The Mycobacterium tuberculosis ideR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages

Molecular Microbiology

Volumn 42, Issue 3, 2001, Pages 851-865

  Gold, Benjamin ^a,b   Marcela Rodriguez, G ^b   Marras, Salvatore A E ^b   Pentecost, Mickey ^c   Smith, Issar ^a,b  

^a NEW YORK UNIVERSITY   (United States)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^c Albert Nerkin School of Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC AMINO ACID; DNA BINDING PROTEIN; IRON; LIPID; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEPTIDOGLYCAN; PROTEIN; PROTEIN BFRA; PROTEIN BFRB; PROTEIN IDER; RNA POLYMERASE; SIDEROPHORE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; ENZYME BINDING; GENE CONTROL; GENE INDUCTION; GENETIC TRANSCRIPTION; GENOME; IRON STORAGE; MACROPHAGE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TECHNIQUE;

BACTERIAL PROTEINS; BASE SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; IRON; MACROPHAGES; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; TUBERCULOSIS; VIRULENCE;

ACTINOBACTERIA (CLASS); MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA; TRIXIS; UNCULTURED ACTINOMYCETE;

EID: 0035169902     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02684.x     Document Type: Article

References (57)

1. Ferritin mutants of Escherichia coli are iron deficient and growth impaired, and fur mutants are iron deficient
2. Iron storage in bacteria
3. Cloning, sequencing, and mapping of the bacterioferritin gene (bfr) of Escherichia coli K-12
4. Overproduction, purification and characterization of the bacterioferritin of Escherichia coli and a C-terminally extended variant
5. The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
6. Interferon gamma-activated human monocytes down-regulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron
7. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
8. Iron acquisition and metabolism by mycobacteria
9. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
10. Genomic organization of the mycobacterial sigma gene cluster
11. Fur positive regulation of iron superoxide dismutase in Escherichia coli: Functional analysis of the sodB promoter
12. An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response
13. Protective role of the Mycobacterium smegmatis IdeR against reactive oxygen species and isoniazid toxicity
14. Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR
15. Identification of genes involved in the sequestration of iron in mycobacteria: The ferric exochelin biosynthetic and uptake pathways
16. Characterization of the micro-environment of Salmonella typhimurium-containing vacuoles within MDCK epithelial cells
17. A [2Fe-2S] protein encoded by an open reading frame upstream of the Escherichia coli bacterioferritin gene
18. Determinants of mycobacterial gene expression
19. The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique, flexible pattern along the DNA helix
20. Iron and metal regulation in bacteria
21. The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium
22. Regulating the fate of mRNA: The control of cellular iron metabolism
23. Identification and characterization of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron
24. Fate of human lactoferrin and myeloperoxidase in phagocytizing human neutrophils: Effects of immunoglobulin G subclasses and immune complexes coated on latex beads
25. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
26. Bacterioferritin A modulates catalase A (KatA) activity and resistance to hydrogen peroxide in Pseudomonas aeruginosa
27. Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host
28. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor
29. Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis
30. Real time PCR using molecular beacons: A new tool to identify point mutations and to analyze gene expression in Mycobacterium tuberculosis
31. Characterization and expression of the Pseudomonas putida bacterioferritin alpha subunit gene
32. SubtiList: A relational database for the Bacillus subtilis genome
33. Changes in iron and transferrin levels and body temperature in experimental airborne legionellosis
34. Siderophores: Structure and function of microbial iron transport compounds
35. Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied
36. Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection
37. Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases
38. Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin
39. Spectroscopic and voltammetric characterisation of the bacterioferritin- associated ferredoxin of Escherichia coli
40. Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins
41. Peptidoglycan structure of Salmonella typhimurium growing within cultured mammalian cells
42. Identification and characterization of two divergently transcribed iron regulated genes in Mycobacterium tuberculosis
43. Cloning, sequence, and footprint analysis of two promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron
44. Purification and characterization of the diphtheria toxin repressor
45. Characterization of an iron-dependent regulatory protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae
46. Fur regulon in gram-negative bacteria. Identification and characterization of newiron-regulatedEscherichia coli genes by a fur titration assay
47. Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR
48. Direct evidence for mRNA binding and post-transcriptional regulation by Escherichia coli aconitases
49. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester
50. Molecular beacons: Probes that fluoresce upon hybridization
51. The response of Pseudomonas aeruginosa to iron: Genetics, biochemistry and virulence
52. Iron withholding: A defense against infection and neoplasia
53. Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex
54. Secretory responses of human neutrophils: Exocytosis of specific (secondary) granules by human neutrophils during adherence in vitro and during exudation in vivo
55. Analysis of the exochelin locus in Mycobacterium smegmatis: Biosynthesis genes have homology with genes of the peptide synthetase family
56. The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages