-
1
-
-
2942720573
-
The nature of small-airway obstruction in chronic obstructive pulmonary disease
-
DOI 10.1056/NEJMoa032158
-
Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-53. (Pubitemid 38787999)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.26
, pp. 2645-2653
-
-
Hogg, J.C.1
Chu, F.2
Utokaparch, S.3
Woods, R.4
Elliott, W.M.5
Buzatu, L.6
Cherniack, R.M.7
Rogers, R.M.8
Sciurba, F.C.9
Coxson, H.O.10
Pare, P.D.11
-
2
-
-
57349134586
-
MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
-
Kirkham S, Kolsum U, Rousseau K, et al. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;178:1033-9.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1033-1039
-
-
Kirkham, S.1
Kolsum, U.2
Rousseau, K.3
-
3
-
-
24944464002
-
Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease
-
Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2004;1:176-83.
-
(2004)
Proc Am Thorac Soc
, vol.1
, pp. 176-183
-
-
Jeffery, P.K.1
-
4
-
-
35448988114
-
Molecular targets in pulmonary fibrosis: The myofibroblast in focus
-
DOI 10.1378/chest.06-2568
-
Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 2007;132:1311-21. (Pubitemid 47621009)
-
(2007)
Chest
, vol.132
, Issue.4
, pp. 1311-1321
-
-
Scotton, C.J.1
Chambers, R.C.2
-
5
-
-
36849021771
-
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
-
DOI 10.1172/JCI30487
-
Higgins DF, Kimura K, Bernhardt WM, et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007;117:3810-20. (Pubitemid 350224091)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3810-3820
-
-
Higgins, D.F.1
Kimura, K.2
Bernhardt, W.M.3
Shrimanker, N.4
Akai, Y.5
Hohenstein, B.6
Saito, Y.7
Johnson, R.S.8
Kretzler, M.9
Cohen, C.D.10
Eckardt, K.-U.11
Iwano, M.12
Haase, V.H.13
-
6
-
-
20544437490
-
Role of reactive oxygen species in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
-
DOI 10.1681/ASN.2004050425
-
Rhyu DY, Yang Y, Ha H, et al. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005;16:667-75. (Pubitemid 41725103)
-
(2005)
Journal of the American Society of Nephrology
, vol.16
, Issue.3
, pp. 667-675
-
-
Rhyu, D.Y.1
Yang, Y.2
Ha, H.3
Lee, G.T.4
Song, J.S.5
Uh, S.-T.6
Lee, H.B.7
-
8
-
-
67650752133
-
Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
-
Hackett TL, Warner SM, Stefanowicz D, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009;180:122-33.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 122-133
-
-
Hackett, T.L.1
Warner, S.M.2
Stefanowicz, D.3
-
9
-
-
33748375828
-
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
-
DOI 10.1073/pnas.0605669103
-
Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 2006;103:13180-5. (Pubitemid 44338936)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.35
, pp. 13180-13185
-
-
Kim, K.K.1
Kugler, M.C.2
Wolters, P.J.3
Robillard, L.4
Galvez, M.G.5
Brumwell, A.M.6
Sheppard, D.7
Chapman, H.A.8
-
10
-
-
33845358419
-
2 is a potent inhibitor of epithelial-to- mesenchymal transition: Interaction with hepatocyte growth factor
-
DOI 10.1152/ajprenal.00480.2005
-
Zhang A, Wang MH, Dong Z, et al. Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor. Am J Physiol Renal Physiol 2006;291:F1323-31. (Pubitemid 44887246)
-
(2006)
American Journal of Physiology - Renal Physiology
, vol.291
, Issue.6
-
-
Zhang, A.1
Wang, M.-H.2
Dong, Z.3
Yang, T.4
-
11
-
-
78049512358
-
Effects of cigarette smoke extract on A549 cells and human lung fibroblasts treated with transforming growth factor-beta1 in a coculture system
-
Liu Y, Gao W, Zhang D. Effects of cigarette smoke extract on A549 cells and human lung fibroblasts treated with transforming growth factor-beta1 in a coculture system. Clin Exp Med 2010;10:159-67.
-
(2010)
Clin Exp Med
, vol.10
, pp. 159-167
-
-
Liu, Y.1
Gao, W.2
Zhang, D.3
-
12
-
-
79151474709
-
Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B
-
Veljkovic E, Jiricny J, Menigatti M, et al. Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicol In Vitro 2011;25:446-53.
-
(2011)
Toxicol in Vitro
, vol.25
, pp. 446-453
-
-
Veljkovic, E.1
Jiricny, J.2
Menigatti, M.3
-
13
-
-
80053485168
-
Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
-
Sohal SS, Reid D, Soltani A, et al. Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease. Respir Res 2011;12:130.
-
(2011)
Respir Res
, vol.12
, pp. 130
-
-
Sohal, S.S.1
Reid, D.2
Soltani, A.3
-
14
-
-
84856066049
-
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
-
Milara J, Navarro R, Juan G, et al. Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. Thorax 2012;67:147-56.
