-
1
-
-
79952284127
-
Hallmarks of Cancer: The Next Generation
-
Hanahan, D.; Weinberg, R. A. Hallmarks of Cancer: The Next Generation Cell 2011, 144, 646-674 10.1016/j.cell.2011.02.013
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
33746622984
-
Strategies for Optimizing Combinations of Molecularly Targeted Anticancer Agents
-
Dancey, J. E.; Chen, H. X. Strategies for Optimizing Combinations of Molecularly Targeted Anticancer Agents Nat. Rev. Drug Discovery 2006, 5, 649-659 10.1038/nrd2089
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 649-659
-
-
Dancey, J.E.1
Chen, H.X.2
-
3
-
-
54449083925
-
Molecular Targeted Therapies in Hepatocellular Carcinoma
-
Llovet, J. M.; Bruix, J. Molecular Targeted Therapies in Hepatocellular Carcinoma Hepatology 2008, 48, 1312-1327 10.1002/hep.22506
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
4
-
-
84929634545
-
Development of an Oral Nanotherapeutics Using Redox Nanoparticles for Treatment of Colitis-Associated Colon Cancer
-
Vong, L. B.; Yoshitomi, T.; Matsui, H.; Nagasaki, Y. Development of an Oral Nanotherapeutics Using Redox Nanoparticles for Treatment of Colitis-Associated Colon Cancer Biomaterials 2015, 55, 54-63 10.1016/j.biomaterials.2015.03.037
-
(2015)
Biomaterials
, vol.55
, pp. 54-63
-
-
Vong, L.B.1
Yoshitomi, T.2
Matsui, H.3
Nagasaki, Y.4
-
5
-
-
84942683629
-
Tumor Phe-Triggered Charge-Reversal and Redox-Responsive Nanoparticles for Docetaxel Delivery in Hepatocellular Carcinoma Treatment
-
Chen, F.; Zhang, J.; Wang, L.; Wang, Y.; Chen, M. Tumor Phe-Triggered Charge-Reversal and Redox-Responsive Nanoparticles for Docetaxel Delivery in Hepatocellular Carcinoma Treatment Nanoscale 2015, 7, 15763-15779 10.1039/C5NR04612B
-
(2015)
Nanoscale
, vol.7
, pp. 15763-15779
-
-
Chen, F.1
Zhang, J.2
Wang, L.3
Wang, Y.4
Chen, M.5
-
6
-
-
84891625661
-
Molecularly Targeted Cancer Therapy: Some Lessons from the Past Decade
-
Huang, M.; Shen, A.; Ding, J.; Geng, M. Molecularly Targeted Cancer Therapy: Some Lessons from the Past Decade Trends Pharmacol. Sci. 2014, 35, 41-50 10.1016/j.tips.2013.11.004
-
(2014)
Trends Pharmacol. Sci.
, vol.35
, pp. 41-50
-
-
Huang, M.1
Shen, A.2
Ding, J.3
Geng, M.4
-
7
-
-
84896699451
-
Cancer Nanotechnology: The Impact of Passive and Active Targeting in the Era of Modern Cancer Biology
-
Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N.; Farokhzad, O. C. Cancer Nanotechnology: The Impact of Passive and Active Targeting in the Era of Modern Cancer Biology Adv. Drug Delivery Rev. 2014, 66, 2-25 10.1016/j.addr.2013.11.009
-
(2014)
Adv. Drug Delivery Rev.
, vol.66
, pp. 2-25
-
-
Bertrand, N.1
Wu, J.2
Xu, X.3
Kamaly, N.4
Farokhzad, O.C.5
-
8
-
-
77951218485
-
Curcumin-Encapsulated Mepeg/Pcl Diblock Copolymeric Micelles: A Novel Controlled Delivery Vehicle for Cancer Therapy
-
Mohanty, C.; Acharya, S.; Mohanty, A. K.; Dilnawaz, F.; Sahoo, S. K. Curcumin-Encapsulated Mepeg/Pcl Diblock Copolymeric Micelles: A Novel Controlled Delivery Vehicle for Cancer Therapy Nanomedicine (London, U. K.) 2010, 5, 433-449 10.2217/nnm.10.9
-
(2010)
Nanomedicine (London, U. K.)
, vol.5
, pp. 433-449
-
-
Mohanty, C.1
Acharya, S.2
Mohanty, A.K.3
Dilnawaz, F.4
Sahoo, S.K.5
-
9
-
-
84906875000
-
Deoxycholic Acid-Modified Chitooligosaccharide/Mpeg-Pdlla Mixed Micelles Loaded with Paclitaxel for Enhanced Antitumor Efficacy
-
Jiang, C.; Wang, H.; Zhang, X.; Sun, Z.; Wang, F.; Cheng, J.; Xie, H.; Yu, B.; Zhou, L. Deoxycholic Acid-Modified Chitooligosaccharide/Mpeg-Pdlla Mixed Micelles Loaded with Paclitaxel for Enhanced Antitumor Efficacy Int. J. Pharm. 2014, 475, 60-68 10.1016/j.ijpharm.2014.08.037
-
(2014)
Int. J. Pharm.
