Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 29, 2014, Pages 10755-10760

  Wydeven, Nicole ^a   Marron Fernandez De Velasco, Ezequiel ^a   Du, Yu ^a   Benneyworth, Michael A ^b   Hearing, Matthew C ^b   Fischer, Rachel A ^b   Thomas, Mark John ^b   Weaver, C David ^a   Wickman, Kevin ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Electrophysiology; Structure activity relationship

Indexed keywords

AMINO ACID; ANXIOLYTIC AGENT; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL 1; ML 297; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SUBUNIT; TRANQUILIZING ACTIVITY;

ELECTROPHYSIOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP;

AMINO ACID SEQUENCE; ANIMALS; ANTI-ANXIETY AGENTS; BACLOFEN; BEHAVIOR, ANIMAL; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HIPPOCAMPUS; ION CHANNEL GATING; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEURONS; PHENYLUREA COMPOUNDS; PYRAZOLES;

EID: 84904607104     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1405190111     Document Type: Article

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