-
1
-
-
1842633820
-
The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations
-
Allen, K.V., B.M. Frier, and M.W. Strachan. 2004. The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations. Eur. J. Pharmacol. 490:169-175. http://dx.doi.org/10.1016/j.ejphar.2004.02.054
-
(2004)
Eur. J. Pharmacol
, vol.490
, pp. 169-175
-
-
Allen, K.V.1
Frier, B.M.2
Strachan, M.W.3
-
2
-
-
78651274000
-
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
-
Baker, L.D., D.J. Cross, S. Minoshima, D. Belongia, G.S. Watson, and S. Craft. 2011. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 68:51-57. http://dx.doi.org/10.1001/archneurol.2010.225
-
(2011)
Arch. Neurol
, vol.68
, pp. 51-57
-
-
Baker, L.D.1
Cross, D.J.2
Minoshima, S.3
Belongia, D.4
Watson, G.S.5
Craft, S.6
-
3
-
-
1842734659
-
The source of cerebral insulin
-
Banks, W.A. 2004. The source of cerebral insulin. Eur. J. Pharmacol. 490:5-12. http://dx.doi.org/10.1016/j.ejphar.2004.02.040
-
(2004)
Eur. J. Pharmacol
, vol.490
, pp. 5-12
-
-
Banks, W.A.1
-
4
-
-
0031456345
-
Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays
-
Banks, W.A., J.B. Jaspan, and A.J. Kastin. 1997. Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides. 18:1257-1262. http://dx.doi.org/10.1016/S0196-9781(97)00198-8
-
(1997)
Peptides
, vol.18
, pp. 1257-1262
-
-
Banks, W.A.1
Jaspan, J.B.2
Kastin, A.J.3
-
5
-
-
84860452103
-
Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo
-
Becker, K., S. Freude, J. Zemva, O. Stöhr, W. Krone, and M. Schubert. 2012. Chronic peripheral hyperinsulinemia has no substantial influence on tau phosphorylation in vivo. Neurosci. Lett. 516:306-310. http://dx.doi.org/10.1016/j.neulet.2012.04.022
-
(2012)
Neurosci. Lett
, vol.516
, pp. 306-310
-
-
Becker, K.1
Freude, S.2
Zemva, J.3
Stöhr, O.4
Krone, W.5
Schubert, M.6
-
6
-
-
84903220594
-
Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?
-
Biessels, G.J., and Y.D. Reijmer. 2014. Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI? Diabetes. 63:2244-2252. http://dx.doi.org/10.2337/db14-0348
-
(2014)
Diabetes
, vol.63
, pp. 2244-2252
-
-
Biessels, G.J.1
Reijmer, Y.D.2
-
7
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
-
Bomfim, T.R., L. Forny-Germano, L.B. Sathler, J. Brito-Moreira, J.C. Houzel, H. Decker, M.A. Silverman, H. Kazi, H.M. Melo, P.L. McClean, et al. 2012. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. J. Clin. Invest. 122:1339-1353. http://dx.doi.org/10.1172/JCI57256
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
Brito-Moreira, J.4
Houzel, J.C.5
Decker, H.6
Silverman, M.A.7
Kazi, H.8
Melo, H.M.9
McClean, P.L.10
-
8
-
-
0021271479
-
Reduction of food intake and body weight by chronic intraventricular insulin infusion
-
Brief, D.J., and J.D. Davis. 1984. Reduction of food intake and body weight by chronic intraventricular insulin infusion. Brain Res. Bull. 12:571-575. http://dx.doi.org/10.1016/0361-9230(84)90174-6
-
(1984)
Brain Res. Bull
, vol.12
, pp. 571-575
-
-
Brief, D.J.1
Davis, J.D.2
-
9
-
-
0020534018
-
Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type
-
Bucht, G., R. Adolfsson, F. Lithner, and B. Winblad. 1983. Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type. Acta Med. Scand. 213:387-392. http://dx.doi.org/10.1111/j.0954-6820.1983.tb03756.x
-
(1983)
Acta Med. Scand
, vol.213
, pp. 387-392
-
-
Bucht, G.1
Adolfsson, R.2
Lithner, F.3
Winblad, B.4
-
10
-
-
84961208572
-
Hyperglycemia Increases the Production of Amyloid β-peptide leading to decreased endothelial tight junction
-
Chao, A.C., T.C. Lee, S.H. Juo, and D.I. Yang. 2016. Hyperglycemia Increases the Production of Amyloid β-peptide leading to decreased endothelial tight junction. CNS Neurosci. Ther. 22:291-297. http://dx.doi.org/10.1111/cns.12503
-
(2016)
CNS Neurosci. Ther
, vol.22
, pp. 291-297
-
-
Chao, A.C.1
Lee, T.C.2
Juo, S.H.3
Yang, D.I.4
-
11
-
-
84906776296
-
Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice
-
Chen, Y., Y. Zhao, C.L. Dai, Z. Liang, X. Run, K. Iqbal, F. Liu, and C.X. Gong. 2014. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Exp. Neurol. 261:610-619. http://dx.doi.org/10.1016/j.expneurol.2014.06.004
-
(2014)
Exp. Neurol
, vol.261
, pp. 610-619
-
-
Chen, Y.1
Zhao, Y.2
Dai, C.L.3
Liang, Z.4
Run, X.5
Iqbal, K.6
Liu, F.7
Gong, C.X.8
-
12
-
-
84860176886
-
Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice
-
Chua, L.M., M.L. Lim, P.R. Chong, Z.P. Hu, N.S. Cheung, and B.S. Wong. 2012. Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice. J. Alzheimers Dis. 29:783-791.