, vol.475
, pp. 60-68
-
-
Jiang, C.1
Wang, H.2
Zhang, X.3
Sun, Z.4
Wang, F.5
Cheng, J.6
Xie, H.7
Yu, B.8
Zhou, L.9
-
10
-
-
28844488494
-
Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles
-
Owens, D. E., 3rd; Peppas, N. A. Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles Int. J. Pharm. 2006, 307, 93-102 10.1016/j.ijpharm.2005.10.010
-
(2006)
Int. J. Pharm.
, vol.307
, pp. 93-102
-
-
Owens, D.E.1
Peppas, N.A.2
-
11
-
-
84924368369
-
Evaluation of Drug Loading, Pharmacokinetic Behavior, and Toxicity of a Cisplatin-Containing Hydrogel Nanoparticle
-
Kai, M. P.; Keeler, A. W.; Perry, J. L.; Reuter, K. G.; Luft, J. C.; O'Neal, S. K.; Zamboni, W. C.; DeSimone, J. M. Evaluation of Drug Loading, Pharmacokinetic Behavior, and Toxicity of a Cisplatin-Containing Hydrogel Nanoparticle J. Controlled Release 2015, 204, 70-77 10.1016/j.jconrel.2015.03.001
-
(2015)
J. Controlled Release
, vol.204
, pp. 70-77
-
-
Kai, M.P.1
Keeler, A.W.2
Perry, J.L.3
Reuter, K.G.4
Luft, J.C.5
O'Neal, S.K.6
Zamboni, W.C.7
DeSimone, J.M.8
-
12
-
-
84939270269
-
Self-Assembling Prodrugs by Precise Programming of Molecular Structures That Contribute Distinct Stability, Pharmacokinetics, and Antitumor Efficacy
-
Wang, H.; Xie, H.; Wang, J.; Wu, J.; Ma, X.; Li, L.; Wei, X.; Ling, Q.; Song, P.; Zhou, L.; Xu, X.; Zheng, S. Self-Assembling Prodrugs by Precise Programming of Molecular Structures That Contribute Distinct Stability, Pharmacokinetics, and Antitumor Efficacy Adv. Funct. Mater. 2015, 25, 4956-4965 10.1002/adfm.201501953
-
(2015)
Adv. Funct. Mater.
, vol.25
, pp. 4956-4965
-
-
Wang, H.1
Xie, H.2
Wang, J.3
Wu, J.4
Ma, X.5
Li, L.6
Wei, X.7
Ling, Q.8
Song, P.9
Zhou, L.10
Xu, X.11
Zheng, S.12
-
13
-
-
84861442552
-
Revival of the Abandoned Therapeutic Wortmannin by Nanoparticle Drug Delivery
-
Karve, S.; Werner, M. E.; Sukumar, R.; Cummings, N. D.; Copp, J. A.; Wang, E. C.; Li, C.; Sethi, M.; Chen, R. C.; Pacold, M. E.; Wang, A. Z. Revival of the Abandoned Therapeutic Wortmannin by Nanoparticle Drug Delivery Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 8230-8235 10.1073/pnas.1120508109
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 8230-8235
-
-
Karve, S.1
Werner, M.E.2
Sukumar, R.3
Cummings, N.D.4
Copp, J.A.5
Wang, E.C.6
Li, C.7
Sethi, M.8
Chen, R.C.9
Pacold, M.E.10
Wang, A.Z.11
-
14
-
-
84942118224
-
Structure-Based Rational Design of Prodrugs to Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy
-
Wang, H.; Xie, H.; Wu, J.; Wei, X.; Zhou, L.; Xu, X.; Zheng, S. Structure-Based Rational Design of Prodrugs to Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy Angew. Chem., Int. Ed. 2014, 53, 11532-11537 10.1002/anie.201406685
-
(2014)
Angew. Chem., Int. Ed.
, vol.53
, pp. 11532-11537
-
-
Wang, H.1
Xie, H.2
Wu, J.3
Wei, X.4
Zhou, L.5
Xu, X.6
Zheng, S.7
-
15
-
-
84901684242
-
Co-Delivery of Cisplatin and Rapamycin for Enhanced Anticancer Therapy through Synergistic Effects and Microenvironment Modulation
-
Guo, S. T.; Lin, C. M.; Xu, Z. H.; Miao, L.; Wang, Y. H.; Huang, L. Co-Delivery of Cisplatin and Rapamycin for Enhanced Anticancer Therapy through Synergistic Effects and Microenvironment Modulation ACS Nano 2014, 8, 4996-5009 10.1021/nn5010815
-
(2014)
ACS Nano
, vol.8
, pp. 4996-5009
-
-
Guo, S.T.1
Lin, C.M.2
Xu, Z.H.3
Miao, L.4
Wang, Y.H.5
Huang, L.6
-
16
-
-
84873325712
-
Vandetanib for the Treatment of Medullary Thyroid Cancer
-
Chau, N. G.; Haddad, R. I. Vandetanib for the Treatment of Medullary Thyroid Cancer Clin. Cancer Res. 2013, 19, 524-529 10.1158/1078-0432.CCR-12-2353
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 524-529
-
-
Chau, N.G.1
Haddad, R.I.2
-
17
-
-
84969533090
-
Effect of the Ret Inhibitor Vandetanib in a Patient with Ret Fusion-Positive Metastatic Non-Small-Cell Lung Cancer
-
Falchook, G. S.; Ordonez, N. G.; Bastida, C. C.; Stephens, P. J.; Miller, V. A.; Gaido, L.; Jackson, T.; Karp, D. D. Effect of the Ret Inhibitor Vandetanib in a Patient with Ret Fusion-Positive Metastatic Non-Small-Cell Lung Cancer J. Clin. Oncol. 2016, 34, e141-144 10.1200/JCO.2013.50.5016
