Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from southern China

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Liang, Yu ^a   Tang, Weizhong ^a   Huang, Tiqiang ^a   Gao, Yong ^a   Tan, Aihua ^a   Yang, Xiaobo ^a   Zhang, Haiying ^a   Hu, Yanling ^a   Qin, Xue ^a   Li, Shan ^a   Zhang, Shijun ^a   Mo, Linjian ^a   Liang, Zhenjia ^b   Shi, Deyi ^b   Huang, Zhang ^c   Guan, Yingyong ^d   Zhou, Jicheng ^a   Winkler, Cheryl ^e   O'Brien, Stephen J ^e,f,g   Xu, Jianfeng ^a,h   Mo, Zengnan ^a   Peng, Tao ^a,e   more..

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b Fangchenggang First People's Hospital   (China)

^c Medical Examination Center Guigang First People's Hospital   (China)

^d Yulin First People's Hospital   (China)

^e NATIONAL CANCER INSTITUTE   (United States)

^f ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^g NOVA SOUTHEASTERN UNIVERSITY   (United States)

^h WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ABO GENE; ADULT; AGE; ARTICLE; BLOOD GROUP ABO SYSTEM; CANCER ADJUVANT THERAPY; CANCER PROGNOSIS; CANCER STAGING; CHINA; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; FUT2 GENE; GENE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TUMOR INVASION; TUMOR RECURRENCE; ADENOCARCINOMA; BLOOD; COLORECTAL TUMOR; GENETIC PREDISPOSITION; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PATHOLOGY; RISK FACTOR; SECONDARY;

ADENOCARCINOMA; CARCINOEMBRYONIC ANTIGEN; CHINA; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84903287464     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097923     Document Type: Article

References (69)

