Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway

Cell Death and Differentiation

Volumn 23, Issue 12, 2016, Pages 1995-2006

  Cunha, Daniel A ^a   Cito, Monia ^a   Carlsson, Per Ola ^b   Vanderwinden, Jean Marie ^a   Molkentin, Jeffery D ^c   Bugliani, Marco ^d   Marchetti, Piero ^d   Eizirik, Décio L ^a   Cnop, Miriam ^a,e  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UPPSALA UNIVERSITY   (Sweden)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF PISA   (Italy)

^e ERASME HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 3; CATALASE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GLUTATHIONE TRANSFERASE M1; INITIATION FACTOR 2; PALMITIC ACID; PKR LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN IRE1; PROTEIN KINASE; PUMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; LIPID; PERK KINASE; PROTEIN KINASE R;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EXPOSURE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; LIPOTOXICITY; MALE; METABOLIC STRESS; MIDDLE AGED; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; CYTOPROTECTION; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; INSULIN-SECRETING CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPIDS; MALE; MICE; MIDDLE AGED; MODELS, BIOLOGICAL; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PALMITIC ACID; PROTEOLYSIS; RATS, WISTAR; SIGNAL TRANSDUCTION; THROMBOSPONDIN 1;

EID: 84984865402     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2016.89     Document Type: Article

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