024 2-s2.0-68949151944 10.1016/j.biocel.2009.05.008
    • (2009) International Journal of Biochemistry and Cell Biology , vol.41 , Issue.10 , pp. 2015-2024
    • Parihar, M.S.1    Parihar, A.2    Fujita, M.3    Hashimoto, M.4    Ghafourifar, P.5
  • 44
    • 32344444326 scopus 로고    scopus 로고
    • Down-regulation of α-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model
    • DOI 10.1016/j.bbrc.2006.01.057, PII S0006291X06001057
    • Hayashita-Kinoh H., Yamada M., Yokota T., Mizuno Y., Mochizuki H., Down-regulation of α -synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model. Biochemical and Biophysical Research Communications 2006 341 4 1088 1095 2-s2.0-32344444326 10.1016/j.bbrc.2006.01.057 (Pubitemid 43221777)
    • (2006) Biochemical and Biophysical Research Communications , vol.341 , Issue.4 , pp. 1088-1095
    • Hayashita-Kinoh, H.1    Yamada, M.2    Yokota, T.3    Mizuno, Y.4    Mochizuki, H.5
  • 45
    • 0037192865 scopus 로고    scopus 로고
    • α-synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells
    • DOI 10.1074/jbc.M111428200
    • Hashimoto M., Hsu L. J., Rockenstein E., Takenouchi T., Mallory M., Masliah E., α -synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. Journal of Biological Chemistry 2002 277 13 11465 11472 2-s2.0-0037192865 10.1074/jbc.M111428200 (Pubitemid 34952915)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11465-11472
    • Hashimoto, M.1    Hsu, L.J.2    Rockenstein, E.3    Takenouchi, T.4    Mallory, M.5    Masliah, E.6
  • 46
    • 79958164975 scopus 로고    scopus 로고
    • Neuroprotective upregulation of endogenous alpha-synuclein precedes ubiquitination in cultured dopaminergic neurons
    • 2-s2.0-79958164975 10.1007/s12640-010-9207-x
    • Musgrove R. E. J., King A. E., Dickson T. C., Neuroprotective upregulation of endogenous alpha-synuclein precedes ubiquitination in cultured dopaminergic neurons. Neurotoxicity Research 2011 19 4 592 602 2-s2.0-79958164975 10.1007/s12640-010-9207-x
    • (2011) Neurotoxicity Research , vol.19 , Issue.4 , pp. 592-602
    • Musgrove, R.E.J.1    King, A.E.2    Dickson, T.C.3
  • 47
    • 61549111872 scopus 로고    scopus 로고
    • Alpha-Synuclein and neuronal cell death
    • 10.1186/1750-1326-4-9
    • Cookson M. R., alpha-Synuclein and neuronal cell death. Molecular Neurodegeneration 2009 4, article 9 10.1186/1750-1326-4-9
    • (2009) Molecular Neurodegeneration , vol.49
    • Cookson, M.R.1
  • 49
    • 61649109808 scopus 로고    scopus 로고
    • Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects
    • 2-s2.0-61649109808 10.1002/mds.22306
    • Shehadeh L., Mitsi G., Adi N., Bishopric N., Papapetropoulos S., Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects. Movement Disorders 2009 24 2 204 210 2-s2.0-61649109808 10.1002/mds.22306
    • (2009) Movement Disorders , vol.24 , Issue.2 , pp. 204-210
    • Shehadeh, L.1    Mitsi, G.2    Adi, N.3    Bishopric, N.4    Papapetropoulos, S.5
  • 50
    • 77955664249 scopus 로고    scopus 로고
    • Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
    • 2-s2.0-77955664249 10.1016/j.expneurol.2010.06.017
    • Wills J., Jones J., Haggerty T., Duka V., Joyce J. N., Sidhu A., Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Experimental Neurology 2010 225 1 210 218 2-s2.0-77955664249 10.1016/j.expneurol.2010.06.017
    • (2010) Experimental Neurology , vol.225 , Issue.1 , pp. 210-218
    • Wills, J.1    Jones, J.2    Haggerty, T.3    Duka, V.4    Joyce, J.N.5    Sidhu, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.