Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial

Journal of Clinical Oncology

Volumn 32, Issue 34, 2014, Pages 3810-3816

  Gondi, Vinai ^a,b   Pugh, Stephanie L ^c   Tome, Wolfgang A ^g   Caine, Chip ^h   Corn, Ben ⁱ   Kanner, Andrew ⁱ   Rowley, Howard ^b   Kundapur, Vijayananda ^j   DeNittis, Albert ^e   Greenspoon, Jeffrey N ^k   Konski, Andre A ^f   Bauman, Glenn S ^l   Shah, Sunjay ^m   Shi, Wenyin ^d   Wendland, Merideth ⁿ   Kachnic, Lisa ^o   Mehta, Minesh P ^p  

^a CDH Proton Center   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c Radiation Therapy Oncology Group Statistical Center   (United States)

^d THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^e LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^f The Chester County Hospital   (United States)

^g ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^h UNIVERSITY OF PHOENIX   (United States)

ⁱ TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^j Saskatoon Cancer Center   (Canada)

^k MCMASTER UNIVERSITY   (Canada)

^l LONDON REGIONAL CANCER PROGRAM   (Canada)

^m CHRISTIANA CARE HEALTH SYSTEM   (United States)

ⁿ Willamette Valley Cancer Center   (United States)

^o BOSTON MEDICAL CENTER   (United States)

^p UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALOPECIA; ARTICLE; BRAIN METASTASIS; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CAUSE OF DEATH; COGNITION; DETERIORATION; FATIGUE; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HEADACHE; HIPPOCAMPUS; HOPKINS VERBAL LEARNING TEST REVISED DELAYED RECALL; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; MEMORY; MULTICENTER STUDY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEURAL STEM CELL; NEUROLOGIC DISEASE; PATIENT COMPLIANCE; PHASE 2 CLINICAL TRIAL; PROGRESSION FREE SURVIVAL; PSYCHOLOGICAL WELL BEING; QUALITY OF LIFE; RADIATION INJURY; TREATMENT OUTCOME; WHOLE BRAIN RADIOTHERAPY; ADVERSE EFFECTS; BRAIN NEOPLASMS; CLINICAL TRIAL; KAPLAN MEIER METHOD; MEMORY DISORDERS; MIDDLE AGED; MORTALITY; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PROCEDURES; PSYCHOLOGY; QUESTIONNAIRE; RADIATION DOSE FRACTIONATION; RADIATION INJURIES; RADIATION RESPONSE; RECALL; RISK FACTOR; SECONDARY; SKULL IRRADIATION; TIME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; COGNITION; CRANIAL IRRADIATION; DOSE FRACTIONATION; FEMALE; HIPPOCAMPUS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MEMORY DISORDERS; MENTAL RECALL; MIDDLE AGED; NEURAL STEM CELLS; NEUROPSYCHOLOGICAL TESTS; QUALITY OF LIFE; RADIATION INJURIES; RADIOTHERAPY, INTENSITY-MODULATED; RISK FACTORS; SURVEYS AND QUESTIONNAIRES; TIME FACTORS; TREATMENT OUTCOME;

EID: 84912138328     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2014.57.2909     Document Type: Article

References (23)

1. Eriksson PS, Perfilieva E, Björk-Eriksson T, et al: Neurogenesis in the adult human hippocampus. Nat Med 4:1313-1317, 1998
2. Gondi V, Tomé WA, Mehta MP: Why avoid the hippocampus? A comprehensive review. Radiother Oncol 97:370-376, 2010
3. Monje ML, Mizumatsu S, Fike JR: Irradiation induces neural precursor-cell dysfunction. Nat Med 8:955-962, 2002
4. Gondi V, Hermann BP, Mehta MP, et al: Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Oncol Biol Phys 85:348-354, 2013
5. Tsao MN, Rades D, Wirth A, et al: Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol 2:210-225, 2012
6. Gaspar LE, Mehta MP, Patchell RA, et al: The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline. J Neurooncol 96:17-32, 2010
7. Chang EL, Wefel JS, Hess KR, et al: Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial. Lancet Oncol 10:1037-1044, 2009
8. Soffietti R, Kocher M, Abacioglu UM, et al: A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: Quality-of-life results. J Clin Oncol 31:65-72, 2013
9. Sun A, Bae K, Gore EM, et al: Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: Neurocognitive and quality-of-life analysis. J Clin Oncol 29:279-286, 2011
10. Gondi V, Paulus R, Bruner DW, et al: Decline in tested and self-reported cognitive functioning after prophylactic cranial irradiation for lung cancer: Pooled secondary analysis of Radiation Therapy Oncology Group randomized trials 0212 and 0214. Int J Radiat Oncol Biol Phys 86:656-664, 2013
11. Gondi V, Tolakanahalli R, Mehta MP, et al: Hippocampal-sparing whole-brain radiotherapy: A "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 78:1244-1252, 2010
12. Hsu F, Carolan H, Nichol A, et al: Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for 1-3 brain metastases: A feasibility study using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 76:1480-1485, 2010
13. Mehta MP, Rodrigus P, Terhaard CH, et al: Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 21:2529-2536, 2003
14. Gondi V, Tome WA, Rowley H, et al: Hippocampal contouring: A contouring atlas for RTOG 0933. http://www.rtog.org/CoreLab/ContouringAtlases/HippocampalSparing.aspx
15. Wolfson AH, Bae K, Komaki R, et al: Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: Impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer. Int J Radiat Oncol Biol Phys 81:77-84, 2011
16. Jacobson NS, Truax P: Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol 59:12-19, 1991
17. Chelune GJ, Naugle RI, Luders H, et al: Individual change after epilepsy surgery: Practice effects and base-rate information. Neuropsychology 7:41-52, 1993
18. Benedict RHB, Schretlen D, Groninger L, et al: Hopkins Verbal Learning Test-Revised: Normative data and analysis of inter-form and test-retest reliability. Clin Neuropsychol 12:43-55, 1998
19. Li J, Bentzen SM, Li J, et al: Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis. Int J Radiat Oncol Biol Phys 71:64-70, 2008
20. Schindler MK, Forbes ME, Robbins ME, et al: Aging-dependent changes in the radiation response of the adult rat brain. Int J Radiat Oncol Biol Phys 70:826-834, 2008
21. Gondi V, Tome WA, Marsh J, et al: Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: Safety profile for RTOG 0933. Radiother Oncol 95:327-331, 2010
22. Brown PD, Pugh S, Laack NN, et al: Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: A randomized, double-blind, placebo-controlled trial. Neuro Oncol 15:1429-1437, 2013
23. Monaco EA 3rd, Faraji AH, Berkowitz O, et al: Leukoencephalopathy after whole-brain radiation therapy plus radiosurgery versus radiosurgery alone for metastatic lung cancer. Cancer 119:226-232, 2013