-
(2012)
J. Alzheimers Dis
, vol.29
, pp. 783-791
-
-
Chua, L.M.1
Lim, M.L.2
Chong, P.R.3
Hu, Z.P.4
Cheung, N.S.5
Wong, B.S.6
-
13
-
-
84878864610
-
Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
-
Claxton, A., L.D. Baker, C.W. Wilkinson, E.H. Trittschuh, D. Chapman, G.S. Watson, B. Cholerton, S.R. Plymate, M. Arbuckle, and S. Craft. 2013. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. J. Alzheimers Dis. 35:789-797. http://dx.doi.org/10.3233/JAD-122308
-
(2013)
J. Alzheimers Dis
, vol.35
, pp. 789-797
-
-
Claxton, A.1
Baker, L.D.2
Wilkinson, C.W.3
Trittschuh, E.H.4
Chapman, D.5
Watson, G.S.6
Cholerton, B.7
Plymate, S.R.8
Arbuckle, M.9
Craft, S.10
-
14
-
-
84928137990
-
Long acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia
-
Claxton, A., L.D. Baker, A. Hanson, E.H. Trittschuh, B. Cholerton, A. Morgan, M. Callaghan, M. Arbuckle, C. Behl, and S. Craft. 2015. Long acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J. Alzheimers Dis. 45:1269-1270. http://dx.doi.org/10.3233/JAD-15900
-
(2015)
J. Alzheimers Dis
, vol.45
, pp. 1269-1270
-
-
Claxton, A.1
Baker, L.D.2
Hanson, A.3
Trittschuh, E.H.4
Cholerton, B.5
Morgan, A.6
Callaghan, M.7
Arbuckle, M.8
Behl, C.9
Craft, S.10
-
15
-
-
0030053556
-
Memory improvement following induced hyperinsulinemia in Alzheimer's disease
-
Craft, S., J. Newcomer, S. Kanne, S. Dagogo-Jack, P. Cryer, Y. Sheline, J. Luby, A. Dagogo-Jack, and A. Alderson. 1996. Memory improvement following induced hyperinsulinemia in Alzheimer's disease. Neurobiol. Aging. 17:123-130.
-
(1996)
Neurobiol. Aging
, vol.17
, pp. 123-130
-
-
Craft, S.1
Newcomer, J.2
Kanne, S.3
Dagogo-Jack, S.4
Cryer, P.5
Sheline, Y.6
Luby, J.7
Dagogo-Jack, A.8
Alderson, A.9
-
16
-
-
0031907459
-
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype
-
Craft, S., E. Peskind, M.W. Schwartz, G.D. Schellenberg, M. Raskind, and D. Porte Jr. 1998. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology. 50:164-168. http://dx.doi.org/10.1212/WNL.50.1.164
-
(1998)
Neurology
, vol.50
, pp. 164-168
-
-
Craft, S.1
Peskind, E.2
Schwartz, M.W.3
Schellenberg, G.D.4
Raskind, M.5
Porte, D.6
-
17
-
-
0032737079
-
Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose
-
Craft, S., S. Asthana, J.W. Newcomer, C.W. Wilkinson, I.T. Matos, L.D. Baker, M. Cherrier, C. Lofgreen, S. Latendresse, A. Petrova, et al. 1999. Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose. Arch. Gen. Psychiatry. 56:1135-1140. http://dx.doi.org/10.1001/archpsyc.56.12.1135
-
(1999)
Arch. Gen. Psychiatry
, vol.56
, pp. 1135-1140
-
-
Craft, S.1
Asthana, S.2
Newcomer, J.W.3
Wilkinson, C.W.4
Matos, I.T.5
Baker, L.D.6
Cherrier, M.7
Lofgreen, C.8
Latendresse, S.9
Petrova, A.10
-
18
-
-
0034016848
-
Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
-
Craft, S., S. Asthana, G. Schellenberg, L. Baker, M. Cherrier, A.A. Boyt, R.N. Martins, M. Raskind, E. Peskind, and S. Plymate. 2000. Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype. Ann. N. Y. Acad. Sci. 903:222-228. http://dx.doi.org/10.1111/j.1749-6632.2000.tb06371.x
-
(2000)
Ann. N. Y. Acad. Sci
, vol.903
, pp. 222-228
-
-
Craft, S.1
Asthana, S.2
Schellenberg, G.3
Baker, L.4
Cherrier, M.5
Boyt, A.A.6
Martins, R.N.7
Raskind, M.8
Peskind, E.9
Plymate, S.10
-
19
-
-
0038177803
-
Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype
-
Craft, S., S. Asthana, D.G. Cook, L.D. Baker, M. Cherrier, K. Purganan, C. Wait, A. Petrova, S. Latendresse, G.S. Watson, et al. 2003. Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype. Psychoneuroendocrinology. 28:809-822. http://dx.doi.org/10.1016/S0306-4530(02)00087-2
-
(2003)
Psychoneuroendocrinology
, vol.28
, pp. 809-822
-
-
Craft, S.1
Asthana, S.2
Cook, D.G.3
Baker, L.D.4
Cherrier, M.5
Purganan, K.6
Wait, C.7
Petrova, A.8
Latendresse, S.9
Watson, G.S.10
-
20
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
-
Craft, S., L.D. Baker, T.J. Montine, S. Minoshima, G.S. Watson, A. Claxton, M. Arbuckle, M. Callaghan, E. Tsai, S.R. Plymate, et al. 2012. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch. Neurol. 69:29-38. http://dx.doi.org/10.1001/archneurol.2011.233
-
(2012)
Arch. Neurol
, vol.69
, pp. 29-38
-
-
Craft, S.1
Baker, L.D.2
Montine, T.J.3
Minoshima, S.4
Watson, G.S.5
Claxton, A.6
Arbuckle, M.7
Callaghan, M.8
Tsai, E.9
Plymate, S.R.10
-
21
-
-
68149091969
-
Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report
-
Dankner, R., A. Chetrit, M.H. Shanik, I. Raz, and J. Roth. 2009. Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report. Diabetes Care. 32:1464-1466. http://dx.doi.org/10.2337/dc09-0153
-
(2009)
Diabetes Care
, vol.32
, pp. 1464-1466
-
-
Dankner, R.1
Chetrit, A.2
Shanik, M.H.3
Raz, I.4
