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Volumn 34, Issue , 2016, Pages S25-S31

Bile acids in regulation of inflammation and immunity: Friend or foe?

Author keywords

Adaptive and innate immunity; Bile acid signalling; Cholangiopathies; G protein coupled receptors; Hepatitis; Nuclear hormone receptors

Indexed keywords

BILE ACID; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; NORURSODEOXYCHOLIC ACID; OBETICHOLIC ACID; PLACEBO; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; ANTIINFLAMMATORY AGENT; AUTACOID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN; LIGAND;

EID: 84984832899     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (62)

References (78)
  • 1
    • 67749146730 scopus 로고
    • Bile: A historical review of studies on its form and function
    • KIRSNER JB (Ed.). New York, Lea & Febiger
    • BEUERS U, BOYER JL: Bile: A historical review of studies on its form and function. In: KIRSNER JB (Ed.): Gastroenterology in the 20th century. New York, Lea & Febiger, 1994: 267-88.
    • (1994) Gastroenterology in the 20th century , pp. 267-288
    • Beuers, U.1    Boyer, J.L.2
  • 2
    • 55949085226 scopus 로고    scopus 로고
    • Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases
    • TRAUNER M, FICKERT P, HALILBASIC E, MOUSTAFA T: Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases. Wien Med Wochenschr 2008; 158: 542-48.
    • (2008) Wien Med Wochenschr , vol.158 , pp. 542-548
    • Trauner, M.1    Fickert, P.2    Halilbasic, E.3    Moustafa, T.4
  • 3
    • 84867795064 scopus 로고    scopus 로고
    • Novel insight into mechanisms of cholestatic liver injury
    • WOOLBRIGHT BL, JAESCHKE H: Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol 2012; 18: 4985-93.
    • (2012) World J Gastroenterol , vol.18 , pp. 4985-4993
    • Woolbright, B.L.1    Jaeschke, H.2
  • 5
    • 84878515934 scopus 로고    scopus 로고
    • The molecular pathogenesis of cholestasis in sepsis
    • BHOGAL HK, SANYAL AJ: The molecular pathogenesis of cholestasis in sepsis. Front Biosci 2013; 5: 87-96.
    • (2013) Front Biosci , vol.5 , pp. 87-96
    • Bhogal, H.K.1    Sanyal, A.J.2
  • 6
    • 0032558588 scopus 로고    scopus 로고
    • Molecular pathogenesis of cholestasis
    • TRAUNER M, MEIER PJ, BOYER JL: Molecular pathogenesis of cholestasis. N Engl J Med 1998; 339: 1217-27.
    • (1998) N Engl J Med , vol.339 , pp. 1217-1227
    • Trauner, M.1    Meier, P.J.2    Boyer, J.L.3
  • 7
    • 0033172845 scopus 로고    scopus 로고
    • Review article: mechanisms of action and therapeutic applications
    • TRAUNER M, GRAZIADEI IW: Review article: mechanisms of action and therapeutic applications. Aliment Pharmacol Ther 1999; 13: 979-95.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 979-995
    • Trauner, M.1    Graziadei, I.W.2
  • 8
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • SMIT JJ, SCHINKEL AH, OUDE ELFERINK RP: Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993; 5: 451-62.
    • (1993) Cell , vol.5 , pp. 451-462
    • Smit, J.J.1    Schinkel, A.H.2    Oude Elferink, R.P.3
  • 10
    • 79953173235 scopus 로고    scopus 로고
    • Nuclear receptors as new perspective for the management of liver diseases
    • 1120-1125.e1-12.
    • TRAUNER M, HALILBASIC E: Nuclear receptors as new perspective for the management of liver diseases. Gastroenterology 2011; 140: 1120-1125. e1-12.
    • (2011) Gastroenterology , vol.140
    • Trauner, M.1    Halilbasic, E.2
  • 11
    • 84942878841 scopus 로고    scopus 로고
    • New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond
    • BEUERS U, TRAUNER M, JANSEN P, POUPON R: New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond. J Hepatol 2015; 62: S25-37.
