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Volumn 28, Issue 6, 2016, Pages 502-510

Treatment of brain metastasis: Current status and future directions

Author keywords

Brain metastasis; Local treatments; Targeted therapies; Whole brain radiotherapy

Indexed keywords

AFATINIB; CAPECITABINE; DABRAFENIB; ERLOTINIB; GEFITINIB; IPILIMUMAB; LAPATINIB; NAVELBINE; NERATINIB; VEMURAFENIB;

EID: 84986193670     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000326     Document Type: Review
Times cited : (8)

References (87)
  • 1
    • 84867494866 scopus 로고    scopus 로고
    • Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data
    • Davis FG, Dolecek TA, McCarthy BJ, et al. Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data. Neuro Oncol 2012; 14:1171-1177.
    • (2012) Neuro Oncol , vol.14 , pp. 1171-1177
    • Davis, F.G.1    Dolecek, T.A.2    McCarthy, B.J.3
  • 2
    • 0030973660 scopus 로고    scopus 로고
    • Recursive partitioning analysis (rpa) of prognostic factors in three radiation therapy oncology group (rtog) brain metastases trials
    • Gaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 1997; 37:745-751.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 745-751
    • Gaspar, L.1    Scott, C.2    Rotman, M.3
  • 3
    • 38149075264 scopus 로고    scopus 로고
    • A new prognostic index and comparison to three other indices for patients with brain metastases: An analysis of 1,960 patients in the rtog database
    • Sperduto PW, Berkey B, Gaspar LE, et al. A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1,960 patients in the RTOG database. Int J Radiat Oncol Biol Phys 2008; 70:510-514.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 510-514
    • Sperduto, P.W.1    Berkey, B.2    Gaspar, L.E.3
  • 4
    • 84858698969 scopus 로고    scopus 로고
    • Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases
    • Sperduto PW, Kased N, Roberge D, et al. Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases. Int J Radiat Oncol Biol Phys 2012; 82:2111-2117.
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 2111-2117
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3
  • 5
    • 84941334997 scopus 로고    scopus 로고
    • Validation and development of a modified breast graded prognostic assessment as a tool for survival in patients with breast cancer and brain metastases
    • Subbiah IM, Lei X, Weinberg JS, et al. Validation and development of a modified breast graded prognostic assessment as a tool for survival in patients with breast cancer and brain metastases. J Clin Oncol 2015; 33:2239-2245.
    • (2015) J Clin Oncol , vol.33 , pp. 2239-2245
    • Subbiah, I.M.1    Lei, X.2    Weinberg, J.S.3
  • 6
    • 0025189608 scopus 로고
    • A randomized trial of surgery in the treatment of single metastases to the brain
    • Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990; 322:494-500.
    • (1990) N Engl J Med , vol.322 , pp. 494-500
    • Patchell, R.A.1    Tibbs, P.A.2    Walsh, J.W.3
  • 7
    • 0027217452 scopus 로고
    • Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery?
    • Vecht CJ, Haaxma-Reiche H, Noordijk EM, et al. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol 1993; 33:583-590.
    • (1993) Ann Neurol , vol.33 , pp. 583-590
    • Vecht, C.J.1    Haaxma-Reiche, H.2    Noordijk, E.M.3
  • 8
    • 10144261882 scopus 로고    scopus 로고
    • A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis
    • Mintz AH, Kestle J, Rathbone MP, et al. A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer 1996; 78:1470-1476.
    • (1996) Cancer , vol.78 , pp. 1470-1476
    • Mintz, A.H.1    Kestle, J.2    Rathbone, M.P.3
  • 9
    • 33644871016 scopus 로고    scopus 로고
    • Resectable brain metastases
    • Vogelbaum MA, Suh JH. Resectable brain metastases. J Clin Oncol 2006; 24:1289-1294.
    • (2006) J Clin Oncol , vol.24 , pp. 1289-1294
    • Vogelbaum, M.A.1    Suh, J.H.2
  • 10
    • 84939268303 scopus 로고    scopus 로고
    • Early postoperative magnet resonance tomography after resection of cerebral metastases
    • Kamp MA, Rapp M, Bünher J, et al. Early postoperative magnet resonance tomography after resection of cerebral metastases. Acta Neurochir 2015; 157:1573-1580.
    • (2015) Acta Neurochir , vol.157 , pp. 1573-1580
    • Kamp, M.A.1    Rapp, M.2    Bünher, J.3
  • 11
    • 84936803100 scopus 로고    scopus 로고
    • Impact of surgical methodology on the complication rate and functional outcome of patients with a single brain metastasis
    • Patel AJ, Suki D, Hatiboglu MA, et al. Impact of surgical methodology on the complication rate and functional outcome of patients with a single brain metastasis. J Neurosurg 2015; 122:1132-1143.
    • (2015) J Neurosurg , vol.122 , pp. 1132-1143
    • Patel, A.J.1    Suki, D.2    Hatiboglu, M.A.3
  • 12
    • 84887116316 scopus 로고    scopus 로고
    • Stereotactic radiosurgery in the treatment of brain metastases: The current evidence
    • Lippitz B, Lindquist C, Paddick I, et al. Stereotactic radiosurgery in the treatment of brain metastases: the current evidence. Cancer Treat Rev 2014; 40:48-59.