Roth, J.5
-
22
-
-
60549084867
-
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers
-
De Felice, F.G., M.N. Vieira, T.R. Bomfim, H. Decker, P.T. Velasco, M.P. Lambert, K.L. Viola, W.Q. Zhao, S.T. Ferreira, and W.L. Klein. 2009. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers. Proc. Natl. Acad. Sci. USA. 106:1971-1976. http://dx.doi.org/10.1073/pnas.0809158106
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.2
Bomfim, T.R.3
Decker, H.4
Velasco, P.T.5
Lambert, M.P.6
Viola, K.L.7
Zhao, W.Q.8
Ferreira, S.T.9
Klein, W.L.10
-
23
-
-
84860389468
-
Insulin effects in muscle and adipose tissue
-
Dimitriadis, G., P. Mitrou, V. Lambadiari, E. Maratou, and S.A. Raptis. 2011. Insulin effects in muscle and adipose tissue. Diabetes Res. Clin. Pract. 93:S52-S59. http://dx.doi.org/10.1016/S0168-8227(11)70014-6
-
(2011)
Diabetes Res. Clin. Pract
, vol.93
, pp. S52-S59
-
-
Dimitriadis, G.1
Mitrou, P.2
Lambadiari, V.3
Maratou, E.4
Raptis, S.A.5
-
24
-
-
33749342069
-
Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin
-
Draznin, B. 2006. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes. 55:2392-2397. http://dx.doi.org/10.2337/db06-0391
-
(2006)
Diabetes
, vol.55
, pp. 2392-2397
-
-
Draznin, B.1
-
25
-
-
84858631674
-
The many faces of insulin-like peptide signalling in the brain
-
Fernandez, A.M., and I. Torres-Alemán. 2012. The many faces of insulin-like peptide signalling in the brain. Nat. Rev. Neurosci. 13:225-239. http://dx.doi.org/10.1038/nrn3209
-
(2012)
Nat. Rev. Neurosci
, vol.13
, pp. 225-239
-
-
Fernandez, A.M.1
Torres-Alemán, I.2
-
26
-
-
26444553356
-
Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
-
Fishel, M.A., G.S. Watson, T.J. Montine, Q. Wang, P.S. Green, J.J. Kulstad, D.G. Cook, E.R. Peskind, L.D. Baker, D. Goldgaber, et al. 2005. Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults. Arch. Neurol. 62:1539-1544. http://dx.doi.org/10.1001/archneur.62.10.noc50112
-
(2005)
Arch. Neurol
, vol.62
, pp. 1539-1544
-
-
Fishel, M.A.1
Watson, G.S.2
Montine, T.J.3
Wang, Q.4
Green, P.S.5
Kulstad, J.J.6
Cook, D.G.7
Peskind, E.R.8
Baker, L.D.9
Goldgaber, D.10
-
27
-
-
33644698732
-
Peripheral hyperinsulinemia promotes tau phosphorylation in vivo
-
Freude, S., L. Plum, J. Schnitker, U. Leeser, M. Udelhoven, W. Krone, J.C. Bruning, and M. Schubert. 2005. Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. Diabetes. 54:3343-3348. http://dx.doi.org/10.2337/diabetes.54.12.3343
-
(2005)
Diabetes
, vol.54
, pp. 3343-3348
-
-
Freude, S.1
Plum, L.2
Schnitker, J.3
Leeser, U.4
Udelhoven, M.5
Krone, W.6
Bruning, J.C.7
Schubert, M.8
-
28
-
-
70349672704
-
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
-
Freude, S., M.M. Hettich, C. Schumann, O. Stöhr, L. Koch, C. Köhler, M. Udelhoven, U. Leeser, M. Müller, N. Kubota, et al. 2009. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FAS EB J. 23:3315-3324. http://dx.doi.org/10.1096/fj.09-132043
-
(2009)
FAS EB J
, vol.23
, pp. 3315-3324
-
-
Freude, S.1
Hettich, M.M.2
Schumann, C.3
Stöhr, O.4
Koch, L.5
Köhler, C.6
Udelhoven, M.7
Leeser, U.8
Müller, M.9
Kubota, N.10
-
29
-
-
15444339756
-
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
-
Frölich, L., D. Blum-Degen, H.G. Bernstein, S. Engelsberger, J. Humrich, S. Laufer, D. Muschner, A. Thalheimer, A. Türk, S. Hoyer, et al. 1998. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm (Vienna). 105:423-438. http://dx.doi.org/10.1007/s007020050068
-
(1998)
J Neural Transm (Vienna)
, vol.105
, pp. 423-438
-
-
Frölich, L.1
Blum-Degen, D.2
Bernstein, H.G.3
Engelsberger, S.4
Humrich, J.5
Laufer, S.6
Muschner, D.7
Thalheimer, A.8
Türk, A.9
Hoyer, S.10
-
30
-
-
0026332340
-
Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type
-
Fujisawa, Y., K. Sasaki, and K. Akiyama. 1991. Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type. Biol. Psychiatry. 30:1219-1228. http://dx.doi.org/10.1016/0006-3223(91)90158-I
-
(1991)
Biol. Psychiatry
, vol.30
, pp. 1219-1228
-
-
Fujisawa, Y.1
Sasaki, K.2
Akiyama, K.3
-
31
-
-
0035871641
-
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling
-
Gasparini, L., G.K. Gouras, R. Wang, R.S. Gross, M.F. Beal, P. Greengard, and H. Xu. 2001. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling. J. Neurosci. 21:2561-2570.
-
(2001)
J. Neurosci
, vol.21
, pp. 2561-2570
-
-
Gasparini, L.1
Gouras, G.K.2
Wang, R.3
Gross, R.S.4
Beal, M.F.5
Greengard, P.6
Xu, H.7
-
32
-
-
78650962354
-
Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease
-
Gil-Bea, F.J., M. Solas, A. Solomon, C. Mugueta, B. Winblad, M. Kivipelto, M.J. Ramirez, and A. Cedazo-Mínguez. 2010. Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease. J. Alzheimers Dis. 22:405-413.
