A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk

Gut

Volumn 63, Issue 1, 2014, Pages 143-151

  He, Meian ^a,b   Wu, Chen ^c   Xu, Jianfeng ^b,d,e,f   Guo, Huan ^a   Yang, Handong ^g   Zhang, Xiaomin ^a,h   Sun, Jielin ⁱ   Yu, Dianke ^c   Zhou, Li ^a   Peng, Tao ^j,k   He, Yunfeng ^a   Gao, Yong ^b,f   Yuan, Jing ^a   Deng, Qifei ^a   Dai, Xiayun ^a   Tan, Aihua ^b   Feng, Yingying ^a   Zhang, Haiying ^b   Min, Xinwen ^g   Yang, Xiaobo ^b   Zhu, Jiang ^g   Zhai, Kan ^c   Chang, Jiang ^c   Qin, Xue ^j   Tan, Wen ^c   Hu, Yanling ^b   Lang, Mingjian ^g   Tao, Sha ^b   Li, Yuanfeng ^l   Li, Yi ^g   Feng, Junjie ⁱ   Li, Dongfeng ^g   Kim, Seong Tae ⁱ   Zhang, Shijun ^b   Zhang, Hongxing ^l   Zheng, S Lilly ⁱ   Gui, Lixuan ^a   Wang, Youjie ^a   Wei, Sheng ^a   Wang, Feng ^a   Fang, Weimin ^a   Liang, Yuan ^a   Zhai, Yun ^l   Chen, Weihong ^a   Miao, Xiaoping ^a   Zhou, Gangqiao ^l   Hu, Frank B ^h   Lin, Dongxin ^c   Mo, Zengnan ^b   Wu, Tangchun ^a   more..

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

^c CANCER HOSPITAL   (China)

^d FUDAN UNIVERSITY   (China)

^e VAN ANDEL RESEARCH INSTITUTE   (United States)

^f FUDAN UNIVERSITY   (China)

^g HUBEI UNIVERSITY OF MEDICINE   (China)

^h HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ WAKE FOREST SCHOOL OF MEDICINE   (United States)

^j FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^k NATIONAL CANCER INSTITUTE   (United States)

^l BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN;

ADOLESCENT; ADULT; AGED; ALPHA FETOPROTEIN GENE; ARTICLE; B3GNT3 GENE; CA11 GENE; CANCER RISK; CHINESE; CHROMOSOME 19P; CHROMOSOME 19Q; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FAM3B GENE; FUT2 GENE; FUT3 GENE; FUT6 GENE; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; HISPPD2A GENE; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PANCREAS CANCER; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY; YOUNG ADULT;

CANCER GENETICS; CANCER SUSCEPTIBILITY;

ADULT; AGED; ALPHA-FETOPROTEINS; ASIAN CONTINENTAL ANCESTRY GROUP; CA-19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CARCINOMA; CARCINOMA, HEPATOCELLULAR; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CHINA; ESOPHAGEAL NEOPLASMS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINEAR MODELS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84889665156     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303434     Document Type: Article

References (51)