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. e141-144
-
-
Falchook, G.S.1
Ordonez, N.G.2
Bastida, C.C.3
Stephens, P.J.4
Miller, V.A.5
Gaido, L.6
Jackson, T.7
Karp, D.D.8
-
18
-
-
84904578792
-
A Randomized Phase II Efficacy and Safety Study of Vandetanib (Zd6474) in Combination with Bicalutamide Versus Bicalutamide Alone in Patients with Chemotherapy Naive Castration-Resistant Prostate Cancer
-
Azad, A. A.; Beardsley, E. K.; Hotte, S. J.; Ellard, S. L.; Klotz, L.; Chin, J.; Kollmannsberger, C.; Mukherjee, S. D.; Chi, K. N. A Randomized Phase Ii Efficacy and Safety Study of Vandetanib (Zd6474) in Combination with Bicalutamide Versus Bicalutamide Alone in Patients with Chemotherapy Naive Castration-Resistant Prostate Cancer Invest. New Drugs 2014, 32, 746-752 10.1007/s10637-014-0091-8
-
(2014)
Invest. New Drugs
, vol.32
, pp. 746-752
-
-
Azad, A.A.1
Beardsley, E.K.2
Hotte, S.J.3
Ellard, S.L.4
Klotz, L.5
Chin, J.6
Kollmannsberger, C.7
Mukherjee, S.D.8
Chi, K.N.9
-
19
-
-
84901189815
-
Randomised Phase II Study of Docetaxel Plus Vandetanib Versus Docetaxel Followed by Vandetanib in Patients with Persistent or Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma: Swog S0904
-
Coleman, R. L.; Moon, J.; Sood, A. K.; Hu, W.; Delmore, J. E.; Bonebrake, A. J.; Anderson, G. L.; Chambers, S. K.; Markman, M. Randomised Phase Ii Study of Docetaxel Plus Vandetanib Versus Docetaxel Followed by Vandetanib in Patients with Persistent or Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma: Swog S0904 Eur. J. Cancer 2014, 50, 1638-1648 10.1016/j.ejca.2014.03.005
-
(2014)
Eur. J. Cancer
, vol.50
, pp. 1638-1648
-
-
Coleman, R.L.1
Moon, J.2
Sood, A.K.3
Hu, W.4
Delmore, J.E.5
Bonebrake, A.J.6
Anderson, G.L.7
Chambers, S.K.8
Markman, M.9
-
20
-
-
84862832278
-
Vandetanib in Patients with Inoperable Hepatocellular Carcinoma: A Phase II, Randomized, Double-Blind, Placebo-Controlled Study
-
Hsu, C.; Yang, T. S.; Huo, T. I.; Hsieh, R. K.; Yu, C. W.; Hwang, W. S.; Hsieh, T. Y.; Huang, W. T.; Chao, Y.; Meng, R.; Cheng, A. L. Vandetanib in Patients with Inoperable Hepatocellular Carcinoma: A Phase Ii, Randomized, Double-Blind, Placebo-Controlled Study J. Hepatol. 2012, 56, 1097-1103 10.1016/j.jhep.2011.12.013
-
(2012)
J. Hepatol.
, vol.56
, pp. 1097-1103
-
-
Hsu, C.1
Yang, T.S.2
Huo, T.I.3
Hsieh, R.K.4
Yu, C.W.5
Hwang, W.S.6
Hsieh, T.Y.7
Huang, W.T.8
Chao, Y.9
Meng, R.10
Cheng, A.L.11
-
21
-
-
79952367827
-
Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma
-
Iwamoto, H.; Torimura, T.; Nakamura, T.; Hashimoto, O.; Inoue, K.; Kurogi, J.; Niizeki, T.; Kuwahara, R.; Abe, M.; Koga, H.; Yano, H.; Kerbel, R. S.; Ueno, T.; Sata, M. Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma Neoplasia 2011, 13, 187-197 10.1593/neo.101186
-
(2011)
Neoplasia
, vol.13
, pp. 187-197
-
-
Iwamoto, H.1
Torimura, T.2
Nakamura, T.3
Hashimoto, O.4
Inoue, K.5
Kurogi, J.6
Niizeki, T.7
Kuwahara, R.8
Abe, M.9
Koga, H.10
Yano, H.11
Kerbel, R.S.12
Ueno, T.13
Sata, M.14
-
22
-
-
84863977102
-
Vandetanib, an Inhibitor of Vegf Receptor-2 and Egf Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice
-
Inoue, K.; Torimura, T.; Nakamura, T.; Iwamoto, H.; Masuda, H.; Abe, M.; Hashimoto, O.; Koga, H.; Ueno, T.; Yano, H.; Sata, M. Vandetanib, an Inhibitor of Vegf Receptor-2 and Egf Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice Clin. Cancer Res. 2012, 18, 3924-3933 10.1158/1078-0432.CCR-11-2041
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 3924-3933
-
-
Inoue, K.1
Torimura, T.2
Nakamura, T.3
Iwamoto, H.4
Masuda, H.5
Abe, M.6
Hashimoto, O.7
Koga, H.8
Ueno, T.9
Yano, H.10
Sata, M.11
-
23
-
-
84872728103
-
Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer-Based Nanocarriers for Drug Delivery
-
Nicolas, J.; Mura, S.; Brambilla, D.; Mackiewicz, N.; Couvreur, P. Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer-Based Nanocarriers for Drug Delivery Chem. Soc. Rev. 2013, 42, 1147-1235 10.1039/C2CS35265F
-
(2013)
Chem. Soc. Rev.
