Berberine treatment prevents cardiac dysfunction and remodeling through activation of 5′-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells

European Journal of Pharmacology

Volumn 769, Issue , 2015, Pages 55-63

  Chang, Wenguang ^a,b   Zhang, Ming ^a   Meng, Zhaojie ^a   Yu, Yang ^a   Yao, Fan ^a   Hatch, Grant M ^b   Chen, Li ^a  

^a JILIN UNIVERSITY   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

AMPK; Berberine; Cardiac function; Diabetes; Hypertrophy

Indexed keywords

BERBERINE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PALMITIC ACID DERIVATIVE; PROTEIN KINASE B;

ANIMAL; CARDIAC MUSCLE; CARDIOMEGALY; CELL LINE; CHEMICALLY INDUCED; COMPLICATION; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DRUG EFFECTS; ENZYME ACTIVATION; FIBROSIS; HEART; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; WISTAR RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BERBERINE; CARDIOMEGALY; CELL LINE; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; ENZYME ACTIVATION; FIBROSIS; GLYCOGEN SYNTHASE KINASE 3; HEART; MALE; MYOCARDIUM; PALMITATES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 84948964564     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.10.043     Document Type: Article

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