A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2α-mediated Rho/ROCK Signaling Pathway

Journal of Biological Chemistry

Volumn 285, Issue 33, 2010, Pages 25624-25636

  Goupil, Eugénie ^a,b   Tassy, Danaë ^c   Bourguet, Carine ^c   Quiniou, Christiane ^d   Wisehart, Veronica ^a   Pétrin, Darlaine ^b   Le Gouill, Christian ^c   Devost, Dominic ^b   Zingg, Hans H ^b   Bouvier, Michel ^c   Uri Saragovi, Horacio ^b   Chemtob, Sylvain ^b,d   Lubell, William D ^c   Claing, Audrey ^c   Hébert, Terence E ^b   Laporte, Stéphane A ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; CELL RESPONSE; EXTRACELLULAR LOOPS; KEY REGULATORS; LIPOPOLYSACCHARIDES; MODULATING EFFECT; PEPTIDOMIMETICS; POSITIVE ALLOSTERIC MODULATOR; PRETERM LABOR; PROTEIN KINASE C; RECEPTOR SIGNALING; SIGNALING PATHWAYS; TERMINAL REGIONS;

MODULATION; MODULATORS; PIGMENTS;

SIGNALING;

ACTIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; PDC 113824; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN RECEPTOR; PROTEIN KINASE C; RHO KINASE; UNCLASSIFIED DRUG; UTERUS SPASMOLYTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; LABOR INHIBITION; MOUSE; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UTERUS CONTRACTION;

ALLOSTERIC REGULATION; ANIMALS; CELL LINE; DINOPROST; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; OBSTETRIC LABOR, PREMATURE; PARTURITION; PEPTIDES; PREGNANCY; PROTEIN KINASE C; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

MUS;

EID: 77955478709     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.115196     Document Type: Article

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