    • (2015) J Hepatol , vol.62 , pp. S25-37
    • Beuers, U.1    Trauner, M.2    Jansen, P.3    Poupon, R.4
  • 12
    • 80053334403 scopus 로고    scopus 로고
    • Dual Farnesoid X Receptor/TGR5 Agonist INT.767 reduces liver injury in the Mdr22/2 (Abcb42/2) mouse cholangiopathy model by promoting biliary HCO3- output
    • BAGHDASARYAN A, CLAUDEL T, GUMHOLD J et al.: Dual Farnesoid X Receptor/TGR5 Agonist INT.767 reduces liver injury in the Mdr22/2 (Abcb42/2) mouse cholangiopathy model by promoting biliary HCO3- output. Hepatology 2011; 54: 1303-12.
    • (2011) Hepatology , vol.54 , pp. 1303-1312
    • Baghdasaryan, A.1    Claudel, T.2    Gumhold, J.3
  • 13
    • 33748809238 scopus 로고    scopus 로고
    • Nuclear receptors in human immune cells: expression and correlations
    • SCHOTE AB, TURNER JD, SCHILTZ J, MULLER CP: Nuclear receptors in human immune cells: expression and correlations. Mol Immunol 2007; 44: 1436-45.
    • (2007) Mol Immunol , vol.44 , pp. 1436-1445
    • Schote, A.B.1    Turner, J.D.2    Schiltz, J.3    Muller, C.P.4
  • 14
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes Nuclear Factor kappa B in hepatic inflammatory response
    • WANG YD, CHEN WD, WANG M, YU D, FORMAN BM, HUANG W: Farnesoid X receptor antagonizes Nuclear Factor kappa B in hepatic inflammatory response. Hepatology 2008; 48: 1632-1643.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 15
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • POLS TW, NOMURA M, HARACH T et al.: TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 2011; 14: 747-57.
    • (2011) Cell Metab , vol.14 , pp. 747-757
    • Pols, T.W.1    Nomura, M.2    Harach, T.3
  • 16
    • 80053308007 scopus 로고    scopus 로고
    • The G-Protein-Coupled Bile Acid Receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor Kappa Light- Chain Enhancer of Activated B Cells (NFkB) in mice
    • WANG YD, CHEN WD, YU D, FORMAN BM, HUANG W: The G-Protein-Coupled Bile Acid Receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing Nuclear Factor Kappa Light- Chain Enhancer of Activated B Cells (NFkB) in mice. Hepatology 2011; 54: 1421-32.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.D.1    Chen, W.D.2    Yu, D.3    Forman, B.M.4    Huang, W.5
  • 17
    • 84926408803 scopus 로고    scopus 로고
    • The critical role of myeloid-derived suppressor cells and FXR activation in immune-mediated liver injury
    • ZHANG H, LIU Y, BIAN Z et al.: The critical role of myeloid-derived suppressor cells and FXR activation in immune-mediated liver injury. J Autoimmun 2014; 53: 55-56.
    • (2014) J Autoimmun , vol.53 , pp. 55-56
    • Zhang, H.1    Liu, Y.2    Bian, Z.3
  • 18
    • 84903386049 scopus 로고    scopus 로고
    • A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces Experimental Autoimmune Encephalitis (EAE) in vivo
    • e100883.
    • LEWIS ND, PATNAUDE LA, PELLETIER J et al.: A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces Experimental Autoimmune Encephalitis (EAE) in vivo. Plos One 2014; 9 e100883: 1-11.
    • (2014) Plos One , vol.9 , pp. 1-11
    • Lewis, N.D.1    Patnaude, L.A.2    Pelletier, J.3
  • 19
    • 84957827786 scopus 로고    scopus 로고
    • Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis
    • HO PP, STEINMAN L: Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2016; 113: 1600-5.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 1600-1605
    • Ho, P.P.1    Steinman, L.2
  • 21
    • 79953173235 scopus 로고    scopus 로고
    • Nuclear receptors as new perspective for the management of liver diseases
    • 1120-1125.e1-12.
    • TRAUNER M, HALILBASIC E: Nuclear receptors as new perspective for the management of liver diseases. Gastroenterology 2011; 40: 1120-1125.e1-12.
    • (2011) Gastroenterology , vol.40
    • Trauner, M.1    Halilbasic, E.2
  • 22
    • 84871242500 scopus 로고    scopus 로고
    • Bile acid transporters and regulatory nuclear receptors in the liver and beyond
    • HALILBASIC E, CLAUDEL T, TRAUNER M: Bile acid transporters and regulatory nuclear receptors in the liver and beyond. J Hepatol 2013; 58: 155-68.