    • (2014) Cancer Treat Rev , vol.40 , pp. 48-59
    • Lippitz, B.1    Lindquist, C.2    Paddick, I.3
  • 13
    • 84897391065 scopus 로고    scopus 로고
    • Stereotactic radiosurgery for patients with multiple brain metastases (jlgk0901): A multiinstitutional prospective observational study
    • Yamamoto M, Serizawa T, Shuto T, et al. Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multiinstitutional prospective observational study. Lancet Oncol 2014; 15:387-395.
    • (2014) Lancet Oncol , vol.15 , pp. 387-395
    • Yamamoto, M.1    Serizawa, T.2    Shuto, T.3
  • 14
    • 84922393882 scopus 로고    scopus 로고
    • Stereotactic radiosurgery for brain metastases: A case-matched study comparing treatment results for patients 80 years of age or older versus patients 65-79 years of age
    • Watanabe S, Yamamoto M, Sato Y, et al. Stereotactic radiosurgery for brain metastases: a case-matched study comparing treatment results for patients 80 years of age or older versus patients 65-79 years of age. J Neurosurg 2014; 121:1148-1157.
    • (2014) J Neurosurg , vol.121 , pp. 1148-1157
    • Watanabe, S.1    Yamamoto, M.2    Sato, Y.3
  • 15
    • 2442713678 scopus 로고    scopus 로고
    • Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the rtog 9508 randomised trial
    • Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 2004; 363:1665-1672.
    • (2004) Lancet , vol.363 , pp. 1665-1672
    • Andrews, D.W.1    Scott, C.B.2    Sperduto, P.W.3
  • 16
    • 84908007206 scopus 로고    scopus 로고
    • Secondary analysis of rtog 9508, a phase 3 randomized trial of whole-brain radiation therapy versus wbrt plus stereotactic radiosurgery in patients with 1-3 metastases; Poststratified by the grade prognostic assessment (gpa)
    • Sperduto PW, Shanley R, Luo X, et al. Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1-3 metastases; poststratified by the Grade Prognostic Assessment (GPA). Int J Radiat Oncol Biol Phys 2014; 90:526-531.
    • (2014) Int J Radiat Oncol Biol Phys , vol.90 , pp. 526-531
    • Sperduto, P.W.1    Shanley, R.2    Luo, X.3
  • 17
    • 84995643718 scopus 로고    scopus 로고
    • Quality of life is maintained using gamma knife radiosurgery: A prospective study of a brain metastases patient cohort
    • Skeie BS, Eide GE, Flatebø M, et al. Quality of life is maintained using Gamma Knife radiosurgery: a prospective study of a brain metastases patient cohort. J Neurosurg 2016; 8:1-18.
    • (2016) J Neurosurg , vol.8 , pp. 1-18
    • Skeie, B.S.1    Eide, G.E.2    Flatebø, M.3
  • 18
    • 79952267015 scopus 로고    scopus 로고
    • Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer. Clinical article
    • Kondziolka D, Kano H, HarrisonGL, et al. Stereotactic radiosurgery as primary and salvage treatment for brain metastases from breast cancer. Clinical article. J Neurosurg 2011; 114:792-800.
    • (2011) J Neurosurg , vol.114 , pp. 792-800
    • Kondziolka, D.1    Kano, H.2    Harrison, G.L.3
  • 19
    • 84960126474 scopus 로고    scopus 로고
    • Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries
    • Marshall DC, Marcus LP, Kim TE, et al. Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries. J Neurooncol 2016; 128:119-128.
    • (2016) J Neurooncol , vol.128 , pp. 119-128
    • Marshall, D.C.1    Marcus, L.P.2    Kim, T.E.3
  • 20
    • 84937402226 scopus 로고    scopus 로고
    • Repeat courses of stereotactic radiosurgery (srs), deferring whole-brain irradiation, for new brain metastases after initial srs
    • Shultz DB, Modlin LA, Jayachandran P, et al. Repeat courses of stereotactic radiosurgery (SRS), deferring whole-brain irradiation, for new brain metastases after initial SRS. Int J Radiat Oncol Biol Phys 2015; 92: 993-999.
    • (2015) Int J Radiat Oncol Biol Phys , vol.92 , pp. 993-999
    • Shultz, D.B.1    Modlin, L.A.2    Jayachandran, P.3
  • 21
    • 84939447429 scopus 로고    scopus 로고
    • Adverse radiation effect after stereotactic radiosurgery for brain metastases: Incidence, time course, and risk factor
    • Sneed P, Mendez J, Vemer-van den Hoek JGM, et al. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factor. J Neurosurg 2015; 123:373-386.
    • (2015) J Neurosurg , vol.123 , pp. 373-386
    • Sneed, P.1    Mendez, J.2    Vemer-Van Den Hoek, J.G.M.3
  • 22
    • 84959911767 scopus 로고    scopus 로고
    • What predicts early volumetric edema increase following stereotactic radiosurgery for brain metastases?
    • Hanna A, Boggs DH, Kwok Y, et al. What predicts early volumetric edema increase following stereotactic radiosurgery for brain metastases? J Neurooncol 2016; 127:303-311.