, vol.42
, pp. 1147-1235
-
-
Nicolas, J.1
Mura, S.2
Brambilla, D.3
Mackiewicz, N.4
Couvreur, P.5
-
24
-
-
84940530859
-
Perfluorocarbon-Encapsulated Plga-Peg Emulsions as Enhancement Agents for Highly Efficient Reoxygenation to Cell and Organism
-
Yao, Y.; Zhang, M.; Liu, T.; Zhou, J.; Gao, Y.; Wen, Z.; Guan, J.; Zhu, J.; Lin, Z.; He, D. Perfluorocarbon-Encapsulated Plga-Peg Emulsions as Enhancement Agents for Highly Efficient Reoxygenation to Cell and Organism ACS Appl. Mater. Interfaces 2015, 7, 18369-18378 10.1021/acsami.5b04226
-
(2015)
ACS Appl. Mater. Interfaces
, vol.7
, pp. 18369-18378
-
-
Yao, Y.1
Zhang, M.2
Liu, T.3
Zhou, J.4
Gao, Y.5
Wen, Z.6
Guan, J.7
Zhu, J.8
Lin, Z.9
He, D.10
-
25
-
-
84930216398
-
Effect of the Polymer Architecture on the Structural and Biophysical Properties of Peg-Pla Nanoparticles
-
Rabanel, J. M.; Faivre, J.; Tehrani, S. F.; Lalloz, A.; Hildgen, P.; Banquy, X. Effect of the Polymer Architecture on the Structural and Biophysical Properties of Peg-Pla Nanoparticles ACS Appl. Mater. Interfaces 2015, 7, 10374-10385 10.1021/acsami.5b01423
-
(2015)
ACS Appl. Mater. Interfaces
, vol.7
, pp. 10374-10385
-
-
Rabanel, J.M.1
Faivre, J.2
Tehrani, S.F.3
Lalloz, A.4
Hildgen, P.5
Banquy, X.6
-
26
-
-
70749103751
-
Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors
-
Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Girard, O. M.; Hanahan, D.; Mattrey, R. F.; Ruoslahti, E. Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors Cancer Cell 2009, 16, 510-520 10.1016/j.ccr.2009.10.013
-
(2009)
Cancer Cell
, vol.16
, pp. 510-520
-
-
Sugahara, K.N.1
Teesalu, T.2
Karmali, P.P.3
Kotamraju, V.R.4
Agemy, L.5
Girard, O.M.6
Hanahan, D.7
Mattrey, R.F.8
Ruoslahti, E.9
-
27
-
-
80054110603
-
Development of Docetaxel-Loaded Intravenous Formulation, Nanoxel-Pm Using Polymer-Based Delivery System
-
Lee, S. W.; Yun, M. H.; Jeong, S. W.; In, C. H.; Kim, J. Y.; Seo, M. H.; Pai, C. M.; Kim, S. O. Development of Docetaxel-Loaded Intravenous Formulation, Nanoxel-Pm Using Polymer-Based Delivery System J. Controlled Release 2011, 155, 262-271 10.1016/j.jconrel.2011.06.012
-
(2011)
J. Controlled Release
, vol.155
, pp. 262-271
-
-
Lee, S.W.1
Yun, M.H.2
Jeong, S.W.3
In, C.H.4
Kim, J.Y.5
Seo, M.H.6
Pai, C.M.7
Kim, S.O.8
-
28
-
-
83555166219
-
Accumulation of Sub-100 Nm Polymeric Micelles in Poorly Permeable Tumours Depends on Size
-
Cabral, H.; Matsumoto, Y.; Mizuno, K.; Chen, Q.; Murakami, M.; Kimura, M.; Terada, Y.; Kano, M. R.; Miyazono, K.; Uesaka, M.; Nishiyama, N.; Kataoka, K. Accumulation of Sub-100 Nm Polymeric Micelles in Poorly Permeable Tumours Depends on Size Nat. Nanotechnol. 2011, 6, 815-823 10.1038/nnano.2011.166
-
(2011)
Nat. Nanotechnol.
, vol.6
, pp. 815-823
-
-
Cabral, H.1
Matsumoto, Y.2
Mizuno, K.3
Chen, Q.4
Murakami, M.5
Kimura, M.6
Terada, Y.7
Kano, M.R.8
Miyazono, K.9
Uesaka, M.10
Nishiyama, N.11
Kataoka, K.12
-
29
-
-
66449116301
-
Mediating Tumor Targeting Efficiency of Nanoparticles through Design
-
Perrault, S. D.; Walkey, C.; Jennings, T.; Fischer, H. C.; Chan, W. C. Mediating Tumor Targeting Efficiency of Nanoparticles through Design Nano Lett. 2009, 9, 1909-1915 10.1021/nl900031y
-
(2009)
Nano Lett.
