Intracranial Metastatic Disease Spares the Limbic Circuit: A Review of 697 Metastatic Lesions in 107 Patients

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 2, 2010, Pages 504-512

  Marsh, James C ^a   Herskovic, Arnold M ^a   Gielda, Benjamin T ^a   Hughes, Frank F ^a   Hoeppner, Thomas ^a   Turian, Julius ^a   Abrams, Ross A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hippocampus; Intracranial; Limbic; Metastatic; Whole brain

Indexed keywords

BREAST CANCER; CONTRAST-ENHANCED CT; CRANIAL IRRADIATION; HIPPOCAMPUS; LIMBIC SYSTEM; METASTATIC DISEASE; METASTATIC LESIONS; MR IMAGES; NON SMALL CELL LUNG CANCER; SMALL-CELL LUNG CANCER; WHOLE BRAIN RADIOTHERAPY;

BIOLOGICAL ORGANS; IRRADIATION; PATIENT MONITORING; RADIOTHERAPY;

PATHOLOGY;

ARTICLE; BRAIN DAMAGE; BRAIN METASTASIS; BRAIN RADIATION; BRAIN STEM; BREAST CANCER; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; FEASIBILITY STUDY; HIPPOCAMPUS; HISTOLOGY; HUMAN; HYPOTHESIS; LIMBIC SYSTEM; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; WHOLE BRAIN RADIOTHERAPY;

BRAIN NEOPLASMS; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CRANIAL IRRADIATION; FEASIBILITY STUDIES; FEMALE; HIPPOCAMPUS; HUMANS; INCIDENCE; LIMBIC SYSTEM; LUNG NEOPLASMS; MALE; RETROSPECTIVE STUDIES; SMALL CELL LUNG CARCINOMA;

EID: 73649134693     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.02.038     Document Type: Article

References (21)

1. Patchell R.A. The management of brain metastases. Cancer Treat Rev 29 (2003) 533-540
2. Auperin A., Arriagada R., Pignon J.P., et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med 341 (1999) 476-484
3. Slotman S., Faivre-Finn C., Kramer G., et al. Prophylactic cranial irradiation in extensive stage small-cell lung cancer. N Engl J Med 357 (2007) 664-672
4. Chen A.M., Jahan T.M., Jablons D.M., et al. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced non small-cell lung cancer. Cancer 109 (2007) 1668-1675
5. Sorenson J.B., Hansen H.H., Hansen M., et al. Brain metastases in adenocarcinoma of the lung: Frequency, risk groups and prognosis. J Clin Oncol 6 (1988) 1474-1480
6. Ghia A., Tome' W.A., Thomas S., et al. Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys 68 (2007) 971-977
7. Gutierrez A.N., Westerly D.C., Tome W.A., et al. Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases;a planning study. Int J Radiat Oncol Biol Phys 69 (2007) 589-597
8. Abayomi O.K. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol 35 (1996) 659-663
9. Mizumatsu S., Monje M.L., Morhardt D.R., et al. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res 63 (2003) 4021-4027
10. Monje M.L., Mizumatsu S., Fike J.R., et al. Irradiation induces neural cell precursor-cell dysfunction. Nature Med 8 (2002) 955-962
11. Monje M.L., and Palmer T. Radiation injury and neurogenesis. Curr Opin Neurol 16 (2003) 129-134
12. Shi L., Adams M.M., Long A., et al. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res 6 (2006) 892-899
13. Shi L., Molina D.P., Robbins M.E., et al. Hippocampal neuron number is unchanged 1 year after fractionated whole-brain irradiation at middle age. Int J Radiat Oncol Biol Phys 71 (2008) 526-532
14. Roman D.D., and Sperduto P.W. Neuropsychological effects of cranial radiation: Current knowledge and future directions. Int J Radiat Oncol Biol Phys 31 (1995) 983-998
15. DeAngelis L.M., Delattre J.Y., and Posner J.B. Radiation-induced dementia in patients cured of brain metastases. Neurology 39 (1989) 789-796
16. Li J., Bentzen S.M., Li J., et al. Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis. Int J Radiat Oncol Biol Phys 71 (2008) 64-70
17. Mulhern R.K., Merchant T.E., Gajjar A., et al. Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol 5 (2004) 399-408
18. Lautin A. The limbic brain (2001), Kluwer Academic/ Plenum Publisher, New York, NY
19. Kier E.L., Fulbright R.K., and Bronen R.A. Limbic lobe embryology and anatomy: Dissection and MR of the medial surface of the fetal cerebral hemisphere. Am J Neuroradiol 16 (1995) 1847-1853
20. Barani I.J., Cuttino L.W., Benedict S.H., et al. Neural stem-cell preserving external-beam radiotherapy of central nervous system malignancies. Int J Radiat Oncol Biol Phys 68 (2007) 978-985
21. Delattre J.Y., Krol G., Thaler H.T., et al. Distribution of brain metastases. Arch Neurol 45 (1988) 741-744