Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels

Methods

Volumn 92, Issue , 2016, Pages 19-35

  Robertson, Derek N ^a   Sleno, Rory ^b   Nagi, Karim ^a,c   Pétrin, Darlaine ^b   Hébert, Terence E ^b   Pineyro, Graciela ^a,c  

^a UNIVERSITY OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Biosensor; BRET; Fluxor ; High throughput screening; Kir3 channels; Nano Luc (NLuc )

Indexed keywords

G PROTEIN COUPLED RECEPTOR; ION CHANNEL; KIR3 CHANNEL; KIR3.2 CHANNEL; NANOLUCIFERASE; NANOPARTICLE; UNCLASSIFIED DRUG; FLUORESCEIN; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; NARCOTIC ANALGESIC AGENT;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; BIOSENSOR; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL BIOSENSOR; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; ION CURRENT; LIGAND BINDING; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN FUNCTION; PROTEIN SUBUNIT; STIMULATION; TRANSPORT KINETICS; ANIMAL; CHANNEL GATING; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; GENETIC PROCEDURES; HEK293 CELL LINE; METABOLISM; MOUSE; PHYSIOLOGY; PROCEDURES; PROTEIN CONFORMATION; SYNTHESIS;

ANALGESICS, OPIOID; ANIMALS; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER TECHNIQUES; BIOSENSING TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FLUORESCEIN; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MICE; PROTEIN CONFORMATION;

EID: 84983195541     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2015.07.011     Document Type: Article

References (47)

1. Wickenden A., Priest B., Erdemli G. Future Med. Chem. 2012, 4(5):661-679.
2. Picones A. Curr. Top. Med. Chem. 2015, 15(7):631-637.
3. Du Y., et al. ACS Chem. Neurosci. 2015.
4. Kofuji P., Davidson N., Lester H.A. Proc. Natl. Acad. Sci. U.S.A. 1995, 92(14):6542-6546.
5. Keith D.E., et al. J. Biol. Chem. 1996, 271(32):19021-19024.
6. Rebois R.V., et al. Cell. Signal. 2012, 24(11):2051-2060.
7. Lavine N., et al. J. Biol. Chem. 2002, 277(48):46010-46019.
8. Richard-Lalonde M., et al. Mol. Pharmacol. 2013, 83(2):416-428.
9. Goupil E., et al. J. Biol. Chem. 2010, 285(33):25624-25636.
10. Hoffmann C., et al. Nat. Protoc. 2010, 5(10):1666-1677.
11. Hibino H., et al. Physiol. Rev. 2010, 90(1):291-366.
12. Luscher C., Slesinger P.A. Nat. Rev. Neurosci. 2010, 11(5):301-315.
13. Wydeven N., et al. Proc. Natl. Acad. Sci. U.S.A. 2014, 111(29):10755-10760.
14. Nagi K., Pineyro G. Front. Cell. Neurosci. 2014, 8:186.
15. McCoy J.G., Nimigean C.M. Biochim. Biophys. Acta 2012, 1818(2):272-285.
16. Loening A.M., Fenn T.D., Gambhir S.S. J. Mol. Biol. 2007, 374(4):1017-1028.
17. Hall M.P., et al. ACS Chem. Biol. 2012, 7(11):1848-1857.
18. Hoffmann C., et al. Nat. Methods 2005, 2(3):171-176.
19. Whorton M.R., MacKinnon R. Nature 2013, 498(7453):190-197.
20. Clarke O.B., et al. Cell 2010, 141(6):1018-1029.
21. Schoots O., et al. Cell. Signal. 1999, 11(12):871-883.
22. Shi Y., et al. Neurosci. Res. 2000, 36(3):209-214.
23. Krapivinsky G., et al. Nature 1995, 374(6518):135-141.
24. Liao Y.J., Jan Y.N., Jan L.Y. J. Neurosci. 1996, 16(22):7137-7150.
25. Ma D., et al. Neuron 2002, 33(5):715-729.
26. Pfleger K.D., Eidne K.A. Nat. Methods 2006, 3(3):165-174.
27. Zylbergold P., et al. Front. Cell. Neurosci. 2014, 8:108.
28. Sleno R., et al. Methods 2016, 92:11-18.
29. Aryal P., et al. Nat. Neurosci. 2009, 12(8):988-995.
30. Kaufmann K., et al. ACS Chem. Neurosci. 2013, 4(9):1278-1286.
31. Dacres H., et al. Biochem. Biophys. Res. Commun. 2012, 425(3):625-629.
32. Hamdan F.F., et al. J. Biomol. Screen. 2005, 10(5):463-475.
33. Tudashki H.B., et al. Mol. Pharmacol. 2014, 85(1):148-161.
34. Plobeck N., et al. J. Med. Chem. 2000, 43(21):3878-3894.
35. Wei Z.Y., et al. J. Med. Chem. 2000, 43(21):3895-3905.
36. Audet N., et al. J. Biol. Chem. 2008, 283(22):15078-15088.
37. Gales C., et al. Nat. Struct. Mol. Biol. 2006, 13(9):778-786.
38. Charfi I., et al. Cell. Mol. Life Sci. 2014, 71(8):1529-1546.
39. Nishida M., et al. EMBO J. 2007, 26(17):4005-4015.
40. Whorton M.R., MacKinnon R. Cell 2011, 147(1):199-208.
41. Sadja R., et al. Neuron 2001, 29(3):669-680.
42. Riven I., et al. Neuron 2003, 38(2):225-235.
43. Pradhan A.A., et al. PLoS One 2009, 4(5):e5425.
44. Scott J.K., et al. EMBO J. 2001, 20(4):767-776.
45. Kobayashi T., et al. Nat. Neurosci. 1999, 2(12):1091-1097.
46. Audet N., et al. J. Neurosci. 2012, 32(14):4827-4840.
47. Nagi K., Charfi I., Pineyro G. Cell. Mol. Life Sci. 2015.