-
(2010)
J. Alzheimers Dis
, vol.22
, pp. 405-413
-
-
Gil-Bea, F.J.1
Solas, M.2
Solomon, A.3
Mugueta, C.4
Winblad, B.5
Kivipelto, M.6
Ramirez, M.J.7
Cedazo-Mínguez, A.8
-
33
-
-
16244391770
-
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
-
Griffin, R.J., A. Moloney, M. Kelliher, J.A. Johnston, R. Ravid, P. Dockery, R. O'Connor, and C. O'Neill. 2005. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93:105-117. http://dx.doi.org/10.1111/j.1471-4159.2004.02949.x
-
(2005)
J. Neurochem
, vol.93
, pp. 105-117
-
-
Griffin, R.J.1
Moloney, A.2
Kelliher, M.3
Johnston, J.A.4
Ravid, R.5
Dockery, P.6
O'Connor, R.7
O'Neill, C.8
-
34
-
-
84862272293
-
Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases
-
Ho, L., S. Yemul, L. Knable, P. Katsel, R. Zhao, V. Haroutunian, and G.M. Pasinetti. 2012. Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases. Int. J. Alzheimers Dis. 2012:321280. http://dx.doi.org/1155/2012/321280
-
(2012)
Int. J. Alzheimers Dis
, vol.2012
, pp. 321280
-
-
Ho, L.1
Yemul, S.2
Knable, L.3
Katsel, P.4
Zhao, R.5
Haroutunian, V.6
Pasinetti, G.M.7
-
35
-
-
79953854897
-
Alzheimer's disease: the challenge of the second century
-
Holtzman, D.M., J.C. Morris, and A.M. Goate. 2011. Alzheimer's disease: the challenge of the second century. Sci. Transl. Med. 3:77sr1. http://dx.doi.org/10.1126/scitranslmed.3002369
-
(2011)
Sci. Transl. Med
, vol.3
, pp. 77-81
-
-
Holtzman, D.M.1
Morris, J.C.2
Goate, A.M.3
-
36
-
-
84974594070
-
Insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of Alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults
-
Hoscheidt, S.M., E.J. Starks, J.M. Oh, H. Zetterberg, K. Blennow, R.A. Krause, C.E. Gleason, L. Puglielli, C.S. Atwood, C.M. Carlsson, et al. 2016. Insulin resistance is associated with increased levels of cerebrospinal fluid biomarkers of Alzheimer's disease and reduced memory function in at-risk healthy middle-aged adults. J. Alzheimers Dis. 12:1373-1383. http://dx.doi.org/10.3233/JAD-160110
-
(2016)
J. Alzheimers Dis
, vol.12
, pp. 1373-1383
-
-
Hoscheidt, S.M.1
Starks, E.J.2
Oh, J.M.3
Zetterberg, H.4
Blennow, K.5
Krause, R.A.6
Gleason, C.E.7
Puglielli, L.8
Atwood, C.S.9
Carlsson, C.M.10
-
37
-
-
0842309993
-
Increased risk of type 2 diabetes in Alzheimer disease
-
Janson, J., T. Laedtke, J.E. Parisi, P. O'Brien, R.C. Petersen, and P.C. Butler. 2004. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes. 53:474-481. http://dx.doi.org/10.2337/diabetes.53.2.474
-
(2004)
Diabetes
, vol.53
, pp. 474-481
-
-
Janson, J.1
Laedtke, T.2
Parisi, J.E.3
O'Brien, P.4
Petersen, R.C.5
Butler, P.C.6
-
38
-
-
84924870696
-
Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease
-
Kapogiannis, D., A. Boxer, J.B. Schwartz, E.L. Abner, A. Biragyn, U. Masharani, L. Frassetto, R.C. Petersen, B.L. Miller, and E.J. Goetzl. 2015. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FAS EB J. 29:589-596. http://dx.doi.org/10.1096/fj.14-262048
-
(2015)
FAS EB J
, vol.29
, pp. 589-596
-
-
Kapogiannis, D.1
Boxer, A.2
Schwartz, J.B.3
Abner, E.L.4
Biragyn, A.5
Masharani, U.6
Frassetto, L.7
Petersen, R.C.8
Miller, B.L.9
Goetzl, E.J.10
-
39
-
-
9844229370
-
Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study
-
Kuusisto, J., K. Koivisto, L. Mykkänen, E.L. Helkala, M. Vanhanen, T. Hänninen, K. Kervinen, Y.A. Kesäniemi, P.J. Riekkinen, and M. Laakso. 1997. Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study. BMJ. 315:1045-1049. http://dx.doi.org/10.1136/bmj.315.7115.1045
-
(1997)
BMJ
, vol.315
, pp. 1045-1049
-
-
Kuusisto, J.1
Koivisto, K.2
Mykkänen, L.3
Helkala, E.L.4
Vanhanen, M.5
Hänninen, T.6
Kervinen, K.7
Kesäniemi, Y.A.8
Riekkinen, P.J.9
Laakso, M.10
-
40
-
-
34247601573
-
Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity
-
Last, D., D.C. Alsop, A.M. Abduljalil, R.P. Marquis, C. de Bazelaire, K. Hu, J. Cavallerano, and V. Novak. 2007. Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care. 30:1193-1199. http://dx.doi.org/10.2337/dc06-2052
-
(2007)
Diabetes Care
, vol.30
, pp. 1193-1199
-
-
Last, D.1
Alsop, D.C.2
Abduljalil, A.M.3
Marquis, R.P.4
de Bazelaire, C.5
Hu, K.6
Cavallerano, J.7
Novak, V.8
-
41
-
-
79960896430
-
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
-
Liu, Y., F. Liu, I. Grundke-Iqbal, K. Iqbal, and C.X. Gong. 2011. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J. Pathol. 225:54-62. http://dx.doi.org/10.1002/path.2912
-
(2011)
J. Pathol
, vol.225
, pp. 54-62
-
-
Liu, Y.1
Liu, F.2
Grundke-Iqbal, I.3
Iqbal, K.4
Gong, C.X.5
-
42
-
-
5344256250
-
Hyperinsulinemia and risk of Alzheimer disease
-
Luchsinger, J.A., M.X. Tang, S. Shea, and R. Mayeux. 2004. Hyperinsulinemia and risk of Alzheimer disease. Neurology. 63:1187-1192. http://dx.doi.org/10.1212/01.WNL.0000140292.04932.87
-
(2004)
Neurology
, vol.63
, pp. 1187-1192
-
-
Luchsinger, J.A.1
Tang, M.X.2
Shea, S.3
Mayeux, R.4
-
43
-
-
84960094032
-
Peripheral blood adipokines and insulin levels in patients with Alzheimer's disease: a replication study and meta-analysis