    • (2013) J Hepatol , vol.58 , pp. 155-168
    • Halilbasic, E.1    Claudel, T.2    Trauner, M.3
  • 23
    • 0037178881 scopus 로고    scopus 로고
    • Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis
    • LI S, ZHAO Y, HE X et al.: Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J Biol Chem 2002; 277: 26912-20.
    • (2002) J Biol Chem , vol.277 , pp. 26912-26920
    • Li, S.1    Zhao, Y.2    He, X.3
  • 24
    • 0035167269 scopus 로고    scopus 로고
    • Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogenactivated protein kinase-signaling module enhances DCA-induced apoptosis
    • QIAO L, STUDER E, LEACH K et al.: Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogenactivated protein kinase-signaling module enhances DCA-induced apoptosis. Mol Biol Cell 2001; 12: 2629-45.
    • (2001) Mol Biol Cell , vol.12 , pp. 2629-2645
    • Qiao, L.1    Studer, E.2    Leach, K.3
  • 25
    • 22844440003 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
    • REINEHR R, BECKER S, EBERLE A, GRETHER- BECK S, HäUSSINGER D: Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem 2005; 280: 27179-94.
    • (2005) J Biol Chem , vol.280 , pp. 27179-27194
    • Reinehr, R.1    Becker, S.2    Eberle, A.3    Grether-Beck, S.4    Häussinger, D.5
  • 27
    • 84897505157 scopus 로고    scopus 로고
    • The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury
    • ADACHI T, KAMINAGA T, YASUDA H, KAMIYA T, HARA H: The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury. J Clin Biochem Nutr 2014; 54: 129-35.
    • (2014) J Clin Biochem Nutr , vol.54 , pp. 129-135
    • Adachi, T.1    Kaminaga, T.2    Yasuda, H.3    Kamiya, T.4    Hara, H.5
  • 28
    • 1342344120 scopus 로고    scopus 로고
    • Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice
    • GUJRAL JS, LIU J, FARHOOD A, HINSON JA, JAESCHKE H: Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol 2004; 286: G499-G507.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286 , pp. G499-G507
    • Gujral, J.S.1    Liu, J.2    Farhood, A.3    Hinson, J.A.4    Jaeschke, H.5
  • 29
    • 0033803827 scopus 로고    scopus 로고
    • Role of neutrophils in sinusoidal endothelial cell injury after extensive hepatectomy in cholestatic rats
    • OHTSUKA M, MIYAZAKI M, KUBOSAWA H et al.: Role of neutrophils in sinusoidal endothelial cell injury after extensive hepatectomy in cholestatic rats. J Gastroenterol Hepatol 2000; 15: 880-6.
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 880-886
    • Ohtsuka, M.1    Miyazaki, M.2    Kubosawa, H.3
  • 30
    • 0042766884 scopus 로고    scopus 로고
    • Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct- ligated mice
    • GUJRAL JS, FARHOOD A, BAJT ML, JAESCHKE H: Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct- ligated mice. Hepatology 2003; 38: 355-63.
    • (2003) Hepatology , vol.38 , pp. 355-363
    • Gujral, J.S.1    Farhood, A.2    Bajt, M.L.3    Jaeschke, H.4
  • 31
    • 84984842809 scopus 로고
    • Neutrophil oxidative response and its relationship to clinical outcomes in jaundiced patients
    • PUNTIS MCA, JIANG WG, HALLET MB: Neutrophil oxidative response and its relationship to clinical outcomes in jaundiced patients. HPB Surg 1992; 5: 204.
    • (1992) HPB Surg , vol.5 , pp. 204
    • Puntis, M.C.A.1    Jiang, W.G.2    Hallet, M.B.3
  • 32
    • 78650793157 scopus 로고    scopus 로고
    • Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
    • ALLEN K, JAESCHKE H, COPPLE BL: Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 2011; 178: 175-86.
