Deoxycholic acid-modified chitooligosaccharide/mPEG-PDLLA mixed micelles loaded with paclitaxel for enhanced antitumor efficacy

International Journal of Pharmaceutics

Volumn 475, Issue 1-2, 2014, Pages 60-68

  Jiang, Chengjun ^a   Wang, Hangxiang ^b   Zhang, Xiaomin ^c   Sun, Zhibin ^c   Wang, Feng ^d   Cheng, Jun ^b   Xie, Haiyang ^b   Yu, Bo ^c   Zhou, Lin ^b  

^a ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c Biotech (Hangzhou) CoLtd   (China)

^d SHANGHAI NORMAL UNIVERSITY   (China)

Author keywords

Chitooligosaccharide; Mixed micelles; Paclitaxel; PEG PDLLA; Polymeric micelles

Indexed keywords

CHITOSE OLIGOSACCHARIDE; COPOLYMER; DEOXYCHOLIC ACID; METHOXY POLY(ETHYLENE GLYCOL) POLYLACTIDE COPOLYMER; OLIGOSACCHARIDE; PACLITAXEL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CHITIN; DELAYED RELEASE FORMULATION; DRUG CARRIER; MACROGOL DERIVATIVE; METHOXY POLY(ETHYLENE GLYCOL)-BLOCK-POLY(LACTIC ACID); MICELLE; NANOPARTICLE; OLIGOCHITOSAN; POLYESTER; CHITOSAN; DEOXYCHOLIC ACID MODIFIED CHITOOLIGOSACCHARIDE; POLY(ETHYLENE GLYCOL) POLYLACTIDE COPOLYMER;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL INTERACTION; CELL MEMBRANE; CIRCULATION TIME; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; EMBRYO; ENDOCYTOSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; MACROPHAGE; MALE; MAXIMUM PLASMA CONCENTRATION; MICELLE; MOLECULAR WEIGHT; MTT ASSAY; NANOENCAPSULATION; NONHUMAN; OPSONIZATION; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; WEIGHT CHANGE; ZEBRA FISH; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG SCREENING; GERMFREE ANIMAL; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHARMACOKINETICS; RANDOMIZATION; SPRAGUE DAWLEY RAT; SURFACE PROPERTY; THERAPEUTIC USE; TUMOR CELL LINE; ANIMAL EXPERIMENT; CYTOTOXICITY; EDEMA; ENCAPSULATION; MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CHITIN; DELAYED-ACTION PREPARATIONS; DEOXYCHOLIC ACID; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICE, NUDE; MICELLES; NANOPARTICLES; OLIGOSACCHARIDES; PACLITAXEL; POLYESTERS; POLYETHYLENE GLYCOLS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SPECIFIC PATHOGEN-FREE ORGANISMS; SURFACE PROPERTIES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZEBRAFISH;

EID: 84906875000     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.037     Document Type: Article

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