Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 5, 2009, Pages 2100-2109

  Mathys, Vanessa ^a,e   Wintjens, René ^d,e   Lefevre, Philippe ^a   Bertout, Julie ^b   Singhal, Amit ^a   Kiass, Mehdi ^a   Kurepina, Natalia ^c   Wang, Xiao Ming ^a   Mathema, Barun ^c   Baulard, Alain ^b   Kreiswirth, Barry N ^c   Bifani, Pablo ^a,f  

^a SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

^b INSTITUT PASTEUR DE LILLE   (France)

^c PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^d UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^e FNRS   (Belgium)

^f NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; AMIKACIN; AMINOSALICYLIC ACID; CAPREOMYCIN; CIPROFLOXACIN; CYCLOSERINE; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KANAMYCIN; OFLOXACIN; POLYPEPTIDE; PYRAZINAMIDE; PYRIMIDINE NUCLEOTIDE; RIFABUTIN; RIFAMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DFRA GENE; FOLATE METABOLISM; FOLC GENE; FOLP1 GENE; FOLP2 GENE; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR GENETICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; THYA GENE; THYX GENE;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; FOLIC ACID; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; P-AMINOSALICYLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE; THYMINE;

EID: 66149143506     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01197-08     Document Type: Article

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