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Volumn 12, Issue 8, 2016, Pages

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

(199)  Sun, Wei a   Kechris, Katerina b   Jacobson, Sean c   Drummond, M Bradley d   Hawkins, Gregory A e   Yang, Jenny a   Chen, Ting Huei a   Quibrera, Pedro Miguel a   Anderson, Wayne f   Barr, R Graham g,y,ao   Basta, Patricia V a   Bleecker, Eugene R e   Beaty, Terri h   Casaburi, Richard i,ac   Castaldi, Peter j   Cho, Michael H j   Comellas, Alejandro P k,w   Crapo, James D c   Criner, Gerard l,ag   Demeo, Dawn m   more..


Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; SURFACTANT PROTEIN D; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; VITAMIN D BINDING PROTEIN; BIOLOGICAL MARKER; BLOOD GROUP ABO SYSTEM; PLASMA PROTEIN;

EID: 84984893097     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006011     Document Type: Article
Times cited : (86)

References (91)
  • 1
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • 25673413,..; ( ): –.; PubMed Central PMCID: PMC4382211.
    • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197–206. doi: 10.1038/nature1417725673413; PubMed Central PMCID: PMC4382211.
    • (2015) Nature , vol.518 , Issue.7538 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3    Justice, A.E.4    Pers, T.H.5    Day, F.R.6
  • 2
    • 84908890496 scopus 로고    scopus 로고
    • Defining the role of common variation in the genomic and biological architecture of adult human height
    • 25282103,..; ( ): –.; PubMed Central PMCID: PMC4250049.
    • Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014;46(11):1173–86. doi: 10.1038/ng.309725282103; PubMed Central PMCID: PMC4250049.
    • (2014) Nat Genet , vol.46 , Issue.11 , pp. 1173-1186
    • Wood, A.R.1    Esko, T.2    Yang, J.3    Vedantam, S.4    Pers, T.H.5    Gustafsson, S.6
  • 3
    • 84929001104 scopus 로고    scopus 로고
    • Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
    • 25954001,.; ( ): –.
    • Consortium GT, Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348(6235):648–60. doi: 10.1126/science.126211025954001.
    • (2015) Science , vol.348 , Issue.6235 , pp. 648-660
    • Consortium, G.T.1
  • 4
    • 84907972474 scopus 로고    scopus 로고
    • From genome to function by studying eQTLs
    • 24798236,.; ( ): –.
    • Westra HJ, Franke L, From genome to function by studying eQTLs. Biochim Biophys Acta. 2014;1842(10):1896–902. doi: 10.1016/j.bbadis.2014.04.02424798236.
    • (2014) Biochim Biophys Acta , vol.1842 , Issue.10 , pp. 1896-1902
    • Westra, H.J.1    Franke, L.2
  • 5
    • 84922469439 scopus 로고    scopus 로고
    • Genomic variation. Impact of regulatory variation from RNA to protein
    • 25657249,..; ( ): –.
    • Battle A, Khan Z, Wang SH, Mitrano A, Ford MJ, Pritchard JK, et al. Genomic variation. Impact of regulatory variation from RNA to protein. Science. 2015;347(6222):664–7. doi: 10.1126/science.126079325657249.
    • (2015) Science , vol.347 , Issue.6222 , pp. 664-667
    • Battle, A.1    Khan, Z.2    Wang, S.H.3    Mitrano, A.4    Ford, M.J.5    Pritchard, J.K.6
  • 6
    • 84898914338 scopus 로고    scopus 로고
    • Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)
    • 24029743,..; ( ): –.; PubMed Central PMCID: PMC3954445.
    • Couper D, LaVange LM, Han M, Barr RG, Bleecker E, Hoffman EA, et al. Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax. 2014;69(5):491–4. doi: 10.1136/thoraxjnl-2013-20389724029743; PubMed Central PMCID: PMC3954445.
    • (2014) Thorax , vol.69 , Issue.5 , pp. 491-494
    • Couper, D.1    LaVange, L.M.2    Han, M.3    Barr, R.G.4    Bleecker, E.5    Hoffman, E.A.6
  • 7
    • 77949363490 scopus 로고    scopus 로고
    • Genetic epidemiology of COPD (COPDGene) study design
    • 20214461,..; ( ): –.; PubMed Central PMCID: PMC2924193.
    • Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, et al. Genetic epidemiology of COPD (COPDGene) study design. COPD. 2010;7(1):32–43. doi: 10.3109/1541255090349952220214461; PubMed Central PMCID: PMC2924193.
    • (2010) COPD , vol.7 , Issue.1 , pp. 32-43
    • Regan, E.A.1    Hokanson, J.E.2    Murphy, J.R.3    Make, B.4    Lynch, D.A.5    Beaty, T.H.6
  • 8
    • 84929011928 scopus 로고    scopus 로고
    • Global and regional trends in COPD mortality, 1990–2010
    • 25837037,.; ( ): –.
    • Burney PG, Patel J, Newson R, Minelli C, Naghavi M, Global and regional trends in COPD mortality, 1990–2010. Eur Respir J. 2015;45(5):1239–47. doi: 10.1183/09031936.0014241425837037.
    • (2015) Eur Respir J , vol.45 , Issue.5 , pp. 1239-1247
    • Burney, P.G.1    Patel, J.2    Newson, R.3    Minelli, C.4    Naghavi, M.5
  • 9
    • 84902164334 scopus 로고    scopus 로고
    • Lessons from ECLIPSE: a review of COPD biomarkers
    • 24310110,..; ( ): –.
    • Faner R, Tal-Singer R, Riley JH, Celli B, Vestbo J, MacNee W, et al. Lessons from ECLIPSE: a review of COPD biomarkers. Thorax. 2014;69(7):666–72. doi: 10.1136/thoraxjnl-2013-20477824310110.
    • (2014) Thorax , vol.69 , Issue.7 , pp. 666-672
    • Faner, R.1    Tal-Singer, R.2    Riley, J.H.3    Celli, B.4    Vestbo, J.5    MacNee, W.6
  • 10
    • 44949201115 scopus 로고    scopus 로고
    • A genome-wide association study identifies protein quantitative trait loci (pQTLs)
    • 18464913,..; ( ):.; PubMed Central PMCID: PMC2362067.
    • Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008;4(5):e1000072. doi: 10.1371/journal.pgen.100007218464913; PubMed Central PMCID: PMC2362067.
    • (2008) PLoS Genet , vol.4 , Issue.5 , pp. e1000072
    • Melzer, D.1    Perry, J.R.2    Hernandez, D.3    Corsi, A.M.4    Stevens, K.5    Rafferty, I.6
  • 11
    • 84907942900 scopus 로고    scopus 로고
    • Prediction of acute respiratory disease in current and former smokers with and without COPD
    • 24945159,..; ( ): –.; PubMed Central PMCID: PMC4188150.