    • (2016) J Neurooncol , vol.127 , pp. 303-311
    • Hanna, A.1    Boggs, D.H.2    Kwok, Y.3
  • 23
    • 84884903622 scopus 로고    scopus 로고
    • Challenges with the diagnosis and treatment of cerebral radiation necrosis
    • Chao ST, Ahluwalia MS, Barnett GH, et al. Challenges with the diagnosis and treatment of cerebral radiation necrosis. Int J Radiat Oncol Biol Phys 2013; 87:449-457.
    • (2013) Int J Radiat Oncol Biol Phys , vol.87 , pp. 449-457
    • Chao, S.T.1    Ahluwalia, M.S.2    Barnett, G.H.3
  • 24
    • 84943147944 scopus 로고    scopus 로고
    • Advances in magnetic resonance imaging and positron emission tomography imaging for grading and molecular characterization of glioma
    • Chung C, Metser U, Menard C. Advances in magnetic resonance imaging and positron emission tomography imaging for grading and molecular characterization of glioma. Semin Radiat Oncol 2015; 25:164-171.
    • (2015) Semin Radiat Oncol , vol.25 , pp. 164-171
    • Chung, C.1    Metser, U.2    Menard, C.3
  • 25
    • 84975132899 scopus 로고    scopus 로고
    • A prospective trial of dynamic contrastenhanced mri perfusion and fluorine-18 fdg pet-ct in differentiating brain tumor progression from radiation injury after cranial irradiation
    • Hatzoglou V, Yang TJ, Omuro A, et al. A prospective trial of dynamic contrastenhanced MRI perfusion and fluorine-18 FDG PET-CT in differentiating brain tumor progression from radiation injury after cranial irradiation. Neuro Oncol 2016; 18:873-880.
    • (2016) Neuro Oncol , vol.18 , pp. 873-880
    • Hatzoglou, V.1    Yang, T.J.2    Omuro, A.3
  • 26
    • 84940706345 scopus 로고    scopus 로고
    • Differentiation of brain tumor recurrence from post-radiotherapy necrosis with 11c-methionine pet: Visual assessment versus quantitative assessment
    • Minamimoto R, Saginoya T, Kondo C, et al. Differentiation of brain tumor recurrence from post-radiotherapy necrosis with 11C-methionine PET: visual assessment versus quantitative assessment. PLoS One 2015; 10:0132515.
    • (2015) PLoS One , vol.10 , pp. 0132515
    • Minamimoto, R.1    Saginoya, T.2    Kondo, C.3
  • 27
    • 0036643964 scopus 로고    scopus 로고
    • A multiinstitutional review of radiosurgery alone vs. Radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    • Sneed PK, Suh JH, Goetsch SJ, et al. A multiinstitutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 2002; 53:519-526.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , pp. 519-526
    • Sneed, P.K.1    Suh, J.H.2    Goetsch, S.J.3
  • 28
    • 0036471049 scopus 로고    scopus 로고
    • Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: Results and implications
    • Regine WF, Huhn JL, Patchell RA, et al. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Int J Radiat Oncol Biol Phys 2002; 52:333-338.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 333-338
    • Regine, W.F.1    Huhn, J.L.2    Patchell, R.A.3
  • 29
    • 0032483685 scopus 로고    scopus 로고
    • Postoperative radiotherapy in the treatment of single metastases to the brain: A randomized trial
    • Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 1998; 280:1485-1489.
    • (1998) JAMA , vol.280 , pp. 1485-1489
    • Patchell, R.A.1    Tibbs, P.A.2    Regine, W.F.3
  • 30
    • 33744954692 scopus 로고    scopus 로고
    • Stereotactic radiosurgery plus wholebrain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial
    • Aoyama H, Shirato H, Tago M, et al. Stereotactic radiosurgery plus wholebrain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 2006; 295:2483-2491.
    • (2006) JAMA , vol.295 , pp. 2483-2491
    • Aoyama, H.1    Shirato, H.2    Tago, M.3
  • 31
    • 79951966253 scopus 로고    scopus 로고
    • Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the eortc 22952-26001 study
    • Kocher M, Soffietti R, Abacioglu U, et al. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 2011; 29:134-141.
    • (2011) J Clin Oncol , vol.29 , pp. 134-141
    • Kocher, M.1    Soffietti, R.2    Abacioglu, U.3
  • 32
    • 84860222241 scopus 로고    scopus 로고
    • A meta-Analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases
    • Tsao M, Xu W, Sahgal A. A meta-Analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases. Cancer 2012; 118:2486-2493.
    • (2012) Cancer , vol.118 , pp. 2486-2493
    • Tsao, M.1    Xu, W.2    Sahgal, A.3
  • 33
    • 84924674427 scopus 로고    scopus 로고
    • Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: Individual patient data meta-Analysis
    • Sahgal A, Aoyama H, Kocher M, et al. Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: individual patient data meta-Analysis. Int J Radiat Oncol Biol Phys 2015; 91:710-717.
