Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3

Phytomedicine

Volumn 23, Issue 12, 2016, Pages 1329-1336

  Zhang, Guangxian ^a   Zeng, Xiancheng ^b   Zhang, Ren ^a   Liu, Juan ^a   Zhang, Weici ^c   Zhao, Yujun ^b   Zhang, Xiaoyuan ^a   Wu, Zhixue ^a   Tan, Yuhui ^a   Wu, Yingya ^a   Du, Biaoyan ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b GUANGDONG SECOND PROVINCIAL GENERAL HOSPITAL   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Dioscin; Hepatocellular carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; DIOSCIN; DNA; FLUOROURACIL; HOE 33342; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; DIOSGENIN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DOWN REGULATION; DRUG DOSE INCREASE; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; CARCINOMA, HEPATOCELLULAR; DRUG EFFECTS; DRUG SCREENING; GENETICS; LIVER NEOPLASMS; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; DIOSGENIN; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-BCL-2; TETRAZOLIUM SALTS; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84982693532     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2016.07.003     Document Type: Article

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