Is DNA methylation of tumour suppressor genes epigenetic?

eLife

Volumn 2014, Issue 3, 2014, Pages

  Struhl, Kevin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA METHYLTRANSFERASE; HISTONE ACETYLTRANSFERASE;

ARTICLE; COLORECTAL CANCER; DNA METHYLATION; DNA REPLICATION; ENZYME ACTIVITY; EPIGENETICS; GENE MUTATION; GENE SILENCING; HISTONE MODIFICATION; HUMAN; NONHUMAN; ONCOGENE; ONCOGENE K RAS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; ANIMAL; CPG ISLAND; GENETIC TRANSCRIPTION; ONCOGENE RAS;

ANIMALS; CPG ISLANDS; DNA METHYLATION; GENE SILENCING; GENES, RAS; HUMANS; TRANSCRIPTION, GENETIC;

EID: 84898725513     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02475     Document Type: Article

References (10)

1. Baylin SB, Jones PA. 2011. A decade of exploring the cancer epigenome-biological and translational implications. Nature Reviews Cancer 11:726-734. doi: 10.1038/nrc3130.
2. Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR. 2007. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449:1073-1077. doi: 10.1038/nature06251.
3. Palakurthy RK, Wajapeyee N, Santra MK, Gazin C, Lin L, Gobeil S, Green MR. 2009. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Molecular Cell 36:219-230. doi: 10.1016/j.molcel.2009.10.009.
4. Ptashne M. 2013. Epigenetics: core misconcept. Proceedings of the National Academy of Sciences of the United States of America 110:7101-7103. doi: 10.1073/pnas.1305399110.
5. Serra RW, Fang M, Park SM, Hutchinson L, Green MR. 2014. A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. eLife 3:e02313. doi: 10.7554/eLife.02313.
6. Struhl K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Development 12:599-606. doi: 10.1101/gad.12.5.599.
7. Takahashi K, Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676. doi: 10.1016/j.cell.2006.07.024.
8. Wajapeyee N, Malonia SK, Palakurthy RK, Green MR. 2013. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Development 27:2221-2226. doi: 10.1101/gad.227413.113.
9. Weintraub H. 1993. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell 75:1241-1244. doi: 10.1016/0092-8674(93)90610-3.
10. Young RA. 2011. Control of the embryonic stem cell state. Cell 144:940-954. doi: 10.1016/j.cell.2011.01.032.