    • (2015) Int J Radiat Oncol Biol Phys , vol.91 , pp. 710-717
    • Sahgal, A.1    Aoyama, H.2    Kocher, M.3
  • 34
    • 84980516693 scopus 로고    scopus 로고
    • Stereotactic radiosurgery with or without whole-brain radiotherapy for brain metastases: Secondary analysis of the jrosg 9-1 randomized clinical trial
    • Aoyama H, Tago M, Shirato H, et al. Stereotactic radiosurgery with or without whole-brain radiotherapy for brain metastases: secondary analysis of the JROSG 9-1 randomized clinical trial. JAMA Oncol 2015; 1:457-464.
    • (2015) JAMA Oncol , vol.1 , pp. 457-464
    • Aoyama, H.1    Tago, M.2    Shirato, H.3
  • 35
    • 34547427370 scopus 로고    scopus 로고
    • Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone
    • Aoyama H, Tago M, Kato N, et al. Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. Iny J Radiat Oncol Biol Phys 2007; 68:1388-1395.
    • (2007) Iny J Radiat Oncol Biol Phys , vol.68 , pp. 1388-1395
    • Aoyama, H.1    Tago, M.2    Kato, N.3
  • 36
    • 71249157772 scopus 로고    scopus 로고
    • Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial
    • Chang EL, Wefel JS, Hess KR, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009; 10:1037-1044.
    • (2009) Lancet Oncol , vol.10 , pp. 1037-1044
    • Chang, E.L.1    Wefel, J.S.2    Hess, K.R.3
  • 37
    • 84936811461 scopus 로고    scopus 로고
    • Ncctg n0574 (alliance): A phase III randomized trial of whole brain radiation therapy (wbrt) in addition to radiosurgery (srs) in patients with 1 to 3 brain metastases
    • Chicago, IL
    • Brown PD. NCCTG N0574 (Alliance): a phase III randomized trial of whole brain radiation therapy (WBRT) in addition to radiosurgery (SRS) in patients with 1 to 3 brain metastases. Paper presented at: 2015 ASCO 51st Annual Meeting 2015. Chicago, IL: ; 2015; 44.
    • (2015) Paper Presented at 2015 ASCO 51st Annual Meeting 2015 , pp. 44
    • Brown, P.D.1
  • 38
    • 84871812928 scopus 로고    scopus 로고
    • A european organisation for research and treatment of cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: Quality-of-life results
    • Soffietti R, Kocher M, Abacioglu U, et al. A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life results. J Clin Oncol 2013; 31:65-72.
    • (2013) J Clin Oncol , vol.31 , pp. 65-72
    • Soffietti, R.1    Kocher, M.2    Abacioglu, U.3
  • 39
    • 84930377020 scopus 로고    scopus 로고
    • Tumor bed radiosurgery: An emerging treatment for brain metastases
    • Amsbaugh MJ, Boling W, Woo S. Tumor bed radiosurgery: an emerging treatment for brain metastases. J Neurooncol 2015; 123:197-203.
    • (2015) J Neurooncol , vol.123 , pp. 197-203
    • Amsbaugh, M.J.1    Boling, W.2    Woo, S.3
  • 40
    • 84890450266 scopus 로고    scopus 로고
    • A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases
    • Brennan C, Yang TJ, Hilden P, et al. A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases. Int J Radiat Oncol Biol Phys 2014; 88:130-136.
    • (2014) Int J Radiat Oncol Biol Phys , vol.88 , pp. 130-136
    • Brennan, C.1    Yang, T.J.2    Hilden, P.3
  • 41
    • 84929840319 scopus 로고    scopus 로고
    • Hypofractionated radiosurgery has a better safety profile than single fraction radiosurgery for large resected brain metastases
    • Eaton BR, LaRiviere MJ, Kim S, et al. Hypofractionated radiosurgery has a better safety profile than single fraction radiosurgery for large resected brain metastases. J Neurooncol 2015; 123:103-111.
    • (2015) J Neurooncol , vol.123 , pp. 103-111
    • Eaton, B.R.1    LaRiviere, M.J.2    Kim, S.3
  • 42
    • 84925956149 scopus 로고    scopus 로고
    • Postoperative stereotactic radiosurgery to the resection cavity for large brain metastases: Clinical outcomes, predictors of intracranial failure, and implications for optimal patient selection
    • Ling DC, Vargo JA, Wegner RE, et al. Postoperative stereotactic radiosurgery to the resection cavity for large brain metastases: clinical outcomes, predictors of intracranial failure, and implications for optimal patient selection. Neurosurgery 2015; 76:150-156.
    • (2015) Neurosurgery , vol.76 , pp. 150-156
    • Ling, D.C.1    Vargo, J.A.2    Wegner, R.E.3
  • 43
    • 84879217200 scopus 로고    scopus 로고
    • Multidose stereotactic radiosurgery (9 gy x 3) of the postoperative resection cavity for treatment of large brain metastases
    • Minniti G, Esposito V, Clarke E, et al. Multidose stereotactic radiosurgery (9 Gy x 3) of the postoperative resection cavity for treatment of large brain metastases. Int J Radiat Oncol Biol Phys 2013; 86:623-629.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , pp. 623-629
    • Minniti, G.1    Esposito, V.2    Clarke, E.3
  • 44
    • 84925120072 scopus 로고    scopus 로고
    • Tumor progression in patients receiving adjuvant whole-brain radiotherapy vs localized radiotherapy after surgical resection of brain metastases
    • Hsieh J, Elson P, Otvos B, et al. Tumor progression in patients receiving adjuvant whole-brain radiotherapy vs localized radiotherapy after surgical resection of brain metastases. Neurosugery 2015; 76:411-420.