, vol.9
, pp. 1909-1915
-
-
Perrault, S.D.1
Walkey, C.2
Jennings, T.3
Fischer, H.C.4
Chan, W.C.5
-
30
-
-
79957918593
-
Neuropilin-1 Is Upregulated in Hepatocellular Carcinoma and Contributes to Tumour Growth and Vascular Remodelling
-
Berge, M.; Allanic, D.; Bonnin, P.; de Montrion, C.; Richard, J.; Suc, M.; Boivin, J. F.; Contreres, J. O.; Lockhart, B. P.; Pocard, M.; Levy, B. I.; Tucker, G. C.; Tobelem, G.; Merkulova-Rainon, T. Neuropilin-1 Is Upregulated in Hepatocellular Carcinoma and Contributes to Tumour Growth and Vascular Remodelling J. Hepatol. 2011, 55, 866-875 10.1016/j.jhep.2011.01.033
-
(2011)
J. Hepatol.
, vol.55
, pp. 866-875
-
-
Berge, M.1
Allanic, D.2
Bonnin, P.3
De Montrion, C.4
Richard, J.5
Suc, M.6
Boivin, J.F.7
Contreres, J.O.8
Lockhart, B.P.9
Pocard, M.10
Levy, B.I.11
Tucker, G.C.12
Tobelem, G.13
Merkulova-Rainon, T.14
-
31
-
-
84921345680
-
Tumor-Penetrating Irgd Peptide Inhibits Metastasis
-
Sugahara, K. N.; Braun, G. B.; de Mendoza, T. H.; Kotamraju, V. R.; French, R. P.; Lowy, A. M.; Teesalu, T.; Ruoslahti, E. Tumor-Penetrating Irgd Peptide Inhibits Metastasis Mol. Cancer Ther. 2015, 14, 120-128 10.1158/1535-7163.MCT-14-0366
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 120-128
-
-
Sugahara, K.N.1
Braun, G.B.2
De Mendoza, T.H.3
Kotamraju, V.R.4
French, R.P.5
Lowy, A.M.6
Teesalu, T.7
Ruoslahti, E.8
-
32
-
-
84942894500
-
Improving Drug Penetrability with Irgd Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma
-
Schmithals, C.; Koberle, V.; Korkusuz, H.; Pleli, T.; Kakoschky, B.; Augusto, E. A.; Ibrahim, A. A.; Arencibia, J. M.; Vafaizadeh, V.; Groner, B.; Korf, H. W.; Kronenberger, B.; Zeuzem, S.; Vogl, T. J.; Waidmann, O.; Piiper, A. Improving Drug Penetrability with Irgd Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma Cancer Res. 2015, 75, 3147-3154 10.1158/0008-5472.CAN-15-0395
-
(2015)
Cancer Res.
, vol.75
, pp. 3147-3154
-
-
Schmithals, C.1
Koberle, V.2
Korkusuz, H.3
Pleli, T.4
Kakoschky, B.5
Augusto, E.A.6
Ibrahim, A.A.7
Arencibia, J.M.8
Vafaizadeh, V.9
Groner, B.10
Korf, H.W.11
Kronenberger, B.12
Zeuzem, S.13
Vogl, T.J.14
Waidmann, O.15
Piiper, A.16
-
33
-
-
84964688286
-
Rational Design of Multifunctional Small-Molecule Prodrugs for Simultaneous Suppression of Cancer Cell Growth and Metastasis in Vitro and in Vivo
-
Xie, H.; Xu, X.; Chen, J.; Li, L.; Wang, J.; Fang, T.; Zhou, L.; Wang, H.; Zheng, S. Rational Design of Multifunctional Small-Molecule Prodrugs for Simultaneous Suppression of Cancer Cell Growth and Metastasis in Vitro and in Vivo Chem. Commun. (Cambridge, U. K.) 2016, 52, 5601-5604 10.1039/C5CC10367C
-
(2016)
Chem. Commun. (Cambridge, U. K.)
, vol.52
, pp. 5601-5604
-
-
Xie, H.1
Xu, X.2
Chen, J.3
Li, L.4
Wang, J.5
Fang, T.6
Zhou, L.7
Wang, H.8
Zheng, S.9
-
34
-
-
37549069901
-
Bcl-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death
-
Danial, N. N. Bcl-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death Clin. Cancer Res. 2007, 13, 7254-7263 10.1158/1078-0432.CCR-07-1598
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7254-7263
-
-
Danial, N.N.1
-
35
-
-
84921291249
-
Plga-Pll-Peg-Tf-Based Targeted Nanoparticles Drug Delivery System Enhance Antitumor Efficacy Via Intrinsic Apoptosis Pathway
-
Bao, W.; Liu, R.; Wang, Y.; Wang, F.; Xia, G.; Zhang, H.; Li, X.; Yin, H.; Chen, B. Plga-Pll-Peg-Tf-Based Targeted Nanoparticles Drug Delivery System Enhance Antitumor Efficacy Via Intrinsic Apoptosis Pathway Int. J. Nanomed. 2015, 10, 557-566 10.2147/IJN.S75090
-
(2015)
Int. J. Nanomed.
