SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 21, 2015, Pages 4787-4792

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

(6) Larraufie, Marie Helene a Yang, Wan Seok a Jiang, Elise a Thomas, Ajit G b Slusher, Barbara S b Stockwell, Brent R a

a Och Spine at New York Presbyterian Hospitals (United States)

b JOHNS HOPKINS UNIVERSITY (United States)

Author keywords

Covalent; Erastin; Ferroptosis; Metabolic stability; Reactive carbonyl

Indexed keywords

ALDEHYDE ERASTIN; ALPHA FLUORO KETONE ERASTIN; ANTINEOPLASTIC AGENT; IMIDAZOLE KETONE ERASTIN; KETONE DERIVATIVE; KETONE ERASTIN; MORPHOLINE KETONE ERASTIN; N 4 METHOXYBENZYLPIPERAZINE KETONE ERASTIN; N ALLYLPIPERAZINE KETONE ERASTIN; N METHYLPIPERAZINE KETONE ERASTIN; PIPERAZINE ERASTIN; PIPERAZINE KETONE ERASTIN; TRIFLUOROKETONE ERASTIN; UNCLASSIFIED DRUG; WATER; ERASTIN; KETONE; MOLECULAR LIBRARY; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG POTENCY; DRUG SOLUBILITY; ELECTROPHILICITY; HUMAN; HUMAN CELL; METABOLIC STABILITY; MOUSE; NONHUMAN; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KETONES; MOLECULAR STRUCTURE; PIPERAZINES; SMALL MOLECULE LIBRARIES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 84944279993 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.07.018 Document Type: Article

Times cited : (99)

References (25)

1
- 79953314480
- J. Singh, R.C. Petter, T.A. Baillie, and A. Whitty Nat. Rev. Drug Disc. 10 2011 307
- (2011) Nat. Rev. Drug Disc. , vol.10 , pp. 307
- Singh, J.¹ Petter, R.C.² Baillie, T.A.³ Whitty, A.⁴

2
- 84859845948
- I.M. Serafimova, M.A. Pufall, S. Krishnan, K. Duda, M.S. Cohen, R.L. Maglathlin, J.M. Mcfarland, R.M. Miller, M. Frödin, and J. Taunton Nat. Chem. Biol. 8 2012 471
- (2012) Nat. Chem. Biol. , vol.8 , pp. 471
- Serafimova, I.M.¹ Pufall, M.A.² Krishnan, S.³ Duda, K.⁴ Cohen, M.S.⁵ Maglathlin, R.L.⁶ Mcfarland, J.M.⁷ Miller, R.M.⁸ Frödin, M.⁹ Taunton, J.¹⁰

3
- 84876016325
- R.M. Miller, V.O. Paavilainen, S. Krishnan, I.M. Serafimova, and J. Taunton J. Am. Chem. Soc. 135 2013 5298
- (2013) J. Am. Chem. Soc. , vol.135 , pp. 5298
- Miller, R.M.¹ Paavilainen, V.O.² Krishnan, S.³ Serafimova, I.M.⁴ Taunton, J.⁵

4
- 84865407060
- C.-U. Lee, and T.N. Grossmann Angew. Chem., Int. Ed. 51 2012 8699
- (2012) Angew. Chem., Int. Ed. , vol.51 , pp. 8699
- Lee, C.-U.¹ Grossmann, T.N.²

5
- 79851480621
- R.J. Patch, L.L. Searle, A.J. Kim, D.Y.D. De, X.Z. Zhu, H.B. Askari, J.C. O'Neill, M.C. Abad, D. Rentzeperis, J.Y. Liu, M. Kemmerer, L. Lin, J. Kasturi, J.G. Geisler, J.M. Lenhard, M.R. Player, and M.D. Gaul J. Med. Chem. 54 2011 788
- (2011) J. Med. Chem. , vol.54 , pp. 788
- Patch, R.J.¹ Searle, L.L.² Kim, A.J.³ De, D.Y.D.⁴ Zhu, X.Z.⁵ Askari, H.B.⁶ O'Neill, J.C.⁷ Abad, M.C.⁸ Rentzeperis, D.⁹ Liu, J.Y.¹⁰ Kemmerer, M.¹¹ Lin, L.¹² Kasturi, J.¹³ Geisler, J.G.¹⁴ Lenhard, J.M.¹⁵ Player, M.R.¹⁶ Gaul, M.D.¹⁷

6
- 84859587957
- B.C.S. Cross, P.J. Bond, P.G. Sadowski, B.K. Jha, J. Zak, J.M. Goodman, R.H. Silverman, T.A. Neubert, I.R. Baxendale, D. Ron, and H.P. Harding Proc. Natl. Acad. Sci. U.S.A. 109 2012 E869
- (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E869
- Cross, B.C.S.¹ Bond, P.J.² Sadowski, P.G.³ Jha, B.K.⁴ Zak, J.⁵ Goodman, J.M.⁶ Silverman, R.H.⁷ Neubert, T.A.⁸ Baxendale, I.R.⁹ Ron, D.¹⁰ Harding, H.P.¹¹