-
(2012)
Thorax
, vol.67
, pp. 147-156
-
-
Milara, J.1
Navarro, R.2
Juan, G.3
-
15
-
-
84864422831
-
Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro
-
Milara J, Armengot M, Banuls P, et al. Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro. Br J Pharmacol 2012;166:2243-62.
-
(2012)
Br J Pharmacol
, vol.166
, pp. 2243-2262
-
-
Milara, J.1
Armengot, M.2
Banuls, P.3
-
16
-
-
79953646222
-
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
-
Cortijo J, Mata M, Milara J, et al. Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways. Eur Respir J 2011;37:244-54.
-
(2011)
Eur Respir J
, vol.37
, pp. 244-254
-
-
Cortijo, J.1
Mata, M.2
Milara, J.3
-
17
-
-
84857444788
-
Aclidinium inhibits human lung fibroblast to myofibroblast transition
-
Milara J, Serrano A, Peiro T, et al. Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax 2012;67:229-37.
-
(2012)
Thorax
, vol.67
, pp. 229-237
-
-
Milara, J.1
Serrano, A.2
Peiro, T.3
-
18
-
-
26944463075
-
Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients
-
DOI 10.1136/thx.2005.043026
-
Ward C, Forrest IA, Murphy DM, et al. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 2005;60:865-71. (Pubitemid 41475217)
-
(2005)
Thorax
, vol.60
, Issue.10
, pp. 865-871
-
-
Ward, C.1
Forrest, I.A.2
Murphy, D.M.3
Johnson, G.E.4
Robertson, H.5
Cawston, T.E.6
Fisher, A.J.7
Dark, J.H.8
Lordan, J.L.9
Kirby, J.A.10
Corris, P.A.11
-
19
-
-
77954919917
-
Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease
-
Sohal SS, Reid D, Soltani A, et al. Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology 2010;15:930-8.
-
(2010)
Respirology
, vol.15
, pp. 930-938
-
-
Sohal, S.S.1
Reid, D.2
Soltani, A.3
-
20
-
-
0033865917
-
Progressive renal fibrosis in routine polycystic kidney disease: An immunohistochemical observation
-
DOI 10.1046/j.1523-1755.2000.00205.x
-
Okada H, Ban S, Nagao S, et al. Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int 2000;58:587-97. (Pubitemid 30620008)
-
(2000)
Kidney International
, vol.58
, Issue.2
, pp. 587-597
-
-
Okada, H.1
Ban, S.2
Nagao, S.3
Takahashi, H.4
Suzuki, H.5
Neilson, E.G.6
-
21
-
-
0029091682
-
Identification and characterization of a fibroblast marker: FSP1
-
Strutz F, Okada H, Lo CW, et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 1995;130:393-405.
-
(1995)
J Cell Biol
, vol.130
, pp. 393-405
-
-
Strutz, F.1
Okada, H.2
Lo, C.W.3
-
22
-
-
79952430815
-
The role of small airways in obstructive airway diseases
-
Burgel PR. The role of small airways in obstructive airway diseases. Eur Respir Rev 2011;20:23-33.
-
(2011)
Eur Respir Rev
, vol.20
, pp. 23-33
-
-
Burgel, P.R.1
-
23
-
-
0036322007
-
Evidence that fibroblasts derive from epithelium during tissue fibrosis
-
DOI 10.1172/JCI200215518
-
Iwano M, Plieth D, Danoff TM, et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002;110:341-50. (Pubitemid 34847966)
-
(2002)
Journal of Clinical Investigation
, vol.110
, Issue.3
, pp. 341-350
-
-
Iwano, M.1
Plieth, D.2
Danoff, T.M.3
Xue, C.4
Okada, H.5
Neilson, E.G.6
-
24
-
-
17844384822
-
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis
-
Willis BC, Liebler JM, Luby-Phelps K, et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005;166:1321-32. (Pubitemid 40586504)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.5
, pp. 1321-1332
-
-
Willis, B.C.1
Liebler, J.M.2
Luby-Phelps, K.3
Nicholson, A.G.4
Crandall, E.D.5
Du Bois, R.M.6
Borok, Z.7
-
25
-
-
34347364932
-
Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse
-
Wu Z, Yang L, Cai L, et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res 2007;8:1.
-
(2007)
Respir Res
, vol.8
, pp. 1
-
-
Wu, Z.1
Yang, L.2
Cai, L.3
-
26
-
-
78649469133
-
Variability in the precursor proteins of collagen I and III in different stages of COPD
-
Harju T, Kinnula VL, Paakko P, et al. Variability in the precursor proteins of collagen I and III in different stages of COPD. Respir Res 2010;11:165.
-
(2010)
Respir Res
, vol.11
, pp. 165
-
-
Harju, T.1
Kinnula, V.L.2
Paakko, P.3
-
27
-
-
76149108446
-
Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium
-
Olivera D, Knall C, Boggs S, et al. Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium. Exp Toxicol Pathol 2010;62:133-43.
