N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 31, 2016, Pages E4523-E4530

  Warrier, Thulasi ^a   Kapilashrami, Kanishk ^b   Argyrou, Argyrides ^c   Ioerger, Thomas R ^d   Little, David ^a   Murphye, Kenan C ^a   Nandakumar, Madhumitha ^e   Park, Suna ^a   Gold, Ben ^a   Mi, Jianjie ^a   Zhang, Tuo ^a   Meiler, Eugenia ^f   Rees, Mike ^c   Somersan Karakaya, Selin ^a   Francisco, Esther Porras De ^a   Martinez Hoyos, Maria ^a   Burns Huang, Kristin ^a   Roberts, Julia ^a   Ling, Yan ^a   Rhee, Kyu Y ^a   Mendoza Losana, Alfonso ^a   Luo, Minkui ^a,b   Nathan, Carl F ^a   more..

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Department of Electrical and Computer Engineering   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f GLAXOSMITHKLINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARABINOGALACTAN; BENZIMIDAZOLE DERIVATIVE; METHYLTRANSFERASE; RNA; BACTERIAL PROTEIN; BENZIMIDAZOLE; REPRESSOR PROTEIN; S ADENOSYLMETHIONINE; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; COLONY FORMING UNIT; CONFERENCE PAPER; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; DNA STRUCTURE; DRUG INACTIVATION; GENE EXPRESSION; GENE SEQUENCE; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; METHYLATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN DOMAIN;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BENZIMIDAZOLES; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; METHYLATION; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN DOMAINS; REPRESSOR PROTEINS; S-ADENOSYLMETHIONINE;

EID: 84982735378     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1606590113     Document Type: Article

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