    • (2015) Neurosugery , vol.76 , pp. 411-420
    • Hsieh, J.1    Elson, P.2    Otvos, B.3
  • 45
    • 84884999605 scopus 로고    scopus 로고
    • Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: A randomized, double-blind, placebo-controlled trial
    • Brown PD, Pugh S, Laack NN, et al. Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro Oncol 2013; 15:1429-1437.
    • (2013) Neuro Oncol , vol.15 , pp. 1429-1437
    • Brown, P.D.1    Pugh, S.2    Laack, N.N.3
  • 46
    • 84868193462 scopus 로고    scopus 로고
    • Effect of cancer therapy on neural stem cells: Implications for cognitive function
    • Gibson E, Monje M. Effect of cancer therapy on neural stem cells: implications for cognitive function. Curr Opin Oncol 2012; 24:672-678.
    • (2012) Curr Opin Oncol , vol.24 , pp. 672-678
    • Gibson, E.1    Monje, M.2
  • 47
    • 78651483077 scopus 로고    scopus 로고
    • Why avoid the hippocampus? A comprehensive review
    • Gondi V, Tome WA, Mehta MP. Why avoid the hippocampus? A comprehensive review. Radiother Oncol 2010; 97:370-376.
    • (2010) Radiother Oncol , vol.97 , pp. 370-376
    • Gondi, V.1    Tome, W.A.2    Mehta, M.P.3
  • 48
    • 84912073096 scopus 로고    scopus 로고
    • Hippocampal-Avoidance whole-brain radiation therapy a new standard for patients with brain metastases?
    • Suh JH. Hippocampal-Avoidance whole-brain radiation therapy: a new standard for patients with brain metastases? J Clin Oncol 2014; 32:3789-3791.
    • (2014) J Clin Oncol , vol.32 , pp. 3789-3791
    • Suh, J.H.1
  • 49
    • 73649134693 scopus 로고    scopus 로고
    • Intracranial metastatic disease spares the limbic circuit: A review of 697 metastatic lesions in 107 patients
    • Marsh JC, Herskovic AM, Gielda BT, et al. Intracranial metastatic disease spares the limbic circuit: a review of 697 metastatic lesions in 107 patients. Int J Radiat Oncol Biol Phys 2010; 76:504-512.
    • (2010) Int J Radiat Oncol Biol Phys , vol.76 , pp. 504-512
    • Marsh, J.C.1    Herskovic, A.M.2    Gielda, B.T.3
  • 50
    • 84912138328 scopus 로고    scopus 로고
    • Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during wholebrain radiotherapy for brain metastases (rtog 0933): A phase II multIInstitutional trial
    • Gondi V, Pugh SL, Tome WA, et al. Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during wholebrain radiotherapy for brain metastases (RTOG 0933): a phase II multiinstitutional trial. J Clin Oncol 2014; 32:3810-3816.
    • (2014) J Clin Oncol , vol.32 , pp. 3810-3816
    • Gondi, V.1    Pugh, S.L.2    Tome, W.A.3
  • 51
    • 84930246930 scopus 로고    scopus 로고
    • Response assessment criteria for brain metastases: Proposal from the rano group
    • Lin NU, Lee EQ, Aoyama H, et al. Response assessment criteria for brain metastases: proposal from the RANO group. Lancet Oncol 2015; 16:270-278.
    • (2015) Lancet Oncol , vol.16 , pp. 270-278
    • Lin, N.U.1    Lee, E.Q.2    Aoyama, H.3
  • 52
    • 84940726872 scopus 로고    scopus 로고
    • Consensus recommendations for a standardized brain tumor imaging protocol in clinical trials
    • Ellingson BM, Bendszus M, Boxerman J, et al. Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. Neuro Oncol 2015; 17:1188-1198.
    • (2015) Neuro Oncol , vol.17 , pp. 1188-1198
    • Ellingson, B.M.1    Bendszus, M.2    Boxerman, J.3
  • 53
    • 84922142034 scopus 로고    scopus 로고
    • Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: A prospective study
    • Morikawa A, Peereboom DM, Thorsheim HR, et al. Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study. Neuro Oncol 2015; 17:289-295.
    • (2015) Neuro Oncol , vol.17 , pp. 289-295
    • Morikawa, A.1    Peereboom, D.M.2    Thorsheim, H.R.3
  • 54
    • 77956060394 scopus 로고    scopus 로고
    • High dose weekly erlotinib achieves therapeutic concentrations in csf and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer
    • Clarke JL, Pao W, Wu N, et al. High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer. J Neurooncol 2010; 99:283-286.
    • (2010) J Neurooncol , vol.99 , pp. 283-286
    • Clarke, J.L.1    Pao, W.2    Wu, N.3
  • 55
    • 84946215072 scopus 로고    scopus 로고
    • Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets
    • Brastianos PK, Carter SL, Santagata S, et al. Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Cancer Discov 2015; 5:1164-1177.
