Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

Neuron

Volumn 89, Issue 1, 2016, Pages 70-82

  Zuchero, Y Joy Yu ^a   Chen, Xiaocheng ^a   Bien Ly, Nga ^a   Bumbaca, Daniela ^a   Tong, Raymond K ^a   Gao, Xiaoying ^a   Zhang, Shuo ^a   Hoyte, Kwame ^a   Luk, Wilman ^a   Huntley, Melanie A ^a   Phu, Lilian ^a   Tan, Christine ^a   Kallop, Dara ^a   Weimer, Robby M ^a   Lu, Yanmei ^a   Kirkpatrick, Donald S ^a   Ernst, James A ^a   Chih, Ben ^a   Dennis, Mark S ^a   Watts, Ryan J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BACE1 ANTIBODY; CD147 ANTIGEN; CD147 ANTIGEN ANTIBODY; CD320 PROTEIN; CD98 ANTIGEN; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 1 ANTIBODY; IMMUNOGLOBULIN G; INSULIN RECEPTOR; IODINE 125; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN ANTIBODY; PROTEIN BACE1 ANTIBODY; PROTEIN CD98 ANTIBODY; PROTEIN CD98HCA ANTIBODY; PROTEIN CD98HCB ANTIBODY; PROTEIN INSR ANTIBODY; PROTEIN LDLRAD3; PROTEIN LRP1; PROTEIN LRP1 ANTIBODY; PROTEIN TFRA ANTIBODY; PROTEIN TFRC; UNCLASSIFIED DRUG; ANTIBODY; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY TRANSPORT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN ENDOTHELIAL CELL; BRAIN PARENCHMA; BRAIN UPTAKE; CELL ISOLATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PARENCHYMA; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TARGETING; PROTEOMICS; RAT; RECEPTOR MEDIATED TRANSCYTOSIS; RNA SEQUENCE; TRANSCRIPTOMICS; TRANSCYTOSIS; TRANSPORT AT THE CELLULAR LEVEL; ANIMAL; BRAIN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES;

ANIMALS; ANTIBODIES; ANTIGENS, CD98 HEAVY CHAIN; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; ENDOTHELIAL CELLS; MICE; PROTEOMICS; RECEPTORS, TRANSFERRIN; TRANSCYTOSIS;

EID: 84953835016     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.11.024     Document Type: Article

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