    • (2011) Am J Pathol , vol.178 , pp. 175-186
    • Allen, K.1    Jaeschke, H.2    Copple, B.L.3
  • 33
    • 0025325698 scopus 로고
    • Differential effects of lithocholate on rat neutrophil activation
    • DAHM LJ, ROTH RA: Differential effects of lithocholate on rat neutrophil activation. J Leuk Biol 1990; 47: 551-60.
    • (1990) J Leuk Biol , vol.47 , pp. 551-560
    • Dahm, L.J.1    Roth, R.A.2
  • 34
    • 0033053956 scopus 로고    scopus 로고
    • Reversible Kupffer cell suppression in biliary obstruction is caused by hydrophobic bile acids
    • SUNG JJY, GO MYY: Reversible Kupffer cell suppression in biliary obstruction is caused by hydrophobic bile acids. J Hepatol 1999; 30: 413-18.
    • (1999) J Hepatol , vol.30 , pp. 413-418
    • Sung, J.J.Y.1    Go, M.Y.Y.2
  • 35
    • 0030909926 scopus 로고    scopus 로고
    • Immune dysfunction in patients with obstructive jaundice, mediators and implications for treatments
    • JIANG WG, PUNTIS MC: Immune dysfunction in patients with obstructive jaundice, mediators and implications for treatments. HPB Surg 1997; 10: 129-42.
    • (1997) HPB Surg , vol.10 , pp. 129-142
    • Jiang, W.G.1    Puntis, M.C.2
  • 36
    • 33644791099 scopus 로고    scopus 로고
    • TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice
    • KERFOOT SM, D'MELLO C, NGUYEN H et al.: TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice. Hepatology 2006; 43: 154-62.
    • (2006) Hepatology , vol.43 , pp. 154-162
    • Kerfoot, S.M.1    D'Mello, C.2    Nguyen, H.3
  • 37
    • 1642495750 scopus 로고    scopus 로고
    • Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition
    • PILLARISETTY VG, SHAH AB, MILLER G, BLEIER JI, DEMATTEO RP: Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition. J Immunol 2004; 15: 1009-17.
    • (2004) J Immunol , vol.15 , pp. 1009-1017
    • Pillarisetty, V.G.1    Shah, A.B.2    Miller, G.3    Bleier, J.I.4    Dematteo, R.P.5
  • 38
    • 33744945790 scopus 로고    scopus 로고
    • Biliary obstruction selectively expands and activates liver myeloid dendritic cells
    • BLEIER JI, KATZ SC, CHAUDHRY UI et al.: Biliary obstruction selectively expands and activates liver myeloid dendritic cells. J Immunol 2006; 176: 7189-95.
    • (2006) J Immunol , vol.176 , pp. 7189-7195
    • Bleier, J.I.1    Katz, S.C.2    Chaudhry, U.I.3
  • 39
    • 70449355084 scopus 로고    scopus 로고
    • In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha
    • CONNOLLY MK, BEDROSIAN AS, MALLENST CLAIR J: In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest 2009; 119: 3213-25.
    • (2009) J Clin Invest , vol.119 , pp. 3213-3225
    • Connolly, M.K.1    Bedrosian, A.S.2    Mallenst Clair, J.3
  • 40
    • 84885958285 scopus 로고    scopus 로고
    • Dendritic cells in liver injury and fibrosis: shortcomings and promises
    • LUKACS-KORNEK V, SCHUPPAN D: Dendritic cells in liver injury and fibrosis: shortcomings and promises. J Hepatol 2013; 59: 1124-6.
    • (2013) J Hepatol , vol.59 , pp. 1124-1126
    • Lukacs-Kornek, V.1    Schuppan, D.2
  • 41
    • 84877073851 scopus 로고    scopus 로고
    • Dendritic cells and liver fibrosis
    • RAHMAN AH, ALOMAN C: Dendritic cells and liver fibrosis. Biochim Biophys Acta 2013; 7: 998-04.
    • (2013) Biochim Biophys Acta , vol.7 , pp. 998-1004
    • Rahman, A.H.1    Aloman, C.2
  • 42
    • 84906319860 scopus 로고    scopus 로고
    • TGF-ß-dependent induction of CD4+CD25+ Foxp3+ Tregs by liver sinusoidal endothelial cells
    • CARAMBIA A, FREUND B, SCHWINGE D: TGF-ß-dependent induction of CD4+CD25+ Foxp3+ Tregs by liver sinusoidal endothelial cells. J Hepatol 2014; 61: 594-99.
