New diarylmethylpiperazines as potent and selective nonpeptidic δ opioid receptor agonists with increased in vitro metabolic stability

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3878-3894

  Plobeck, N ^a   Delorme, D ^a,b   Wei, Z Y ^a   Yang, H ^a   Zhou, F ^a   Schwarz, P ^a   Gawell, L ^a   Gagnon, H ^a   Pelcman, B ^a   Schmidt, R ^a   Yue, S Y ^a   Walpole, C ^a   Brown, W ^a   Zhou, E ^a   Labare, M ^a   Payza, K ^a   St Ogne, S ^a   Kamassah, A ^a   Morin, P E ^a   Projean, D ^a   Ducharme, J ^a   Roberts, E ^a,c   more..

^a ASTRAZENECA   (United Kingdom)

^b METHYLGENE INC   (Canada)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 HYDROXYBENZYL] N,N DIETHYLBENZAMIDE; 4 [ALPHA (4 ALLYL 2,5 DIMETHYL 1 PIPERAZINYL) 3 METHOXYBENZYL] N,N DIETHYLBENZAMIDE; ANALGESIC AGENT; DELTA OPIATE RECEPTOR AGONIST; N,N DIETHYL 4 [1 PIPERAZINYL(8 QUINOLINYL) METHYL]BENZAMIDE; PHENYL GROUP; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHEMICAL MUTAGENESIS; CHIRALITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; MOLECULAR WEIGHT; NONHUMAN; PHARMACOPHORE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; BIOLOGICAL AVAILABILITY; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; PIPERAZINES; QUINOLINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRANSFECTION;

EID: 0034687224     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000228x     Document Type: Article

References (33)

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