-
Ma, J., W. Zhang, H.F. Wang, Z.X. Wang, T. Jiang, M.S. Tan, J.T. Yu, and L. Tan. 2016. Peripheral blood adipokines and insulin levels in patients with Alzheimer's disease: a replication study and meta-analysis. Curr. Alzheimer Res. 13:223-233. http://dx.doi.org/10.2174/156720501303160217111434
-
(2016)
Curr. Alzheimer Res
, vol.13
, pp. 223-233
-
-
Ma, J.1
Zhang, W.2
Wang, H.F.3
Wang, Z.X.4
Jiang, T.5
Tan, M.S.6
Yu, J.T.7
Tan, L.8
-
44
-
-
67650729973
-
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin
-
Ma, Q.L., F. Yang, E.R. Rosario, O.J. Ubeda, W. Beech, D.J. Gant, P.P. Chen, B. Hudspeth, C. Chen, Y. Zhao, et al. 2009. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J. Neurosci. 29:9078-9089. http://dx.doi.org/10.1523/JNEUROSCI.1071-09.2009
-
(2009)
J. Neurosci
, vol.29
, pp. 9078-9089
-
-
Ma, Q.L.1
Yang, F.2
Rosario, E.R.3
Ubeda, O.J.4
Beech, W.5
Gant, D.J.6
Chen, P.P.7
Hudspeth, B.8
Chen, C.9
Zhao, Y.10
-
45
-
-
84930405360
-
Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo
-
Macauley, S.L., M. Stanley, E.E. Caesar, S.A. Yamada, M.E. Raichle, R. Perez, T.E. Mahan, C.L. Sutphen, and D.M. Holtzman. 2015. Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo. J. Clin. Invest. 125:2463-2467. http://dx.doi.org/10.1172/JCI79742
-
(2015)
J. Clin. Invest
, vol.125
, pp. 2463-2467
-
-
Macauley, S.L.1
Stanley, M.2
Caesar, E.E.3
Yamada, S.A.4
Raichle, M.E.5
Perez, R.6
Mahan, T.E.7
Sutphen, C.L.8
Holtzman, D.M.9
-
46
-
-
84922702230
-
Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease
-
Alzheimer's Disease Neuroimaging Initiative
-
Maioli, S., M. Lodeiro, P. Merino-Serrais, F. Falahati, W. Khan, E. Puerta, A. Codita, R. Rimondini, M.J. Ramirez, A. Simmons, et al. Alzheimer's Disease Neuroimaging Initiative. 2015. Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease. Aging Cell. 14:122-129. http://dx.doi.org/10.1111/acel.12281
-
(2015)
Aging Cell
, vol.14
, pp. 122-129
-
-
Maioli, S.1
Lodeiro, M.2
Merino-Serrais, P.3
Falahati, F.4
Khan, W.5
Puerta, E.6
Codita, A.7
Rimondini, R.8
Ramirez, M.J.9
Simmons, A.10
-
47
-
-
80053624120
-
Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes
-
McNay, E.C., and A.K. Recknagel. 2011. Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiol. Learn. Mem. 96:432-442. http://dx.doi.org/10.1016/j.nlm.2011.08.005
-
(2011)
Neurobiol. Learn. Mem
, vol.96
, pp. 432-442
-
-
McNay, E.C.1
Recknagel, A.K.2
-
48
-
-
77952545095
-
Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance
-
McNay, E.C., C.T. Ong, R.J. McCrimmon, J. Cresswell, J.S. Bogan, and R.S. Sherwin. 2010. Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiol. Learn. Mem. 93:546-553. http://dx.doi.org/10.1016/j.nlm.2010.02.002
-
(2010)
Neurobiol. Learn. Mem
, vol.93
, pp. 546-553
-
-
McNay, E.C.1
Ong, C.T.2
McCrimmon, R.J.3
Cresswell, J.4
Bogan, J.S.5
Sherwin, R.S.6
-
49
-
-
0036917633
-
Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease
-
Molina, J.A., F.J. Jiménez-Jiménez, C. Vargas, P. Gómez, F. de Bustos, C. Gómez-Escalonilla, M. Zurdo, A. Tallón, A. Martínez-Salio, J. Porta-Etessam, et al. 2002. Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease. Acta Neurol. Scand. 106:347-350. http://dx.doi.org/10.1034/j.1600-0404.2002.01326.x
-
(2002)
Acta Neurol. Scand
, vol.106
, pp. 347-350
-
-
Molina, J.A.1
Jiménez-Jiménez, F.J.2
Vargas, C.3
Gómez, P.4
de Bustos, F.5
Gómez-Escalonilla, C.6
Zurdo, M.7
Tallón, A.8
Martínez-Salio, A.9
Porta-Etessam, J.10
-
50
-
-
71349085957
-
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
-
Moloney, A.M., R.J. Griffin, S. Timmons, R. O'Connor, R. Ravid, and C. O'Neill. 2010. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging. 31:224-243. http://dx.doi.org/10.1016/j.neurobiolaging.2008.04.002
-
(2010)
Neurobiol. Aging
, vol.31
, pp. 224-243
-
-
Moloney, A.M.1
Griffin, R.J.2
Timmons, S.3
O'Connor, R.4
Ravid, R.5
O'Neill, C.6
-
51
-
-
84929938315
-
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
-
Musiek, E.S., and D.M. Holtzman. 2015. Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat. Neurosci. 18:800-806. http://dx.doi.org/10.1038/nn.4018
-
(2015)
Nat. Neurosci
, vol.18
, pp. 800-806
-
-
Musiek, E.S.1
Holtzman, D.M.2
-
52
-
-
84896692580
-
Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes
-
Novak, V., W. Milberg, Y. Hao, M. Munshi, P. Novak, A. Galica, B. Manor, P. Roberson, S. Craft, and A. Abduljalil. 2014. Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care. 37:751-759. http://dx.doi.org/10.2337/dc13-1672
-
(2014)
Diabetes Care
, vol.37
, pp. 751-759
-
-
Novak, V.1
Milberg, W.2
Hao, Y.3
Munshi, M.4
Novak, P.5
Galica, A.6
Manor, B.7
Roberson, P.8
Craft, S.9
Abduljalil, A.10
-
53
-
-
0038100358
-
Role of protein kinase B in Alzheimer's neurofibrillary pathology
-
Pei, J.J., S. Khatoon, W.L. An, M. Nordlinder, T. Tanaka, H. Braak, I. Tsujio, M. Takeda, I. Alafuzoff, B. Winblad, et al. 2003. Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathol. 105:381-392.