, vol.10
, pp. 557-566
-
-
Bao, W.1
Liu, R.2
Wang, Y.3
Wang, F.4
Xia, G.5
Zhang, H.6
Li, X.7
Yin, H.8
Chen, B.9
-
36
-
-
9244251125
-
Cell-Cycle Checkpoints and Cancer
-
Kastan, M. B.; Bartek, J. Cell-Cycle Checkpoints and Cancer Nature 2004, 432, 316-323 10.1038/nature03097
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
37
-
-
69249230769
-
Mammalian Cell-Cycle Regulation: Several Cdks, Numerous Cyclins and Diverse Compensatory Mechanisms
-
Satyanarayana, A.; Kaldis, P. Mammalian Cell-Cycle Regulation: Several Cdks, Numerous Cyclins and Diverse Compensatory Mechanisms Oncogene 2009, 28, 2925-2939 10.1038/onc.2009.170
-
(2009)
Oncogene
, vol.28
, pp. 2925-2939
-
-
Satyanarayana, A.1
Kaldis, P.2
-
38
-
-
84931044324
-
Silver Nanoparticles Protect Human Keratinocytes against Uvb Radiation-Induced DNA Damage and Apoptosis: Potential for Prevention of Skin Carcinogenesis
-
Arora, S.; Tyagi, N.; Bhardwaj, A.; Rusu, L.; Palanki, R.; Vig, K.; Singh, S. R.; Singh, A. P.; Palanki, S.; Miller, M. E.; Carter, J. E.; Singh, S. Silver Nanoparticles Protect Human Keratinocytes against Uvb Radiation-Induced DNA Damage and Apoptosis: Potential for Prevention of Skin Carcinogenesis Nanomedicine 2015, 11, 1265-1275 10.1016/j.nano.2015.02.024
-
(2015)
Nanomedicine
, vol.11
, pp. 1265-1275
-
-
Arora, S.1
Tyagi, N.2
Bhardwaj, A.3
Rusu, L.4
Palanki, R.5
Vig, K.6
Singh, S.R.7
Singh, A.P.8
Palanki, S.9
Miller, M.E.10
Carter, J.E.11
Singh, S.12
-
39
-
-
36749023902
-
Dulxanthone a Induces Cell Cycle Arrest and Apoptosis Via up-Regulation of P53 through Mitochondrial Pathway in Hepg2 Cells
-
Tian, Z.; Shen, J.; Moseman, A. P.; Yang, Q.; Yang, J.; Xiao, P.; Wu, E.; Kohane, I. S. Dulxanthone a Induces Cell Cycle Arrest and Apoptosis Via up-Regulation of P53 through Mitochondrial Pathway in Hepg2 Cells Int. J. Cancer 2008, 122, 31-38 10.1002/ijc.23048
-
(2008)
Int. J. Cancer
, vol.122
, pp. 31-38
-
-
Tian, Z.1
Shen, J.2
Moseman, A.P.3
Yang, Q.4
Yang, J.5
Xiao, P.6
Wu, E.7
Kohane, I.S.8
-
40
-
-
84922011528
-
Biology of the Cell Cycle Inhibitor P21(Cdkn1a): Molecular Mechanisms and Relevance in Chemical Toxicology
-
Dutto, I.; Tillhon, M.; Cazzalini, O.; Stivala, L. A.; Prosperi, E. Biology of the Cell Cycle Inhibitor P21(Cdkn1a): Molecular Mechanisms and Relevance in Chemical Toxicology Arch. Toxicol. 2015, 89, 155-178 10.1007/s00204-014-1430-4
-
(2015)
Arch. Toxicol.
, vol.89
, pp. 155-178
-
-
Dutto, I.1
Tillhon, M.2
Cazzalini, O.3
Stivala, L.A.4
Prosperi, E.5
-
41
-
-
0027717617
-
P21 Is a Universal Inhibitor of Cyclin Kinases
-
Xiong, Y.; Hannon, G. J.; Zhang, H.; Casso, D.; Kobayashi, R.; Beach, D. P21 Is a Universal Inhibitor of Cyclin Kinases Nature 1993, 366, 701-704 10.1038/366701a0
-
(1993)
Nature
, vol.366
, pp. 701-704
-
-
Xiong, Y.1
Hannon, G.J.2
Zhang, H.3
Casso, D.4
Kobayashi, R.5
Beach, D.6
-
42
-
-
84964311256
-
Infiltration of Plasma Rich in Growth Factors Enhances in Vivo Angiogenesis and Improves Reperfusion and Tissue Remodeling after Severe Hind Limb Ischemia
-
Anitua, E.; Pelacho, B.; Prado, R.; Aguirre, J. J.; Sanchez, M.; Padilla, S.; Aranguren, X. L.; Abizanda, G.; Collantes, M.; Hernandez, M.; Perez-Ruiz, A.; Penuelas, I.; Orive, G.; Prosper, F. Infiltration of Plasma Rich in Growth Factors Enhances in Vivo Angiogenesis and Improves Reperfusion and Tissue Remodeling after Severe Hind Limb Ischemia J. Controlled Release 2015, 202, 31-39 10.1016/j.jconrel.2015.01.029
-
(2015)
J. Controlled Release
, vol.202
, pp. 31-39
-
-
Anitua, E.1
Pelacho, B.2
Prado, R.3
Aguirre, J.J.4
Sanchez, M.5
Padilla, S.6
Aranguren, X.L.7
Abizanda, G.8
Collantes, M.9
Hernandez, M.10
Perez-Ruiz, A.11
Penuelas, I.12
Orive, G.13
Prosper, F.14
-
43
-
-
84866757805
-
