Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: Individual patient data meta-analysis

International Journal of Radiation Oncology Biology Physics

Volumn 91, Issue 4, 2015, Pages 710-717

  Sahgal, Arjun ^a   Aoyama, Hidefumi ^b   Kocher, Martin ^c   Neupane, Binod ^d   Collette, Sandra ^e   Tago, Masao ^f   Shaw, Prakesh ^g   Beyene, Joseph ^d   Chang, Eric L ^h,i  

^a UNIVERSITY OF TORONTO   (Canada)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c UNIVERSITY OF COLOGNE   (Germany)

^d MCMASTER UNIVERSITY   (Canada)

^e EORTC DATA CENTER   (Belgium)

^f TEIKYO UNIVERSITY MIZONOKUCHI HOSPITAL   (Japan)

^g UNIVERSITY OF TORONTO   (Canada)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

ⁱ UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; HOSPITAL DATA PROCESSING; RADIOTHERAPY; REGRESSION ANALYSIS;

CONFIDENCE INTERVAL; ELIGIBILITY CRITERION; INDIVIDUAL PATIENT DATA; RANDOMIZED CONTROLLED TRIAL; RECURSIVE PARTITIONING ANALYSIS; STEREOTACTIC RADIOSURGERY; TREATMENT EFFECTS; WHOLE BRAIN RADIATION THERAPIES;

PATHOLOGY;

ADULT; AGED; ARTICLE; BRAIN DYSFUNCTION; BRAIN METASTASIS; BRAIN RADIATION; CANCER RISK; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; LITERATURE; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); OUTCOME ASSESSMENT; PATIENT CODING; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORING SYSTEM; STEREOTACTIC RADIOSURGERY; AGE; BRAIN NEOPLASMS; META ANALYSIS; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; PHASE 3 CLINICAL TRIAL (TOPIC); PROCEDURES; RADIOSURGERY; SECONDARY; SKULL IRRADIATION; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; CLINICAL TRIALS, PHASE III AS TOPIC; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RADIOSURGERY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84924674427     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2014.10.024     Document Type: Article

References (27)

1. M. Tsao, W. Xu, and A. Sahgal A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases Cancer 118 2012 2486 2493
2. M.N. Tsao, D. Rades, and A. Wirth Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline Pract Radiat Oncol 2 2012 210 225
3. H. Aoyama, H. Shirato, and M. Tago Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial JAMA 295 2006 2483 2491
4. E.L. Chang, J.S. Wefel, and K.R. Hess Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial Lancet Oncol 10 2009 1037 1044
5. M. Kocher, R. Soffietti, and U. Abacioglu Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952-26001 study J Clin Oncol 29 2010 134 141
6. M.N. Tsao, N. Lloyd, and R.K. Wong Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases Cochrane Database Syst Rev 4 2012 CD003869
7. L. Gaspar, C. Scott, and M. Rotman Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 1997 745 751
8. M. Yamamoto, T. Serizawa, and T. Shuto Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): A multi-institutional prospective observational study Lancet Oncol 15 2014 387 395
9. J. Bowden, J. Tierney, and M. Simmonds Individual patient data meta-analysis of time-to-event outcomes: One-stage versus two-stage approaches for estimating the hazard ratio under a random effects model Res Synth Methods 2 2011 150 162
10. S. Teramukai, Y. Matsuyama, and S. Mizuno Individual patient-level and study-level meta-analysis for investigating modifiers of treatment effect Jpn J Clin Oncol 34 2004 717 721
11. G.B. Stewart, D.G. Altman, and L.M. Askie Statistical analysis of individual participant data meta-analyses: A comparison of methods and recommendations for practice PLoS One 7 2012 e46042
12. L.A. Stewart, and J.F. Tierney To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data Eval Health Prof 25 2002 76 97
13. D.E. Roos, A. Wirth, and B.H. Burmeister Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: Mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05) Radiother Oncol 80 2006 318 322
14. A.P. Mintz, and J.G. Cairncross Treatment of a single brain metastasis: The role of radiation following surgical resection JAMA 280 1998 1527 1529
15. R.A. Patchell, P.A. Tibbs, and W.F. Regine Postoperative radiotherapy in the treatment of single metastases to the brain: A randomized trial JAMA 280 1998 1485 1489
16. R.A. Patchell, P.A. Tibbs, and J.W. Walsh A randomized trial of surgery in the treatment of single metastases to the brain N Engl J Med 322 1990 494 500
17. D.W. Andrews, C.B. Scott, and P.W. Sperduto Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial Lancet 363 2004 1665 1672
18. D. Kondziolka, A. Patel, and L.D. Lunsford Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases Int J Radiat Oncol Biol Phys 45 1999 427 434
19. A. Muacevic, B. Wowra, and A. Siefert Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: A randomized controlled multicentre phase III trial J Neurooncol 87 2008 299 307
20. P.W. Sperduto, M. Wang, and H.I. Robins A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320 Int J Radiat Oncol Biol Phys 85 2013 1312 1318
21. C.J. Vecht, H. Haaxma-Reiche, and E.M. Noordijk Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery? Ann Neurol 33 1993 583 590
22. A.H. Mintz, J. Kestle, and M.P. Rathbone A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis Cancer 78 1996 1470 1476
23. A. Sun, K. Bae, and E.M. Gore Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: Neurocognitive and quality-of-life analysis J Clin Oncol 29 2011 279 286
24. R. Soffietti, M. Kocher, and U.M. Abacioglu A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: Quality-of-life results J Clin Oncol 31 2012 65 72
25. B. Movsas, C. Hu, and J. Sloan Quality of life (QOL) analysis of the randomized radiation (RT) dose-escalation NSCLC trial (RTOG 0617): The rest of the story Int J Radiat Oncol Biol Phys 87 suppl 2 2013 S1
26. N.K. Gerber, Y. Yamada, and A. Rimner Erlotinib versus radiation therapy for brain metastases in patients with EGFR-mutant lung adenocarcinoma Int J Radiat Oncol Biol Phys 89 2014 322 329
27. A.W. Silk, M.F. Bassetti, and B.T. West Ipilimumab and radiation therapy for melanoma brain metastases Cancer Med 2 2013 899 906