1. Um SH, Mulhall C, Alisa A, et al. Alpha-fetoprotein impairs APC function and induces their apoptosis. J Immunol 2004;173:1772-8. (Pubitemid 38971609)
2. Li M, Liu X, Zhou S, et al. Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes. BMC Cancer 2005;5:96.
3. Yeatman TJ. Predictive biomarkers: identification and verification. J Clin Oncol 2009;27:2743-4.
4. Berger AC, Garcia M Jr, Hoffman JP, et al. Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704. J Clin Oncol 2008;26:5918-22.
5. Yakabe T, Nakafusa Y, Sumi K, et al. Clinical significance of CEA and CA19-9 in postoperative follow-up of colorectal cancer. Ann Surg Oncol 2010;17:2349-56.
6. Polanski M, Anderson NL. A list of candidate cancer biomarkers for targeted proteomics. Biomark Insights 2007;1:1-48.
7. Zhang G, Xu Y, Lu X, et al. Diagnosis value of serum B7-H3 expression in non-small cell lung cancer. Lung Cancer 2009;66:245-9.
8. Evdokimova VN, Liu Y, Potter DM, et al. AFP-specific CD4+helper T-cell responses in healthy donors and HCC patients. J Immunother 2007;30:425-37. (Pubitemid 46684432)
9. Hatate K, Yamashita K, Hirai K, et al. Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9. Oncol Rep 2008;20:737-43.
10. Wang F, Zhu J, Yao P, et al. Cohort profile: the Dongfeng-Tongji cohort study of retired workers. Int J Epidemiol Published Online First: 24 Apr 2012. doi: 10.1093/ije/dys053
11. Tan A, Gao Y, Yang X, et al. Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metabolism 2011;60:1186-92.
12. Wu C, Hu Z, He Z, et al. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet 2011;43:679-84.
13. Wu C, Miao X, Huang L, et al. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet 2011;44:62-6.
14. Zhang H, Zhai Y, Hu Z, et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 2010;42:755-8.
15. Price AL, Patterson NJ, Plenge RM, et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904-9. (Pubitemid 44141658)
16. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-75. (Pubitemid 47330214)
17. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5. (Pubitemid 40202029)
18. Marchini J, Howie B, Myers S, et al. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 2007;39:906-13. (Pubitemid 47014502)
19. Aulchenko YS, Struchalin MV, van Duijn CM. ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinformatics 2010;11:134.
20. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 2010;26:2190-1.
21. Cochran WG. The combination of estimates from different experiments. Biometrics 1954;10:101-29.
22. Johnson AD, Handsaker RE, Pulit SL, et al. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008;24:2938-9.
23. Tanikawa C, Urabe Y, Matsuo K, et al. A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet 2012;44:430-4, S1-2.
24. Pleskow DK, Berger HJ, Gyves J, et al. Evaluation of a serologic marker, CA19-9, in the diagnosis of pancreatic cancer. Ann Intern Med 1989;110:704-9. (Pubitemid 19121224)
25. Magnani JL, Nilsson B, Brockhaus M, et al. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem 1982;257:14365-69. (Pubitemid 13141316)
26. Narimatsu H, Iwasaki H, Nakayama F, et al. Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 1998;58:512-18. (Pubitemid 28087416)
27. Kawai S, Suzuki K, Nishio K, et al. Smoking and serum CA19-9 levels according to Lewis and secretor genotypes. Int J Cancer 2008;123:2880-4.
28. Shiraishi N, Natsume A, Togayachi A, et al. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. J Biol Chem 2001;276:3498-507.
29. Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 1965;121:439-62.
30. Mach JP, Vienny H, Jaeger P, et al. Long-term follow-up of colorectal carcinoma patients by repeated CEA radioimmunoassay. Cancer 1978;42:1439-47. (Pubitemid 9038272)
31. Yeh CY, Hsieh PS, Chiang JM, et al. Preoperative carcinoembryonic antigen (CEA) elevation in colorectal cancer. Hepatogastroenterology 2011;58:1171-6.
32. Holburn AM, Mach JP, MacDonald D, et al. Studies of the association of the A, B and Lewis blood group antigens with carcinoembryonic antigen (CEA). Immunology 1974;26:831-43.
33. Yamashita K, Totani K, Kuroki M, et al. Structural studies of the carbohydrate moieties of carcinoembryonic antigens. Cancer Res 1987;47:3451-9. (Pubitemid 17096001)
34. Kudo T, Iwasaki H, Nishihara S, et al. Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. J Biol Chem 1996;271:9830-7.
35. Martin-Satue M, Marrugat R, Cancelas JA, et al. Enhanced expression of alpha (1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells. Cancer Res 1998;58:1544-50. (Pubitemid 28193622)
36. Zhu Y, Xu G, Patel A, et al. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 2002;80:144-50. (Pubitemid 36197956)
37. Ball D, Rose E, Alpert E. Alpha-fetoprotein levels in normal adults. Am J Med Sci 1992;303:157-9.
38. Farinati F, Marino D, De Giorgio M, et al. Diagnostic and prognostic role of alpha-fetoprotein in hepatocellular carcinoma: both or neither? Am J Gastroenterol 2006;101:524-32. (Pubitemid 43340928)
39. Johnson PJ. The role of serum alpha-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma. Clin Liver Dis 2001;5:145-59. (Pubitemid 32118643)
40. Wolpin BM, Kraft P, Gross M, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res 2010;70:1015-23.
41. Wolpin BM, Chan AT, Hartge P, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst 2009;101:424-31
42. Ben Q, Wang K, Yuan Y, et al. Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: a case-control study. Int J Cancer 2011;128:1179-86.
43. Nakao M, Matsuo K, Ito H, et al. ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. Cancer Epidemiol Biomarkers Prev 2011;20:1665-72.
44. Mourant AE, Kopen AC, Domaniewska-Sobczak K. Blood group and disease. Oxford: Oxford University Press, 1978.
45. Gong Y, Yang YS, Zhang XM, et al. ABO blood type, diabetes and risk of gastrointestinal cancer in northern China. World J Gastroenterol 2012;18: 563-9.
46. Pare G, Chasman DI, Kellogg M, et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6578 women. PLoS Genet 2008;4:e1000118.
47. Hakomori S. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta 1999;1473:247-66.
48. Kelly RJ, Rouquier S, Giorgi D, et al. Sequence and expression of a candidate for the human secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J Biol Chem 1995;270:4640-9.
49. Ferrer-Admetlla A, Sikora M, Laayouni H, et al. A natural history of FUT2 polymorphism in humans. Mol Biol Evol 2009;26:1993-2003.
50. Ikehara Y, Nishihara S, Yasutomi H, et al. Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody. Cancer Epidemiol Biomarkers Prev 2001;10:971-7. (Pubitemid 32844906)
51. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology 2007;133:659-72. (Pubitemid 47187360)