7
- 79251589342
- I. Papandreou, N.C. Denko, M. Olson, H. Van Melckebeke, S. Lust, A. Tam, D.E. Solow-Cordero, D.M. Bouley, F. Offner, M. Niwa, and A.C. Koong Blood 117 2011 1311
- (2011) Blood , vol.117 , pp. 1311
- Papandreou, I.¹ Denko, N.C.² Olson, M.³ Van Melckebeke, H.⁴ Lust, S.⁵ Tam, A.⁶ Solow-Cordero, D.E.⁷ Bouley, D.M.⁸ Offner, F.⁹ Niwa, M.¹⁰ Koong, A.C.¹¹

8
- 80053248961
- Y. Ma, B. Xu, Y. Fang, Z. Yang, J. Cui, L. Zhang, and L. Zhang Molecules 16 2011 7551
- (2011) Molecules , vol.16 , pp. 7551
- Ma, Y.¹ Xu, B.² Fang, Y.³ Yang, Z.⁴ Cui, J.⁵ Zhang, L.⁶ Zhang, L.⁷

9
- 67651160771
- W. Li, J.B. Sperry, A. Crowe, J.Q. Trojanowski, A.B. Smith III, and V.M.-Y. Lee J. Neurochem. 110 2009 1339
- (2009) J. Neurochem. , vol.110 , pp. 1339
- Li, W.¹ Sperry, J.B.² Crowe, A.³ Trojanowski, J.Q.⁴ Smith, A.B.⁵ Lee, V.M.-Y.⁶

10
- 84883441798
- S.M. Tomasio, H.P. Harding, D. Ron, B.C.S. Cross, and P.J. Bond Mol. BioSyst. 9 2013 2408
- (2013) Mol. BioSyst. , vol.9 , pp. 2408
- Tomasio, S.M.¹ Harding, H.P.² Ron, D.³ Cross, B.C.S.⁴ Bond, P.J.⁵

11
- 0031457319
- C.F. Barbas III, A. Heine, G. Zhong, T. Hoffmann, S. Gramatikova, R. Bjornestedt, B. List, J. Anderson, E.A. Stura, I.A. Wilson, and R.A. Lerner Science 278 1997 2085
- (1997) Science , vol.278 , pp. 2085
- Barbas, C.F.¹ Heine, A.² Zhong, G.³ Hoffmann, T.⁴ Gramatikova, S.⁵ Bjornestedt, R.⁶ List, B.⁷ Anderson, J.⁸ Stura, E.A.⁹ Wilson, I.A.¹⁰ Lerner, R.A.¹¹

12
- 79955092337
- D.G. Isom, C.A. Castañeda, B.R. Cannon, and E.B. Garcia-Moreno Proc. Natl. Acad. Sci. U.S.A. 108 2011 5260
- (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 5260
- Isom, D.G.¹ Castañeda, C.A.² Cannon, B.R.³ Garcia-Moreno, E.B.⁴

13
- 33846471592
- D. Conklin, R. Prough, and A. Bhatanagar Mol. BioSyst. 3 2007 136
- (2007) Mol. BioSyst. , vol.3 , pp. 136
- Conklin, D.¹ Prough, R.² Bhatanagar, A.³

14
- 0037932865
- S. Dolma, S.L. Lessnick, W.C. Hahn, and B.R. Stockwell Cancer Cell 3 2003 285
- (2003) Cancer Cell , vol.3 , pp. 285
- Dolma, S.¹ Lessnick, S.L.² Hahn, W.C.³ Stockwell, B.R.⁴

15
- 84861541814
- S.J. Dixon, K.M. Lemberg, M.R. Lamprecht, R. Skouta, E.M. Zaitsev, C.E. Gleason, D.N. Patel, A.J. Bauer, A.M. Cantley, W.S. Yang, B. Morrison, and B.R. Stockwell Cell 149 2012 1060
- (2012) Cell , vol.149 , pp. 1060
- Dixon, S.J.¹ Lemberg, K.M.² Lamprecht, M.R.³ Skouta, R.⁴ Zaitsev, E.M.⁵ Gleason, C.E.⁶ Patel, D.N.⁷ Bauer, A.J.⁸ Cantley, A.M.⁹ Yang, W.S.¹⁰ Morrison, B.¹¹ Stockwell, B.R.¹²

16
- 84892685001
- W.S. Yang, R. SriRamaratnam, M.E. Welsch, K. Shimada, R. Skouta, V.S. Viswanathan, J.H. Cheah, P.A. Clemons, A.F. Shamji, C.B. Clish, L.M. Brown, A.W. Girotti, V.W. Cornish, S.L. Schreiber, and B.R. Stockwell Cell 156 2014 317
- (2014) Cell , vol.156 , pp. 317
- Yang, W.S.¹ SriRamaratnam, R.² Welsch, M.E.³ Shimada, K.⁴ Skouta, R.⁵ Viswanathan, V.S.⁶ Cheah, J.H.⁷ Clemons, P.A.⁸ Shamji, A.F.⁹ Clish, C.B.¹⁰ Brown, L.M.¹¹ Girotti, A.W.¹² Cornish, V.W.¹³ Schreiber, S.L.¹⁴ Stockwell, B.R.¹⁵