1. Kamangar F, Dores GM, Anderson WF (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24: 2137-2150. (Pubitemid 46655601)
2. Yang L, Parkin DM, Li LD, Chen YD, Bray F (2004) Estimation and projection of the national profile of cancer mortality in China: 1991-2005.British journal of cancer 90: 2157-2166. (Pubitemid 38869723)
3. Staib L, Link KH, Blatz A, Beger HG (2002) Surgery of colorectal cancer: surgical morbidity and five- and ten-year results in 2400 patients- monoinstitutional experience. World J Surg 26: 59-66. (Pubitemid 36918819)
4. Bentzen SM, Balslev I, Pedersen M, Teglbjaerg PS, Hanberg-Sorensen F, et al. (1990) Blood transfusion and prognosis in Dukes' B and C colorectal cancer. Eur J Cancer 26: 457-463. (Pubitemid 20209975)
5. Zeng Z, Cohen AM, Urmacher C (1993) Usefulness of carcinoembryonic antigen monitoring despite normal preoperative values in node-positive colon cancer patients. Dis Colon Rectum 36: 1063-1068. (Pubitemid 23335256)
6. Herbeth B, Bagrel A (1980) A study of factors influencing plasma CEA levels in an unselected population. Oncodev Biol Med 1: 191-198. (Pubitemid 11181524)
7. Beaudonnet A, Gounon G, Pichot J, Revenant MC (1981) Sex- and age-related influences on carcinoembryonic antigen in blood. Clin Chem 27: 771.
8. Haines AP, Levin AG, Fritsche HA (1979) Ethnic-group differences in serum levels of carcinoembryonic antigen. Lancet 2: 969.
9. Søreide K, Søreide JA, Kørner H (2011) Prognostic role of carcinoembryonic antigen is influenced by microsatellite instability genotype and stage in locally advanced colorectal cancers. World journal of surgery 35: 888-894.
10. Qin X, Lin L, Mo Z, Lv H, Gao Y, et al. (2011) Reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen in Chinese Han ethnic males from the Fangchenggang Area Male Health and Examination Survey. Int J Biol Markers 26: 65-71.
11. He M, Wu C, Xu J, Guo H, Yang H, et al. (2014). A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Gut 63: 143-151.
12. Alexander JC, Silverman NA, Chretien PB (1976) Effect of age and cigarette smoking on carcinoembryonic antigen levels. JAMA 235: 1975-1979.
13. Olsen GW, Mandel JS, Gibson RW, Wattenberg LW, Schuman LM (1989) A case-control study of pancreatic cancer and cigarettes, alcohol, coffee and diet. Am J Public Health 79: 1016-1019. (Pubitemid 19207435)
14. Garrote LF, Herrero R, Reyes RM, Vaccarella S, Anta JL, et al. (2001) Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer 85: 46-54. (Pubitemid 32695715)
15. Salgia R, Harpole D, Herndon JE 2nd, Pisick E, Elias A, et al. (2001) Role of serum tumor markers CA 125 and CEA in non-small cell lung cancer. Anticancer Res 21: 1241-1246. (Pubitemid 32494128)
16. Ni XG, Bai XF, Mao YL, Shao YF, Wu JX, et al. (2005) The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer. Eur J Surg Oncol 31: 164-169. (Pubitemid 40214752)
17. Kurokawa H, Yamashita Y, Tokudome S, Kajiyama M (1997) Combination assay for tumor markers in oral squamous cell carcinoma. J Oral Maxillofac Surg 55: 964-966. (Pubitemid 27386263)
18. Touitou Y, Proust J, Klinger E, Nakache JP, Huard D, et al. (1984) Cumulative effects of age and pathology on plasma carcinoembryonic antigen in an unselected elderly population. Eur J Cancer Clin Oncol 20: 369-374. (Pubitemid 14157814)
19. Herbeth B, Bagrel A (1980) A study of factors influencing plasma CEA levels in an unselected population. Oncodev Biol Med 1: 191-198. (Pubitemid 11181524)
20. Fletcher RH (1986) Carcinoembryonic antigen. Annals of internal medicine104: 66-73.
21. Park JS, Choi GS, Jang YS, Jun SH, Kang H (2010) Influence of obesity on the serum carcinoembryonic antigen value in patients with colorectal cancer. Cancer Epidemiol Biomarkers Prev 19: 2461-2468.
22. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4: 579-591. (Pubitemid 39025053)
23. Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, et al. (2007) Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro. Am J Physiol Gastrointest Liver Physiol 292: G923-929.
24. Beasley RP, Hwang LY, Lin CC, Chien CS (1981) Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 2: 1129-1133.
25. Hong SG, Kim JH, Lee YS, Yoon E, Lee HJ, et al. (2010) The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study. The Korean journal of hepatology 16: 49-56.
26. Loewenstein MS, Zamcheck N (1978) Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states. Cancer 42: 1412-1418. (Pubitemid 9038266)
27. Maestranzi S, Przemioslo R, Mitchell H, Sherwood RA (1998) The effect of benign and malignant liver disease on the tumour markers CA19-9 and CEA. Ann Clin Biochem 35 (Pt 1): 99-103. (Pubitemid 28043632)
28. Booth SN, King JP, Leonard JC, Dykes PW (1973) Serum carcinoembryonic antigen in clinical disorders. Gut 14: 794-799.
29. Haines AP, Levin AG, Fritsche HA (1979) Ethnic-group differences in serum levels of carcinoembryonic antigen. Lancet 2: 969.
30. Kudo T, Iwasaki H, Nishihara S, Shinya N, Ando T, et al. (1996) Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. J Biol Chem 271: 9830-9837.
31. Magous R, Lecou C, Bali JP (1980) Evidences for the association of blood group determinants with the carcinoembryonic antigen molecule. Mol Immunol 17: 1039-1043. (Pubitemid 10087385)
32. Holburn AM, Mach JP, MacDonald D, Newlands M (1974) Studies of the association of the A, B and Lewis Blood group antigens with carcinoembryonic antigen (CEA). Immunology 26: 831-843.
33. Pare G, Chasman DI, Kellogg M, Zee RY, Rifai N, et al. (2008) Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet 4: e1000118.
34. Risch HA (2012) Pancreatic cancer: Helicobacter pylori colonization, N-nitrosamine exposures, and ABO blood group. Mol Carcinog 51: 109-118.
35. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, et al. (2010) Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol 172: 1280-1285.
36. Prado IB, Laudanna AA, Carneiro CR (1995) Susceptibility of colorectal-carcinoma cells to natural-killer-mediated lysis: relationship to CEA expression and degree of differentiation. Int J Cancer 61: 854-860.
