Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway

Circulation

Volumn 127, Issue 16, 2013, Pages 1692-1701

  Lai, Lo ^a   Yan, Lin ^a   Gao, Shumin ^a   Hu, Che Lin ^a   Ge, Hui ^a   Davidow, Amy ^a   Park, Misun ^a   Bravo, Claudio ^a   Iwatsubo, Kousaku ^a   Ishikawa, Yoshihiro ^a   Auwerx, Johan ^c   Sinclair, David A ^b   Vatner, Stephen F ^a   Vatner, Dorothy E ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EPFL   (Switzerland)

Author keywords

adenylyl; adrenergic receptors; cardiomyopathies; oxidative stress

Indexed keywords

ADENYLATE CYCLASE; ADENYLYL CYCLASE 5; MANGANESE SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE PREDISPOSITION; HEART HYPERTROPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENYLATE CYCLASE; ANIMALS; CARDIOMYOPATHIES; CROSSES, GENETIC; CYCLIC N-OXIDES; ENZYME INDUCTION; FORKHEAD TRANSCRIPTION FACTORS; ISOPROTERENOL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; SIRTUIN 1; SPIN LABELS; SUPEROXIDE DISMUTASE; TRANSCRIPTION, GENETIC;

EID: 84876513141     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.001212     Document Type: Article

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