Neurobiology of periventricular leukomalacia in the premature infant

Pediatric Research

Volumn 50, Issue 5, 2001, Pages 553-562

  Volpe, Joseph J ^a,b   Zipurksy, Alvin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTIBIOTIC AGENT; CYTOKINE; FREE RADICAL; GLUTAMIC ACID; IRON; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; REACTIVE OXYGEN METABOLITE; SCAVENGER;

APOPTOSIS; BIOACCUMULATION; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; HUMAN; INFECTION; INFLAMMATION; INFRARED SPECTROSCOPY; LEUKOMALACIA; NEUROBIOLOGY; NONHUMAN; OLIGODENDROGLIA; PATHOGENESIS; PREMATURITY; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; STEM CELL; WHITE MATTER;

EID: 0034770283     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200111000-00003     Document Type: Review

References (175)

1. Annual summary of vital statistics - 1998
2. Neurologic and developmental disability after extremely preterm birth
3. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g
4. Functional limitations and special health care needs of 10- to 14-year old children weighing less than 750 grams at birth
5. Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques
6. Cerebral angioarchitecture and perinatal brain lesions in premature and full-term infants
7. Development of cerebrovascular architecture and its relationship to periventricular leukomalacia
8. Pathology on neonatal hypoxic brain damage and intracranial hemorrhage: Factors important in their pathogenesis
9. Anatomical features of the developing brain implicated in pathogenesis of hypoxic-ischemic injury
10. Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults
11. Cerebral blood flow in preterm infants during the first week of life
12. 2 changes, and visual evoked potentials in mechanically ventilated, preterm infants
13. Compensatory increase of CBF in preterm infants during hypoglycaemia
14. 2 and haemoglobin concentration on day to day variation of CBF in preterm neonates
15. Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates
16. Vasoparalysis associated with brain damage in asphyxiated term infants
17. Preservation of single-flash visual evoked potentials at very low cerebral oxygen delivery in preterm infants
18. Blood flow distribution in the normal human preterm brain
19. Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans
20. Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia
21. Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilation
22. Cerebral blood flow in the newborn infant
23. 2 reactivity of cerebral blood flow is associated with severe brain damage in mechanically ventilated very low birth weight infants
24. Control of cerebral circulation in the high-risk neonate
25. The effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants
26. Dynamic cerebral autoregulation in sick newborn infants
27. Autoregulation of cerebral blood flow in the preterm fetal lamb
28. Regional cerebral blood flow after hemorrhagic hypotension in the preterm, near-term, and newborn lamb
29. Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets
30. Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus
31. Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants
32. Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia
33. The vulnerability of the fetal sheep brain to hypoxemia at mid-gestation
34. Effects of chronic placental insufficiency on brain development in fetal sheep
35. Maturational change in the cortical response to hypoperfusion injury in the fetal sheep
36. Physiologic and histologic changes in near- term fetal lambs exposed to asphyxia by partial umbilical cord occlusion
37. Preferential injury of oligodendroblasts by a short hypoxic-ischemic insult
38. A new model of white matter injury in neonatal rats with bilateral carotid artery occlusion
39. NBQX attenuates excitotoxic injury in developing white matter
40. Induction of antenatal periventricular leukomalacia by hemorrhagic hypotension in the chronically instrumented fetal sheep
41. Relation between damage to the placenta and the fetal brain after late-gestation placental embolization and fetal growth restriction in sheep
42. Late oligodendrocyte progenitors coincide with the developmental window of vunerability for human perinatal white matter injury
43. Maturation-dependent vulnerability of oligodendmcytes to oxidative stress-induced death caused by glutathione depletion
44. Role of free radicals and catalytic metal ions in human disease: An overview
45. Oxygen radicals in focal cerebral ischemia
46. Prospects for treatment of free radical mediated injury
47. Reperfusion injury as the mechanism of brain damage after perinatal asphyxia
48. Postischemic generation of superoxide anion by newborn pig brain
49. Allopurinol preserves cerebral energy metabolism during perinatal hypoxic-ischemic injury and reduces brain damage in a dose dependent manner
50. Allopurlnol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats
51. Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose
52. Direct measurement for free radicals in the neonatal mouse brain subjected to hypoxia: An electron spin resonance spectroscopic study
53. Extracellular increase of hypoxanthine and xanthine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia
54. Reduction of perinatal hypoxic-ischemic brain damage with allopurinol
55. The role of oxygen free radicals in postasphyxia cerebral hypoperfusion in newborn lambs
56. Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxicischemic brain damage in the rat
57. Free radicals are formed in the brain of fetal sheep during repeffusion after cerebral ischemia
58. Formation of free radicals in hypoxic ischemic brain damage in the neonatal rat, assessed by an endogenous spin trap and lipid peroxidation
59. Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat
60. Oxidative metabolism, apoptosis and perinatal brain injury
61. Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion: Relation to arachidonic acid peroxidation
62. Increased injury following intermittent fetal hypoxia-reoxygenation is associated with increased free radical production in fetal rabbit brain
63. The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain
64. Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia
65. Reactive oxygen radicals in signaling and damage in the ischemic brain
66. Intracellular redox state determines whether nitric oxide is toxic or protective to rat oligodendrocytes in culture
67. Vulnerability of oligodendroglia to glutamate: Pharmacology, mechanisms and prevention
68. Cystine deprivation induces oligodendroglial death: Rescue by free radical scavengers and by a diffusible glial factor
69. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
70. Ischemia-induced neuronal apoptosis
71. Development of transferrin-positive oligodendrocytes in the rat central nervous system
72. Altered distribution of iron in the central nervous system of myelin deficient rats
73. Relationship of iron to oligodendrocytes and myelination
74. Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress
75. Response of glial cells to ischemia: Roles of reactive oxygen species and glutathione
76. Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress
77. Delayed oligodendrocyte degeneration induced by brief exposure to hydrogen peroxide
78. Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice
79. +-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs
80. Developmental immunohistochemistry of catalase in the human brain
81. Development of ferritin-positive cells in cerebrum of human brain
82. Immunohistochemical study of myelination and oligodendrocyte in infants with periventricular leukomalacia
83. Immaturity-dependent free radical activity in premature infants
84. New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease
85. The correlation of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birthweight infant
86. Hydroxyl radical generation in oxygen-treated infants
87. Reduced iron-associated antioxidants in premature newborns suffering intracerebral hemorrhage
88. Bronchopulmonary dysplasia and oxidative stress: Are we closer to an understanding of the pathogenesis of BPD?
89. Antioxidant activity, packed cell transfusions, and outcome in premature infants
90. Plasma chain-breaking antioxidants in preterm infants with good and poor short-term outcome
91. Antioxidant capacity and oxygen radical diseases in the preterm newborn
92. Total hydroperoxide and advanced oxidation protein products in preterm hypoxic babies
93. Elevated free radical products in the cerebrospinal fluid of premature infants with white matter injury
94. Neuropathologic findings in short-term survivors of intraventricular hemorrhage
95. Relationship between periventricular hemorrhage, leukomalacia and brainstem lesions in prematurely born infants
96. Ventriculomegaly, delayed myelination, white matter hypoplasia, and "periventricular" leukomalacia. How are they related?
97. White matter disorders of prematurity: Association with intraventricular hemorrhage and ventriculomegaly
98. Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilation
99. Periventricular leukomalacia of infancy
100. Early detection of axonal and neuronal lesions in prenatal-onset periventricular leukomalacia
101. Periventricular leukomalacia: Relation to gestational age and axonal injury
102. Early axonal and glial pathology in fetal sheep brains with leukomalacia induced by repeated umbilical cord occlusion
103. The uptake of various amino acids by the mouse brain in vivo
104. Glutamate: A neurotransmitter in mammalian brain
105. The excitotoxin hypothesis in relation to cerebral ischemia
106. Rapid ischemic cell death in immature oligodendrocytes: A fatal glutamate release feedback loop
107. The release and uptake of excitatory amino acids
108. Pathophysiology of oligodendroglial excitotoxicity
109. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity
110. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes
111. Stage-specific vulnerability of rat oligodendrocytes in culture to non-NMDA receptor mediated toxicity
112. Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve
113. AMPA and kainate receptors each mediate excitotoxicity in oligodendroglial cultures
114. Glutamate excitotoxicity in a model of multiple sclerosis
115. Non-N-methyl-D-aspartate glutamate receptors mediate oxygen-glucose deprivation-induced oligodendroglial injury
116. Protective effects of topiramate in a rodent model of periventricular leukomalacia
117. Susceptibility of the neonatal feline telencephalic white matter to a lipopolysaccharide
118. Neonatal endotoxin encephalopathy
119. Acquired perinatal leukoencephalopathy
120. Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits
121. Intrauterine infection induces programmed cell death in rabbit periventricular white matter
122. Bilateral cystic periventricular leukomalacia in the premature infant: Associated risk factors
123. Periventricular leukomalacia: Risk factors revisited
124. Prenatal and perinatal factors and cerebral palsy in very low birth weight infants
125. Intrauterine infection and the risk of cerebral palsy in very low-birthweight infants
126. Are neonatal brain lesions due to intrauterine infection related to mode of delivery?
127. Increased risk of spastic diplegia among very low birth weight children after preterm labor or prelabor rupture of membranes
128. Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants
129. Labor and delivery characteristics and risks of cranial ultrasonographic abnormalities among very-low-birth-weight infants
130. The relationship between placental and other perinatal risk factors for neurologic impairment in very low birth weight children
131. Risk factors and determinants of neurodevelopmental outcome in cystic periventricular leucomalacia
132. Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis
133. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years
134. Early neonatal brain injury in histologic chorioamnionitis
135. Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia
136. Amniotic fluid inflammatory, cytokines (interleukin-6, interleukin-1β, and tumor necrosis factor-α), neontal brian white matter lesions, and cerebral palsy
137. Maternal infection and cerebral palsy in infants of normal birth weight
138. Neonatal cytokines and coagulation factors in children with cerebral palsy
139. Interferons and cerebral palsy
140. Immunohistochemical expression of tumor necrosis factor α in neonatal leukomalacia
141. Characteristic neuropathology of leukomalacia in extremely low birth weight infants
142. High expression of tumor necrosis factor-alpha and interleukin-6 in periventricular leukomalacia
143. Cytokine cytotoxicity against oligodendrocytes: Apoptosis induced by lymphotoxin
144. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death
145. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro
146. Interferon-γ-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis
147. Reversible inhibitory effects of interferon-γ- and tumour necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro
148. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
149. TNFα potentiates IFNγ-induced cell death in oligodendrocyte progenitors
150. Association of increased Bcl-2 expression with rescue from tumor necrosis factor-α-induced cell death in the oligodendrocyte cell line OLN-93
151. Oligodendroglial response to the immune cytokine interferon gamma
152. Developing and mature oligodendrocytes respond differently to the immune cytokine interferon-gamma
153. Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium
154. Central role of microglia in neonatal excitotoxic lesions ef the murine periventricular white matter
155. Reactive microglia in cerebral ischaemia: An early mediator of tissue damage?
156. Overexpression of HSP25 reduces the level of TNFα-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells
157. Oxidative injury and survival during endotoxemia
158. Antioxidants attenuate acute toxicity of tumor necrosis factor-alpha induced by brain injury in rat
159. Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro
160. Vascular lesions: Possible pathogenetic basis of the generalized Shwartzman reaction
161. The effects of endotoxin on vascular endothelium
162. Systemic and neuropathologic effects of E. coli endotoxin in neonatal dogs
163. Endotoxin, cerebral blood flow, amino acids and brain damage in young rabbits
164. Tumor necrosis factor-α-induced dilatation of cerebral arterioles
165. Magnesium sulfate for tocolysis and risk of spastic cerebral palsy in premature children born to women without preeclampsia
166. Antenatal corticosteroids and cranial ultrasonographic abnormalities
167. Antenatal steroids and neonatal periventricular leukomalacia
168. Antenatal steroids and the developing brain
169. Early postnatal dexamethasone treatment and increased incidence of cerebral palsy
170. Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease
171. Postnatal glucocorticoids in very preterm infants: "The good, the bad, and the ugly"?