    • Bowler RP, Kim V, Regan E, Williams AA, Santorico SA, Make BJ, et al. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014;146(4):941–50. doi: 10.1378/chest.13-294624945159; PubMed Central PMCID: PMC4188150.
    • (2014) Chest , vol.146 , Issue.4 , pp. 941-950
    • Bowler, R.P.1    Kim, V.2    Regan, E.3    Williams, A.A.4    Santorico, S.A.5    Make, B.J.6
  • 12
    • 84892173588 scopus 로고    scopus 로고
    • Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study
    • 24397870,..;:.; PubMed Central PMCID: PMC3928911.
    • O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, et al. Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med. 2014;12:9. doi: 10.1186/1479-5876-12-924397870; PubMed Central PMCID: PMC3928911.
    • (2014) J Transl Med , vol.12 , pp. 9
    • O'Neal, W.K.1    Anderson, W.2    Basta, P.V.3    Carretta, E.E.4    Doerschuk, C.M.5    Barr, R.G.6
  • 13
    • 84964315666 scopus 로고    scopus 로고
    • The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
    • 25306249,..;:.; PubMed Central PMCID: PMC4198701.
    • Carolan BJ, Hughes G, Morrow J, Hersh CP, O'Neal WK, Rennard S, et al. The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. Respir Res. 2014;15:127. doi: 10.1186/s12931-014-0127-925306249; PubMed Central PMCID: PMC4198701.
    • (2014) Respir Res , vol.15 , pp. 127
    • Carolan, B.J.1    Hughes, G.2    Morrow, J.3    Hersh, C.P.4    O'Neal, W.K.5    Rennard, S.6
  • 14
    • 84886441236 scopus 로고    scopus 로고
    • Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease
    • 23947473,..; ( ): –.
    • Cheng DT, Kim DK, Cockayne DA, Belousov A, Bitter H, Cho MH, et al. Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188(8):948–57. doi: 10.1164/rccm.201302-0247OC23947473.
    • (2013) Am J Respir Crit Care Med , vol.188 , Issue.8 , pp. 948-957
    • Cheng, D.T.1    Kim, D.K.2    Cockayne, D.A.3    Belousov, A.4    Bitter, H.5    Cho, M.H.6
  • 15
    • 84862100999 scopus 로고    scopus 로고
    • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
    • 22624038,..; ( ):.; PubMed Central PMCID: PMCPMC3356313.
    • Agusti A, Edwards LD, Rennard SI, MacNee W, Tal-Singer R, Miller BE, et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One. 2012;7(5):e37483. doi: 10.1371/journal.pone.003748322624038; PubMed Central PMCID: PMCPMC3356313.
    • (2012) PLoS One , vol.7 , Issue.5 , pp. e37483
    • Agusti, A.1    Edwards, L.D.2    Rennard, S.I.3    MacNee, W.4    Tal-Singer, R.5    Miller, B.E.6
  • 16
    • 69249133317 scopus 로고    scopus 로고
    • Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD
    • 19164344,..; ( ): –.
    • Lomas DA, Silverman EK, Edwards LD, Locantore NW, Miller BE, Horstman DH, et al. Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J. 2009;34(1):95–102. doi: 10.1183/09031936.0015650819164344.
    • (2009) Eur Respir J , vol.34 , Issue.1 , pp. 95-102
    • Lomas, D.A.1    Silverman, E.K.2    Edwards, L.D.3    Locantore, N.W.4    Miller, B.E.5    Horstman, D.H.6
  • 17
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • 17701901,..; ( ): –.; PubMed Central PMCID: PMC1950838.
    • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559–75. doi: 10.1086/51979517701901; PubMed Central PMCID: PMC1950838.
    • (2007) Am J Hum Genet , vol.81 , Issue.3 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5    Bender, D.6
  • 18
    • 84895799527 scopus 로고    scopus 로고
    • Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
    • 24621683,..; ( ): –.; PubMed Central PMCID: PMC4176924.
    • Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, et al. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014;2(3):214–25. doi: 10.1016/S2213-2600(14)70002-524621683; PubMed Central PMCID: PMC4176924.
    • (2014) Lancet Respir Med , vol.2 , Issue.3 , pp. 214-225
    • Cho, M.H.1    McDonald, M.L.2    Zhou, X.3    Mattheisen, M.4    Castaldi, P.J.5    Hersh, C.P.6
  • 19
    • 85160389746 scopus 로고    scopus 로고
    • .:;., 1177 p. p.
    • Greene WH, Econometric analysis. 6th ed.Upper Saddle River, N.J.: Prentice Hall; 2008. xxxvii, 1177 p. p.
    • (2008) , pp. xxxvii
    • Greene, W.H.1
  • 20
    • 84899642574 scopus 로고    scopus 로고
    • Heritability and genomics of gene expression in peripheral blood
    • 24728292,..; ( ): –.; PubMed Central PMCID: PMC4012342.
    • Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, et al. Heritability and genomics of gene expression in peripheral blood. Nat Genet. 2014;46(5):430–7. doi: 10.1038/ng.295124728292; PubMed Central PMCID: PMC4012342.
    • (2014) Nat Genet , vol.46 , Issue.5 , pp. 430-437
    • Wright, F.A.1    Sullivan, P.F.2    Brooks, A.I.3    Zou, F.4    Sun, W.5    Xia, K.6
  • 21
    • 0037442208 scopus 로고    scopus 로고
    • Effects of exposure measurement error when an exposure variable is constrained by a lower limit
    • 12578806,.; ( ): –.
    • Richardson DB, Ciampi A, Effects of exposure measurement error when an exposure variable is constrained by a lower limit. Am J Epidemiol. 2003;157(4):355–63. 12578806.
    • (2003) Am J Epidemiol , vol.157 , Issue.4 , pp. 355-363
    • Richardson, D.B.1    Ciampi, A.2
  • 22
    • 22844446947 scopus 로고    scopus 로고
    • An integrative genomics approach to infer causal associations between gene expression and disease
    • 15965475,..; ( ): –.; PubMed Central PMCID: PMC2841396.
    • Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet. 2005;37(7):710–7. doi: 10.1038/ng158915965475; PubMed Central PMCID: PMC2841396.
    • (2005) Nat Genet , vol.37 , Issue.7 , pp. 710-717
    • Schadt, E.E.1    Lamb, J.2    Yang, X.3    Zhu, J.4    Edwards, S.5    Guhathakurta, D.6
  • 23
    • 40749105508 scopus 로고    scopus 로고
    • Variations in DNA elucidate molecular networks that cause disease
    • 18344982,..; ( ): –.; PubMed Central PMCID: PMCPMC2841398.
    • Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, et al. Variations in DNA elucidate molecular networks that cause disease. Nature. 2008;452(7186):429–35. doi: 10.1038/nature0675718344982; PubMed Central PMCID: PMCPMC2841398.