Sklb1002, a Novel Inhibitor of Vegf Receptor 2 Signaling, Induces Vascular Normalization to Improve Systemically Administered Chemotherapy Efficacy
-
Shen, G.; Li, Y.; Du, T.; Shi, G.; Dai, L.; Chen, X.; Zheng, R.; Li, W.; Su, X.; Zhang, S.; Wei, Y.; Yang, S.; Deng, H. Sklb1002, a Novel Inhibitor of Vegf Receptor 2 Signaling, Induces Vascular Normalization to Improve Systemically Administered Chemotherapy Efficacy Neoplasma 2012, 59, 486-493 10.4149/neo-2012-062
-
(2012)
Neoplasma
, vol.59
, pp. 486-493
-
-
Shen, G.1
Li, Y.2
Du, T.3
Shi, G.4
Dai, L.5
Chen, X.6
Zheng, R.7
Li, W.8
Su, X.9
Zhang, S.10
Wei, Y.11
Yang, S.12
Deng, H.13
-
44
-
-
0034648765
-
Angiogenesis in Cancer and Other Diseases
-
Carmeliet, P.; Jain, R. K. Angiogenesis in Cancer and Other Diseases Nature 2000, 407, 249-257 10.1038/35025220
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
45
-
-
84881002286
-
Microrna-195 Suppresses Angiogenesis and Metastasis of Hepatocellular Carcinoma by Inhibiting the Expression of Vegf, Vav2, and Cdc42
-
Wang, R.; Zhao, N.; Li, S.; Fang, J. H.; Chen, M. X.; Yang, J.; Jia, W. H.; Yuan, Y.; Zhuang, S. M. Microrna-195 Suppresses Angiogenesis and Metastasis of Hepatocellular Carcinoma by Inhibiting the Expression of Vegf, Vav2, and Cdc42 Hepatology 2013, 58, 642-653 10.1002/hep.26373
-
(2013)
Hepatology
, vol.58
, pp. 642-653
-
-
Wang, R.1
Zhao, N.2
Li, S.3
Fang, J.H.4
Chen, M.X.5
Yang, J.6
Jia, W.H.7
Yuan, Y.8
Zhuang, S.M.9
-
46
-
-
84940210504
-
Immunoglobulin Fc-Fused, Neuropilin-1-Specific Peptide Shows Efficient Tumor Tissue Penetration and Inhibits Tumor Growth Via Anti-Angiogenesis
-
Kim, Y. J.; Bae, J.; Shin, T. H.; Kang, S. H.; Jeong, M.; Han, Y.; Park, J. H.; Kim, S. K.; Kim, Y. S. Immunoglobulin Fc-Fused, Neuropilin-1-Specific Peptide Shows Efficient Tumor Tissue Penetration and Inhibits Tumor Growth Via Anti-Angiogenesis J. Controlled Release 2015, 216, 56-68 10.1016/j.jconrel.2015.08.016
-
(2015)
J. Controlled Release
, vol.216
, pp. 56-68
-
-
Kim, Y.J.1
Bae, J.2
Shin, T.H.3
Kang, S.H.4
Jeong, M.5
Han, Y.6
Park, J.H.7
Kim, S.K.8
Kim, Y.S.9
-
47
-
-
77952901022
-
Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs
-
Sugahara, K. N.; Teesalu, T.; Karmali, P. P.; Kotamraju, V. R.; Agemy, L.; Greenwald, D. R.; Ruoslahti, E. Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs Science 2010, 328, 1031-1035 10.1126/science.1183057
-
(2010)
Science
, vol.328
, pp. 1031-1035
-
-
Sugahara, K.N.1
Teesalu, T.2
Karmali, P.P.3
Kotamraju, V.R.4
Agemy, L.5
Greenwald, D.R.6
Ruoslahti, E.7
-
48
-
-
84921038666
-
Cell Penetrating Peptides Improve Tumor Delivery of Cargos through Neuropilin-1-Dependent Extravasation
-
Kadonosono, T.; Yamano, A.; Goto, T.; Tsubaki, T.; Niibori, M.; Kuchimaru, T.; Kizaka-Kondoh, S. Cell Penetrating Peptides Improve Tumor Delivery of Cargos through Neuropilin-1-Dependent Extravasation J. Controlled Release 2015, 201, 14-21 10.1016/j.jconrel.2015.01.011
-
(2015)
J. Controlled Release
, vol.201
, pp. 14-21
-
-
Kadonosono, T.1
Yamano, A.2
Goto, T.3
Tsubaki, T.4
Niibori, M.5
Kuchimaru, T.6
Kizaka-Kondoh, S.7
-
49
-
-
84872530496
-
De Novo Design of a Tumor-Penetrating Peptide
-
Alberici, L.; Roth, L.; Sugahara, K. N.; Agemy, L.; Kotamraju, V. R.; Teesalu, T.; Bordignon, C.; Traversari, C.; Rizzardi, G. P.; Ruoslahti, E. De Novo Design of a Tumor-Penetrating Peptide Cancer Res. 2013, 73, 804-812 10.1158/0008-5472.CAN-12-1668
-
(2013)
Cancer Res.
, vol.73
, pp. 804-812
-
-
Alberici, L.1
Roth, L.2
Sugahara, K.N.3
Agemy, L.4
Kotamraju, V.R.5
Teesalu, T.6
Bordignon, C.7
Traversari, C.8
Rizzardi, G.P.9
Ruoslahti, E.10
-
50
-
-
84864125045
-
Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles
-
Ruoslahti, E. Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles Adv. Mater. 2012, 24, 3747-3756 10.1002/adma.201200454
-
(2012)
Adv. Mater.