    • (2015) Cancer Discov , vol.5 , pp. 1164-1177
    • Brastianos, P.K.1    Carter, S.L.2    Santagata, S.3
  • 56
    • 84945176534 scopus 로고    scopus 로고
    • Treatment of brain metastases
    • Lin X, DeAngelis LM. Treatment of brain metastases. J Clin Oncol 2015; 33:3475-3484.
    • (2015) J Clin Oncol , vol.33 , pp. 3475-3484
    • Lin, X.1    DeAngelis, L.M.2
  • 57
    • 84927721214 scopus 로고    scopus 로고
    • Brain metastases: The changing landscape
    • Mehta MP. Brain metastases: the changing landscape. Oncology (Williston Park) 2015; 29:257-260.
    • (2015) Oncology (Williston Park) , vol.29 , pp. 257-260
    • Mehta, M.P.1
  • 58
    • 84905859056 scopus 로고    scopus 로고
    • Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American society of clinical oncology clinical practice guideline
    • Ramakrishna N, Temin S, Chandarlapaty S, et al. Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 2014; 32:2100-2108.
    • (2014) J Clin Oncol , vol.32 , pp. 2100-2108
    • Ramakrishna, N.1    Temin, S.2    Chandarlapaty, S.3
  • 59
    • 63149110733 scopus 로고    scopus 로고
    • Multicenter phase II study of lapatinib in patients with brain metastases from her2-positive breast cancer
    • Lin NU, Dieras V, Paul D, et al. Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res 2009; 15:1452-1459.
    • (2009) Clin Cancer Res , vol.15 , pp. 1452-1459
    • Lin, N.U.1    Dieras, V.2    Paul, D.3
  • 60
    • 84871722407 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in patients with previously untreated brain metastases from her2-positive metastatic breast cancer (landscape): A single-group phase 2 study
    • Bachelot T, Romieu G, Campone M, et al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study. Lancet Oncol 2013; 14:64-71.
    • (2013) Lancet Oncol , vol.14 , pp. 64-71
    • Bachelot, T.1    Romieu, G.2    Campone, M.3
  • 61
    • 84962094467 scopus 로고    scopus 로고
    • Translational breast cancer research consortium (tbcrc) 022: A phase II trial of neratinib for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases
    • Freedman RA, Gelman RS, Wefel JS, et al. Translational Breast Cancer Research Consortium (TBCRC) 022: a phase II trial of neratinib for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases. J Clin Oncol 2016; 34:945-952.
    • (2016) J Clin Oncol , vol.34 , pp. 945-952
    • Freedman, R.A.1    Gelman, R.S.2    Wefel, J.S.3
  • 62
    • 84948808453 scopus 로고    scopus 로고
    • Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for her2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (luxbreast 3): A randomised, open-label, multicentre, phase 2 trial
    • Cortes J, Dieras V, Ro J, et al. Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUXBreast 3): a randomised, open-label, multicentre, phase 2 trial. Lancet Oncol 2015; 16:1700-1710.
    • (2015) Lancet Oncol , vol.16 , pp. 1700-1710
    • Cortes, J.1    Dieras, V.2    Ro, J.3
  • 63
    • 84942372167 scopus 로고    scopus 로고
    • Activity of t-dm1 in her2-positive breast cancer brain metastases
    • First trial on neratinib in brain metastasis from breast cancer
    • Bartsch R, Berghoff AS, Vogl U, et al. Activity of T-DM1 in Her2-positive breast cancer brain metastases. Clin Exp Metastasis 2015; 32:729-737; First trial on neratinib in brain metastasis from breast cancer.
    • (2015) Clin Exp Metastasis , vol.32 , pp. 729-737
    • Bartsch, R.1    Berghoff, A.S.2    Vogl, U.3
  • 64
    • 4143110253 scopus 로고    scopus 로고
    • Gefitinib in patients with brain metastases from nonsmall-cell lung cancer: A prospective trial
    • Ceresoli GL, Cappuzzo F, Gregorc V, et al. Gefitinib in patients with brain metastases from nonsmall-cell lung cancer: a prospective trial. Ann Oncol 2004; 15:1042-1047.
    • (2004) Ann Oncol , vol.15 , pp. 1042-1047
    • Ceresoli, G.L.1    Cappuzzo, F.2    Gregorc, V.3
  • 65
    • 84875632711 scopus 로고    scopus 로고
    • Erlotinib as second-line treatment in patients with advanced nonsmall-cell lung cancer and asymptomatic brain metastases: A phase II study (ctong-0803)
    • Wu YL, Zhou C, Cheng Y, et al. Erlotinib as second-line treatment in patients with advanced nonsmall-cell lung cancer and asymptomatic brain metastases: a phase II study (CTONG-0803). Ann Oncol 2013; 24:993-999.
    • (2013) Ann Oncol , vol.24 , pp. 993-999
    • Wu, Y.L.1    Zhou, C.2    Cheng, Y.3
  • 66
    • 84946013619 scopus 로고    scopus 로고
    • Brain metastases in NSCLC: Are tkis changing the treatment strategy?
    • Dempke WC, Edvardsen K, Lu S, et al. Brain metastases in NSCLC: are TKIs changing the treatment strategy? Anticancer Res 2015; 35:5797-5806.