    • (2008) Nature , vol.452 , Issue.7186 , pp. 429-435
    • Chen, Y.1    Zhu, J.2    Lum, P.Y.3    Yang, X.4    Pinto, S.5    MacNeil, D.J.6
  • 24
    • 67650258730 scopus 로고    scopus 로고
    • Disentangling molecular relationships with a causal inference test
    • 19473544,.;:.; PubMed Central PMCID: PMCPMC3224661.
    • Millstein J, Zhang B, Zhu J, Schadt EE, Disentangling molecular relationships with a causal inference test. BMC Genet. 2009;10:23. doi: 10.1186/1471-2156-10-2319473544; PubMed Central PMCID: PMCPMC3224661.
    • (2009) BMC Genet , vol.10 , pp. 23
    • Millstein, J.1    Zhang, B.2    Zhu, J.3    Schadt, E.E.4
  • 25
    • 78549270383 scopus 로고    scopus 로고
    • Critical reasoning on causal inference in genome-wide linkage and association studies
    • 20951462,.; ( ): –.; PubMed Central PMCID: PMCPMC2991400.
    • Li Y, Tesson BM, Churchill GA, Jansen RC, Critical reasoning on causal inference in genome-wide linkage and association studies. Trends Genet. 2010;26(12):493–8. doi: 10.1016/j.tig.2010.09.00220951462; PubMed Central PMCID: PMCPMC2991400.
    • (2010) Trends Genet , vol.26 , Issue.12 , pp. 493-498
    • Li, Y.1    Tesson, B.M.2    Churchill, G.A.3    Jansen, R.C.4
  • 26
    • 84902455852 scopus 로고    scopus 로고
    • Employment arrangements and mental health in a cohort of working Australians: are transitions from permanent to temporary employment associated with changes in mental health?
    • 24872351,.; ( ): –.
    • LaMontagne AD, Milner A, Krnjacki L, Kavanagh AM, Blakely TA, Bentley R, Employment arrangements and mental health in a cohort of working Australians: are transitions from permanent to temporary employment associated with changes in mental health?Am J Epidemiol. 2014;179(12):1467–76. doi: 10.1093/aje/kwu09324872351.
    • (2014) Am J Epidemiol , vol.179 , Issue.12 , pp. 1467-1476
    • LaMontagne, A.D.1    Milner, A.2    Krnjacki, L.3    Kavanagh, A.M.4    Blakely, T.A.5    Bentley, R.6
  • 27
    • 42949144555 scopus 로고    scopus 로고
    • Harnessing naturally randomized transcription to infer regulatory relationships among genes
    • 17931418,.; ( ):.; PubMed Central PMCID: PMCPMC2246293.
    • Chen LS, Emmert-Streib F, Storey JD, Harnessing naturally randomized transcription to infer regulatory relationships among genes. Genome Biol. 2007;8(10):R219. doi: 10.1186/gb-2007-8-10-r21917931418; PubMed Central PMCID: PMCPMC2246293.
    • (2007) Genome Biol , vol.8 , Issue.10 , pp. R219
    • Chen, L.S.1    Emmert-Streib, F.2    Storey, J.D.3
  • 28
    • 34548711825 scopus 로고    scopus 로고
    • Detection of eQTL modules mediated by activity levels of transcription factors
    • 17599927,.; ( ): –.
    • Sun W, Yu T, Li KC, Detection of eQTL modules mediated by activity levels of transcription factors. Bioinformatics. 2007;23(17):2290–7. doi: 10.1093/bioinformatics/btm32717599927.
    • (2007) Bioinformatics , vol.23 , Issue.17 , pp. 2290-2297
    • Sun, W.1    Yu, T.2    Li, K.C.3
  • 29
    • 0032924944 scopus 로고    scopus 로고
    • Causal diagrams for epidemiologic research
    • 9888278,.; ( ): –.
    • Greenland S, Pearl J, Robins JM, Causal diagrams for epidemiologic research. Epidemiology. 1999;10(1):37–48. 9888278.
    • (1999) Epidemiology , vol.10 , Issue.1 , pp. 37-48
    • Greenland, S.1    Pearl, J.2    Robins, J.M.3
  • 30
    • 84925390239 scopus 로고    scopus 로고
    • Rich annotation of DNA sequencing variants by leveraging the Ensembl Variant Effect Predictor with plugins
    • 24626529,.; ( ): –.
    • Yourshaw M, Taylor SP, Rao AR, Martin MG, Nelson SF, Rich annotation of DNA sequencing variants by leveraging the Ensembl Variant Effect Predictor with plugins. Brief Bioinform. 2015;16(2):255–64. doi: 10.1093/bib/bbu00824626529.
    • (2015) Brief Bioinform , vol.16 , Issue.2 , pp. 255-264
    • Yourshaw, M.1    Taylor, S.P.2    Rao, A.R.3    Martin, M.G.4    Nelson, S.F.5
  • 31
    • 84891790401 scopus 로고    scopus 로고
    • The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
    • 24316577,..; (Database issue): –.; PubMed Central PMCID: PMC3965119.
    • Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 2014;42(Database issue):D1001–6. doi: 10.1093/nar/gkt122924316577; PubMed Central PMCID: PMC3965119.
    • (2014) Nucleic Acids Res , vol.42 , pp. D1001-6
    • Welter, D.1    MacArthur, J.2    Morales, J.3    Burdett, T.4    Hall, P.5    Junkins, H.6
  • 32
    • 84883185155 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease
    • 23590301,..; ( ): –.; PubMed Central PMCID: PMC3824029.
    • Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, et al. Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2013;49(2):316–23. doi: 10.1165/rcmb.2012-0230OC23590301; PubMed Central PMCID: PMC3824029.
    • (2013) Am J Respir Cell Mol Biol , vol.49 , Issue.2 , pp. 316-323
    • Bahr, T.M.1    Hughes, G.J.2    Armstrong, M.3    Reisdorph, R.4    Coldren, C.D.5    Edwards, M.G.6
  • 33
    • 84983096378 scopus 로고    scopus 로고
    • LocusZoom: regional visualization of genome-wide association scan results
    • 20634204,..; ( ): –.; PubMed Central PMCID: PMCPMC2935401.
    • Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, Gliedt TP, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics. 2010;26(18):2336–7. doi: 10.1093/bioinformatics/btq41920634204; PubMed Central PMCID: PMCPMC2935401.
    • (2010) Bioinformatics , vol.26 , Issue.18 , pp. 2336-2337
    • Pruim, R.J.1    Welch, R.P.2    Sanna, S.3    Teslovich, T.M.4    Chines, P.S.5    Gliedt, T.P.6
  • 34
    • 84858779229 scopus 로고    scopus 로고
    • HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    • 22064851,.; (Database issue): –.; PubMed Central PMCID: PMCPMC3245002.
    • Ward LD, Kellis M, HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012;40(Database issue):D930–4. doi: 10.1093/nar/gkr91722064851; PubMed Central PMCID: PMCPMC3245002.