-
(2003)
Acta Neuropathol
, vol.105
, pp. 381-392
-
-
Pei, J.J.1
Khatoon, S.2
An, W.L.3
Nordlinder, M.4
Tanaka, T.5
Braak, H.6
Tsujio, I.7
Takeda, M.8
Alafuzoff, I.9
Winblad, B.10
-
54
-
-
3242765976
-
Fasting insulin and incident dementia in an elderly population of Japanese-American men
-
Peila, R., B.L. Rodriguez, L.R. White, and L.J. Launer. 2004. Fasting insulin and incident dementia in an elderly population of Japanese-American men. Neurology. 63:228-233. http://dx.doi.org/10.1212/01.WNL.0000129989.28404.9B
-
(2004)
Neurology
, vol.63
, pp. 228-233
-
-
Peila, R.1
Rodriguez, B.L.2
White, L.R.3
Launer, L.J.4
-
55
-
-
0038187674
-
GSK-3alpha regulates production of Alzheimer's disease amyloid-βpeptides
-
Phiel, C.J., C.A. Wilson, V.M. Lee, and P.S. Klein. 2003. GSK-3alpha regulates production of Alzheimer's disease amyloid-βpeptides. Nature. 423:435-439. http://dx.doi.org/10.1038/nature01640
-
(2003)
Nature
, vol.423
, pp. 435-439
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.3
Klein, P.S.4
-
56
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
-
Qiu, W.Q., D.M. Walsh, Z. Ye, K. Vekrellis, J. Zhang, M.B. Podlisny, M.R. Rosner, A. Safavi, L.B. Hersh, and D.J. Selkoe. 1998. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J. Biol. Chem. 273:32730-32738. http://dx.doi.org/10.1074/jbc.273.49.32730
-
(1998)
J. Biol. Chem
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
57
-
-
40349091597
-
Intranasal insulin improves cognition and modulates β-amyloid in early AD
-
Reger, M.A., G.S. Watson, P.S. Green, C.W. Wilkinson, L.D. Baker, B. Cholerton, M.A. Fishel, S.R. Plymate, J.C. Breitner, W. DeGroodt, et al. 2008. Intranasal insulin improves cognition and modulates β-amyloid in early AD. Neurology. 70:440-448. http://dx.doi.org/10.1212/01.WNL.0000265401.62434.36
-
(2008)
Neurology
, vol.70
, pp. 440-448
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Wilkinson, C.W.4
Baker, L.D.5
Cholerton, B.6
Fishel, M.A.7
Plymate, S.R.8
Breitner, J.C.9
DeGroodt, W.10
-
58
-
-
33644591150
-
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
-
Rivera, E.J., A. Goldin, N. Fulmer, R. Tavares, J.R. Wands, and S.M. de la Monte. 2005. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J. Alzheimers Dis. 8:247-268.
-
(2005)
J. Alzheimers Dis
, vol.8
, pp. 247-268
-
-
Rivera, E.J.1
Goldin, A.2
Fulmer, N.3
Tavares, R.4
Wands, J.R.5
de la Monte, S.M.6
-
59
-
-
84901299033
-
Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
-
Roberts, R.O., D.S. Knopman, R.H. Cha, M.M. Mielke, V.S. Pankratz, B.F. Boeve, K. Kantarci, Y.E. Geda, C.R. Jack Jr., R.C. Petersen, and V.J. Lowe. 2014. Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. J. Nucl. Med. 55:759-764. http://dx.doi.org/10.2967/jnumed.113.132647
-
(2014)
J. Nucl. Med
, vol.55
, pp. 759-764
-
-
Roberts, R.O.1
Knopman, D.S.2
Cha, R.H.3
Mielke, M.M.4
Pankratz, V.S.5
Boeve, B.F.6
Kantarci, K.7
Geda, Y.E.8
Jack, C.R.9
Petersen, R.C.10
Lowe, V.J.11
-
60
-
-
84975862605
-
Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and PGC-1α and increases in Aβ1-40/42 and phospho-tau may abet Alzheimer development
-
Sajan, M., B. Hansen, R. Ivey III, J. Sajan, C. Ari, S. Song, U. Braun, M. Leitges, M. Farese-Higgs, and R.V. Farese. 2016. Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and PGC-1α and increases in Aβ1-40/42 and phospho-tau may abet Alzheimer development. Diabetes. 65:1892-1903. http://dx.doi.org/10.2337/db15-1428
-
(2016)
Diabetes
, vol.65
, pp. 1892-1903
-
-
Sajan, M.1
Hansen, B.2
Ivey, R.3
Sajan, J.4
Ari, C.5
Song, S.6
Braun, U.7
Leitges, M.8
Farese-Higgs, M.9
Farese, R.V.10
-
61
-
-
84938691342
-
Central nervous system delivery of intranasal insulin: mechanisms of uptake and effects on cognition
-
Salameh, T.S., K.M. Bullock, I.A. Hujoel, M.L. Niehoff, T. Wolden-Hanson, J. Kim, J.E. Morley, S.A. Farr, and W.A. Banks. 2015. Central nervous system delivery of intranasal insulin: mechanisms of uptake and effects on cognition. J. Alzheimers Dis. 47:715-728. http://dx.doi.org/10.3233/JAD-150307
-
(2015)
J. Alzheimers Dis
, vol.47
, pp. 715-728
-
-
Salameh, T.S.1
Bullock, K.M.2
Hujoel, I.A.3
Niehoff, M.L.4
Wolden-Hanson, T.5
Kim, J.6
Morley, J.E.7
Farr, S.A.8
Banks, W.A.9
-
62
-
-
84930660574
-
The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier?
-
Sartorius, T., A. Peter, M. Heni, W. Maetzler, A. Fritsche, H.U. Häring, and A.M. Hennige. 2015. The brain response to peripheral insulin declines with age: a contribution of the blood-brain barrier? PLoS One. 10:e0126804. http://dx.doi.org/10.1371/journal.pone.0126804
-
(2015)
PLoS One
, vol.10
, pp. e0126804
-
-
Sartorius, T.1
Peter, A.2
Heni, M.3
Maetzler, W.4
Fritsche, A.5
Häring, H.U.6
Hennige, A.M.7
-
63
-
-
33746652117
-
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits
-
Schindowski, K., A. Bretteville, K. Leroy, S. Bégard, J.P. Brion, M. Hamdane, and L. Buée. 2006. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am. J. Pathol. 169:599-616. http://dx.doi.org/10.2353/ajpath.2006.060002
-
(2006)
Am. J. Pathol
, vol.169
, pp. 599-616
-
-
Schindowski, K.1
Bretteville, A.2
Leroy, K.3
Bégard, S.4
Brion, J.P.5
Hamdane, M.6
Buée, L.7
-
64
-
-
12144290448
-
Role for neuronal insulin resistance in neurodegenerative diseases
-
Schubert, M., D. Gautam, D. Surjo, K. Ueki, S. Baudler, D. Schubert, T. Kondo, J. Alber, N. Galldiks, E. Küstermann, et al. 2004. Role for neuronal insulin resistance in neurodegenerative diseases. Proc. Natl. Acad. Sci. USA. 101:3100-3105. http://dx.doi.org/10.1073/pnas.0308724101
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3100-3105
-
-
Schubert, M.1
Gautam, D.2
Surjo, D.3
Ueki, K.4
Baudler, S.5
Schubert, D.6
Kondo, T.7
Alber, J.8
Galldiks, N.9
Küstermann, E.10
-
65
-
-
7444265179
-
Brain insulin impairs amyloid-beta(1-40) clearance from the brain
-
Shiiki, T., S. Ohtsuki, A. Kurihara, H. Naganuma, K. Nishimura, M. Tachikawa, K. Hosoya, and T. Terasaki. 2004. Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J. Neurosci. 24:9632-9637. http://dx.doi.org/10.1523/JNEUROSCI.2236-04.2004
-
(2004)
J. Neurosci
, vol.24
, pp. 9632-9637
-
-
Shiiki, T.1
Ohtsuki, S.2
Kurihara, A.3
Naganuma, H.4
Nishimura, K.5
Tachikawa, M.6
Hosoya, K.7
Terasaki, T.8
-
66
-
-
77957898888
-
How does diabetes accelerate Alzheimer disease pathology?