    • (2014) J Hepatol , vol.61 , pp. 594-599
    • Carambia, A.1    Freund, B.2    Schwinge, D.3
  • 43
    • 84884836878 scopus 로고    scopus 로고
    • Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils
    • LICATA LA, NGUYEN CT, BURGA RA: Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils. J Leukoc Biol 2013; 94: 813-23.
    • (2013) J Leukoc Biol , vol.94 , pp. 813-823
    • Licata, L.A.1    Nguyen, C.T.2    Burga, R.A.3
  • 44
  • 45
    • 79956088562 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
    • POLS TW, NORIEGA LG, NOMURA M, AUWERX J, SCHOONJANS K: The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol 2011; 54: 1263-72.
    • (2011) J Hepatol , vol.54 , pp. 1263-1272
    • Pols, T.W.1    Noriega, L.G.2    Nomura, M.3    Auwerx, J.4    Schoonjans, K.5
  • 46
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor kappa B in hepatic inflammatory response
    • WANG YD, CHEN WD, WANG M, YU D, FORMAN BM, HUANG W: Farnesoid X receptor antagonizes nuclear factor kappa B in hepatic inflammatory response. Hepatology 2008; 48: 1632-43.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 47
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • MENCARELLI A, RENGA B, MIGLIORATI M et al.: The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 2009; 183: 6657-66.
    • (2009) J Immunol , vol.183 , pp. 6657-6666
    • Mencarelli, A.1    Renga, B.2    Migliorati, M.3
  • 48
    • 84922397855 scopus 로고    scopus 로고
    • The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats
    • VERBEKE L, FARRE R, VERBINNEN B et al.: The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats. Am J Pathol 2015; 185: 409-19.
    • (2015) Am J Pathol , vol.185 , pp. 409-419
    • Verbeke, L.1    Farre, R.2    Verbinnen, B.3
  • 49
    • 84879103477 scopus 로고    scopus 로고
    • Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
    • KIDA T, TSUBOSAKA Y, HORI M, OZAKI H, MURATA T: Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Arterioscler Thromb Vasc Biol 2013; 33: 1663-9.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1663-1669
    • Kida, T.1    Tsubosaka, Y.2    Hori, M.3    Ozaki, H.4    Murata, T.5
  • 50
    • 84876896348 scopus 로고    scopus 로고
    • Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
    • McMAHAN RH, WANG XX, CHENG LL et al.: Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem 2013; 288: 11761-70.
    • (2013) J Biol Chem , vol.288 , pp. 11761-11770
    • Mcmahan, R.H.1    Wang, X.X.2    Cheng, L.L.3
  • 51
    • 84860253913 scopus 로고    scopus 로고
    • Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
    • ICHIKAWA R, TAKAYAMA T, YONENO K et al.: Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 2012; 136: 153-62.
    • (2012) Immunology , vol.136 , pp. 153-162
    • Ichikawa, R.1    Takayama, T.2    Yoneno, K.3
  • 53
    • 84925362562 scopus 로고    scopus 로고
    • Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
    • HIRSCHFIELD GM, MASON A, LUKETIC V et al.: Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology 2015; 148: 751-61.
    • (2015) Gastroenterology , vol.148 , pp. 751-761
    • Hirschfield, G.M.1    Mason, A.2    Luketic, V.3
  • 54
    • 84929266699 scopus 로고    scopus 로고
    • NASH Clinical Research Network. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, nonalcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • NEUSCHWANDER-TETRI BA, LOOMBA R, SANYAL AJ et al.: NASH Clinical Research Network. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, nonalcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015; 14: 956-65.
    • (2015) Lancet , vol.14 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3
  • 55
    • 84922322650 scopus 로고    scopus 로고
    • Farnesoid X Receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3
    • WANG YD, CHEN WD, LI C et al.: Farnesoid X Receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3. Mol Endocrinol 2015: 29: 322-31.
    • (2015) Mol Endocrinol , vol.29 , pp. 322-331
    • Wang, Y.D.1    Chen, W.D.2    Li, C.3
  • 56
    • 33744920572 scopus 로고    scopus 로고
    • Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis
    • BEUERS U: Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 318-28.