, vol.24
, pp. 3747-3756
-
-
Ruoslahti, E.1
-
51
-
-
72949119124
-
Integrins in Cancer: Biological Implications and Therapeutic Opportunities
-
Desgrosellier, J. S.; Cheresh, D. A. Integrins in Cancer: Biological Implications and Therapeutic Opportunities Nat. Rev. Cancer 2010, 10, 9-22 10.1038/nrc2748
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
52
-
-
84904727941
-
Tumor Penetrability and Anti-Angiogenesis Using Irgd-Mediated Delivery of Doxorubicin-Polymer Conjugates
-
Wang, K.; Zhang, X.; Liu, Y.; Liu, C.; Jiang, B.; Jiang, Y. Tumor Penetrability and Anti-Angiogenesis Using Irgd-Mediated Delivery of Doxorubicin-Polymer Conjugates Biomaterials 2014, 35, 8735-8747 10.1016/j.biomaterials.2014.06.042
-
(2014)
Biomaterials
, vol.35
, pp. 8735-8747
-
-
Wang, K.1
Zhang, X.2
Liu, Y.3
Liu, C.4
Jiang, B.5
Jiang, Y.6
-
53
-
-
84877037947
-
The Influence of the Penetrating Peptide Irgd on the Effect of Paclitaxel-Loaded Mt1-Af7p-Conjugated Nanoparticles on Glioma Cells
-
Gu, G.; Gao, X.; Hu, Q.; Kang, T.; Liu, Z.; Jiang, M.; Miao, D.; Song, Q.; Yao, L.; Tu, Y.; Pang, Z.; Chen, H.; Jiang, X.; Chen, J. The Influence of the Penetrating Peptide Irgd on the Effect of Paclitaxel-Loaded Mt1-Af7p-Conjugated Nanoparticles on Glioma Cells Biomaterials 2013, 34, 5138-5148 10.1016/j.biomaterials.2013.03.036
-
(2013)
Biomaterials
, vol.34
, pp. 5138-5148
-
-
Gu, G.1
Gao, X.2
Hu, Q.3
Kang, T.4
Liu, Z.5
Jiang, M.6
Miao, D.7
Song, Q.8
Yao, L.9
Tu, Y.10
Pang, Z.11
Chen, H.12
Jiang, X.13
Chen, J.14
-
54
-
-
84935013113
-
A Tumor-Penetrating Peptide Enhances Circulation-Independent Targeting of Peritoneal Carcinomatosis
-
Sugahara, K. N.; Scodeller, P.; Braun, G. B.; de Mendoza, T. H.; Yamazaki, C. M.; Kluger, M. D.; Kitayama, J.; Alvarez, E.; Howell, S. B.; Teesalu, T.; Ruoslahti, E.; Lowy, A. M. A Tumor-Penetrating Peptide Enhances Circulation-Independent Targeting of Peritoneal Carcinomatosis J. Controlled Release 2015, 212, 59-69 10.1016/j.jconrel.2015.06.009
-
(2015)
J. Controlled Release
, vol.212
, pp. 59-69
-
-
Sugahara, K.N.1
Scodeller, P.2
Braun, G.B.3
De Mendoza, T.H.4
Yamazaki, C.M.5
Kluger, M.D.6
Kitayama, J.7
Alvarez, E.8
Howell, S.B.9
Teesalu, T.10
Ruoslahti, E.11
Lowy, A.M.12
-
55
-
-
84921059222
-
Tumor-Penetrating Peptide Fused Egfr Single-Domain Antibody Enhances Cancer Drug Penetration into 3d Multicellular Spheroids and Facilitates Effective Gastric Cancer Therapy
-
Sha, H.; Zou, Z.; Xin, K.; Bian, X.; Cai, X.; Lu, W.; Chen, J.; Chen, G.; Huang, L.; Blair, A. M.; Cao, P.; Liu, B. Tumor-Penetrating Peptide Fused Egfr Single-Domain Antibody Enhances Cancer Drug Penetration into 3d Multicellular Spheroids and Facilitates Effective Gastric Cancer Therapy J. Controlled Release 2015, 200, 188-200 10.1016/j.jconrel.2014.12.039
-
(2015)
J. Controlled Release
, vol.200
, pp. 188-200
-
-
Sha, H.1
Zou, Z.2
Xin, K.3
Bian, X.4
Cai, X.5
Lu, W.6
Chen, J.7
Chen, G.8
Huang, L.9
Blair, A.M.10
Cao, P.11
Liu, B.12
-
56
-
-
78049457409
-
Utilizing Targeted Cancer Therapeutic Agents in Combination: Novel Approaches and Urgent Requirements
-
Kummar, S.; Chen, H. X.; Wright, J.; Holbeck, S.; Millin, M. D.; Tomaszewski, J.; Zweibel, J.; Collins, J.; Doroshow, J. H. Utilizing Targeted Cancer Therapeutic Agents in Combination: Novel Approaches and Urgent Requirements Nat. Rev. Drug Discovery 2010, 9, 843-856 10.1038/nrd3216
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 843-856
-
-
Kummar, S.1
Chen, H.X.2
Wright, J.3
Holbeck, S.4
Millin, M.D.5
Tomaszewski, J.6
Zweibel, J.7
Collins, J.8
Doroshow, J.H.9
|