    • (2012) Nucleic Acids Res , vol.40 , pp. D930-4
    • Ward, L.D.1    Kellis, M.2
  • 35
    • 69349097813 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
    • 19648918,..; ( ): –.; PubMed Central PMCID: PMCPMC2839871.
    • Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 2009;41(9):986–90. doi: 10.1038/ng.42919648918; PubMed Central PMCID: PMCPMC2839871.
    • (2009) Nat Genet , vol.41 , Issue.9 , pp. 986-990
    • Amundadottir, L.1    Kraft, P.2    Stolzenberg-Solomon, R.Z.3    Fuchs, C.S.4    Petersen, G.M.5    Arslan, A.A.6
  • 36
    • 84878485201 scopus 로고    scopus 로고
    • Imputation-based meta-analysis of severe malaria in three African populations
    • 23717212,..; ( ):.; PubMed Central PMCID: PMCPMC3662650.
    • Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, et al. Imputation-based meta-analysis of severe malaria in three African populations. PLoS Genet. 2013;9(5):e1003509. doi: 10.1371/journal.pgen.100350923717212; PubMed Central PMCID: PMCPMC3662650.
    • (2013) PLoS Genet , vol.9 , Issue.5 , pp. e1003509
    • Band, G.1    Le, Q.S.2    Jostins, L.3    Pirinen, M.4    Kivinen, K.5    Jallow, M.6
  • 37
    • 77952534219 scopus 로고    scopus 로고
    • Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
    • 20167578,..; ( ): –.; PubMed Central PMCID: PMCPMC2850624.
    • Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, et al. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010;19(9):1863–72. doi: 10.1093/hmg/ddq06120167578; PubMed Central PMCID: PMCPMC2850624.
    • (2010) Hum Mol Genet , vol.19 , Issue.9 , pp. 1863-1872
    • Barbalic, M.1    Dupuis, J.2    Dehghan, A.3    Bis, J.C.4    Hoogeveen, R.C.5    Schnabel, R.B.6
  • 38
    • 80055024880 scopus 로고    scopus 로고
    • Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    • 22001757,..; ( ): –.; PubMed Central PMCID: PMCPMC3482372.
    • Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011;43(11):1131–8. doi: 10.1038/ng.97022001757; PubMed Central PMCID: PMCPMC3482372.
    • (2011) Nat Genet , vol.43 , Issue.11 , pp. 1131-1138
    • Chambers, J.C.1    Zhang, W.2    Sehmi, J.3    Li, X.4    Wass, M.N.5    Van der Harst, P.6
  • 39
    • 80052260527 scopus 로고    scopus 로고
    • A genome-wide association study identifies two new risk loci for Graves' disease
    • 21841780,..; ( ): –.
    • Chu X, Pan CM, Zhao SX, Liang J, Gao GQ, Zhang XM, et al. A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet. 2011;43(9):897–901. doi: 10.1038/ng.89821841780.
    • (2011) Nat Genet , vol.43 , Issue.9 , pp. 897-901
    • Chu, X.1    Pan, C.M.2    Zhao, S.X.3    Liang, J.4    Gao, G.Q.5    Zhang, X.M.6
  • 40
    • 78649328373 scopus 로고    scopus 로고
    • A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor
    • 20066004,..; ( ): –.
    • Chung CM, Wang RY, Chen JW, Fann CS, Leu HB, Ho HY, et al. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. Pharmacogenomics J. 2010;10(6):537–44. doi: 10.1038/tpj.2009.7020066004.
    • (2010) Pharmacogenomics J , vol.10 , Issue.6 , pp. 537-544
    • Chung, C.M.1    Wang, R.Y.2    Chen, J.W.3    Fann, C.S.4    Leu, H.B.5    Ho, H.Y.6
  • 41
    • 84871267657 scopus 로고    scopus 로고
    • Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population
    • 23251661,..; ( ):.; PubMed Central PMCID: PMCPMC3522587.
    • Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, et al. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PLoS One. 2012;7(12):e51954. doi: 10.1371/journal.pone.005195423251661; PubMed Central PMCID: PMCPMC3522587.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e51954
    • Comuzzie, A.G.1    Cole, S.A.2    Laston, S.L.3    Voruganti, V.S.4    Haack, K.5    Gibbs, R.A.6
  • 42
    • 84867315226 scopus 로고    scopus 로고
    • A genome-wide association study of circulating galectin-3
    • 23056639,..; ( ):.; PubMed Central PMCID: PMCPMC3467202.
    • de Boer RA, Verweij N, van Veldhuisen DJ, Westra HJ, Bakker SJ, Gansevoort RT, et al. A genome-wide association study of circulating galectin-3. PLoS One. 2012;7(10):e47385. doi: 10.1371/journal.pone.004738523056639; PubMed Central PMCID: PMCPMC3467202.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e47385
    • de Boer, R.A.1    Verweij, N.2    van Veldhuisen, D.J.3    Westra, H.J.4    Bakker, S.J.5    Gansevoort, R.T.6
  • 43
    • 84872180690 scopus 로고    scopus 로고
    • Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association
    • 23267103,..; ( ): –.; PubMed Central PMCID: PMCPMC3545809.
    • Desch KC, Ozel AB, Siemieniak D, Kalish Y, Shavit JA, Thornburg CD, et al. Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci U S A. 2013;110(2):588–93. doi: 10.1073/pnas.121988511023267103; PubMed Central PMCID: PMCPMC3545809.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.2 , pp. 588-593
    • Desch, K.C.1    Ozel, A.B.2    Siemieniak, D.3    Kalish, Y.4    Shavit, J.A.5    Thornburg, C.D.6
  • 44
    • 84893659261 scopus 로고    scopus 로고
    • Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    • 24262325,..; ( ): –.; PubMed Central PMCID: PMCPMC4112102.
    • Dichgans M, Malik R, Konig IR, Rosand J, Clarke R, Gretarsdottir S, et al. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014;45(1):24–36. doi: 10.1161/STROKEAHA.113.00270724262325; PubMed Central PMCID: PMCPMC4112102.
    • (2014) Stroke , vol.45 , Issue.1 , pp. 24-36
    • Dichgans, M.1    Malik, R.2    Konig, I.R.3    Rosand, J.4    Clarke, R.5    Gretarsdottir, S.6
  • 45
    • 80053224243 scopus 로고    scopus 로고
    • Genetics of venous thrombosis: insights from a new genome wide association study
    • 21980494,..; ( ):.; PubMed Central PMCID: PMCPMC3181335.
    • Germain M, Saut N, Greliche N, Dina C, Lambert JC, Perret C, et al. Genetics of venous thrombosis: insights from a new genome wide association study. PLoS One. 2011;6(9):e25581. doi: 10.1371/journal.pone.002558121980494; PubMed Central PMCID: PMCPMC3181335.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e25581
    • Germain, M.1    Saut, N.2    Greliche, N.3    Dina, C.4    Lambert, J.C.5    Perret, C.6
  • 46
    • 84889665156 scopus 로고    scopus 로고
    • A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19–9, carcinoembryonic antigen and alpha fetoprotein and their associations with cancer risk
    • 23300138,..; ( ): –.
