Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy

Journal of Controlled Release

Volumn 200, Issue , 2015, Pages 188-200

  Sha, Huizi ^a   Zou, Zhengyun ^a   Xin, Kai ^a   Bian, Xinyu ^a   Cai, Xueting ^b,c   Lu, Wuguang ^b,c   Chen, Jiao ^b,c   Chen, Gang ^d   Huang, Leaf ^e   Blair, Andrew M ^e   Cao, Peng ^b,c   Liu, Baorui ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b Jiangsu Provincial Hospital of Chinese Medicine   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d CHINA PHARMACEUTICAL UNIVERSITY   (China)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Anti EGFR sdAb; Drug delivery; Drug penetration; iRGD; Multicellular spheroids; Recombinant protein

Indexed keywords

ANTIBODIES; CELL CULTURE; DIAGNOSIS; DISEASES; DRUG DELIVERY; DRUG PRODUCTS; HISTOLOGY; PEPTIDES; PROTEINS; RECOMBINANT PROTEINS; TISSUE; TUMORS;

ANTI-EGFR; DRUG PENETRATION; EPIDERMAL GROWTH FACTOR RECEPTORS; IRGD; MULTICELLULAR SPHEROID; SINGLE-DOMAIN ANTIBODIES; TUMOR MICROENVIRONMENT; TUMOR-PENETRATING PEPTIDES;

DRUG THERAPY;

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CETUXIMAB; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; IRGD EPIDERMAL GROWTH FACTOR RECEPTOR SINGLE DOMAIN ANTIBODY; NANOBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ARGINYL-GLYCYL-ASPARTIC ACID; OLIGOPEPTIDE;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER INHIBITION; COMPETITIVE BINDING ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MEMBRANE PERMEABILITY; MOUSE; MULTICELLULAR SPHEROID; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; STOMACH CANCER; TUMOR CELL LINE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; STOMACH NEOPLASMS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; MALE; MICE, INBRED BALB C; MICE, INBRED ICR; OLIGOPEPTIDES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SINGLE-DOMAIN ANTIBODIES; SPHEROIDS, CELLULAR; STOMACH NEOPLASMS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84921059222     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.12.039     Document Type: Article

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