Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1822-1826

  Weïwer, Michel ^a   Bittker, Joshua A ^a   Lewis, Timothy A ^a   Shimada, Kenichi ^b   Yang, Wan Seok ^b   MacPherson, Lawrence ^a   Dandapani, Sivaraman ^a   Palmer, Michelle ^a   Stockwell, Brent R ^b   Schreiber, Stuart L ^a,c   Munoz, Benito ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

MLPCN probes; Nitroisoxazole; RAS oncogene; Synthetic lethal; Chloroamide

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER CELL; CELL IMMORTALIZATION; CELL KILLING; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE EXPRESSION; GENE IDENTIFICATION; HIGH THROUGHPUT SCREENING; MOLECULAR LIBRARY; MOLECULAR PROBE; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE RAS;

EID: 84862779149     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.047     Document Type: Article

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