Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial

JAMA

Volumn 295, Issue 21, 2006, Pages 2483-2491

  Aoyama, Hidefumi ^a   Shirato, Hiroki ^a   Tago, Masao ^b   Nakagawa, Keiichi ^b   Toyoda, Tatsuya ^c   Hatano, Kazuo ^d   Kenjyo, Masahiro ^e   Oya, Natsuo ^f   Hirota, Saeko ^g   Shioura, Hiroki ^h   Kunieda, Etsuo ⁱ   Inomata, Taisuke ^j   Hayakawa, Kazushige ^k   Katoh, Norio ^a   Kobashi, Gen ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^c Kanto Teishin Hospital   (Japan)

^d CHIBA CANCER CENTER   (Japan)

^e HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^f KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g HYOGO MEDICAL CENTER FOR ADULTS   (Japan)

^h Izumisano Municipal Hospital   (Japan)

ⁱ KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^j OSAKA MEDICAL COLLEGE   (Japan)

^k KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN METASTASIS; BRAIN RADIATION; CANCER CONTROL; CANCER RADIOTHERAPY; CAUSE OF DEATH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEADACHE; HUMAN; INTERMETHOD COMPARISON; LETHARGY; LEUKOENCEPHALOPATHY; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RADIATION NECROSIS; RADIATION RESPONSE; RADIOSURGERY; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SEIZURE; STEREOTAXIC SURGERY; TUMOR RECURRENCE; TUMOR VOLUME;

EID: 33744954692     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.295.21.2483     Document Type: Article

References (24)

1. Patchell RA. The management of brain metastases. Cancer Treat Rev. 2003;29:533-540.
2. Bradley KA, Mehta MP. Management of brain metastases. Semin Oncol. 2004;31:693-701.
3. Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45:427-434.
4. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363:1665-1672.
5. DeAngelis LM, Delattre JY, Posner JB. Radiation-induced dementia in patients cured of brain metastases. Neurology. 1989;39:789-796.
6. Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain. JAMA. 1998;280:1485-1489.
7. Sneed PK, Suh JH, Goetsch SJ, et al. A multi-institutional review of radiosurgery alone vs radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys. 2002;53:519-526.
8. Flickinger JC, Kondziolka D, Lunsford LD, et al. A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys. 1994;28:797-802.
9. Regine WF, Huhn JL, Patchell RA, et al. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Int J Radiat Oncol Biol Phys. 2002;52:333-338.
10. Pirzkall A, Debus J, Lohr F, et al. Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol. 1998;16:3563-3569.
11. Aoyama H, Shirato H, Onimaru R, et al. Hypofractionated stereotactic radiotherapy alone without whole brain irradiation for patients with solitary and oligo brain metastasis using non-invasive fixation of the skull. Int J Radiat Oncol Biol Phys. 2003;56:793-800.
12. Chidel MA, Suh JH, Reddy CA, Chao ST, Lundbeck MF, Barnett GH. Application of recursive partitioning analysis and evaluation of the use of whole brain radiation among patients treated with stereotactic radiosurgery for newly diagnosed brain metastases. Int J Radiat Oncol Biol Phys. 2000;47:993-999.
13. Shirato H, Takamura A, Tomita M, et al. Stereotactic irradiation without whole-brain irradiation for single brain metastasis. Int J Radiat Oncol Biol Phys. 1997;37:385-391.
14. Shaw E, Scott C, Souhami L, et al. Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: initial report of Radiation Therapy Oncology Group protocol (90-05). Int J Radiat Oncol Biol Phys. 1996;34:647-654.
15. Joseph J, Adler JR, Cox RS, Hancock SL. Linear accelerator-based stereotaxic radiosurgery for brain metastases: the influence of number of lesions on survival. J Clin Oncol. 1996;14:1085-1092.
16. Trotti A, Byhardt R, Stetz J, et al. Common Toxicity Criteria version 2.0: an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:13-47.
17. Gaspar L, Scott C, Rotman M, et al. Recursive partition analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 1997;37:745-751.
18. Radiation Therapy Oncology Group. RTOG/EORTC late radiation morbidity scoring schema. http: //www.rtog.org/members/toxicity/late.html. Accessed June 15, 1999.
19. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
20. Cox D. Regression models and life tables. J R Stat Soc [Ser A]. 1972;34:187-220.
21. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102:316-319.
22. Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 1990;322:494-500.
23. Mintz AH, Kestle J, Rathbone MP, et al. A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with single cerebral metastasis. Cancer. 1996;78:1470-1476.
24. Vecht CJ, Haaxma-Reiche H, Noordijk EM, et al. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery. Ann Neurol. 1993;33:583-590.