Influence of gold nanoparticles on the kinetics of α-synuclein aggregation

Nano Letters

Volumn 13, Issue 12, 2013, Pages 6156-6163

  Álvarez, Yanina D ^a,b   Fauerbach, Jonathan A ^a,c   Pellegrotti, Jésica V ^a,b   Jovin, Thomas M ^d   Jares Erijman, Elizabeth A ^a,c   Stefani, Fernando D ^a,b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c DEPARTAMENTO DE QUÍMICA ORGÁNICA   (Argentina)

^d MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

amyloid aggregation; amyloid proteins; Gold nanoparticles; Parkinson

Indexed keywords

AGGREGATION KINETICS; AMYLOID PROTEINS; EXCITED-STATE INTRAMOLECULAR PROTON TRANSFER; GOLD NANOPARTICLES; NUCLEATION AND GROWTH; PARKINSON; SECONDARY STRUCTURES; STRUCTURAL TRANSITIONS;

AGGLOMERATION; AMINO ACIDS; GLYCOPROTEINS; GOLD; KINETICS; METAL NANOPARTICLES; NEURONS;

PROTEINS;

ALPHA SYNUCLEIN; AMYLOID; GOLD; METAL NANOPARTICLE;

ARTICLE; CHEMISTRY; HUMAN; KINETICS; PARKINSON DISEASE; PATHOLOGY; PROTEIN SECONDARY STRUCTURE;

ALPHA-SYNUCLEIN; AMYLOID; GOLD; HUMANS; KINETICS; METAL NANOPARTICLES; PARKINSON DISEASE; PROTEIN STRUCTURE, SECONDARY;

EID: 84890413185     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/nl403490e     Document Type: Article

References (45)