17
- 84901323900
- S.J. Dixon, D.N. Patel, M.E. Welsch, R. Skouta, E.D. Lee, M. Hayano, A.G. Thomas, C.E. Gleason, N.P. Tatonetti, B.S. Slusher, and B.R. Stockwell eLife 3 2014 e02523
- (2014) ELife , vol.3 , pp. e02523
- Dixon, S.J.¹ Patel, D.N.² Welsch, M.E.³ Skouta, R.⁴ Lee, E.D.⁵ Hayano, M.⁶ Thomas, A.G.⁷ Gleason, C.E.⁸ Tatonetti, N.P.⁹ Slusher, B.S.¹⁰ Stockwell, B.R.¹¹

18
- 84900844060
- H. Wu, W. Wang, F. Liu, E.L. Weisberg, B. Tian, Y. Chen, B. Li, A. Wang, B. Wang, Z. Zhao, D.W. McMillin, C. Hu, H. Li, J. Wang, Y. Liang, S.J. Buhrlage, J. Liang, J. Liu, G. Yang, J.R. Brown, S.P. Treon, C.S. Mitsiades, J.D. Griffin, Q. Liu, and N.S. Gray ACS Chem. Biol. 9 2014 1086
- (2014) ACS Chem. Biol. , vol.9 , pp. 1086
- Wu, H.¹ Wang, W.² Liu, F.³ Weisberg, E.L.⁴ Tian, B.⁵ Chen, Y.⁶ Li, B.⁷ Wang, A.⁸ Wang, B.⁹ Zhao, Z.¹⁰ McMillin, D.W.¹¹ Hu, C.¹² Li, H.¹³ Wang, J.¹⁴ Liang, Y.¹⁵ Buhrlage, S.J.¹⁶ Liang, J.¹⁷ Liu, J.¹⁸ Yang, G.¹⁹ Brown, J.R.²⁰ more..

19
- 84906307152
- B.R. Lanning, L.R. Whitby, M.M. Dix, J. Douhan, A.M. Gilbert, E.C. Hett, T.O. Johnson, C. Joslyn, J.C. Kath, S. Niessen, L.R. Roberts, M.E. Schnute, C. Wang, J.J. Hulce, B. Wei, L.O. Whiteley, M.M. Hayward, and B.F. Cravatt Nat. Chem. Biol. 10 2014 760
- (2014) Nat. Chem. Biol. , vol.10 , pp. 760
- Lanning, B.R.¹ Whitby, L.R.² Dix, M.M.³ Douhan, J.⁴ Gilbert, A.M.⁵ Hett, E.C.⁶ Johnson, T.O.⁷ Joslyn, C.⁸ Kath, J.C.⁹ Niessen, S.¹⁰ Roberts, L.R.¹¹ Schnute, M.E.¹² Wang, C.¹³ Hulce, J.J.¹⁴ Wei, B.¹⁵ Whiteley, L.O.¹⁶ Hayward, M.M.¹⁷ Cravatt, B.F.¹⁸

20
- 84891496533
- R. Maha, J.R. Thomas, and C.M. Shafer Bioorg. Med. Chem. Lett. 24 2014 33
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 33
- Maha, R.¹ Thomas, J.R.² Shafer, C.M.³

21
- 19744364796
- M.S. Cohen, C. Zhang, K.M. Shokat, and J. Taunton Science 308 2005 1318
- (2005) Science , vol.308 , pp. 1318
- Cohen, M.S.¹ Zhang, C.² Shokat, K.M.³ Taunton, J.⁴

22
- 77949558462
- W. Zhou, W. Hur, U. McDermott, A. Dutt, W. Xian, S.B. Ficarro, J. Zhang, S.V. Sharma, J. Brugge, M. Meyerson, and et al. Chem. Biol. 17 2010 285
- (2010) Chem. Biol. , vol.17 , pp. 285
- Zhou, W.¹ Hur, W.² McDermott, U.³ Dutt, A.⁴ Xian, W.⁵ Ficarro, S.B.⁶ Zhang, J.⁷ Sharma, S.V.⁸ Brugge, J.⁹ Meyerson, M.¹⁰

23
- 84869479566
- F.E. Kwarcinski, C.C. Fox, M.E. Steffey, and M.B. Soellner ACS Chem. Biol. 7 2012 1910
- (2012) ACS Chem. Biol. , vol.7 , pp. 1910
- Kwarcinski, F.E.¹ Fox, C.C.² Steffey, M.E.³ Soellner, M.B.⁴

24
- 84884243421
- R.A. Ward, and et al. J. Med. Chem. 56 2013 7025
- (2013) J. Med. Chem. , vol.56 , pp. 7025
- Ward, R.A.¹

25
- 84863056297
- T. Zhang, and et al. Chem. Biol. 19 2012 140
- (2012) Chem. Biol. , vol.19 , pp. 140
- Zhang, T.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.