-
Sims-Robinson, C., B. Kim, A. Rosko, and E.L. Feldman. 2010. How does diabetes accelerate Alzheimer disease pathology? Nat. Rev. Neurol. 6:551-559. http://dx.doi.org/10.1038/nrneurol.2010.130
-
(2010)
Nat. Rev. Neurol
, vol.6
, pp. 551-559
-
-
Sims-Robinson, C.1
Kim, B.2
Rosko, A.3
Feldman, E.L.4
-
67
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling, R.A., P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, A.M. Fagan, T. Iwatsubo, C.R. Jack Jr., J. Kaye, T.J. Montine, et al. 2011. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:280-292. http://dx.doi.org/10.1016/j.jalz.2011.03.003
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
Bennett, D.A.4
Craft, S.5
Fagan, A.M.6
Iwatsubo, T.7
Jack, C.R.8
Kaye, J.9
Montine, T.J.10
-
68
-
-
84930453413
-
Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOEe4 carriers
-
Starks, E.J., J. Patrick O'Grady, S.M. Hoscheidt, A.M. Racine, C.M. Carlsson, H. Zetterberg, K. Blennow, O.C. Okonkwo, L. Puglielli, S. Asthana, et al. 2015. Insulin resistance is associated with higher cerebrospinal fluid tau levels in asymptomatic APOEe4 carriers. J. Alzheimers Dis. 46:525-533. http://dx.doi.org/10.3233/JAD-150072
-
(2015)
J. Alzheimers Dis
, vol.46
, pp. 525-533
-
-
Starks, E.J.1
Patrick O'Grady, J.2
Hoscheidt, S.M.3
Racine, A.M.4
Carlsson, C.M.5
Zetterberg, H.6
Blennow, K.7
Okonkwo, O.C.8
Puglielli, L.9
Asthana, S.10
-
69
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
-
Steen, E., B.M. Terry, E.J. Rivera, J.L. Cannon, T.R. Neely, R. Tavares, X.J. Xu, J.R. Wands, and S.M. de la Monte. 2005. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J. Alzheimers Dis. 7:63-80.
-
(2005)
J. Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
de la Monte, S.M.9
-
70
-
-
84872603163
-
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease
-
Stöhr, O., K. Schilbach, L. Moll, M.M. Hettich, S. Freude, F.T. Wunderlich, M. Ernst, J. Zemva, J.C. Brüning, W. Krone, et al. 2013. Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. Age (Dordr.). 35:83-101. http://dx.doi.org/10.1007/s11357-011-9333-2
-
(2013)
Age (Dordr.)
, vol.35
, pp. 83-101
-
-
Stöhr, O.1
Schilbach, K.2
Moll, L.3
Hettich, M.M.4
Freude, S.5
Wunderlich, F.T.6
Ernst, M.7
Zemva, J.8
Brüning, J.C.9
Krone, W.10
-
71
-
-
0030997637
-
Insulin and cognitive function in an elderly population. The Rotterdam Study
-
Stolk, R.P., M.M. Breteler, A. Ott, H.A. Pols, S.W. Lamberts, D.E. Grobbee, and A. Hofman. 1997. Insulin and cognitive function in an elderly population. The Rotterdam Study. Diabetes Care. 20:792-795. http://dx.doi.org/10.2337/diacare.20.5.792
-
(1997)
Diabetes Care
, vol.20
, pp. 792-795
-
-
Stolk, R.P.1
Breteler, M.M.2
Ott, A.3
Pols, H.A.4
Lamberts, S.W.5
Grobbee, D.E.6
Hofman, A.7
-
72
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot, K., H.Y. Wang, H. Kazi, L.Y. Han, K.P. Bakshi, A. Stucky, R.L. Fuino, K.R. Kawaguchi, A.J. Samoyedny, R.S. Wilson, et al. 2012. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122:1316-1338. http://dx.doi.org/10.1172/JCI59903
-
(2012)
J. Clin. Invest
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.Y.2
Kazi, H.3
Han, L.Y.4
Bakshi, K.P.5
Stucky, A.6
Fuino, R.L.7
Kawaguchi, K.R.8
Samoyedny, A.J.9
Wilson, R.S.10
-
73
-
-
0024345665
-
Distribution of insulin receptor-like immunoreactivity in the rat forebrain
-
Unger, J., T.H. McNeill, R.T. Moxley III, M. White, A. Moss, and J.N. Livingston. 1989. Distribution of insulin receptor-like immunoreactivity in the rat forebrain. Neuroscience. 31:143-157. http://dx.doi.org/10.1016/0306-4522(89)90036-5
-
(1989)
Neuroscience
, vol.31
, pp. 143-157
-
-
Unger, J.1
McNeill, T.H.2
Moxley, R.T.3
White, M.4
Moss, A.5
Livingston, J.N.6
-
74
-
-
84911895310
-
Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease
-
Vandal, M., P.J. White, C. Tremblay, I. St-Amour, G. Chevrier, V. Emond, D. Lefrançois, J. Virgili, E. Planel, Y. Giguere, et al. 2014. Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease. Diabetes. 63:4291-4301. http://dx.doi.org/10.2337/db14-0375
-
(2014)
Diabetes
, vol.63
, pp. 4291-4301
-
-
Vandal, M.1
White, P.J.2
Tremblay, C.3
St-Amour, I.4
Chevrier, G.5
Emond, V.6
Lefrançois, D.7
Virgili, J.8
Planel, E.9
Giguere, Y.10
-
75
-
-
84861418086
-
US government sets out Alzheimer's plan
-
Wadman, M. 2012. US government sets out Alzheimer's plan. Nature. 485:426-427. http://dx.doi.org/10.1038/485426a
-
(2012)
Nature
, vol.485
, pp. 426-427
-
-
Wadman, M.1
-
76
-
-
77958592688