1. Breydo, L.; Wu, J. W.; Uversky, V. N. α-synuclein misfolding and Parkinson's disease Biochim. Biophys. Acta 2012, 1822, 261-85
2. Lansbury, P. T.; Lashuel, H. A. Review Article A century-old debate on protein aggregation and neurodegeneration enters the clinic Nature 2006, 443, 774-779
3. Winner, B. In vivo demonstration that alpha-synuclein oligomers are toxic Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 4194-9
4. Steiner, J. A; Angot, E.; Brundin, P. A deadly spread: cellular mechanisms of α-synuclein transfer Cell Death Differ. 2011, 18, 1425-33
5. Luk, K. C. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice Science 2012, 338, 949-53
6. Pornsuwan, S. Long-Range Distances in Amyloid Fibrils of α-Synuclein from PELDOR Spectroscopy Angew. Chem. 2013, 10.1002/ange.201304747
7. Fauerbach, J. A. Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation Biophys. J. 2012, 102, 1127-36
8. Roberti, M. J. Imaging nanometer-sized α-synuclein aggregates by superresolution fluorescence localization microscopy Biophys. J. 2012, 102, 1598-607
9. Linse, S. Nucleation of protein fibrillation by nanoparticles Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 8691-6
10. Cabaleiro-Lago, C.; Szczepankiewicz, O.; Linse, S. The Effect of Nanoparticles on Amyloid Aggregation Depends on the Protein Stability and Intrinsic Aggregation Rate Langmuir 2012, 28, 1852-7
11. Cabaleiro-Lago, C.; Quinlan-Pluck, F.; Lynch, I.; Dawson, K. A.; Linse, S. Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid β Protein Fibrillation ACS Chem. Neurosci. 2010, 1, 279-87
12. Cabaleiro-Lago, C. Inhibition of Amyloid Beta Protein Fibrillation by Polymeric Nanoparticles J. Am. Chem. Soc. 2008, 130, 15437-15443
13. Brambilla, D. PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Toward Engineering of Functional Nanomedicines for Alzheimer's Disease ACS Nano 2012, 6, 5897-5908
14. Roberti, M. J. Quantum Dots as Ultrasensitive Nanoactuatorsand Sensors of Amyloid Aggregation in Live Cells J. Am. Chem. Soc. 2009, 131, 8102-8107
15. Roberti, M. J.; Giordano, L.; Jovin, T. M.; Jares-Erijman, E. A. FRET imaging by k(t)/k(f) ChemPhysChem 2011, 12, 563-6
16. Jain, P. K.; Lee, K. S.; El-Sayad, I. H.; El-Sayed, M. A. Calculated Absorption and Scattering Properties of Gold Nanoparticles of Different Size, Shape, and Composition: Applications in Biological Imaging and Biomedicine J. Phys. Chem. B 2006, 110, 7238
17. Chithrani, B. D.; Ghazani, A. A.; Chan, W. C. W. Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells Nano Lett. 2006, 6, 662-8
18. Shukla, R. Biocompatibility of Gold Nanoparticles and Their Endocytotic Fate Inside the Cellular Compartment: A Microscopic Overview Langmuir 2005, 21, 10644-54
19. Sperling, R. A.; Rivera Gil, P.; Zhang, F.; Zanella, M.; Parak, W. J. Biological applications of gold nanoparticles Chem. Soc. Rev. 2008, 37, 1896-908
20. Murphy, C. J. Gold nanoparticles in biology: beyond toxicity to cellular imaging Acc. Chem. Res. 2008, 41, 1721-30
21. Khlebtsov, N.; Dykman, L. Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies Chem. Soc. Rev. 2011, 40, 1647-71
22. Yang, J. A. Study of Wild-Type α-Synuclein Binding and Orientation on Gold Nanoparticles Langmuir 2013, 29, 4603-15
23. Ai Tran, H. N. A novel class of potential prion drugs: preliminary in vitro and in vivo data for multilayer coated gold nanoparticles Nanoscale 2010, 2, 2724-32
24. Bastus, N. G. Gold nanoparticles for selective and remote heating of β-amyloid protein aggregates Mater. Sci. Eng., C 2007, 27, 1236-1240
25. Kogan, M. J. Nanoparticle-Mediated Local and Remote Manipulation of Protein Aggregation Nano Lett. 2006, 6, 110-5
26. Fink, A. L. The Aggregation and Fibrillation of alpha-Synuclein Acc. Chem. Res. 2006, 39, 628-634
27. Giehm, L.; Lorenzen, N.; Otzen, D. E. Assays for α-synuclein aggregation Methods 2011, 53, 295-305
28. Kaylor, J. Characterization of Oligomeric Intermediates in a-Synuclein Fibrillation: FRET Studies of Y125W/Y133F/Y136F alpha-Synuclein J. Mol. Biol. 2005, 353, 357-372
29. Outeiro, T. F. Formation of toxic oligomeric alpha-synuclein species in living cells PLoS One 2008, 3, e1867
30. Morris, A. M.; Finke, R. G. Alpha-synuclein aggregation variable temperature and variable pH kinetic data: a re-analysis using the Finke-Watzky 2-step model of nucleation and autocatalytic growth Biophys. Chem. 2009, 140, 9-15
31. Morris, A. M.; Watzky, M. A; Finke, R. G. Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature Biochim. Biophys. Acta 2009, 1794, 375-97
32. Lee, C. C.; Nayak, A.; Sethuraman, A.; Belfort, G.; McRae, G. J. A three-stage kinetic model of amyloid fibrillation Biophys. J. 2007, 92 (10) 3448-3458
33. Bertoncini, C. W. Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 1430-5
34. Yushchenko, D. a; Fauerbach, J. A.; Thirunavukkuarasu, S.; Jares-erijman, E. a; Jovin, T. M. Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of Alpha-Synuclein Aggregation J. Am. Chem. Soc. 2010, 132, 7860-1
35. Bertoncini, C. W.; Celej, M. S. Small molecule fluorescent probes for the detection of amyloid self-assembly in vitro and in vivo Curr. Protein Pept. Sci. 2011, 12, 205-20
36. Groenning, M. Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status J. Chem. Biol. 2010, 3, 1-18
37. Coronado, E. a; Encina, E. R.; Stefani, F. D. Optical properties of metallic nanoparticles: manipulating light, heat and forces at the nanoscale Nanoscale 2011, 3, 4042-4059
38. Morris, A. M.; Watzky, M. A.; Agar, J. N.; Finke, R. G. Fitting neurological protein aggregation kinetic data via a 2-step, minimal/ "Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth Biochemistry 2008, 47, 2413-27
39. Watzky, M. A; Morris, A. M.; Ross, E. D.; Finke, R. G. Fitting Yeast and Mammalian Prion Aggregation Kinetic Data with the Finke-Watzky Two-Step Model of Nucleation and Autocatalytic Growth Biochemistry 2008, 47, 10790-800
40. Vertegel, A. a; Siegel, R. W.; Dordick, J. S. Silica Nanoparticle Size Influences the Structure and Enzymatic Activity of Adsorbed Lysozyme Langmuir 2004, 20, 6800-7
41. Shang, W.; Nuffer, J. H.; Dordick, J. S.; Siegel, R. W. Unfolding of ribonuclease A on silica nanoparticle surfaces Nano Lett. 2007, 7, 1991-5
42. Goy-López, S. Physicochemical Characteristics of Protein-NP Bioconjugates: The Role of Particle Curvature and Solution Conditions on Human Serum Albumin Conformation and Fibrillogenesis Inhibition Langmuir 2012, 28, 9113-26
43. Fei, L.; Perrett, S. Effect of nanoparticles on protein folding and fibrillogenesis Int. J. Mol. Sci. 2009, 10, 646-55
44. Martin, M. N.; Basham, J. I.; Chando, P.; Eah, S.-K. Charged Gold Nanoparticles in Non-Polar Solvents: 10-min Synthesis and 2D Self-Assembly Langmuir 2010, 26, 7410-7
45. Kimling, J. Turkevich Method for Gold Nanoparticle Synthesis Revisited J. Phys. Chem. B 2006, 110, 15700-15707