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 318-328
    • Beuers, U.1
  • 57
    • 84862663864 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health
    • DILGER K, HOHENESTER S, WINKLERBUDENHOFER U: Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. J Hepatol 2012; 57: 133-40.
    • (2012) J Hepatol , vol.57 , pp. 133-140
    • Dilger, K.1    Hohenester, S.2    Winklerbudenhofer, U.3
  • 58
    • 0033600824 scopus 로고    scopus 로고
    • Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants
    • MITSUYOSHI H, NAKASHIMA T, SUMIDA Y et al.: Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochem Biophys Res Commun 1999; 263: 537-42.
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 537-542
    • Mitsuyoshi, H.1    Nakashima, T.2    Sumida, Y.3
  • 59
    • 0033740305 scopus 로고    scopus 로고
    • Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease
    • LJUBUNCIC P, TANNE Z, BOMZON A: Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease. Dig Dis Sci 2000; 45: 1921-28.
    • (2000) Dig Dis Sci , vol.45 , pp. 1921-1928
    • Ljubuncic, P.1    Tanne, Z.2    Bomzon, A.3
  • 60
    • 0028816461 scopus 로고
    • Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection
    • BOTLA R, SPIVEY JR, AGUILAR H, BRONK SF, GORES GJ: Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J Pharmacol Exp Ther 1995; 272: 930-38.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 930-938
    • Botla, R.1    Spivey, J.R.2    Aguilar, H.3    Bronk, S.F.4    Gores, G.J.5
  • 61
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • RODRIGUES CM, FAN G, MA X, KREN BT, STEER CJ: A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 1998; 101: 2790-99.
    • (1998) J Clin Invest , vol.101 , pp. 2790-2799
    • Rodrigues, C.M.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 62
    • 0035038177 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
    • BEUERS U, BILZER M, CHITTATTU A et al.: Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 2001; 33: 1206-16.
    • (2001) Hepatology , vol.33 , pp. 1206-1216
    • Beuers, U.1    Bilzer, M.2    Chittattu, A.3
  • 64
    • 84155175630 scopus 로고    scopus 로고
    • A biliary HCO3 - umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
    • HOHENESTER S, WENNIGER LM, PAULUSMA CC et al.: A biliary HCO3 - umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 2012; 55: 173-83.
    • (2012) Hepatology , vol.55 , pp. 173-183
    • Hohenester, S.1    Wenniger, L.M.2    Paulusma, C.C.3
  • 65
    • 0026642157 scopus 로고
    • Immunomodulatory effects of ursodeoxycholic acid on immune responses
    • YOSHIKAWA M, TSUJII T, MATSUMURA K et al.: Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992; 16: 358-64.
    • (1992) Hepatology , vol.16 , pp. 358-364
    • Yoshikawa, M.1    Tsujii, T.2    Matsumura, K.3
  • 66
    • 36749040213 scopus 로고    scopus 로고
    • A largescale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C.
    • OMATA M, YOSHIDA H, TOYOTA J et al.: A largescale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C. Gut 2007; 56:; 1747-53.
    • (2007) Gut , vol.56 , pp. 1747-1753
    • Omata, M.1    Yoshida, H.2    Toyota, J.3
  • 67
    • 0035120816 scopus 로고    scopus 로고
    • Bile acids induce eosinophil degranulation by two different mechanisms
    • YAMAZAKI K, GLEICH GJ, KITA H: Bile acids induce eosinophil degranulation by two different mechanisms. Hepatology 2001; 33: 582-90.
    • (2001) Hepatology , vol.33 , pp. 582-590
    • Yamazaki, K.1    Gleich, G.J.2    Kita, H.3
  • 68
    • 0033026044 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis
    • YAMAZAKI K, SUZUKI K, NAKAMURA A et al.: Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis. Hepatology 1999; 30: 71-78.
    • (1999) Hepatology , vol.30 , pp. 71-78
    • Yamazaki, K.1    Suzuki, K.2    Nakamura, A.3
  • 69
    • 0035861563 scopus 로고    scopus 로고
    • Functional modulation of the glucocorticoid receptor and suppression of NF-kappa B dependent transcription by ursodeoxycholic acid
    • MIURA T, OUCHIDA R, YOSHIKAWA N et al.: Functional modulation of the glucocorticoid receptor and suppression of NF-kappa B dependent transcription by ursodeoxycholic acid. J Biol Chem 2001; 276: 47371-78.