    • He M, Wu C, Xu J, Guo H, Yang H, Zhang X, et al. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19–9, carcinoembryonic antigen and alpha fetoprotein and their associations with cancer risk. Gut. 2014;63(1):143–51. doi: 10.1136/gutjnl-2012-30343423300138.
    • (2014) Gut , vol.63 , Issue.1 , pp. 143-151
    • He, M.1    Wu, C.2    Xu, J.3    Guo, H.4    Yang, H.5    Zhang, X.6
  • 47
    • 84865254028 scopus 로고    scopus 로고
    • A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q
    • 22672568,..; ( ): –.; PubMed Central PMCID: PMCPMC3419811.
    • Heit JA, Armasu SM, Asmann YW, Cunningham JM, Matsumoto ME, Petterson TM, et al. A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q. J Thromb Haemost. 2012;10(8):1521–31. doi: 10.1111/j.1538-7836.2012.04810.x22672568; PubMed Central PMCID: PMCPMC3419811.
    • (2012) J Thromb Haemost , vol.10 , Issue.8 , pp. 1521-1531
    • Heit, J.A.1    Armasu, S.M.2    Asmann, Y.W.3    Cunningham, J.M.4    Matsumoto, M.E.5    Petterson, T.M.6
  • 48
    • 77649184039 scopus 로고    scopus 로고
    • Genome-wide association study of hematological and biochemical traits in a Japanese population
    • 20139978,..; ( ): –.
    • Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, et al. Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet. 2010;42(3):210–5. doi: 10.1038/ng.53120139978.
    • (2010) Nat Genet , vol.42 , Issue.3 , pp. 210-215
    • Kamatani, Y.1    Matsuda, K.2    Okada, Y.3    Kubo, M.4    Hosono, N.5    Daigo, Y.6
  • 49
    • 80053384809 scopus 로고    scopus 로고
    • Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits
    • 21909109,..; ( ): –.
    • Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, et al. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet. 2011;43(10):990–5. doi: 10.1038/ng.93921909109.
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 990-995
    • Kim, Y.J.1    Go, M.J.2    Hu, C.3    Hong, C.B.4    Kim, Y.K.5    Lee, J.Y.6
  • 50
    • 84884957730 scopus 로고    scopus 로고
    • Genome-wide association study on serum alkaline phosphatase levels in a Chinese population
    • 24094242,..;:.; PubMed Central PMCID: PMCPMC3851471.
    • Li J, Gui L, Wu C, He Y, Zhou L, Guo H, et al. Genome-wide association study on serum alkaline phosphatase levels in a Chinese population. BMC Genomics. 2013;14:684. doi: 10.1186/1471-2164-14-68424094242; PubMed Central PMCID: PMCPMC3851471.
    • (2013) BMC Genomics , vol.14 , pp. 684
    • Li, J.1    Gui, L.2    Wu, C.3    He, Y.4    Zhou, L.5    Guo, H.6
  • 51
    • 84903287464 scopus 로고    scopus 로고
    • Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China
    • 24941225,..; ( ):.; PubMed Central PMCID: PMCPMC4062418.
    • Liang Y, Tang W, Huang T, Gao Y, Tan A, Yang X, et al. Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. PLoS One. 2014;9(6):e97923. doi: 10.1371/journal.pone.009792324941225; PubMed Central PMCID: PMCPMC4062418.
    • (2014) PLoS One , vol.9 , Issue.6 , pp. e97923
    • Liang, Y.1    Tang, W.2    Huang, T.3    Gao, Y.4    Tan, A.5    Yang, X.6
  • 52
    • 84857467976 scopus 로고    scopus 로고
    • A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation
    • 22291609,..; ( ):.; PubMed Central PMCID: PMCPMC3266885.
    • Naitza S, Porcu E, Steri M, Taub DD, Mulas A, Xiao X, et al. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 2012;8(1):e1002480. doi: 10.1371/journal.pgen.100248022291609; PubMed Central PMCID: PMCPMC3266885.
    • (2012) PLoS Genet , vol.8 , Issue.1 , pp. e1002480
    • Naitza, S.1    Porcu, E.2    Steri, M.3    Taub, D.D.4    Mulas, A.5    Xiao, X.6
  • 53
    • 79955618781 scopus 로고    scopus 로고
    • Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci
    • 21533024,..; ( ):.; PubMed Central PMCID: PMCPMC3080865.
    • Pare G, Ridker PM, Rose L, Barbalic M, Dupuis J, Dehghan A, et al. Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. PLoS Genet. 2011;7(4):e1001374. doi: 10.1371/journal.pgen.100137421533024; PubMed Central PMCID: PMCPMC3080865.
    • (2011) PLoS Genet , vol.7 , Issue.4 , pp. e1001374
    • Pare, G.1    Ridker, P.M.2    Rose, L.3    Barbalic, M.4    Dupuis, J.5    Dehghan, A.6
  • 54
    • 73949157547 scopus 로고    scopus 로고
    • Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin
    • 19729612,..; ( ): –.; PubMed Central PMCID: PMCPMC3147250.
    • Paterson AD, Lopes-Virella MF, Waggott D, Boright AP, Hosseini SM, Carter RE, et al. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol. 2009;29(11):1958–67. doi: 10.1161/ATVBAHA.109.19297119729612; PubMed Central PMCID: PMCPMC3147250.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.11 , pp. 1958-1967
    • Paterson, A.D.1    Lopes-Virella, M.F.2    Waggott, D.3    Boright, A.P.4    Hosseini, S.M.5    Carter, R.E.6
  • 55
    • 84874781557 scopus 로고    scopus 로고
    • A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
    • 23408906,..; ( ):.; PubMed Central PMCID: PMCPMC3567175.
    • Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, et al. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet. 2013;9(2):e1003266. doi: 10.1371/journal.pgen.100326623408906; PubMed Central PMCID: PMCPMC3567175.
    • (2013) PLoS Genet , vol.9 , Issue.2 , pp. e1003266
    • Porcu, E.1    Medici, M.2    Pistis, G.3    Volpato, C.B.4    Wilson, S.G.5    Cappola, A.R.6
  • 56
    • 77952510546 scopus 로고    scopus 로고
    • Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    • 20147318,..; ( ): –.; PubMed Central PMCID: PMCPMC2850622.
    • Qi L, Cornelis MC, Kraft P, Jensen M, van Dam RM, Sun Q, et al. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet. 2010;19(9):1856–62. doi: 10.1093/hmg/ddq05720147318; PubMed Central PMCID: PMCPMC2850622.