    • (2015) Anticancer Res , vol.35 , pp. 5797-5806
    • Dempke, W.C.1    Edvardsen, K.2    Lu, S.3
  • 67
    • 84962521878 scopus 로고    scopus 로고
    • First-line afatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growth factor receptor gene mutations and brain metastases
    • Schuler M, Wu YL, Hirsh V, et al. First-line afatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growth factor receptor gene mutations and brain metastases. J Thorac Oncol 2016; 11:380-390.
    • (2016) J Thorac Oncol , vol.11 , pp. 380-390
    • Schuler, M.1    Wu, Y.L.2    Hirsh, V.3
  • 68
    • 84991522367 scopus 로고    scopus 로고
    • Radiotherapy plus EGFR tkis in nonsmall cell lung cancer patients with brain metastases: An update meta-Analysis
    • Jiang T, Min W, Li Y, et al. Radiotherapy plus EGFR TKIs in nonsmall cell lung cancer patients with brain metastases: an update meta-Analysis. Cancer Med 2016; 5:1055-1065.
    • (2016) Cancer Med , vol.5 , pp. 1055-1065
    • Jiang, T.1    Min, W.2    Li, Y.3
  • 69
    • 84953874716 scopus 로고    scopus 로고
    • Targeting brain metastases in alkrearranged nonsmall-cell lung cancer
    • Zhang I, Zaorsky NG, Palmer JD, et al. Targeting brain metastases in ALKrearranged nonsmall-cell lung cancer. Lancet Oncol 2015; 16:510-521.
    • (2015) Lancet Oncol , vol.16 , pp. 510-521
    • Zhang, I.1    Zaorsky, N.G.2    Palmer, J.D.3
  • 70
    • 84929508050 scopus 로고    scopus 로고
    • Clinical experience with crizotinib in patients with advanced alk-rearranged non-small-cell lung cancer and brain metastases
    • Costa DB, Shaw AT, Ou SH, et al. Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases. J Clin Oncol 2015; 33:1881-1888.
    • (2015) J Clin Oncol , vol.33 , pp. 1881-1888
    • Costa, D.B.1    Shaw, A.T.2    Ou, S.H.3
  • 71
    • 84954318418 scopus 로고    scopus 로고
    • Extended survival and prognostic factors for patients with alk-rearranged non-small-cell lung cancer and brain metastasis
    • Johung KL, Yeh N, Desai NB, et al. Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis. J Clin Oncol 2016; 34:123-129.
    • (2016) J Clin Oncol , vol.34 , pp. 123-129
    • Johung, K.L.1    Yeh, N.2    Desai, N.B.3
  • 72
    • 84919779490 scopus 로고    scopus 로고
    • Antitumor activity of the selective alk inhibitor alectinib in models of intracranial metastases
    • Kodama T, Hasegawa M, Takanashi K, et al. Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother Pharmacol 2014; 74:1023-1028.
    • (2014) Cancer Chemother Pharmacol , vol.74 , pp. 1023-1028
    • Kodama, T.1    Hasegawa, M.2    Takanashi, K.3
  • 73
    • 84983438273 scopus 로고    scopus 로고
    • Management of brain metastases in alkpositive non-small-cell lung cancer
    • Rusthoven CG, Doebele RC. Management of brain metastases in ALKpositive non-small-cell lung cancer. J Clin Oncol 2016; 34:2814-2819.
    • (2016) J Clin Oncol , vol.34 , pp. 2814-2819
    • Rusthoven, C.G.1    Doebele, R.C.2
  • 74
    • 84908569219 scopus 로고    scopus 로고
    • Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant alk-rearranged nonsmall-cell lung cancer (af-002jg): Results from the dose-finding portion of a phase 1/2 study
    • Gadgeel SM,Gandhi L, Riely GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged nonsmall-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol 2014; 15:1119-1128.
    • (2014) Lancet Oncol , vol.15 , pp. 1119-1128
    • Gadgeel, S.M.1    Gandhi, L.2    Riely, G.J.3
  • 75
    • 84964343904 scopus 로고    scopus 로고
    • Alectinib in crizotinib-refractory alkrearranged non-small-cell lung cancer: A phase II global study
    • Ou SI, Ahn JS, De Petris L, et al. Alectinib in crizotinib-refractory ALKrearranged non-small-cell lung cancer: a phase II global study. J Clin Oncol 2016; 34:661-668.
    • (2016) J Clin Oncol , vol.34 , pp. 661-668
    • Ou, S.I.1    Ahn, J.S.2    De Petris, L.3
  • 76
    • 84927655714 scopus 로고    scopus 로고
    • Bevacizumab in patients with nonsquamous non-small cell lung cancer and asymptomatic, untreated brain metastases (brain): A nonrandomized, phase II study
    • Besse B, Le Moulec S, Mazié res J, et al. Bevacizumab in patients with nonsquamous non-small cell lung cancer and asymptomatic, untreated brain metastases (BRAIN): a nonrandomized, phase II study. Clin Cancer Res 2015; 21:1896-1903.