-
(2010)
Exp Toxicol Pathol
, vol.62
, pp. 133-143
-
-
Olivera, D.1
Knall, C.2
Boggs, S.3
-
28
-
-
0036901407
-
Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-β-catenin complexes from the cytoskeleton by oxidative stress
-
DOI 10.1042/BJ20011804
-
Rao RK, Basuroy S, Rao VU, et al. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J 2002;368:471-81. (Pubitemid 35454525)
-
(2002)
Biochemical Journal
, vol.368
, Issue.2
, pp. 471-481
-
-
Rao, R.K.1
Basuroy, S.2
Rao, V.U.3
Karnaky Jr., K.J.4
Gupta, A.5
-
29
-
-
73949126042
-
Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: The role of phosphodiesterase 4
-
Kolosionek E, Savai R, Ghofrani HA, et al. Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Mol Biol Cell 2009;20:4751-65.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 4751-4765
-
-
Kolosionek, E.1
Savai, R.2
Ghofrani, H.A.3
-
30
-
-
0030811545
-
Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients
-
Finlay GA, Russell KJ, McMahon KJ, et al. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 1997;52:502-6. (Pubitemid 27298499)
-
(1997)
Thorax
, vol.52
, Issue.6
, pp. 502-506
-
-
Finlay, G.A.1
Russell, K.J.2
McMahon, K.J.3
D'arcy, E.M.4
Masterson, J.B.5
FitzGerald, M.X.6
O'Connor, C.M.7
-
31
-
-
80052403945
-
The EMT regulator slug and lung carcinogenesis
-
Shih JY, Yang PC. The EMT regulator slug and lung carcinogenesis. Carcinogenesis 2011;32:1299-304.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1299-1304
-
-
Shih, J.Y.1
Yang, P.C.2
-
32
-
-
0036212004
-
Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD
-
DOI 10.1183/09031936.02.00245902
-
Santos S, Peinado VI, Ramirez J, et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 2002;19:632-8. (Pubitemid 34285159)
-
(2002)
European Respiratory Journal
, vol.19
, Issue.4
, pp. 632-638
-
-
Santos, S.1
Peinado, V.I.2
Ramirez, J.3
Melgosa, T.4
Roca, J.5
Rodriguez-Roisin, R.6
Barbera, J.A.7
-
33
-
-
0037633017
-
Small airway morphology and lung function in the transition from normality to chronic airway obstruction
-
Corsico A, Milanese M, Baraldo S, et al. Small airway morphology and lung function in the transition from normality to chronic airway obstruction. J Appl Physiol 2003;95:441-7. (Pubitemid 36753831)
-
(2003)
Journal of Applied Physiology
, vol.95
, Issue.1
, pp. 441-447
-
-
Corsico, A.1
Milanese, M.2
Baraldo, S.3
Casoni, G.L.4
Papi, A.5
Riccio, A.M.6
Cerveri, I.7
Saetta, M.8
Brusasco, V.9
-
34
-
-
61549116234
-
Expression of profibrotic mediators in small airways versus parenchyma after cigarette smoke exposure
-
Churg A, Zhou S, Preobrazhenska O, et al. Expression of profibrotic mediators in small airways versus parenchyma after cigarette smoke exposure. Am J Respir Cell Mol Biol 2009;40:268-76.
-
(2009)
Am J Respir Cell Mol Biol
, vol.40
, pp. 268-276
-
-
Churg, A.1
Zhou, S.2
Preobrazhenska, O.3
-
35
-
-
58149390632
-
Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines
-
Dasgupta P, Rizwani W, Pillai S, et al. Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer 2009;124:36-45.
-
(2009)
Int J Cancer
, vol.124
, pp. 36-45
-
-
Dasgupta, P.1
Rizwani, W.2
Pillai, S.3
-
36
-
-
34547221175
-
Induction of epithelial-mesenchymal transition-related genes by benzo[a]pyrene in lung cancer cells
-
DOI 10.1002/cncr.22728
-
Yoshino I, Kometani T, Shoji F, et al. Induction of epithelial- mesenchymal transition-related genes by benzo[a]pyrene in lung cancer cells. Cancer 2007;110:369-74. (Pubitemid 47121898)
-
(2007)
Cancer
, vol.110
, Issue.2
, pp. 369-374
-
-
Yoshino, I.1
Kometani, T.2
Shoji, F.3
Osoegawa, A.4
Ohba, T.5
Kouso, H.6
Takenaka, T.7
Yohena, T.8
Maehara, Y.9
-
38
-
-
25444480482
-
Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells
-
Hellermann GR, Nagy SB, Kong X, et al. Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells. Respir Res 2002;3:22.
-
(2002)
Respir Res
, vol.3
, pp. 22
-
-
Hellermann, G.R.1
Nagy, S.B.2
Kong, X.3
-
39
-
-
69949114515
-
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
-
Hecker L, Vittal R, Jones T, et al. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med 2009;15:1077-81.
-
(2009)
Nat Med
, vol.15
, pp. 1077-1081
-
-
Hecker, L.1
Vittal, R.2
Jones, T.3
|