    • (2010) Hum Mol Genet , vol.19 , Issue.9 , pp. 1856-1862
    • Qi, L.1    Cornelis, M.C.2    Kraft, P.3    Jensen, M.4    van Dam, R.M.5    Sun, Q.6
  • 57
    • 79251619566 scopus 로고    scopus 로고
    • Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    • 21239051,..; ( ): –.; PubMed Central PMCID: PMCPMC3297116.
    • Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 2011;377(9763):383–92. doi: 10.1016/S0140-6736(10)61996-421239051; PubMed Central PMCID: PMCPMC3297116.
    • (2011) Lancet , vol.377 , Issue.9763 , pp. 383-392
    • Reilly, M.P.1    Li, M.2    He, J.3    Ferguson, J.F.4    Stylianou, I.M.5    Mehta, N.N.6
  • 58
    • 84901742293 scopus 로고    scopus 로고
    • Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links
    • 24586186,..; ( ):.; PubMed Central PMCID: PMCPMC3930510.
    • Rueedi R, Ledda M, Nicholls AW, Salek RM, Marques-Vidal P, Morya E, et al. Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet. 2014;10(2):e1004132. doi: 10.1371/journal.pgen.100413224586186; PubMed Central PMCID: PMCPMC3930510.
    • (2014) PLoS Genet , vol.10 , Issue.2 , pp. e1004132
    • Rueedi, R.1    Ledda, M.2    Nicholls, A.W.3    Salek, R.M.4    Marques-Vidal, P.5    Morya, E.6
  • 59
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • 21378990,..; ( ): –.; PubMed Central PMCID: PMCPMC3119261.
    • Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43(4):333–8. doi: 10.1038/ng.78421378990; PubMed Central PMCID: PMCPMC3119261.
    • (2011) Nat Genet , vol.43 , Issue.4 , pp. 333-338
    • Schunkert, H.1    Konig, I.R.2    Kathiresan, S.3    Reilly, M.P.4    Assimes, T.L.5    Holm, H.6
  • 60
    • 84901686870 scopus 로고    scopus 로고
    • An atlas of genetic influences on human blood metabolites
    • 24816252,..; ( ): –.; PubMed Central PMCID: PMCPMC4064254.
    • Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, et al. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014;46(6):543–50. doi: 10.1038/ng.298224816252; PubMed Central PMCID: PMCPMC4064254.
    • (2014) Nat Genet , vol.46 , Issue.6 , pp. 543-550
    • Shin, S.Y.1    Fauman, E.B.2    Petersen, A.K.3    Krumsiek, J.4    Santos, R.5    Huang, J.6
  • 61
    • 79955635525 scopus 로고    scopus 로고
    • Genetic predictors of fibrin D-dimer levels in healthy adults
    • 21502573,..; ( ): –.; PubMed Central PMCID: PMCPMC3095913.
    • Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, et al. Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011;123(17):1864–72. doi: 10.1161/CIRCULATIONAHA.110.00948021502573; PubMed Central PMCID: PMCPMC3095913.
    • (2011) Circulation , vol.123 , Issue.17 , pp. 1864-1872
    • Smith, N.L.1    Huffman, J.E.2    Strachan, D.P.3    Huang, J.4    Dehghan, A.5    Trompet, S.6
  • 62
    • 80052398214 scopus 로고    scopus 로고
    • Human metabolic individuality in biomedical and pharmaceutical research
    • 21886157,..; ( ): –.; PubMed Central PMCID: PMCPMC3832838.
    • Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wagele B, et al. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2011;477(7362):54–60. doi: 10.1038/nature1035421886157; PubMed Central PMCID: PMCPMC3832838.
    • (2011) Nature , vol.477 , Issue.7362 , pp. 54-60
    • Suhre, K.1    Shin, S.Y.2    Petersen, A.K.3    Mohney, R.P.4    Meredith, D.5    Wagele, B.6
  • 63
    • 84863985392 scopus 로고    scopus 로고
    • Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease
    • 22703881,..; ( ): –.; PubMed Central PMCID: PMCPMC3397273.
    • Tang W, Schwienbacher C, Lopez LM, Ben-Shlomo Y, Oudot-Mellakh T, Johnson AD, et al. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. Am J Hum Genet. 2012;91(1):152–62. doi: 10.1016/j.ajhg.2012.05.00922703881; PubMed Central PMCID: PMCPMC3397273.
    • (2012) Am J Hum Genet , vol.91 , Issue.1 , pp. 152-162
    • Tang, W.1    Schwienbacher, C.2    Lopez, L.M.3    Ben-Shlomo, Y.4    Oudot-Mellakh, T.5    Johnson, A.D.6
  • 64
    • 84859436351 scopus 로고    scopus 로고
    • A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
    • 22387998,..; ( ): –, S1-2.
    • Tanikawa C, Urabe Y, Matsuo K, Kubo M, Takahashi A, Ito H, et al. A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet. 2012;44(4):430–4, S1-2. doi: 10.1038/ng.110922387998.
    • (2012) Nat Genet , vol.44 , Issue.4 , pp. 430-434
    • Tanikawa, C.1    Urabe, Y.2    Matsuo, K.3    Kubo, M.4    Takahashi, A.5    Ito, H.6
  • 65
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • 20686565,..; ( ): –.; PubMed Central PMCID: PMCPMC3039276.
    • Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466(7307):707–13. doi: 10.1038/nature0927020686565; PubMed Central PMCID: PMCPMC3039276.
    • (2010) Nature , vol.466 , Issue.7307 , pp. 707-713
    • Teslovich, T.M.1    Musunuru, K.2    Smith, A.V.3    Edmondson, A.C.4    Stylianou, I.M.5    Koseki, M.6
  • 66
    • 77956824626 scopus 로고    scopus 로고
    • Genetic regulation of serum phytosterol levels and risk of coronary artery disease
    • 20529992,..; ( ): –.
    • Teupser D, Baber R, Ceglarek U, Scholz M, Illig T, Gieger C, et al. Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet. 2010;3(4):331–9. doi: 10.1161/CIRCGENETICS.109.90787320529992.
    • (2010) Circ Cardiovasc Genet , vol.3 , Issue.4 , pp. 331-339
    • Teupser, D.1    Baber, R.2    Ceglarek, U.3    Scholz, M.4    Illig, T.5    Gieger, C.6
  • 67
    • 84866524806 scopus 로고    scopus 로고
    • Genome-wide association study indicates two novel resistance loci for severe malaria
    • 22895189,..; ( ): –.
    • Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, et al. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature. 2012;489(7416):443–6. doi: 10.1038/nature1133422895189.
    • (2012) Nature , vol.489 , Issue.7416 , pp. 443-446
    • Timmann, C.1    Thye, T.2    Vens, M.3    Evans, J.4    May, J.5    Ehmen, C.6
  • 68
    • 67149087360 scopus 로고    scopus 로고
    • Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach
    • 19278955,..; ( ): –.
