Designing BRET-based conformational biosensors for G protein-coupled receptors

Methods

Volumn 92, Issue , 2016, Pages 11-18

  Sleno, Rory ^a   Pétrin, Darlaine ^a   Devost, Dominic ^a   Goupil, Eugénie ^a   Zhang, Alice ^a   Hébert, Terence E ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Biased signaling; Biosensor; G protein coupled receptor; Resonance energy transfer; Screening

Indexed keywords

G PROTEIN COUPLED RECEPTOR; HOMODIMER; PROSTAGLANDIN F2 ALPHA; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; FLUORESCENT DYE; RENILLA LUCIFERIN 2 MONOOXYGENASE;

ARTICLE; BIOSENSOR; CARBOXY TERMINAL SEQUENCE; CELL DENSITY; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EQUIPMENT DESIGN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROTEIN CONFORMATION; PROTEIN MOTIF; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CHEMISTRY; DRUG DESIGN; GENETIC PROCEDURES; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN SECONDARY STRUCTURE; SYNTHESIS;

ADENOSINE A2 RECEPTOR ANTAGONISTS; AMINO ACID SEQUENCE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER TECHNIQUES; BIOSENSING TECHNIQUES; DRUG DESIGN; FLUORESCENT DYES; HEK293 CELLS; HUMANS; LUCIFERASES, RENILLA; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, ADENOSINE A2A; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84983138417     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2015.05.003     Document Type: Article

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