    • (2001) J Biol Chem , vol.276 , pp. 47371-47378
    • Miura, T.1    Ouchida, R.2    Yoshikawa, N.3
  • 70
    • 84869494434 scopus 로고    scopus 로고
    • Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor
    • WILLART MA, van NIMWEGEN M, GREFHORST A et al.: Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor. Allergy 2012; 67: 1501-10.
    • (2012) Allergy , vol.67 , pp. 1501-1510
    • Willart, M.A.1    Van Nimwegen, M.2    Grefhorst, A.3
  • 71
    • 68049143345 scopus 로고    scopus 로고
    • Side chain structure determines unique physiologic and therapeutic properties of norUrsodeoxycholic acid in Mdr2-/-Mice
    • HALILBASIC E, FIOROTTO R, FICKERT P et al.: Side chain structure determines unique physiologic and therapeutic properties of norUrsodeoxycholic acid in Mdr2-/-Mice. Hepatology 2009; 49: 1972-81.
    • (2009) Hepatology , vol.49 , pp. 1972-1981
    • Halilbasic, E.1    Fiorotto, R.2    Fickert, P.3
  • 72
    • 84930582859 scopus 로고    scopus 로고
    • Potential of nor-ursodeoxycholic acid in cholestatic and metabolic disorders
    • TRAUNER M, HALILBASIC E, CLAUDEL T et al.: Potential of nor-ursodeoxycholic acid in cholestatic and metabolic disorders. Dig Dis 2015; 33: 433-9.
    • (2015) Dig Dis , vol.33 , pp. 433-439
    • Trauner, M.1    Halilbasic, E.2    Claudel, T.3
  • 73
    • 84877924280 scopus 로고    scopus 로고
    • Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
    • FICKERT P, POLLHEIMER MJ, SILBERT D et al.: Differential effects of norUDCA and UDCA in obstructive cholestasis in mice. J Hepatol 2013; 58: 1201-08.
    • (2013) J Hepatol , vol.58 , pp. 1201-1208
    • Fickert, P.1    Pollheimer, M.J.2    Silbert, D.3
  • 74
    • 83755181906 scopus 로고    scopus 로고
    • Alterationsin lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury
    • 140-151 e12.
    • MOUSTAFA T, FICKERT P, MAGNES C et al.: Alterationsin lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury. Gastroenterology 2012; 142: 140-151 e12.
    • (2012) Gastroenterology , vol.142
    • Moustafa, T.1    Fickert, P.2    Magnes, C.3
  • 75
    • 84930612525 scopus 로고    scopus 로고
    • Side chain modified bile acids modulate endoplasmic reticulum stress in Mdr2 -/- mice in vivo and bile duct epithelial cells in vitro
    • MOUSTAFA T, HALILBASIC E, FICKERT P et al.: Side chain modified bile acids modulate endoplasmic reticulum stress in Mdr2 -/- mice in vivo and bile duct epithelial cells in vitro. J Hepatol 2008; 48: S54-S55.
    • (2008) J Hepatol , vol.48 , pp. S54-S55
    • Moustafa, T.1    Halilbasic, E.2    Fickert, P.3
  • 77
    • 84930584535 scopus 로고    scopus 로고
    • Norursodeoxycholic acid modulates LPS-induced inflammatory response by interfering with NF-ΚB signalling pathway
    • HALILBASIC E, CLAUDEL T, BACHHOFNER N, KAPUSTA C, TRAUNER M: Norursodeoxycholic acid modulates LPS-induced inflammatory response by interfering with NF-ΚB signalling pathway. J Hepatol 2012; 56: S140.
    • (2012) J Hepatol , vol.56 , pp. S140
    • Halilbasic, E.1    Claudel, T.2    Bachhofner, N.3    Kapusta, C.4    Trauner, M.5
  • 78
    • 84926421958 scopus 로고    scopus 로고
    • 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis
    • SOMBETZKI M, FUCHS CD, FICKERT P et al.: 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis. J Hepatol 2015; 62: 871-78.
    • (2015) J Hepatol , vol.62 , pp. 871-878
    • Sombetzki, M.1    Fuchs, C.D.2    Fickert, P.3


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