    • (2015) Clin Cancer Res , vol.21 , pp. 1896-1903
    • Besse, B.1    Le Moulec, S.2    Mazié Res, J.3
  • 77
    • 84953869069 scopus 로고    scopus 로고
    • Evolving treatment options for melanoma brain metastases
    • Ajithkumar T, Parkinson C, Fife K, et al. Evolving treatment options for melanoma brain metastases. Lancet Oncol 2015; 16:486-497.
    • (2015) Lancet Oncol , vol.16 , pp. 486-497
    • Ajithkumar, T.1    Parkinson, C.2    Fife, K.3
  • 78
    • 84974588244 scopus 로고    scopus 로고
    • Brain metastases in melanoma: Moving toward curing the incurable
    • Margolin KA. Brain metastases in melanoma: moving toward curing the incurable. J Oncol Pract 2016; 12:545-546.
    • (2016) J Oncol Pract , vol.12 , pp. 545-546
    • Margolin, K.A.1
  • 79
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial
    • Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol 2012; 13:459-465.
    • (2012) Lancet Oncol , vol.13 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3
  • 80
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with val600glu or val600lys braf-mutant melanoma metastatic to the brain (break-mb): A multicentre, open-label, phase 2 trial
    • Long GV, Trefzer U, Davies MA, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol 2012; 13:1087-1095.
    • (2012) Lancet Oncol , vol.13 , pp. 1087-1095
    • Long, G.V.1    Trefzer, U.2    Davies, M.A.3
  • 81
    • 84893661769 scopus 로고    scopus 로고
    • Vemurafenib in patients with braf (v600) mutation-positive melanoma with symptomatic brain metastases: Final results of an open-label pilot study
    • Dummer R, Goldinger SM, Turtschi CP, et al. Vemurafenib in patients with BRAF (V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study. Eur J Cancer 2014; 50:611-621.
    • (2014) Eur J Cancer , vol.50 , pp. 611-621
    • Dummer, R.1    Goldinger, S.M.2    Turtschi, C.P.3
  • 82
    • 84920394727 scopus 로고    scopus 로고
    • Improved overall survival in melanoma with combined dabrafenib and trametinib
    • Robert C, Karaszewska B, Schachter J, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 2015; 372:30-39.
    • (2015) N Engl J Med , vol.372 , pp. 30-39
    • Robert, C.1    Karaszewska, B.2    Schachter, J.3
  • 83
    • 84943420158 scopus 로고    scopus 로고
    • Two heads better than one? Ipilimumab immunotherapy and radiation therapy for melanoma brain metastases
    • Patel KR, Lawson DH, Kudchadkar RR, et al. Two heads better than one? Ipilimumab immunotherapy and radiation therapy for melanoma brain metastases. Neuro Oncol 2015; 17:1312-1321.
    • (2015) Neuro Oncol , vol.17 , pp. 1312-1321
    • Patel, K.R.1    Lawson, D.H.2    Kudchadkar, R.R.3
  • 84
    • 84957583663 scopus 로고    scopus 로고
    • The rationale for targeted therapies and stereotactic radiosurgery in the treatment of brain metastases
    • Moraes FY, Taunk NK, Marta GN, et al. The rationale for targeted therapies and stereotactic radiosurgery in the treatment of brain metastases. Oncologist 2016; 21:244-251.
    • (2016) Oncologist , vol.21 , pp. 244-251
    • Moraes, F.Y.1    Taunk, N.K.2    Marta, G.N.3
  • 85
    • 84957575093 scopus 로고    scopus 로고
    • Impact on overall survival of the combination of braf inhibitors and stereotactic radiosurgery in patients with melanoma brain metastases
    • Wolf A, Zia S, Verma R, et al. Impact on overall survival of the combination of BRAF inhibitors and stereotactic radiosurgery in patients with melanoma brain metastases. J Neurooncol 2016; 127:607-615.
    • (2016) J Neurooncol , vol.127 , pp. 607-615
    • Wolf, A.1    Zia, S.2    Verma, R.3
  • 86
    • 84995696438 scopus 로고    scopus 로고
    • Braf v600e mutation and braf kinase inhibitors in conjunction with stereotactic radiosurgery for intracranial melanoma metastases
    • Xu Z, Lee CC, Ramesh A, et al. BRAF V600E mutation and BRAF kinase inhibitors in conjunction with stereotactic radiosurgery for intracranial melanoma metastases. J Neurosurg 2016; 20:1-9.
    • (2016) J Neurosurg , vol.20 , pp. 1-9
    • Xu, Z.1    Lee, C.C.2    Ramesh, A.3
  • 87
    • 84971619894 scopus 로고    scopus 로고
    • Pembrolizumab for patients with melanoma or nonsmall-cell lung cancer and untreated brain metastases: Early analysis of a nonrandomised, open-label, phase 2 trial
    • Goldberg SB, Gettinger SN, Mahajan A, et al. Pembrolizumab for patients with melanoma or nonsmall-cell lung cancer and untreated brain metastases: early analysis of a nonrandomised, open-label, phase 2 trial. Lancet Oncol 2016; 17:976-983.
    • (2016) Lancet Oncol , vol.17 , pp. 976-983
    • Goldberg, S.B.1    Gettinger, S.N.2    Mahajan, A.3


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