    • Tregouet DA, Heath S, Saut N, Biron-Andreani C, Schved JF, Pernod G, et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood. 2009;113(21):5298–303. doi: 10.1182/blood-2008-11-19038919278955.
    • (2009) Blood , vol.113 , Issue.21 , pp. 5298-5303
    • Tregouet, D.A.1    Heath, S.2    Saut, N.3    Biron-Andreani, C.4    Schved, J.F.5    Pernod, G.6
  • 69
    • 84871464519 scopus 로고    scopus 로고
    • Seventy-five genetic loci influencing the human red blood cell
    • 23222517,..; ( ): –.; PubMed Central PMCID: PMCPMC3623669.
    • van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. 2012;492(7429):369–75. doi: 10.1038/nature1167723222517; PubMed Central PMCID: PMCPMC3623669.
    • (2012) Nature , vol.492 , Issue.7429 , pp. 369-375
    • van der Harst, P.1    Zhang, W.2    Mateo Leach, I.3    Rendon, A.4    Verweij, N.5    Sehmi, J.6
  • 70
    • 84875299446 scopus 로고    scopus 로고
    • Ischemic stroke is associated with the ABO locus: the EuroCLOT study
    • 23381943,..; ( ): –.; PubMed Central PMCID: PMCPMC3582024.
    • Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol. 2013;73(1):16–31. doi: 10.1002/ana.2383823381943; PubMed Central PMCID: PMCPMC3582024.
    • (2013) Ann Neurol , vol.73 , Issue.1 , pp. 16-31
    • Williams, F.M.1    Carter, A.M.2    Hysi, P.G.3    Surdulescu, G.4    Hodgkiss, D.5    Soranzo, N.6
  • 71
    • 53049090077 scopus 로고    scopus 로고
    • Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    • 18940312,..; ( ): –.; PubMed Central PMCID: PMCPMC2561937.
    • Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet. 2008;83(4):520–8. doi: 10.1016/j.ajhg.2008.09.01218940312; PubMed Central PMCID: PMCPMC2561937.
    • (2008) Am J Hum Genet , vol.83 , Issue.4 , pp. 520-528
    • Yuan, X.1    Waterworth, D.2    Perry, J.R.3    Lim, N.4    Song, K.5    Chambers, J.C.6
  • 72
    • 84881260633 scopus 로고    scopus 로고
    • Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis
    • 23612905,..; ( ): –.
    • Zhao SX, Xue LQ, Liu W, Gu ZH, Pan CM, Yang SY, et al. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet. 2013;22(16):3347–62. doi: 10.1093/hmg/ddt18323612905.
    • (2013) Hum Mol Genet , vol.22 , Issue.16 , pp. 3347-3362
    • Zhao, S.X.1    Xue, L.Q.2    Liu, W.3    Gu, Z.H.4    Pan, C.M.5    Yang, S.Y.6
  • 73
    • 84893551953 scopus 로고    scopus 로고
    • A genome wide association study identifies common variants associated with lipid levels in the Chinese population
    • 24386095,..; ( ):.; PubMed Central PMCID: PMCPMC3875415.
    • Zhou L, He M, Mo Z, Wu C, Yang H, Yu D, et al. A genome wide association study identifies common variants associated with lipid levels in the Chinese population. PLoS One. 2013;8(12):e82420. doi: 10.1371/journal.pone.008242024386095; PubMed Central PMCID: PMCPMC3875415.
    • (2013) PLoS One , vol.8 , Issue.12 , pp. e82420
    • Zhou, L.1    He, M.2    Mo, Z.3    Wu, C.4    Yang, H.5    Yu, D.6
  • 74
    • 69949176863 scopus 로고    scopus 로고
    • Common regulatory variation impacts gene expression in a cell type-dependent manner
    • 19644074,..; ( ): –.; PubMed Central PMCID: PMCPMC2867218.
    • Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, Attar-Cohen H, et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science. 2009;325(5945):1246–50. doi: 10.1126/science.117414819644074; PubMed Central PMCID: PMCPMC2867218.
    • (2009) Science , vol.325 , Issue.5945 , pp. 1246-1250
    • Dimas, A.S.1    Deutsch, S.2    Stranger, B.E.3    Montgomery, S.B.4    Borel, C.5    Attar-Cohen, H.6
  • 75
    • 84943573162 scopus 로고    scopus 로고
    • Vitamin D-Binding Protein Concentrations Quantified by Mass Spectrometry
    • 26397952,.; ( ): –.; PubMed Central PMCID: PMCPMC4654614.
    • Hoofnagle AN, Eckfeldt JH, Lutsey PL, Vitamin D-Binding Protein Concentrations Quantified by Mass Spectrometry. N Engl J Med. 2015;373(15):1480–2. doi: 10.1056/NEJMc150260226397952; PubMed Central PMCID: PMCPMC4654614.
    • (2015) N Engl J Med , vol.373 , Issue.15 , pp. 1480-1482
    • Hoofnagle, A.N.1    Eckfeldt, J.H.2    Lutsey, P.L.3
  • 77
  • 78
    • 0024256019 scopus 로고
    • ABO blood groups, intestinal alkaline phosphatase and haptoglobin types in patients with serum hepatitis
    • 3246377,.; ( ): –.
    • Padma T, Valli VV, ABO blood groups, intestinal alkaline phosphatase and haptoglobin types in patients with serum hepatitis. Hum Hered. 1988;38(6):367–71. 3246377.
    • (1988) Hum Hered , vol.38 , Issue.6 , pp. 367-371
    • Padma, T.1    Valli, V.V.2
  • 79
    • 84949035652 scopus 로고    scopus 로고
    • The Effect of Statins on Blood Gene Expression in COPD
    • 26462087,..; ( ):.; PubMed Central PMCID: PMCPMC4604084.
    • Obeidat M, Fishbane N, Nie Y, Chen V, Hollander Z, Tebbutt SJ, et al. The Effect of Statins on Blood Gene Expression in COPD. PLoS One. 2015;10(10):e0140022. doi: 10.1371/journal.pone.014002226462087; PubMed Central PMCID: PMCPMC4604084.
    • (2015) PLoS One , vol.10 , Issue.10 , pp. e0140022
    • Obeidat, M.1    Fishbane, N.2    Nie, Y.3    Chen, V.4    Hollander, Z.5    Tebbutt, S.J.6
  • 80
    • 84938915394 scopus 로고    scopus 로고
    • Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease
    • 25514360,..; ( ): –.; PubMed Central PMCID: PMCPMC4566043.
    • Hansel NN, Pare PD, Rafaels N, Sin DD, Sandford A, Daley D, et al. Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2015;53(2):226–34. doi: 10.1165/rcmb.2014-0198OC25514360; PubMed Central PMCID: PMCPMC4566043.