37. Huang F, Wang XL, Yang L, Yin BX, Geng Y, et al. (2008) [Clinical value of combined determination of serum and pleural effusion level of CEA,CYFRA21-1, TPS in the diagnosis of lung cancer]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 370-372.
38. Lin X, Lu D, Gao Y, Tao S, Yang X, et al. (2012) Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. Hum Mol Genet 21: 2610-2617.
39. Vrieling A, Kampman E (2010) The role of body mass index, physical activity, and diet in colorectal cancer recurrence and survival: a review of the literature. Am J Clin Nutr 92: 471-490.
40. Sakuma K, Aoki M, Kannagi R (2012) Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A 109: 7776-7781.
41. Salvini R, Bardoni A, Valli M, Trinchera M (2001) beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1->3Galbeta 1->4GlcNAcbeta 1->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas. J Biol Chem 276: 3564-3573.
42. Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, et al. (2003) Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 302: 2141-2144. (Pubitemid 38017950)
43. Kim YJ, Park SC, Kim DY, Moon SH, Chang HJ, et al. (2012) No correlation between pretreatment serum CEA levels and tumor volume in locally advanced rectal cancer patients. Clinica Chimica Acta 413: 511-515.
44. Coelho MS, Assis MA, Moura EC (2009) [Body mass index increase after the age of 20 and associations with risk or protection factors for chronic non-communicable diseases]. Arq Bras Endocrinol Metabol 53: 1146-1156.
45. Fietkau R, Zettl H, Klocking S, Kundt G (2004) Incidence, therapy and prognosis of colorectal cancer in different age groups. A population-based cohort study of the Rostock Cancer Registry. Strahlenther Onkol 180: 478-487. (Pubitemid 39062338)
46. Demetriades H, Kanellos I, Vasiliadis K, Angelopoulos S, Vergos O, et al. (2004) Age-associated prognosis following curative resection for colorectal cancer. Tech Coloproctol 8 Suppl 1: s144-146. (Pubitemid 40394540)
47. Chao A, Thun MJ, Jacobs EJ, Henley SJ, Rodriguez C, et al. (2000) Cigarette smoking and colorectal cancer mortality in the cancer prevention study II. J Natl Cancer Inst 92: 1888-1896. (Pubitemid 32036919)
48. Hoffmann D, Hoffmann I (1997) The changing cigarette, 1950-1995. J Toxicol Environ Health 50: 307-364.
49. Pfohl-Leszkowicz A, Grosse Y, Carriere V, Cugnenc PH, Berger A, et al. (1995) High levels of DNA adducts in human colon are associated with colorectal cancer. Cancer Res 55: 5611-5616.
50. Gutierrez DA, Puglisi MJ, Hasty AH (2009) Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Curr Diab Rep 9: 26-32.
51. Wichmann MW, Muller C, Hornung HM, Lau-Werner U, Schildberg FW, et al. (2001) Gender differences in long-term survival of patients with colorectal cancer. Br J Surg 88: 1092-1098. (Pubitemid 32868664)
52. Ilantzis C, Jothy S, Alpert LC, Draber P, Stanners CP (1997) Cell-surface levels of human carcinoembryonic antigen are inversely correlated with colonocyte differentiation in colon carcinogenesis. Lab Invest 76: 703-716. (Pubitemid 27225100)
53. Kim J, Kaye FJ, Henslee JG, Shively JE, Park JG, et al. (1992) Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers. Int J Cancer 52: 718-725.
54. Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002) Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia 4: 151-163. (Pubitemid 34218683)
55. Gobbi PG, Valentino F, Berardi E, Tronconi C, Brugnatelli S, et al. (2007) New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer. British journal of cancer 98: 328-334.
56. Lee SY, Min KS, Chung JK, Jung IM, Ahn YJ, et al. (2011). Carcinoembryonic antigen level of draining venous blood as a predictor of recurrence in colorectal cancer patient. Journal of the Korean Surgical Society 81: 387-393.
57. Yang XQ, Chen C, Wang FB, Peng CW, Li Y (2011) Preoperative serum carcinoembryonic antigen, carbohydrate antigen19-9 and carbohydrate antigen 125 as prognostic factors for recurrence-free survival in colorectal cancer. Asian Pacific J Cancer Prev 12: 1251-1256.
58. Zimmer R, Thomas P (2001) Mutations in the carcinoembryonic antigen gene in colorectal cancer patients: implications on liver metastasis. Cancer Res 61: 2822-2826. (Pubitemid 32691918)
59. Plotnikov AN, Schlessinger J, Hubbard SR, Mohammadi M (1999) Structural basis for FGF receptor dimerization and activation. Cell 98: 641-650. (Pubitemid 29418955)
60. Zimmer R, Thomas P (2001) Mutations in the carcinoembryonic antigen gene in colorectal cancer patients: implications on liver metastasis. Cancer Res 61: 2822-2826. (Pubitemid 32691918)
61. Gangopadhyay A, Bajenova O, Kelly TM, Thomas P (1996) Carcinoembryonic antigen induces cytokine expression in Kupffer cells: implications for hepatic metastasis from colorectal cancer. Cancer research 56: 4805-4810. (Pubitemid 26338088)
62. Dai J, Gu J, Huang M, Eng C, Kopetz ES, et al. (2012) GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes. Carcinogenesis 33: 1327-1331.
63. Kim CJ, Choi BJ, Song JH, Park YK, Cho YG, et al. (2007) Overexpression of serine-threonine receptor kinase-associated protein in colorectal cancers. Pathology international 57: 178-182. (Pubitemid 46279945)
64. Li Y, Cao H, Jiao Z, Pakala SB, Sirigiri DNR, et al. (2010) Carcinoembryonic antigen interacts with TGF-β receptor and inhibits TGF-β signaling in colorectal cancers. Cancer research 70: 8159-8168.
65. Saltz LB, Niedzwiecki D, Hollis D, Goldberg RM, Hantel A, et al. (2007) Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. Journal of Clinical Oncology 25: 3456-3461. (Pubitemid 47310883)
66. Kuebler JP, Wieand HS, O'Connell MJ, Smith RE, Colangelo LH, et al. (2007) Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. Journal of clinical oncology 25: 2198-2204. (Pubitemid 46954643)
67. Quasar Collaborative G, Gray R, Barnwell J, McConkey C, Hills RK, et al. (2007) Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 370: 2020-2029.
68. Sargent DJ, Wieand HS, Haller DG, Gray R, Benedetti JK, et al. (2005) Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials. Journal of Clinical Oncology 23: 8664-8670. (Pubitemid 46211509)
69. Biagi JJ, Raphael MJ, Mackillop WJ, Kong W, King WD, et al. (2011) Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer: a systematic review and meta-analysis. Jama 305: 2335-2342.