-
Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
-
Wang, X., W. Zheng, J.W. Xie, T. Wang, S.L. Wang, W.P. Teng, and Z.Y. Wang. 2010. Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. Mol. Neurodegener. 5:46. http://dx.doi.org/10.1186/1750-1326-5-46
-
(2010)
Mol. Neurodegener
, vol.5
, pp. 46
-
-
Wang, X.1
Zheng, W.2
Xie, J.W.3
Wang, T.4
Wang, S.L.5
Teng, W.P.6
Wang, Z.Y.7
-
77
-
-
0038038865
-
Insulin increases CSF Aβ42 levels in normal older adults
-
Watson, G.S., E.R. Peskind, S. Asthana, K. Purganan, C. Wait, D. Chapman, M.W. Schwartz, S. Plymate, and S. Craft. 2003. Insulin increases CSF Aβ42 levels in normal older adults. Neurology. 60:1899-1903. http://dx.doi.org/10.1212/01.WNL.0000065916.25128.25
-
(2003)
Neurology
, vol.60
, pp. 1899-1903
-
-
Watson, G.S.1
Peskind, E.R.2
Asthana, S.3
Purganan, K.4
Wait, C.5
Chapman, D.6
Schwartz, M.W.7
Plymate, S.8
Craft, S.9
-
78
-
-
84929295476
-
Insulin resistance predicts brain amyloid deposition in late middle-aged adults
-
Willette, A.A., S.C. Johnson, A.C. Birdsill, M.A. Sager, B. Christian, L.D. Baker, S. Craft, J. Oh, E. Statz, B.P. Hermann, et al. 2015. Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimers Dement. 11:504-510.e1. http://dx.doi.org/10.1016/j.jalz.2014.03.011
-
(2015)
Alzheimers Dement
, vol.11
, pp. 504-510.e1
-
-
Willette, A.A.1
Johnson, S.C.2
Birdsill, A.C.3
Sager, M.A.4
Christian, B.5
Baker, L.D.6
Craft, S.7
Oh, J.8
Statz, E.9
Hermann, B.P.10
-
79
-
-
18744438248
-
Alzheimer's β-amyloid peptides compete for insulin binding to the insulin receptor
-
Xie, L., E. Helmerhorst, K. Taddei, B. Plewright, W. Van Bronswijk, and R. Martins. 2002. Alzheimer's β-amyloid peptides compete for insulin binding to the insulin receptor. J. Neurosci. 22:RC221.
-
(2002)
J. Neurosci
, vol.22
, pp. RC221
-
-
Xie, L.1
Helmerhorst, E.2
Taddei, K.3
Plewright, B.4
Van Bronswijk, W.5
Martins, R.6
-
80
-
-
84939895058
-
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies
-
Yarchoan, M., J.B. Toledo, E.B. Lee, Z. Arvanitakis, H. Kazi, L.Y. Han, N. Louneva, V.M. Lee, S.F. Kim, J.Q. Trojanowski, and S.E. Arnold. 2014. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathol. 128:679-689. http://dx.doi.org/10.1007/s00401-014-1328-5
-
(2014)
Acta Neuropathol
, vol.128
, pp. 679-689
-
-
Yarchoan, M.1
Toledo, J.B.2
Lee, E.B.3
Arvanitakis, Z.4
Kazi, H.5
Han, L.Y.6
Louneva, N.7
Lee, V.M.8
Kim, S.F.9
Trojanowski, J.Q.10
Arnold, S.E.11
-
81
-
-
84906901689
-
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
-
Zhang, Y., K. Chen, S.A. Sloan, M.L. Bennett, A.R. Scholze, S. O'Keeffe, H.P. Phatnani, P. Guarnieri, C. Caneda, N. Ruderisch, et al. 2014. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34:11929-11947. http://dx.doi.org/10.1523/JNEUROSCI.1860-14.2014
-
(2014)
J. Neurosci
, vol.34
, pp. 11929-11947
-
-
Zhang, Y.1
Chen, K.2
Sloan, S.A.3
Bennett, M.L.4
Scholze, A.R.5
O'Keeffe, S.6
Phatnani, H.P.7
Guarnieri, P.8
Caneda, C.9
Ruderisch, N.10
-
82
-
-
84958581287
-
Intranasal insulin prevents anesthesia-induced spatial learning and memory deficit in mice
-
Zhang, Y., C.L. Dai, Y. Chen, K. Iqbal, F. Liu, and C.X. Gong. 2016. Intranasal insulin prevents anesthesia-induced spatial learning and memory deficit in mice. Sci. Rep. 6:21186. http://dx.doi.org/10.1038/srep21186
-
(2016)
Sci. Rep
, vol.6
, pp. 21186
-
-
Zhang, Y.1
Dai, C.L.2
Chen, Y.3
Iqbal, K.4
Liu, F.5
Gong, C.X.6
-
83
-
-
38049110692
-
Amyloid beta oligomers induce impairment of neuronal insulin receptors
-
Zhao, W.Q., F.G. De Felice, S. Fernandez, H. Chen, M.P. Lambert, M.J. Quon, G.A. Krafft, and W.L. Klein. 2008. Amyloid beta oligomers induce impairment of neuronal insulin receptors. FAS EB J. 22:246-260. http://dx.doi.org/10.1096/fj.06-7703com
-
(2008)
FAS EB J
, vol.22
, pp. 246-260
-
-
Zhao, W.Q.1
De Felice, F.G.2
Fernandez, S.3
Chen, H.4
Lambert, M.P.5
Quon, M.J.6
Krafft, G.A.7
Klein, W.L.8
-
84
-
-
84953835016
-
Discovery of novel blood-brain barrier targets to enhance brain uptake of therapeutic antibodies
-
Zuchero, Y.J., X. Chen, N. Bien-Ly, D. Bumbaca, R.K. Tong, X. Gao, S. Zhang, K. Hoyte, W. Luk, M.A. Huntley, et al. 2016. Discovery of novel blood-brain barrier targets to enhance brain uptake of therapeutic antibodies. Neuron. 89:70-82. http://dx.doi.org/10.1016/j.neuron.2015.11.024
-
(2016)
Neuron
, vol.89
, pp. 70-82
-
-
Zuchero, Y.J.1
Chen, X.2
Bien-Ly, N.3
Bumbaca, D.4
Tong, R.K.5
Gao, X.6
Zhang, S.7
Hoyte, K.8
Luk, W.9
Huntley, M.A.10
|