    • (2015) Am J Respir Cell Mol Biol , vol.53 , Issue.2 , pp. 226-234
    • Hansel, N.N.1    Pare, P.D.2    Rafaels, N.3    Sin, D.D.4    Sandford, A.5    Daley, D.6
  • 81
    • 82755165236 scopus 로고    scopus 로고
    • The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility
    • 21659657,..; ( ): –.; PubMed Central PMCID: PMCPMC3262664.
    • Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, et al. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011;45(6):1147–53. doi: 10.1165/rcmb.2011-0055OC21659657; PubMed Central PMCID: PMCPMC3262664.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , Issue.6 , pp. 1147-1153
    • Castaldi, P.J.1    Cho, M.H.2    Litonjua, A.A.3    Bakke, P.4    Gulsvik, A.5    Lomas, D.A.6
  • 82
    • 84905912559 scopus 로고    scopus 로고
    • Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels
    • 25087611,..; ( ): –.; PubMed Central PMCID: PMC4129400.
    • Hause RJ, Stark AL, Antao NN, Gorsic LK, Chung SH, Brown CD, et al. Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels. Am J Hum Genet. 2014;95(2):194–208. doi: 10.1016/j.ajhg.2014.07.00525087611; PubMed Central PMCID: PMC4129400.
    • (2014) Am J Hum Genet , vol.95 , Issue.2 , pp. 194-208
    • Hause, R.J.1    Stark, A.L.2    Antao, N.N.3    Gorsic, L.K.4    Chung, S.H.5    Brown, C.D.6
  • 83
    • 84891780584 scopus 로고    scopus 로고
    • Proteomic studies related to genetic determinants of variability in protein concentrations
    • 24237071,.; ( ): –.
    • Horvatovich P, Franke L, Bischoff R, Proteomic studies related to genetic determinants of variability in protein concentrations. J Proteome Res. 2014;13(1):5–14. doi: 10.1021/pr400765y24237071.
    • (2014) J Proteome Res , vol.13 , Issue.1 , pp. 5-14
    • Horvatovich, P.1    Franke, L.2    Bischoff, R.3
  • 84
    • 84943328857 scopus 로고    scopus 로고
    • Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of Emphysema and the RAGE Axis in the Lung
    • 26132989,..; ( ): –.
    • Yonchuk JG, Silverman EK, Bowler RP, Agusti A, Lomas DA, Miller BE, et al. Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of Emphysema and the RAGE Axis in the Lung. Am J Respir Crit Care Med. 2015;192(7):785–92. doi: 10.1164/rccm.201501-0137PP26132989.
    • (2015) Am J Respir Crit Care Med , vol.192 , Issue.7 , pp. 785-792
    • Yonchuk, J.G.1    Silverman, E.K.2    Bowler, R.P.3    Agusti, A.4    Lomas, D.A.5    Miller, B.E.6
  • 85
    • 84884642095 scopus 로고    scopus 로고
    • Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels
    • 23990791,..; ( ):.; PubMed Central PMCID: PMCPMC3749935.
    • Thun GA, Imboden M, Ferrarotti I, Kumar A, Obeidat M, Zorzetto M, et al. Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet. 2013;9(8):e1003585. doi: 10.1371/journal.pgen.100358523990791; PubMed Central PMCID: PMCPMC3749935.
    • (2013) PLoS Genet , vol.9 , Issue.8 , pp. e1003585
    • Thun, G.A.1    Imboden, M.2    Ferrarotti, I.3    Kumar, A.4    Obeidat, M.5    Zorzetto, M.6
  • 86
    • 0018844653 scopus 로고
    • Serum concentrations of C3 and C4 of the complement system in patients with chronic obstructive pulmonary disease
    • 7354236,.; ( ): –.
    • Miller RD, Kueppers F, Offord KP, Serum concentrations of C3 and C4 of the complement system in patients with chronic obstructive pulmonary disease. J Lab Clin Med. 1980;95(2):266–71. 7354236.
    • (1980) J Lab Clin Med , vol.95 , Issue.2 , pp. 266-271
    • Miller, R.D.1    Kueppers, F.2    Offord, K.P.3
  • 87
    • 0025200488 scopus 로고
    • Alterations in immunoglobulin & complement levels in chronic obstructive pulmonary disease
    • 2228068,.;: –.
    • Chauhan S, Gupta MK, Goyal A, Dasgupta DJ, Alterations in immunoglobulin & complement levels in chronic obstructive pulmonary disease. Indian J Med Res. 1990;92:241–5. 2228068.
    • (1990) Indian J Med Res , vol.92 , pp. 241-245
    • Chauhan, S.1    Gupta, M.K.2    Goyal, A.3    Dasgupta, D.J.4
  • 88
    • 84934934654 scopus 로고    scopus 로고
    • Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients
    • 26081431,..;:.; PubMed Central PMCID: PMCPMC4473826.
    • Nishioka M, Venkatesan N, Dessalle K, Mogas A, Kyoh S, Lin TY, et al. Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. Respir Res. 2015;16:72. doi: 10.1186/s12931-015-0232-426081431; PubMed Central PMCID: PMCPMC4473826.
    • (2015) Respir Res , vol.16 , pp. 72
    • Nishioka, M.1    Venkatesan, N.2    Dessalle, K.3    Mogas, A.4    Kyoh, S.5    Lin, T.Y.6
  • 89
    • 84876282871 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
    • 23299965,.; ( ): –.
    • Milara J, Peiro T, Serrano A, Cortijo J, Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Thorax. 2013;68(5):410–20. doi: 10.1136/thoraxjnl-2012-20176123299965.
    • (2013) Thorax , vol.68 , Issue.5 , pp. 410-420
    • Milara, J.1    Peiro, T.2    Serrano, A.3    Cortijo, J.4
  • 90
    • 84875238998 scopus 로고    scopus 로고
    • Identification of genetic variants influencing the human plasma proteome
    • 23487758,.; ( ): –.; PubMed Central PMCID: PMC3606982.
    • Johansson A, Enroth S, Palmblad M, Deelder AM, Bergquist J, Gyllensten U, Identification of genetic variants influencing the human plasma proteome. Proc Natl Acad Sci U S A. 2013;110(12):4673–8. doi: 10.1073/pnas.121723811023487758; PubMed Central PMCID: PMC3606982.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.12 , pp. 4673-4678
    • Johansson, A.1    Enroth, S.2    Palmblad, M.3    Deelder, A.M.4    Bergquist, J.5    Gyllensten, U.6
  • 91
    • 84865083411 scopus 로고    scopus 로고
    • Identification of cis-regulatory variation influencing protein abundance levels in human plasma
    • 22595970,..; ( ): –.
    • Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, et al. Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet. 2012;21(16):3719–26. doi: 10.1093/hmg/dds18622595970.
    • (2012) Hum Mol Genet , vol.21 , Issue.16 , pp. 3719-3726
    • Lourdusamy, A.1    Newhouse, S.2    Lunnon, K.3    Proitsi, P.4    Powell, J.5    Hodges, A.6


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